ES2566335T3 - Método de activación de linfocitos citolíticos naturales mediante preparaciones de células tumorales in vitro - Google Patents

Método de activación de linfocitos citolíticos naturales mediante preparaciones de células tumorales in vitro Download PDF

Info

Publication number
ES2566335T3
ES2566335T3 ES06726410.1T ES06726410T ES2566335T3 ES 2566335 T3 ES2566335 T3 ES 2566335T3 ES 06726410 T ES06726410 T ES 06726410T ES 2566335 T3 ES2566335 T3 ES 2566335T3
Authority
ES
Spain
Prior art keywords
lymphocytes
cells
lysis
cell
lymphocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06726410.1T
Other languages
English (en)
Spanish (es)
Inventor
Mark W. Lowdell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCL Business Ltd
Original Assignee
UCL Business Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0505508A external-priority patent/GB0505508D0/en
Priority claimed from GB0514288A external-priority patent/GB0514288D0/en
Application filed by UCL Business Ltd filed Critical UCL Business Ltd
Application granted granted Critical
Publication of ES2566335T3 publication Critical patent/ES2566335T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/15Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49Breast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/50Cellular immunotherapy characterised by the use of allogeneic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mycology (AREA)
  • Compounds Of Unknown Constitution (AREA)
ES06726410.1T 2005-03-17 2006-03-16 Método de activación de linfocitos citolíticos naturales mediante preparaciones de células tumorales in vitro Active ES2566335T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0505508A GB0505508D0 (en) 2005-03-17 2005-03-17 Method
GB0505508 2005-03-17
GB0514288 2005-07-12
GB0514288A GB0514288D0 (en) 2005-07-12 2005-07-12 Method
PCT/GB2006/000960 WO2006097743A2 (en) 2005-03-17 2006-03-16 Method for actvating natural killer cells by tumor cell preparation in vitro

Publications (1)

Publication Number Publication Date
ES2566335T3 true ES2566335T3 (es) 2016-04-12

Family

ID=36992099

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06726410.1T Active ES2566335T3 (es) 2005-03-17 2006-03-16 Método de activación de linfocitos citolíticos naturales mediante preparaciones de células tumorales in vitro

Country Status (9)

Country Link
US (3) US8257970B2 (cg-RX-API-DMAC7.html)
EP (2) EP1863905B1 (cg-RX-API-DMAC7.html)
JP (3) JP5663135B2 (cg-RX-API-DMAC7.html)
AU (1) AU2006224313B2 (cg-RX-API-DMAC7.html)
CA (1) CA2601197C (cg-RX-API-DMAC7.html)
DK (1) DK1863905T3 (cg-RX-API-DMAC7.html)
ES (1) ES2566335T3 (cg-RX-API-DMAC7.html)
PL (1) PL1863905T3 (cg-RX-API-DMAC7.html)
WO (1) WO2006097743A2 (cg-RX-API-DMAC7.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2013331A2 (en) 2006-04-14 2009-01-14 Advanced Cell Technology, Inc. Hemangio-colony forming cells
MX2010012827A (es) * 2008-05-29 2010-12-20 Transgene Sa Biomarcador para seleccionar pacientes y metodos relacionados.
US8735148B2 (en) * 2009-07-10 2014-05-27 Ucl Business Plc Preserved compositions of activated NK cells and methods of using the same
CN104136034B (zh) 2011-11-30 2018-04-24 安斯泰来再生医药协会 间充质基质细胞及其相关用途
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
WO2013132256A1 (en) 2012-03-07 2013-09-12 Ucl Business Plc Compositions and methods for treating viral-mediated infection and disease in immunocompromised individuals
WO2013168978A1 (ko) * 2012-05-07 2013-11-14 고려대학교 산학협력단 말초혈액단핵구 유래 자연 살해세포의 유도 및 증식 방법
US9938498B2 (en) 2012-05-07 2018-04-10 Nkmax Co., Ltd. Method for the induction and expansion of natural killer cells derived from peripheral blood mononuclear cells
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
WO2014100779A1 (en) 2012-12-21 2014-06-26 Advanced Cell Technology, Inc. Methods ofr production of platelets from pluripotent stem cells and compositions thereof
BR112017004270B1 (pt) * 2014-09-04 2023-03-07 Stemcell Technologies Inc Método de ativação de células t ou células nk
US10758567B2 (en) 2015-09-16 2020-09-01 Immune Ventures LLC In vivo priming of natural killer cells
ES2871100T3 (es) * 2015-12-07 2021-10-28 Immune Ventures LLC Cebado in vivo de linfocitos citolíticos naturales
BR112019019241A2 (pt) * 2017-03-15 2020-04-14 Immune Ventures LLC preparação de célula de tumor de iniciação
MY199514A (en) 2018-02-01 2023-11-02 Nkmax Co Ltd Method of producing natural killer cells and composition for treating cancer
EP4659757A2 (en) 2018-08-30 2025-12-10 ImmunityBio, Inc. Multi-chain chimeric polypeptides and uses thereof
CA3109361A1 (en) * 2018-08-30 2020-03-05 HCW Biologics, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
JP7407822B2 (ja) 2018-08-30 2024-01-04 エイチシーダブリュー バイオロジックス インコーポレイテッド 単鎖キメラポリペプチドおよびその使用
JP6838750B2 (ja) * 2019-01-21 2021-03-03 株式会社ガイアバイオメディシン Nk細胞を含む細胞集団の製造方法
CN114269903B (zh) 2019-06-21 2025-11-25 免疫生物公司 多链嵌合多肽和其用途
US12398189B2 (en) 2020-02-11 2025-08-26 HCW Biologics, Inc. Methods of activating regulatory T cells
US12115191B2 (en) 2020-02-11 2024-10-15 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
AU2021219720B2 (en) 2020-02-11 2025-10-02 Immunitybio, Inc. Chromatography resin and uses thereof
JP7734693B2 (ja) 2020-04-29 2025-09-05 イミュニティーバイオ インコーポレイテッド 抗cd26タンパク質及びそれらの使用法
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
KR20250118299A (ko) * 2024-01-29 2025-08-06 인하대학교 산학협력단 전기자극 시스템을 활용한 자연살해세포의 암세포 살상 능력 증진 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049268A1 (en) * 1997-04-30 1998-11-05 Hans Klingemann Natural killer cell lines and methods of use
US6849452B1 (en) * 1998-03-03 2005-02-01 Institut Gustave Roussy Methods for activating natural killer (NK) cells and means for carrying out said methods
US7662387B2 (en) 2003-02-20 2010-02-16 Seattle Genetics Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
US7435596B2 (en) * 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell

Also Published As

Publication number Publication date
JP5663135B2 (ja) 2015-02-04
EP1863905B1 (en) 2016-01-20
HK1112483A1 (zh) 2008-09-05
US8637308B2 (en) 2014-01-28
EP1863905A2 (en) 2007-12-12
EP2399594B1 (en) 2019-08-14
CA2601197C (en) 2017-06-06
US20120328587A1 (en) 2012-12-27
AU2006224313B2 (en) 2011-08-11
JP5906168B2 (ja) 2016-04-20
US9655925B2 (en) 2017-05-23
EP2399594A1 (en) 2011-12-28
PL1863905T3 (pl) 2016-07-29
JP2013009686A (ja) 2013-01-17
US20080166326A1 (en) 2008-07-10
JP2008536487A (ja) 2008-09-11
AU2006224313A1 (en) 2006-09-21
CA2601197A1 (en) 2006-09-21
WO2006097743A3 (en) 2006-12-14
DK1863905T3 (en) 2016-04-04
JP2015012876A (ja) 2015-01-22
US8257970B2 (en) 2012-09-04
WO2006097743A2 (en) 2006-09-21
US20140079678A1 (en) 2014-03-20

Similar Documents

Publication Publication Date Title
ES2566335T3 (es) Método de activación de linfocitos citolíticos naturales mediante preparaciones de células tumorales in vitro
US9834753B2 (en) Method for producing natural killer cells, natural killer cells produced thereby, and composition for treating cancers and infectious diseases containing the same
US20190175649A1 (en) Combination immune therapy and cytokine control therapy for cancer treatment
US20240254446A1 (en) Population of CD3-negative cells that express chemokine receptor and cell adhesion molecule, use of the same, and method for producing the same
JP7239567B2 (ja) Nk細胞画分の増殖及び増殖nk細胞画分の使用
Ashizuka et al. Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation
JP2025072546A (ja) 血液疾患を治療するためのキット
Xu EpCAM CAR T cells for the treatment of lung cancer brain metastasis-an in vivo imaging study in the mouse
Córdoba-Espejo et al. GMP-compliant manufacturing of allogeneic peripheral blood CAR-NK cells for the treatment of acute myeloid leukemia
WO2025022372A1 (ja) 細胞集団の製造方法
HK1112483B (en) Method for activating natural killer cells by tumour cell preparations in vitro