ES2562428T3 - Inhibidores de cinasa y sus usos - Google Patents
Inhibidores de cinasa y sus usos Download PDFInfo
- Publication number
- ES2562428T3 ES2562428T3 ES06840283.3T ES06840283T ES2562428T3 ES 2562428 T3 ES2562428 T3 ES 2562428T3 ES 06840283 T ES06840283 T ES 06840283T ES 2562428 T3 ES2562428 T3 ES 2562428T3
- Authority
- ES
- Spain
- Prior art keywords
- exo
- hept
- diamine
- racemic
- aminocarbonylbicyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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Applications Claiming Priority (3)
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| US75139305P | 2005-12-15 | 2005-12-15 | |
| US751393P | 2005-12-15 | ||
| PCT/US2006/062162 WO2007070872A1 (en) | 2005-12-15 | 2006-12-15 | Kinase inhibitors and their uses |
Publications (1)
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| ES2562428T3 true ES2562428T3 (es) | 2016-03-04 |
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| EP (1) | EP1960372B1 (enExample) |
| JP (1) | JP5400388B2 (enExample) |
| CA (1) | CA2633035C (enExample) |
| ES (1) | ES2562428T3 (enExample) |
| WO (1) | WO2007070872A1 (enExample) |
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| EP1885369B1 (en) | 2005-05-04 | 2015-09-23 | Evotec AG | Fused heterocyclic compounds, and compositions and uses thereof |
| WO2007070872A1 (en) * | 2005-12-15 | 2007-06-21 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| TW201336514A (zh) * | 2006-04-13 | 2013-09-16 | Alcon Res Ltd | ＲＮＡ干擾（ＲＮＡｉ）所媒介之與脾酪胺酸激酶相關之發炎症狀的抑制作用（二） |
| US8097630B2 (en) | 2006-10-10 | 2012-01-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors |
| GEP20125691B (en) | 2006-12-08 | 2012-11-26 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| JPWO2008081928A1 (ja) | 2006-12-28 | 2010-04-30 | 大正製薬株式会社 | ピラゾロピリミジン化合物 |
| EP2170395A1 (en) * | 2007-07-02 | 2010-04-07 | Wyeth LLC | Modulators of axl for use in treating bone disorders |
| RU2472797C2 (ru) * | 2007-08-08 | 2013-01-20 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | ПРОИЗВОДНЫЕ 2-[(2-(ФЕНИЛАМИНО)-1Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)АМИНО]БЕНЗАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ IGF-1R ДЛЯ ЛЕЧЕНИЯ РАКА |
| WO2009032694A1 (en) * | 2007-08-28 | 2009-03-12 | Dana Farber Cancer Institute | Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis |
| WO2009029682A1 (en) * | 2007-08-28 | 2009-03-05 | Rigel Pharmaceuticals, Inc. | Combination therapy with syk kinase inhibitor |
| EP2219671A4 (en) | 2007-11-09 | 2011-02-09 | Salk Inst For Biological Studi | USE OF TAM RECEPTOR INHIBITORS AS IMMU ENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS |
| AU2008323628B2 (en) * | 2007-11-15 | 2013-10-17 | Ym Biosciences Australia Pty Ltd | N-containing heterocyclic compounds |
| TW200942537A (en) * | 2008-02-01 | 2009-10-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| WO2009131687A2 (en) * | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| EP2296475A4 (en) | 2008-06-20 | 2014-03-05 | Genentech Inc | TRIAZOLOPYRIDINE COMPOUNDS JAK KINASE INHIBITORS AND METHODS |
| AU2009259853A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
| CA2749843C (en) | 2009-01-16 | 2017-09-05 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| TW201041892A (en) * | 2009-02-09 | 2010-12-01 | Supergen Inc | Pyrrolopyrimidinyl Axl kinase inhibitors |
| WO2010114894A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| CN105037364B (zh) * | 2009-04-03 | 2018-04-27 | 维拉斯通股份有限公司 | 作为激酶抑制剂的嘧啶取代的嘌呤化合物 |
| CA2950529C (en) * | 2009-04-03 | 2019-04-30 | Verastem, Inc. | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
| TW201105669A (en) * | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
| WO2011014795A2 (en) | 2009-07-30 | 2011-02-03 | Irm Llc | Compounds and compositions as syk kinase inhibitors |
| SG178273A1 (en) * | 2009-08-07 | 2012-03-29 | Merck Patent Gmbh | Novel azaheterocyclic compounds |
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| CN100526315C (zh) * | 2005-06-16 | 2009-08-12 | 浙江医药股份有限公司新昌制药厂 | N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途 |
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| EP1960372B1 (en) | 2015-12-09 |
| EP1960372A1 (en) | 2008-08-27 |
| WO2007070872A1 (en) | 2007-06-21 |
| CA2633035C (en) | 2016-05-10 |
| US20160024116A1 (en) | 2016-01-28 |
| CA2633035A1 (en) | 2007-06-21 |
| US20100069369A1 (en) | 2010-03-18 |
| US9834568B2 (en) | 2017-12-05 |
| US7601713B2 (en) | 2009-10-13 |
| JP2009519979A (ja) | 2009-05-21 |
| US9096542B2 (en) | 2015-08-04 |
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