ES2563246T3 - Polímeros reticulados y productos médicos derivados de polioxazolina nucleofílicamente activada - Google Patents

Polímeros reticulados y productos médicos derivados de polioxazolina nucleofílicamente activada Download PDF

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Publication number
ES2563246T3
ES2563246T3 ES13712382.4T ES13712382T ES2563246T3 ES 2563246 T3 ES2563246 T3 ES 2563246T3 ES 13712382 T ES13712382 T ES 13712382T ES 2563246 T3 ES2563246 T3 ES 2563246T3
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groups
pox
electrophilic
crosslinking agent
polymer
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ES13712382.4T
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English (en)
Spanish (es)
Inventor
Johannes Caspar Mathias Elizabeth Bender
Richard Hoogenboom
Jan Cornelis Maria Van Hest
Harry Van Goor
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Bender Analytical Holding BV
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Bender Analytical Holding BV
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2379/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2361/00 - C08J2377/00
    • C08J2379/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
ES13712382.4T 2012-03-16 2013-03-15 Polímeros reticulados y productos médicos derivados de polioxazolina nucleofílicamente activada Active ES2563246T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12159982 2012-03-16
EP12159982 2012-03-16
PCT/NL2013/050187 WO2013137736A1 (en) 2012-03-16 2013-03-15 Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline

Publications (1)

Publication Number Publication Date
ES2563246T3 true ES2563246T3 (es) 2016-03-11

Family

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ES13712382.4T Active ES2563246T3 (es) 2012-03-16 2013-03-15 Polímeros reticulados y productos médicos derivados de polioxazolina nucleofílicamente activada

Country Status (7)

Country Link
US (2) US9416228B2 (https=)
EP (1) EP2825582B1 (https=)
JP (2) JP6178399B2 (https=)
CN (1) CN104271638B (https=)
BR (1) BR112014022821B1 (https=)
ES (1) ES2563246T3 (https=)
WO (1) WO2013137736A1 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2593755C2 (ru) 2011-01-04 2016-08-10 Бендер Аналитикал Холдинг Б.В. Сшитые полимеры и имплантаты, произведенные из электрофильно активированного полиоксазолина
US9416228B2 (en) * 2012-03-16 2016-08-16 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline
DE102013016750A1 (de) * 2013-10-02 2015-04-02 Friedrich-Schiller-Universität Jena Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung
EP3000489B1 (en) * 2014-09-24 2017-04-05 Sofradim Production Method for preparing an anti-adhesion barrier film
BR112017006943B1 (pt) * 2014-10-06 2020-12-01 Gatt Technologies B.V produto hemostático poroso adesivo de tecido
US20180243465A1 (en) * 2015-09-01 2018-08-30 Baxter International Inc. Hemostatic material
HRP20211306T1 (hr) * 2015-09-09 2021-11-26 ETH Zürich Injektibilni makroporozni hidrogelovi
KR102489614B1 (ko) * 2016-05-27 2023-01-16 삼성전자주식회사 옥사졸린계 공중합체, 이를 포함하는 조성물, 및 상기 조성물로부터 제조되는 성형품
CN106075549B (zh) * 2016-06-17 2020-02-14 广州迈普再生医学科技股份有限公司 组织封闭胶组合物，组织封闭胶及其制备方法和应用
KR101892955B1 (ko) * 2017-01-25 2018-08-29 국방과학연구소 치환된 Poly[2-(3-butenyl)-2-oxazoline] 및 Nylon-6,6를 포함하는 섬유 및 그 제조방법
US12102729B2 (en) 2017-08-04 2024-10-01 Hcs Innovation, Llc Natural polymer-based tissue adhesive with healing-promoting properties
US11571492B2 (en) * 2017-08-04 2023-02-07 Hcs Innovation, Llc Natural polymer-based tissue adhesive with healing-promoting properties
US20200277449A1 (en) * 2017-09-15 2020-09-03 Université De Strasbourg Injectable hybrid alginate hydrogels and uses thereof
CN109694484B (zh) * 2017-10-20 2021-08-27 四川大学华西医院 一种免疫佐剂及其制备方法
CN108939174B (zh) * 2018-07-16 2020-06-19 浙江大学 一种pH响应型聚噁唑啉-纳米银的层层自组装多层膜及其制备方法
CN109182260A (zh) * 2018-09-11 2019-01-11 邵勇 一种体外培养胎膜间充质干细胞的方法
CN109731133B (zh) * 2019-02-01 2020-09-01 浙江大学 一种抗菌、抗粘附、可注射式温敏壳聚糖凝胶敷料及其制备方法
CN109776808B (zh) * 2019-02-01 2020-06-30 浙江大学 一种水溶性改性壳聚糖的制备方法
AU2020275382B2 (en) * 2019-05-10 2026-01-22 Massachusetts Institute Of Technology Dry double-sided material for adhesion of wet tissues and devices
CN114096287B (zh) 2019-07-12 2023-05-02 加特技术公司 用于制备组织粘附片的方法
AU2020313510B2 (en) * 2019-07-12 2025-08-21 Ethicon, Inc. Biocompatible, flexible, haemostatic sheet
EP3996757B1 (en) * 2019-07-12 2023-04-19 GATT Technologies B.V. Biocompatible, flexible, haemostatic sheet
EP3996758B1 (en) * 2019-07-12 2023-07-26 Cilag GmbH International Haemostatic powder
EP4004085B1 (en) * 2019-07-30 2025-07-30 Cilag GmbH International Polyoxazoline copolymer comprising calcium binding groups
EP3958907A1 (en) * 2019-08-28 2022-03-02 Boston Scientific Scimed Inc. Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same
JP2023510380A (ja) * 2020-01-16 2023-03-13 香港科技大学 標的剤の放出制御のための組成物及び方法
CN115697426A (zh) * 2020-06-04 2023-02-03 麻省理工学院 具有可触发按需拆离的粘合剂材料
CN111803454B (zh) * 2020-07-01 2022-05-06 中国科学院长春应用化学研究所 一种支架材料、其制备方法及应用
WO2022023375A1 (en) * 2020-07-28 2022-02-03 Gatt Technologies B.V. Bone-adhesive sheet
EP4274624B1 (en) * 2021-01-08 2024-09-25 Cilag GmbH International Bioresorbable sealing powder
US12251466B2 (en) 2022-04-20 2025-03-18 Pramand LLC Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels
CN119403898A (zh) * 2022-05-05 2025-02-07 普渡研究基金会 来自可持续组分的高强度粘合剂
US12440599B2 (en) 2022-05-06 2025-10-14 Pramand LLC Water activated hydrogel-based medical patches, and methods of making and using such patches
WO2024161367A1 (en) 2023-02-03 2024-08-08 Ethicon, Inc. System and methods for using tissue-adhesive porous hemostatic products with severe surface and cavity bleeding
KR20250145635A (ko) 2023-02-03 2025-10-13 에디컨인코포레이티드 최소 침습 수술 기법을 이용한 조직-접착성 다공성 지혈 제품의 사용을 위한 시스템 및 방법
DE102023108039A1 (de) 2023-03-29 2024-10-02 Dwi - Leibniz-Institut Für Interaktive Materialien E.V. Ein System zur Herstellung eines degradierbaren Hydrogels
US12576182B2 (en) 2023-08-11 2026-03-17 Ethicon, Inc. Absorbable dressings for sealing sensitive neural tissue and dura matter
US20260030999A1 (en) * 2024-07-28 2026-01-29 Ward Shalash Synthetic tissue models, materials, and methods for thermal treatment training and simulation
CN118721925A (zh) * 2024-09-03 2024-10-01 四川固朔新材料有限公司 一种电子多晶硅多用功能性内包装材料及其制备方法
CN120904315A (zh) * 2025-10-13 2025-11-07 武汉医佳宝生物材料有限公司 一种交联胶原蛋白及其制备方法和在医美领域中的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760311A (en) 1951-10-06 1956-10-31 Allied Colloids Mfg Company Lt Improvements in and relating to derivatives of ethylene imine
US3442975A (en) 1967-01-11 1969-05-06 Allied Chem Polyimine/polycarbonamide graft polymers
US3996237A (en) 1974-07-17 1976-12-07 The Dow Chemical Company Oxazoline- or oxazine-substituted acrylic esters
US5635571A (en) 1995-06-30 1997-06-03 Cornell Research Foundation, Inc. Polymerizable macromonomers and polymers prepared therefrom
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
JP2002531217A (ja) * 1998-12-04 2002-09-24 チャンドラシェカー ピー． パサック， 生体適合性架橋ポリマー
WO2000071600A1 (de) 1999-05-19 2000-11-30 Basf Aktiengesellschaft Vernetzte, kondensierte basische aminosäuren enthaltende polymere und verfahren zu ihrer herstellung
DE10152407A1 (de) 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten
US7300738B2 (en) 2003-02-10 2007-11-27 Fujifilm Corporation Azolinyl acetic acid derivative and azolinyl acetic acid derivative containing recording material
JP2005161698A (ja) 2003-12-03 2005-06-23 Fuji Photo Film Co Ltd 記録材料
US20050238825A1 (en) 2004-04-26 2005-10-27 Isp Investments Inc. Crosslinked polymeric composition
WO2006078282A2 (en) 2004-04-28 2006-07-27 Angiotech Biomaterials Corporation Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
EP1796602A4 (en) 2004-09-17 2016-10-19 Angiotech Pharm Inc MULTIFUNCTIONAL COMPOUNDS FOR PRODUCING NETWORKED BIOMATERIALS AND MANUFACTURING AND USE METHOD THEREFOR
EP1988939A2 (en) 2006-03-01 2008-11-12 Tissuemed Limited Tissue-adhesive formulations
KR101508621B1 (ko) * 2007-02-28 2015-04-07 세리나 쎄라퓨틱스, 인코포레이티드 활성화된 폴리옥사졸린 및 이를 포함하는 조성물
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8088884B2 (en) * 2007-09-27 2012-01-03 Serina Therapeutics, Inc. Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
US8110651B2 (en) 2008-01-11 2012-02-07 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
FR2928373B1 (fr) 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
JP5642673B2 (ja) 2008-07-10 2014-12-17 セリナ・セラピユーテイツクス・インコーポレーテツド 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物
EP2341942A1 (en) 2008-09-19 2011-07-13 Nektar Therapeutics Polymer conjugates of therapeutic peptides
WO2010043979A2 (en) 2008-10-17 2010-04-22 Sofradim Production Auto-sealant matrix for tissue repair
WO2010059280A2 (en) 2008-11-19 2010-05-27 E. I. Du Pont De Nemours And Company Fibrous tissue sealant and method of using same
RU2593755C2 (ru) * 2011-01-04 2016-08-10 Бендер Аналитикал Холдинг Б.В. Сшитые полимеры и имплантаты, произведенные из электрофильно активированного полиоксазолина
US9416228B2 (en) * 2012-03-16 2016-08-16 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline

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Publication number Publication date
US9416228B2 (en) 2016-08-16
US20160319075A1 (en) 2016-11-03
JP6178399B2 (ja) 2017-08-09
EP2825582A1 (en) 2015-01-21
JP2017221679A (ja) 2017-12-21
WO2013137736A1 (en) 2013-09-19
BR112014022821A8 (pt) 2018-07-31
CN104271638A (zh) 2015-01-07
CN104271638B (zh) 2016-11-02
HK1206049A1 (zh) 2015-12-31
EP2825582B1 (en) 2016-01-13
US20150045507A1 (en) 2015-02-12
US9868822B2 (en) 2018-01-16
JP2015511507A (ja) 2015-04-20
BR112014022821A2 (https=) 2017-06-20
BR112014022821B1 (pt) 2021-03-30
JP6372000B2 (ja) 2018-08-15

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