ES2563751T3 - Uso de 4-aminopiridina sostenida de liberación para mejorar el deterioro neuro-cognitivo y / o neuro-psiquiátrico de los pacientes con esclerosis múltiple (EM) - Google Patents

Uso de 4-aminopiridina sostenida de liberación para mejorar el deterioro neuro-cognitivo y / o neuro-psiquiátrico de los pacientes con esclerosis múltiple (EM) Download PDF

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Publication number
ES2563751T3
ES2563751T3 ES10808713.1T ES10808713T ES2563751T3 ES 2563751 T3 ES2563751 T3 ES 2563751T3 ES 10808713 T ES10808713 T ES 10808713T ES 2563751 T3 ES2563751 T3 ES 2563751T3
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ES
Spain
Prior art keywords
aminopyridine
cminss
therapeutically effective
effective amount
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10808713.1T
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English (en)
Spanish (es)
Inventor
Thomas C. Wessel
Andrew Blight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acorda Therapeutics Inc
Original Assignee
Acorda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics Inc filed Critical Acorda Therapeutics Inc
Application granted granted Critical
Publication of ES2563751T3 publication Critical patent/ES2563751T3/es
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES10808713.1T 2009-08-11 2010-08-11 Uso de 4-aminopiridina sostenida de liberación para mejorar el deterioro neuro-cognitivo y / o neuro-psiquiátrico de los pacientes con esclerosis múltiple (EM) Active ES2563751T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23306909P 2009-08-11 2009-08-11
US23307709P 2009-08-11 2009-08-11
US233077P 2009-08-11
US233069P 2009-08-11
US23987709P 2009-09-04 2009-09-04
US239877P 2009-09-04
PCT/US2010/045211 WO2011019845A1 (en) 2009-08-11 2010-08-11 Use of 4-aminopyridine to improve neuro-cognitive and/or neuro-psychiatric impairment in patients with demyelinating and other nervous system conditions

Publications (1)

Publication Number Publication Date
ES2563751T3 true ES2563751T3 (es) 2016-03-16

Family

ID=43586462

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10808713.1T Active ES2563751T3 (es) 2009-08-11 2010-08-11 Uso de 4-aminopiridina sostenida de liberación para mejorar el deterioro neuro-cognitivo y / o neuro-psiquiátrico de los pacientes con esclerosis múltiple (EM)

Country Status (17)

Country Link
US (8) US20130053420A1 (enExample)
EP (1) EP2464229B1 (enExample)
JP (2) JP6137833B2 (enExample)
KR (2) KR20170128633A (enExample)
CN (1) CN102143687B (enExample)
AR (1) AR077858A1 (enExample)
AU (1) AU2010282509B2 (enExample)
BR (1) BRPI1003991A2 (enExample)
CA (1) CA2770698C (enExample)
ES (1) ES2563751T3 (enExample)
JO (1) JO3348B1 (enExample)
MX (1) MX2012001814A (enExample)
RU (1) RU2563821C2 (enExample)
TW (2) TWI549678B (enExample)
UY (1) UY32837A (enExample)
WO (1) WO2011019845A1 (enExample)
ZA (1) ZA201201001B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8007826B2 (en) 2003-12-11 2011-08-30 Acorda Therapeutics, Inc. Sustained release aminopyridine composition
US8354437B2 (en) 2004-04-09 2013-01-15 Acorda Therapeutics, Inc. Method of using sustained release aminopyridine compositions
WO2012009204A1 (en) * 2010-07-15 2012-01-19 The Trustees Of Columbia University In The City Of New York Methods for diagnosing and treating concussive disorders
EP2995305B1 (en) * 2011-01-28 2020-03-04 Acorda Therapeutics, Inc. Use of potassium channel blockers to treat cerebral palsy
CA2840591A1 (en) 2011-06-30 2013-01-03 Biomarin Pharmaceuticals, Inc. Methods of administering 3,4-diaminopyridine
US10905663B2 (en) 2013-03-05 2021-02-02 The University Of Chicago Treatment of demyelinating disorders
EP3243516A1 (en) * 2013-04-15 2017-11-15 Acorda Therapeutics, Inc. Methods for treating sensorimotor impairments associated with certain types of stroke using aminopyridines
DE102014221687B4 (de) * 2014-10-24 2019-07-04 Danfoss Silicon Power Gmbh Leistungshalbleitermodul mit kurzschluss-ausfallmodus
DE102017115701B4 (de) * 2017-07-12 2022-03-03 Lts Lohmann Therapie-Systeme Ag Fampridin-TTS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE82916B1 (en) * 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
US5977131A (en) 1997-04-09 1999-11-02 Pfizer Inc. Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
WO2002072025A2 (en) * 2001-03-14 2002-09-19 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Improving postsynaptic response by a combination of 4-minopyridine and agonist
US8007826B2 (en) * 2003-12-11 2011-08-30 Acorda Therapeutics, Inc. Sustained release aminopyridine composition
US8354437B2 (en) * 2004-04-09 2013-01-15 Acorda Therapeutics, Inc. Method of using sustained release aminopyridine compositions

Also Published As

Publication number Publication date
BRPI1003991A2 (pt) 2015-09-15
EP2464229A4 (en) 2013-02-13
US20190015399A1 (en) 2019-01-17
CN102143687A (zh) 2011-08-03
AU2010282509A1 (en) 2012-03-01
UY32837A (es) 2011-03-31
TW201613585A (en) 2016-04-16
US20130053420A1 (en) 2013-02-28
RU2563821C2 (ru) 2015-09-20
HK1173911A1 (zh) 2013-05-31
US20170056385A1 (en) 2017-03-02
CA2770698C (en) 2018-01-30
JO3348B1 (ar) 2019-03-13
ZA201201001B (en) 2014-10-29
KR20120050473A (ko) 2012-05-18
US20200113882A1 (en) 2020-04-16
CN102143687B (zh) 2015-11-25
AR077858A1 (es) 2011-09-28
US20160213661A1 (en) 2016-07-28
EP2464229B1 (en) 2015-11-25
MX2012001814A (es) 2012-06-01
EP2464229A1 (en) 2012-06-20
CA2770698A1 (en) 2011-02-17
US20170281608A1 (en) 2017-10-05
US20190247379A1 (en) 2019-08-15
US20180147193A1 (en) 2018-05-31
TWI549678B (zh) 2016-09-21
TW201110967A (en) 2011-04-01
AU2010282509B2 (en) 2015-07-30
JP6137833B2 (ja) 2017-05-31
WO2011019845A1 (en) 2011-02-17
JP2016074728A (ja) 2016-05-12
JP2013501805A (ja) 2013-01-17
KR20170128633A (ko) 2017-11-22
RU2012108656A (ru) 2013-09-20

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