CN102256953B - 哌嗪盐及其制备方法 - Google Patents

哌嗪盐及其制备方法 Download PDF

Info

Publication number
CN102256953B
CN102256953B CN200980150465.2A CN200980150465A CN102256953B CN 102256953 B CN102256953 B CN 102256953B CN 200980150465 A CN200980150465 A CN 200980150465A CN 102256953 B CN102256953 B CN 102256953B
Authority
CN
China
Prior art keywords
trans
tert
butoxycarbonyl
cyclohexyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980150465.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN102256953A (zh
Inventor
L·兹布拉
E·阿盖恩切森格
K·诺拉迪
B·朱哈兹
F·西部克
J·加兰博斯
I·瓦高
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of CN102256953A publication Critical patent/CN102256953A/zh
Application granted granted Critical
Publication of CN102256953B publication Critical patent/CN102256953B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN200980150465.2A 2008-12-17 2009-12-17 哌嗪盐及其制备方法 Active CN102256953B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP0800763 2008-12-17
HU0800763A HU230067B1 (hu) 2008-12-17 2008-12-17 Új piperazin só és eljárás előállítására
PCT/HU2009/000108 WO2010070369A1 (en) 2008-12-17 2009-12-17 Piperazine salt and a process for the preparation thereof

Publications (2)

Publication Number Publication Date
CN102256953A CN102256953A (zh) 2011-11-23
CN102256953B true CN102256953B (zh) 2016-06-01

Family

ID=89988672

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980150465.2A Active CN102256953B (zh) 2008-12-17 2009-12-17 哌嗪盐及其制备方法

Country Status (22)

Country Link
US (1) US8569496B2 (https=)
EP (1) EP2358690B1 (https=)
JP (1) JP5735923B2 (https=)
CN (1) CN102256953B (https=)
AU (1) AU2009329294B2 (https=)
BR (1) BRPI0923007B8 (https=)
CA (1) CA2743924C (https=)
DK (1) DK2358690T3 (https=)
EA (1) EA019024B1 (https=)
ES (1) ES2573957T3 (https=)
GE (1) GEP20125711B (https=)
HR (1) HRP20160726T1 (https=)
HU (2) HU230067B1 (https=)
IL (1) IL212639A0 (https=)
MX (1) MX2011006591A (https=)
NZ (1) NZ592907A (https=)
PL (1) PL2358690T3 (https=)
PT (1) PT2358690E (https=)
SI (1) SI2358690T1 (https=)
TW (1) TWI448455B (https=)
UA (1) UA104163C2 (https=)
WO (1) WO2010070369A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
ITMI20131693A1 (it) 2013-10-14 2015-04-15 Chemo Res S L Derivati della 1,4-cicloesilammina e loro preparazione
CN104496854B (zh) * 2015-01-06 2017-09-22 上海医药工业研究院 3‑环己基‑1,1‑二甲基脲类化合物及其制备方法和应用
HU231173B1 (hu) 2016-07-08 2021-06-28 Richter Gedeon Nyrt. Ipari eljárás cariprazine előállítására
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN111269199B (zh) * 2018-12-05 2022-04-08 浙江京新药业股份有限公司 一种卡利拉嗪的制备方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 新的卡利拉嗪制备方法
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂
CN114539185B (zh) * 2020-11-24 2024-12-24 上海新礼泰药业有限公司 一种卡利拉嗪及其中间体的制备方法
HUP2100108A1 (hu) 2021-03-12 2022-09-28 Richter Gedeon Nyrt Eljárás és berendezés gyógyászatilag alkalmazható piperazin származékok folyamatos áramú, áramlásos konszekutív redukálással történõ elõállítására
CN119874636A (zh) * 2025-01-16 2025-04-25 鲁南制药集团股份有限公司 一种卡利拉嗪的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008139235A2 (en) * 2007-05-11 2008-11-20 Richter Gedeon Nyrt. Novel piperazine salts as d3/d2 antagonists

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
WO1997011070A1 (en) 1995-09-22 1997-03-27 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
BR9909277A (pt) 1998-03-31 2001-10-16 Acadia Pharm Inc Compostos com atividade em receptores muscarìnicos
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
JP2000191570A (ja) * 1998-12-24 2000-07-11 Sumitomo Chem Co Ltd ヒドロキシフェニルプロパノール類の製造法
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
PL364640A1 (en) 2001-02-27 2004-12-13 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating bipolar disorder
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6833459B2 (en) * 2002-04-26 2004-12-21 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of thiazole intermediate
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
JP2008001633A (ja) * 2006-06-22 2008-01-10 Showa Denko Kk テトラヒドロピランを溶媒とする塩化アルミニウム存在下での水素化ホウ素化合物による還元反応
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
EP2155200B1 (en) 2007-05-11 2016-12-07 Richter Gedeon Nyrt. Crystalline form of a carbamoyl-cyclohexane derivative
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
AR070513A1 (es) 2007-08-01 2010-04-14 Lundbeck & Co As H Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008139235A2 (en) * 2007-05-11 2008-11-20 Richter Gedeon Nyrt. Novel piperazine salts as d3/d2 antagonists

Also Published As

Publication number Publication date
EP2358690B1 (en) 2016-03-30
AU2009329294A1 (en) 2010-06-24
CN102256953A (zh) 2011-11-23
UA104163C2 (ru) 2014-01-10
TW201035056A (en) 2010-10-01
EA201170810A1 (ru) 2011-12-30
SI2358690T1 (sl) 2016-07-29
US20110275816A1 (en) 2011-11-10
US8569496B2 (en) 2013-10-29
HUE029667T2 (en) 2017-04-28
HRP20160726T1 (hr) 2016-07-15
BRPI0923007B8 (pt) 2021-10-26
JP2012512239A (ja) 2012-05-31
BRPI0923007B1 (pt) 2021-08-17
CA2743924C (en) 2015-03-31
PL2358690T3 (pl) 2016-10-31
EA019024B1 (ru) 2013-12-30
EP2358690A1 (en) 2011-08-24
DK2358690T3 (en) 2016-07-18
BRPI0923007A2 (pt) 2015-08-11
MX2011006591A (es) 2011-07-12
AU2009329294B2 (en) 2014-04-10
HUP0800763A2 (en) 2010-11-29
NZ592907A (en) 2013-05-31
HU0800763D0 (en) 2009-03-02
CA2743924A1 (en) 2010-06-24
PT2358690E (pt) 2016-06-03
GEP20125711B (en) 2012-12-10
HU230067B1 (hu) 2015-06-29
JP5735923B2 (ja) 2015-06-17
WO2010070369A8 (en) 2011-04-28
WO2010070369A1 (en) 2010-06-24
ES2573957T3 (es) 2016-06-13
IL212639A0 (en) 2011-07-31
TWI448455B (zh) 2014-08-11

Similar Documents

Publication Publication Date Title
CN102256953B (zh) 哌嗪盐及其制备方法
CN105283442B (zh) 用于合成1‑(2‑((2,4‑二甲基苯基)硫代)苯基)哌嗪的方法
JP4386723B2 (ja) 新規方法
US8188285B2 (en) Purification process of Montelukast and its amine salts
US10227317B2 (en) Process for the preparation of vortioxetine
CN102007119B (zh) 嘧啶系化合物的制造方法
WO2015169130A1 (zh) 新的沃替西汀中间体及其合成方法
CN101356162A (zh) 旋光性氨基甲酸酯、其制备方法和作为药物中间体的用途
CN101321732B (zh) 制备白细胞三烯拮抗剂的方法及其中间体
CN101360727A (zh) 药物中间体的制备方法
HK1161587B (en) Piperazine salt and a process for the preparation thereof
HK1161587A (en) Piperazine salt and a process for the preparation thereof
CN102548951A (zh) 作为中间体的二氢化茚衍生物
CN1315781C (zh) 制备4－氨基－1－萘酚醚类化合物的方法
CN104169280A (zh) 制备索利那辛或其盐的方法和用于该方法的新型中间体
CN110627704A (zh) 巴多昔芬的制备方法
WO2004020401A1 (en) Synthesis of sulfonamide derivatives

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1161587

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1161587

Country of ref document: HK