ES2567161T3 - Procedimiento para el cultivo de células para la producción de sustancias - Google Patents
Procedimiento para el cultivo de células para la producción de sustancias Download PDFInfo
- Publication number
- ES2567161T3 ES2567161T3 ES10152393.4T ES10152393T ES2567161T3 ES 2567161 T3 ES2567161 T3 ES 2567161T3 ES 10152393 T ES10152393 T ES 10152393T ES 2567161 T3 ES2567161 T3 ES 2567161T3
- Authority
- ES
- Spain
- Prior art keywords
- glucose
- procedure
- qglcmáx
- consumption rate
- limitation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 7
- 239000000126 substance Substances 0.000 title abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 11
- 239000008103 glucose Substances 0.000 abstract description 11
- 210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 5
- 238000012423 maintenance Methods 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- VOZDNCFKGOLECZ-BTVCFUMJSA-N 2-hydroxypropanoic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O VOZDNCFKGOLECZ-BTVCFUMJSA-N 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10255508A DE10255508A1 (de) | 2002-11-27 | 2002-11-27 | Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen |
| DE10255508 | 2002-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2567161T3 true ES2567161T3 (es) | 2016-04-20 |
Family
ID=32318751
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03767406T Expired - Lifetime ES2340377T3 (es) | 2002-11-27 | 2003-11-07 | Procedimiento para el cultivo de celulas para la produccion de substancias. |
| ES10152393.4T Expired - Lifetime ES2567161T3 (es) | 2002-11-27 | 2003-11-07 | Procedimiento para el cultivo de células para la producción de sustancias |
| ES10176622T Expired - Lifetime ES2749217T3 (es) | 2002-11-27 | 2003-11-07 | Procedimiento para cultivar células para la producción de sustancias |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03767406T Expired - Lifetime ES2340377T3 (es) | 2002-11-27 | 2003-11-07 | Procedimiento para el cultivo de celulas para la produccion de substancias. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10176622T Expired - Lifetime ES2749217T3 (es) | 2002-11-27 | 2003-11-07 | Procedimiento para cultivar células para la producción de sustancias |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060127975A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1585810B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4469283B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE462013T1 (cg-RX-API-DMAC7.html) |
| CY (2) | CY1110267T1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE10255508A1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK2226381T3 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2340377T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE028862T2 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1585810E (cg-RX-API-DMAC7.html) |
| SI (3) | SI2226381T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004048556A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998042377A1 (fr) | 1997-03-21 | 1998-10-01 | Chugai Seiyaku Kabushiki Kaisha | Substances servant a la prevention ou au traitement de maladies liees a la cellule-t sensibilisee contenant comme principe actif des antagonistes de l'il-6 |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| DK1623019T4 (en) | 2003-05-15 | 2017-03-27 | Wyeth Llc | LIMITED GLUCOSE SUPPLY TO ANIMAL CELL CULTURE |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| DE102008002210A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Erythropoietin |
| AU2016210748B2 (en) * | 2009-10-26 | 2018-03-01 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| SG10201510640QA (en) | 2009-10-26 | 2016-01-28 | Hoffmann La Roche | Method For The Production Of A Glycosylated Immunoglobulin |
| AU2015203309B2 (en) * | 2009-10-26 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| TWI624546B (zh) * | 2009-12-22 | 2018-05-21 | Ｄｓｍ智慧財產有限公司 | 由發酵法獲得的６-胺己酸製備己內醯胺（三） |
| KR102116202B1 (ko) | 2010-11-08 | 2020-05-28 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| EP3017303B1 (en) | 2013-07-04 | 2018-01-03 | F.Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
| EP3119876B1 (en) | 2014-03-19 | 2024-12-18 | Pfizer Inc. | Method of cell culture |
| EP4446338A3 (en) | 2015-09-23 | 2025-05-07 | Pfizer Inc. | Cells and method of cell culture |
| EP3891292A1 (en) | 2018-12-06 | 2021-10-13 | Pfizer Inc. | Cells with reduced inhibitor production and methods of use thereof |
| WO2025088516A1 (en) | 2023-10-26 | 2025-05-01 | Pfizer Inc. | Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657863A (en) * | 1982-07-02 | 1987-04-14 | Celanese Corporation | Stabilization of a mutant microorganism population |
| JPH066054B2 (ja) * | 1987-10-15 | 1994-01-26 | 帝人株式会社 | 動物細胞の培養方法 |
| JP3494300B2 (ja) * | 1990-04-03 | 2004-02-09 | ジェネンテック・インコーポレーテッド | Ｈｉｖに対する予防接種のための方法および組成物 |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| JPH08508875A (ja) | 1992-05-01 | 1996-09-24 | 帝人株式会社 | 蛋白分泌細胞の流加回分培養法 |
| GB9506249D0 (en) * | 1995-03-27 | 1995-05-17 | Karobio Ab | Media for insect cell cultures |
| WO1998041611A1 (en) * | 1997-03-20 | 1998-09-24 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
| US6338964B1 (en) * | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
-
2002
- 2002-11-27 DE DE10255508A patent/DE10255508A1/de not_active Withdrawn
-
2003
- 2003-11-07 DE DE50312554T patent/DE50312554D1/de not_active Expired - Lifetime
- 2003-11-07 EP EP03767406A patent/EP1585810B1/de not_active Expired - Lifetime
- 2003-11-07 WO PCT/DE2003/003693 patent/WO2004048556A1/de not_active Ceased
- 2003-11-07 EP EP10176622.8A patent/EP2275530B1/de not_active Expired - Lifetime
- 2003-11-07 DK DK10152393.4T patent/DK2226381T3/en active
- 2003-11-07 HU HUE10152393A patent/HUE028862T2/en unknown
- 2003-11-07 DK DK03767406.6T patent/DK1585810T3/da active
- 2003-11-07 ES ES03767406T patent/ES2340377T3/es not_active Expired - Lifetime
- 2003-11-07 PT PT03767406T patent/PT1585810E/pt unknown
- 2003-11-07 ES ES10152393.4T patent/ES2567161T3/es not_active Expired - Lifetime
- 2003-11-07 SI SI200332473A patent/SI2226381T1/sl unknown
- 2003-11-07 EP EP10152393.4A patent/EP2226381B1/de not_active Expired - Lifetime
- 2003-11-07 SI SI200331791T patent/SI1585810T1/sl unknown
- 2003-11-07 ES ES10176622T patent/ES2749217T3/es not_active Expired - Lifetime
- 2003-11-07 SI SI200332602T patent/SI2275530T1/sl unknown
- 2003-11-07 JP JP2004554195A patent/JP4469283B2/ja not_active Expired - Lifetime
- 2003-11-07 US US10/535,581 patent/US20060127975A1/en not_active Abandoned
- 2003-11-07 AT AT03767406T patent/ATE462013T1/de active
-
2010
- 2010-01-19 JP JP2010009094A patent/JP5221573B2/ja not_active Expired - Lifetime
- 2010-06-11 CY CY20101100518T patent/CY1110267T1/el unknown
-
2014
- 2014-01-21 US US14/160,336 patent/US20140329277A1/en not_active Abandoned
-
2016
- 2016-05-13 CY CY20161100413T patent/CY1117558T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006507821A (ja) | 2006-03-09 |
| US20140329277A1 (en) | 2014-11-06 |
| JP4469283B2 (ja) | 2010-05-26 |
| CY1117558T1 (el) | 2017-04-26 |
| SI2275530T1 (sl) | 2019-11-29 |
| ES2749217T3 (es) | 2020-03-19 |
| ES2340377T3 (es) | 2010-06-02 |
| EP2226381A1 (de) | 2010-09-08 |
| HUE028862T2 (en) | 2017-01-30 |
| JP2010110331A (ja) | 2010-05-20 |
| CY1110267T1 (el) | 2015-01-14 |
| EP2275530A2 (de) | 2011-01-19 |
| EP2226381B1 (de) | 2016-03-09 |
| DE50312554D1 (de) | 2010-05-06 |
| ATE462013T1 (de) | 2010-04-15 |
| SI2226381T1 (sl) | 2016-05-31 |
| EP1585810B1 (de) | 2010-03-24 |
| SI1585810T1 (sl) | 2010-06-30 |
| WO2004048556A1 (de) | 2004-06-10 |
| JP5221573B2 (ja) | 2013-06-26 |
| EP2275530A3 (de) | 2012-05-23 |
| EP1585810A1 (de) | 2005-10-19 |
| DK1585810T3 (da) | 2010-06-07 |
| DE10255508A1 (de) | 2004-06-17 |
| US20060127975A1 (en) | 2006-06-15 |
| DK2226381T3 (en) | 2016-04-11 |
| EP2275530B1 (de) | 2019-08-07 |
| PT1585810E (pt) | 2010-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2567161T3 (es) | Procedimiento para el cultivo de células para la producción de sustancias | |
| CN101914495A (zh) | 用于体外大量扩增毛囊干细胞的培养方法 | |
| Chan | What Is Physiology? | |
| CN113073121A (zh) | 一种含高聚合度多聚磷酸盐的纳米碳材料及高聚合度多聚磷酸盐的制备方法 | |
| CN106577278B (zh) | 促进牛大力毛状根多糖积累的方法 | |
| CN103316046B (zh) | 一种体外培育牛黄的酶促生产工艺 | |
| CN110615434A (zh) | 一种利用骨灰制备人工钻石的方法及其产品 | |
| CN110551772A (zh) | 一种提高l-异亮氨酸产量的方法 | |
| CN102239783B (zh) | 一种抑制真姬菇生育后期菌盖结瘤的方法 | |
| CN1343523A (zh) | 微孔异体(种)无细胞真皮替代物 | |
| CN107974470B (zh) | 一种提高被孢霉合成多不饱和脂肪酸油脂的方法 | |
| CN110938138B (zh) | 一种同时提取藻蓝蛋白和甘油葡萄糖苷的方法 | |
| CN116083340A (zh) | 一种抑制黑化反应、低内毒素的家蚕血淋巴液的制备方法 | |
| CN1543866A (zh) | 林蛙高蛋白钙粉及生产工艺 | |
| WO2017221591A1 (ja) | 細胞処理システム及び細胞供給方法 | |
| CN201319786Y (zh) | 闭锁式超声波生物育苗装置 | |
| CN104293733B (zh) | 卵巢组织冻融后早期体外培养液及培养方法 | |
| JPH08154663A (ja) | 生体組織維持容器 | |
| Holmes et al. | Comparison of humidified versus non-humidified incubation with sequential culture media in a time-lapse incubator using sibling oocyte splits | |
| TW200827440A (en) | An attacking separation method for embryonic stem cell membrane | |
| JP6735460B2 (ja) | 分化細胞の生産方法 | |
| KR100371274B1 (ko) | 모발 이식용 키트 | |
| KR20020005331A (ko) | 모낭 세포의 배양 방법 및 모발 이식용 키트 | |
| Krugluger et al. | Induction of vascular endothelial growth factor messenger ribonucleic acid expression in stored micrografts by aminoguanidine | |
| CN117264874A (zh) | 用于治疗白癜风的黑色素细胞的培养方法及应用 |