ES2567160T3 - Modulador de la expresión para el gen reloj Period - Google Patents
Modulador de la expresión para el gen reloj Period Download PDFInfo
- Publication number
- ES2567160T3 ES2567160T3 ES11762283.7T ES11762283T ES2567160T3 ES 2567160 T3 ES2567160 T3 ES 2567160T3 ES 11762283 T ES11762283 T ES 11762283T ES 2567160 T3 ES2567160 T3 ES 2567160T3
- Authority
- ES
- Spain
- Prior art keywords
- expression modulator
- expression
- period gene
- clock gene
- period clock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 101150038243 CLOCK gene Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract description 11
- 230000027288 circadian rhythm Effects 0.000 abstract description 3
- 239000000284 extract Substances 0.000 abstract description 2
- 241000949456 Zanthoxylum Species 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000033764 rhythmic process Effects 0.000 abstract 1
- 239000010678 thyme oil Substances 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- -1 sorbitan monolaurate ester Chemical class 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 101000801619 Homo sapiens Long-chain-fatty-acid-CoA ligase ACSBG1 Proteins 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 102100033564 Long-chain-fatty-acid-CoA ligase ACSBG1 Human genes 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 235000010634 bubble gum Nutrition 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000002166 wet spinning Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
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- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso cosmético de extracto de Zanthoxylum para modular el ritmo circadiano para mejorar la piel áspera resultante de la disfunción de los ritmos circadianos induciendo ritmos de expresión de un gen Period o promoviendo la expresión de un gen Period.
Description
5
10
15
- (10)
- Hidróxido de potasio 0,15
- (11)
- Modulador de la expresión para gen Period (aceite de tomillo) 1,0 [Crema de masaje]
- (1)
- Parafina sólida 5,0
- (2)
- Cera de abeja 10,0
- (3)
- Vaselina 15,0
- (4)
- Parafina fluida 41,0
- (5)
- 1,3-Butilenglicol 4,0
- (6) (7)
- Monoestearato de glicerina Éster de monolaurato de sorbitano POE (20) 2,0 2,0
- (8)
- Bórax 0,2
- (9)
- Cafeína 2,0
- (10)
- Conservante según sea necesario
- (11)
- Antioxidante según sea necesario
- (12)
- Modulador de la expresión para gen Period (aceite de tomillo) 1,0
- (13)
- Agua purificada resto
[Fibra aromática]
Se añadieron microcápsulas que contenían el modulador de la expresión para el gen Period (diámetro de partícula: no mayor de 50 m (micrómetros); porcentaje de aceite esencial en la microcápsula: 50% en peso) a una disolución de celulosa de cupramonio (concentración de celulosa; 10% en peso; concentración de amonio: 7% en peso; concentración de cobre: 3,6% en peso) en el intervalo del 0,1% en peso al 20% en peso del peso de la celulosa, se mezcló y se hiló mediante un método de hilatura en húmedo convencional, y se obtuvo fibra aromática tras una etapa de refinado y una etapa de secado.
[Gránulos]
- (1)
- Sucralosa 0,1
- (2)
- Modulador de la expresión para gen Period (aceite de tomillo) 0,1
- (3)
- Saborizante 5,0
- (4)
- Excipiente (Ceolus) 10,0
- (5)
- Maltitol resto
[Comprimidos (de tipo masticable)]
- (1)
- Inositol 11,0
- (2)
- Maltitol 21,0
- (3)
- Sacarosa 0,5
- (4)
- Extracto de esperma de salmón (DNA Na) 0,1
- (5)
- Extracto de levadura 0,1
- (6)
- Modulador de la expresión para gen Period (aceite de tomillo) 0,1
- (7)
- Saborizante 5,0
- (8)
- Excipiente resto
[Comprimidos]
- (1)
- Lubricante (éster de ácido graso de sacarosa, etc.) 1,0
- (2)
- Disolución acuosa de goma arábiga (5%) 2,0
- (3)
- Acidulante 1,0
- (4)
- Colorante según sea necesario
- (5)
- Modulador de la expresión para gen Period (aceite de tomillo) 0,1
- (6)
- Azúcares (azúcar en polvo, sorbitol, etc.) resto
[Caramelo]
- (1)
- Azúcar 50,0
- (2)
- Sirope de almidón 47,95
- (3)
- Ácidos orgánicos 2,0
- (4)
- Modulador de la expresión para gen Period (aceite de tomillo) 0,05
[Chicle]
- (1)
- Azúcar 43,0
- (2)
- Base de chicle 30,95
- (3)
- Glucosa 10,0
- (4)
- Sirope de almidón 16,0
- (5)
- Modulador de la expresión para gen Period (aceite de tomillo) 0,05
Los productos de estos ejemplos de composición pueden regular la expresión del gen Period y modular el ritmo circadiano del organismo vivo mediante un uso de prueba de cada forma de producto de una manera típica de uso.
8
Claims (1)
-
imagen1
Applications Claiming Priority (5)
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JP2010083016 | 2010-03-31 | ||
JP2010083016 | 2010-03-31 | ||
JP2010083017 | 2010-03-31 | ||
JP2010083017 | 2010-03-31 | ||
PCT/JP2011/001941 WO2011122041A1 (ja) | 2010-03-31 | 2011-03-30 | 時計遺伝子Periodの発現調節剤 |
Publications (1)
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ES2567160T3 true ES2567160T3 (es) | 2016-04-20 |
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ES11762283.7T Active ES2567160T3 (es) | 2010-03-31 | 2011-03-30 | Modulador de la expresión para el gen reloj Period |
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US (1) | US20130022692A1 (es) |
EP (1) | EP2554178B1 (es) |
JP (1) | JP5868313B2 (es) |
KR (1) | KR101770706B1 (es) |
CN (1) | CN103025339B (es) |
ES (1) | ES2567160T3 (es) |
HK (1) | HK1183450A1 (es) |
TW (1) | TWI552756B (es) |
WO (1) | WO2011122041A1 (es) |
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JPWO2013046272A1 (ja) * | 2011-09-29 | 2015-03-26 | 株式会社 資生堂 | 時計遺伝子およびヒアルロン酸合成酵素遺伝子発現促進剤 |
CN103857381B (zh) | 2011-09-29 | 2016-06-22 | 株式会社资生堂 | 时钟基因和透明质酸合成酶基因表达促进剂 |
JP2013184921A (ja) | 2012-03-07 | 2013-09-19 | Shiseido Co Ltd | 時計遺伝子の発現調節剤 |
JP5487227B2 (ja) * | 2012-03-09 | 2014-05-07 | 株式会社 資生堂 | ヒアルロン酸合成酵素遺伝子の発現促進剤 |
DE102012205059A1 (de) * | 2012-03-29 | 2013-10-02 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen enthaltend eine oder mehrere Substanzen die das Gen für den "Krüppel-like factor 9" (Klf9) modulieren |
DE102012205062A1 (de) * | 2012-03-29 | 2013-10-02 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen enthaltend eine mehere Substanzen die das Gen für den "Krüppel-like factor 9" (Klf9) modulieren |
DE102012205050A1 (de) * | 2012-03-29 | 2013-10-02 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen enthaltend eine oder mehrere Sustanzen die das Gen für den "Krüppel-like factor 9" (Klf9) modulieren |
DE102012205066A1 (de) * | 2012-03-29 | 2013-10-02 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen enthaltend eine oder mehrere Substanzen die das Gen für den "Krüppel-like factor 9" (Klf9) modulieren |
JP6049289B2 (ja) * | 2012-04-11 | 2016-12-21 | サントリーホールディングス株式会社 | 概日リズム調整剤 |
WO2014024518A1 (ja) * | 2012-08-10 | 2014-02-13 | 株式会社資生堂 | フィラグリン遺伝子発現促進剤 |
CA2922714A1 (en) | 2013-08-27 | 2015-03-05 | Suntory Holdings Limited | Clock gene expression level regulator |
JP2014074063A (ja) * | 2013-12-27 | 2014-04-24 | Shiseido Co Ltd | ヒアルロン酸合成酵素遺伝子の発現促進剤 |
JP6188881B2 (ja) * | 2016-07-12 | 2017-08-30 | 株式会社 資生堂 | ヒアルロン酸合成酵素遺伝子発現促進剤 |
KR102070391B1 (ko) * | 2018-05-10 | 2020-01-29 | 오세웅 | 화초 열매 추출물을 포함하는 입술 화장료 조성물 |
CN110305956B (zh) * | 2019-08-09 | 2021-07-06 | 北京大学 | 影响抑郁行为或抗抑郁行为的主效标记及其应用 |
JPWO2021182538A1 (es) * | 2020-03-10 | 2021-09-16 | ||
KR102607662B1 (ko) | 2021-04-08 | 2023-12-01 | 재단법인대구경북과학기술원 | 시계 유전자 Period의 발현 억제용 단일 가이드 RNA 조합, 및 이의 용도 |
WO2024106205A1 (ja) * | 2022-11-16 | 2024-05-23 | 株式会社豊田中央研究所 | 体内時計調整剤 |
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JP2003342123A (ja) * | 2002-05-31 | 2003-12-03 | Ichimaru Pharcos Co Ltd | コラゲナーゼ活性阻害剤、エラスターゼ活性阻害剤及び化粧料組成物 |
JP2003342184A (ja) * | 2002-05-31 | 2003-12-03 | Ichimaru Pharcos Co Ltd | ヒアルロニダーゼ活性阻害剤及び化粧料組成物 |
JP2004051486A (ja) * | 2002-07-16 | 2004-02-19 | Pola Chem Ind Inc | 熱産生交感神経活性化剤 |
JP2006034177A (ja) * | 2004-07-27 | 2006-02-09 | Hirose Yukihiro | 安眠を促進する作用を有する飲料 |
US20070086972A1 (en) * | 2005-09-12 | 2007-04-19 | Jacob Birnbaum | Hair growth compositions and methods for treating hair loss or related conditions |
JP2007197334A (ja) * | 2006-01-24 | 2007-08-09 | Lion Corp | 自律神経調整剤、睡眠改善剤又はストレス緩和剤用組成物 |
JP2007277149A (ja) * | 2006-04-06 | 2007-10-25 | Kao Corp | インボルクリン発現促進剤 |
JP2007320956A (ja) * | 2006-05-01 | 2007-12-13 | Uha Mikakuto Co Ltd | 動脈硬化抑制剤 |
JP4598740B2 (ja) * | 2006-09-22 | 2010-12-15 | 株式会社ファンケル | グルタチオン増強用組成物 |
GB0620279D0 (en) * | 2006-10-13 | 2006-11-22 | Reckitt Benckiser Uk Ltd | Compositions |
JP5414192B2 (ja) * | 2007-03-29 | 2014-02-12 | 江崎グリコ株式会社 | 概日リズム調整組成物 |
JP2009084216A (ja) * | 2007-09-28 | 2009-04-23 | Maruzen Pharmaceut Co Ltd | Atp産生促進剤および表皮細胞賦活化剤。 |
JP2009132662A (ja) | 2007-11-30 | 2009-06-18 | Maruzen Pharmaceut Co Ltd | グルタチオン産生促進剤 |
CN101327329A (zh) * | 2008-06-25 | 2008-12-24 | 海信科龙电器股份有限公司 | 一种含有挥发性成分的植物提取物组合物 |
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2011
- 2011-03-30 KR KR1020127028529A patent/KR101770706B1/ko active IP Right Grant
- 2011-03-30 CN CN201180017292.4A patent/CN103025339B/zh active Active
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- 2011-03-30 WO PCT/JP2011/001941 patent/WO2011122041A1/ja active Application Filing
- 2011-03-30 ES ES11762283.7T patent/ES2567160T3/es active Active
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- 2011-03-30 US US13/638,633 patent/US20130022692A1/en not_active Abandoned
- 2011-03-31 TW TW100111422A patent/TWI552756B/zh not_active IP Right Cessation
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Publication number | Publication date |
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EP2554178A4 (en) | 2013-08-28 |
CN103025339A (zh) | 2013-04-03 |
KR101770706B1 (ko) | 2017-08-23 |
EP2554178B1 (en) | 2016-01-13 |
WO2011122041A1 (ja) | 2011-10-06 |
CN103025339B (zh) | 2015-06-17 |
HK1183450A1 (en) | 2013-12-27 |
JPWO2011122041A1 (ja) | 2013-07-04 |
KR20130040854A (ko) | 2013-04-24 |
US20130022692A1 (en) | 2013-01-24 |
JP5868313B2 (ja) | 2016-02-24 |
EP2554178A1 (en) | 2013-02-06 |
TW201201824A (en) | 2012-01-16 |
TWI552756B (zh) | 2016-10-11 |
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