JPS6468367A - Novel bicyclic ethers or lactones - Google Patents

Novel bicyclic ethers or lactones

Info

Publication number
JPS6468367A
JPS6468367A JP22315687A JP22315687A JPS6468367A JP S6468367 A JPS6468367 A JP S6468367A JP 22315687 A JP22315687 A JP 22315687A JP 22315687 A JP22315687 A JP 22315687A JP S6468367 A JPS6468367 A JP S6468367A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound expressed
lactones
novel bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP22315687A
Other languages
Japanese (ja)
Inventor
Hirohisa Wakatsuka
Yoichi Iguchi
Yoshinobu Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP22315687A priority Critical patent/JPS6468367A/en
Publication of JPS6468367A publication Critical patent/JPS6468367A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I [A is formula II (R<5> is H or 1-4C alkyl) or formula III; R<1> is H or 1-4C alkyl (excluding tert. butyl); R<2> is methyl and R<3> is H, 1-4C alkyl or R<2> and R<3> are together oxo; R<4> is 1-8C alkyl; n is 1 or 2 (provided that when R<2> and R<3> are together oxo, n is only 2)] or nontoxic salt when A is formula II and R<5> is H. EXAMPLE:3,5-Dihydroxy-7-[3-methyl-5S-(2-methylbutylyloxy)-2-oxa-1R,6R- bicyclo [4,3,0] nona 7S-yl]heptanoic acid. USE:A HMG-CoA reductase inhibitor. PREPARATION:For example, a compound expressed by formula IV (R<5a> is 1-4C alkyl) is reduced to provide the compound expressed by formula V which is one compound expressed by formula I.
JP22315687A 1987-09-08 1987-09-08 Novel bicyclic ethers or lactones Pending JPS6468367A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22315687A JPS6468367A (en) 1987-09-08 1987-09-08 Novel bicyclic ethers or lactones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22315687A JPS6468367A (en) 1987-09-08 1987-09-08 Novel bicyclic ethers or lactones

Publications (1)

Publication Number Publication Date
JPS6468367A true JPS6468367A (en) 1989-03-14

Family

ID=16793669

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22315687A Pending JPS6468367A (en) 1987-09-08 1987-09-08 Novel bicyclic ethers or lactones

Country Status (1)

Country Link
JP (1) JPS6468367A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011013651A1 (en) * 2009-07-28 2011-02-03 小野薬品工業株式会社 Bicyclic compound and use thereof for medical purposes
WO2012102357A1 (en) * 2011-01-27 2012-08-02 小野薬品工業株式会社 Bicyclic compound and use thereof for medical purposes
US9150537B2 (en) 2011-01-27 2015-10-06 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
JP2016196499A (en) * 2010-07-15 2016-11-24 チェーチャン オーサン ファーマシューティカル カンパニー，リミティド Synthesis method of entecavir, and intermediate compound thereof
US10899729B2 (en) 2016-06-30 2021-01-26 Ono Pharmaceutical Co.. Ltd. Method for producing bicyclic compound

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201520B2 (en) 2009-07-28 2019-02-12 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
US9889114B2 (en) 2009-07-28 2018-02-13 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
US11617733B2 (en) 2009-07-28 2023-04-04 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
EP2653468A1 (en) * 2009-07-28 2013-10-23 Ono Pharmaceutical Co., Ltd. Bicyclic Compound and Use Thereof for Medical Purposes
US10940134B2 (en) 2009-07-28 2021-03-09 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
JP5652397B2 (en) * 2009-07-28 2015-01-14 小野薬品工業株式会社 Bicyclic compounds and their pharmaceutical uses
CN102498105A (en) * 2009-07-28 2012-06-13 小野药品工业株式会社 Bicyclic compound and use thereof for medical purposes
US8962868B2 (en) 2009-07-28 2015-02-24 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
US8614340B2 (en) 2009-07-28 2013-12-24 Ono Pharmaceuticals Co., Ltd. Bicyclic compound and use thereof for medical purposes
US9388157B2 (en) 2009-07-28 2016-07-12 Ono Pharmaceuticals Co., Ltd. Bicyclic compound and use thereof for medical purposes
WO2011013651A1 (en) * 2009-07-28 2011-02-03 小野薬品工業株式会社 Bicyclic compound and use thereof for medical purposes
JP2016196499A (en) * 2010-07-15 2016-11-24 チェーチャン オーサン ファーマシューティカル カンパニー，リミティド Synthesis method of entecavir, and intermediate compound thereof
US9029574B2 (en) 2011-01-27 2015-05-12 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
US9150537B2 (en) 2011-01-27 2015-10-06 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
WO2012102357A1 (en) * 2011-01-27 2012-08-02 小野薬品工業株式会社 Bicyclic compound and use thereof for medical purposes
US10899729B2 (en) 2016-06-30 2021-01-26 Ono Pharmaceutical Co.. Ltd. Method for producing bicyclic compound

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