CN102143687B - 4-氨基吡啶在改善具有脱髓鞘和其它神经系统状况的患者的神经-认知和/或神经-精神病学损伤中的用途 - Google Patents

4-氨基吡啶在改善具有脱髓鞘和其它神经系统状况的患者的神经-认知和/或神经-精神病学损伤中的用途 Download PDF

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Publication number
CN102143687B
CN102143687B CN201080002517.4A CN201080002517A CN102143687B CN 102143687 B CN102143687 B CN 102143687B CN 201080002517 A CN201080002517 A CN 201080002517A CN 102143687 B CN102143687 B CN 102143687B
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China
Prior art keywords
aminopyridine
impairment
patient
neurocognitive
neuropsychiatric
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Expired - Fee Related
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CN201080002517.4A
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English (en)
Chinese (zh)
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CN102143687A (zh
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托马斯·C·韦赛尔
A·布莱特
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Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201080002517.4A 2009-08-11 2010-08-11 4-氨基吡啶在改善具有脱髓鞘和其它神经系统状况的患者的神经-认知和/或神经-精神病学损伤中的用途 Expired - Fee Related CN102143687B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23306909P 2009-08-11 2009-08-11
US23307709P 2009-08-11 2009-08-11
US61/233,077 2009-08-11
US61/233,069 2009-08-11
US23987709P 2009-09-04 2009-09-04
US61/239,877 2009-09-04
PCT/US2010/045211 WO2011019845A1 (en) 2009-08-11 2010-08-11 Use of 4-aminopyridine to improve neuro-cognitive and/or neuro-psychiatric impairment in patients with demyelinating and other nervous system conditions

Publications (2)

Publication Number Publication Date
CN102143687A CN102143687A (zh) 2011-08-03
CN102143687B true CN102143687B (zh) 2015-11-25

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CN201080002517.4A Expired - Fee Related CN102143687B (zh) 2009-08-11 2010-08-11 4-氨基吡啶在改善具有脱髓鞘和其它神经系统状况的患者的神经-认知和/或神经-精神病学损伤中的用途

Country Status (17)

Country Link
US (8) US20130053420A1 (enExample)
EP (1) EP2464229B1 (enExample)
JP (2) JP6137833B2 (enExample)
KR (2) KR20170128633A (enExample)
CN (1) CN102143687B (enExample)
AR (1) AR077858A1 (enExample)
AU (1) AU2010282509B2 (enExample)
BR (1) BRPI1003991A2 (enExample)
CA (1) CA2770698C (enExample)
ES (1) ES2563751T3 (enExample)
JO (1) JO3348B1 (enExample)
MX (1) MX2012001814A (enExample)
RU (1) RU2563821C2 (enExample)
TW (2) TWI549678B (enExample)
UY (1) UY32837A (enExample)
WO (1) WO2011019845A1 (enExample)
ZA (1) ZA201201001B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8007826B2 (en) 2003-12-11 2011-08-30 Acorda Therapeutics, Inc. Sustained release aminopyridine composition
US8354437B2 (en) 2004-04-09 2013-01-15 Acorda Therapeutics, Inc. Method of using sustained release aminopyridine compositions
WO2012009204A1 (en) * 2010-07-15 2012-01-19 The Trustees Of Columbia University In The City Of New York Methods for diagnosing and treating concussive disorders
EP2995305B1 (en) * 2011-01-28 2020-03-04 Acorda Therapeutics, Inc. Use of potassium channel blockers to treat cerebral palsy
CA2840591A1 (en) 2011-06-30 2013-01-03 Biomarin Pharmaceuticals, Inc. Methods of administering 3,4-diaminopyridine
US10905663B2 (en) 2013-03-05 2021-02-02 The University Of Chicago Treatment of demyelinating disorders
EP3243516A1 (en) * 2013-04-15 2017-11-15 Acorda Therapeutics, Inc. Methods for treating sensorimotor impairments associated with certain types of stroke using aminopyridines
DE102014221687B4 (de) * 2014-10-24 2019-07-04 Danfoss Silicon Power Gmbh Leistungshalbleitermodul mit kurzschluss-ausfallmodus
DE102017115701B4 (de) * 2017-07-12 2022-03-03 Lts Lohmann Therapie-Systeme Ag Fampridin-TTS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072025A2 (en) * 2001-03-14 2002-09-19 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Improving postsynaptic response by a combination of 4-minopyridine and agonist
US20050228030A1 (en) * 2004-04-09 2005-10-13 Blight Andrew R Method of using sustained release aminopyridine compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE82916B1 (en) * 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
US5977131A (en) 1997-04-09 1999-11-02 Pfizer Inc. Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
US8007826B2 (en) * 2003-12-11 2011-08-30 Acorda Therapeutics, Inc. Sustained release aminopyridine composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072025A2 (en) * 2001-03-14 2002-09-19 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Improving postsynaptic response by a combination of 4-minopyridine and agonist
US20050228030A1 (en) * 2004-04-09 2005-10-13 Blight Andrew R Method of using sustained release aminopyridine compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Aminopyridines for symptomatic treatment in multiplesclerosis(Review);Solari A,等;《The Cochrane Collaboration》;20090121(第1期);第3页主要结果 *

Also Published As

Publication number Publication date
BRPI1003991A2 (pt) 2015-09-15
ES2563751T3 (es) 2016-03-16
EP2464229A4 (en) 2013-02-13
US20190015399A1 (en) 2019-01-17
CN102143687A (zh) 2011-08-03
AU2010282509A1 (en) 2012-03-01
UY32837A (es) 2011-03-31
TW201613585A (en) 2016-04-16
US20130053420A1 (en) 2013-02-28
RU2563821C2 (ru) 2015-09-20
HK1173911A1 (zh) 2013-05-31
US20170056385A1 (en) 2017-03-02
CA2770698C (en) 2018-01-30
JO3348B1 (ar) 2019-03-13
ZA201201001B (en) 2014-10-29
KR20120050473A (ko) 2012-05-18
US20200113882A1 (en) 2020-04-16
AR077858A1 (es) 2011-09-28
US20160213661A1 (en) 2016-07-28
EP2464229B1 (en) 2015-11-25
MX2012001814A (es) 2012-06-01
EP2464229A1 (en) 2012-06-20
CA2770698A1 (en) 2011-02-17
US20170281608A1 (en) 2017-10-05
US20190247379A1 (en) 2019-08-15
US20180147193A1 (en) 2018-05-31
TWI549678B (zh) 2016-09-21
TW201110967A (en) 2011-04-01
AU2010282509B2 (en) 2015-07-30
JP6137833B2 (ja) 2017-05-31
WO2011019845A1 (en) 2011-02-17
JP2016074728A (ja) 2016-05-12
JP2013501805A (ja) 2013-01-17
KR20170128633A (ko) 2017-11-22
RU2012108656A (ru) 2013-09-20

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Granted publication date: 20151125