ES2557633T3 - Ribonucleasa H modificada por ingeniería específica de secuencia y el método para determinar la preferencia de secuencia de proteínas de unión de híbrido de ADN-ARN - Google Patents

Ribonucleasa H modificada por ingeniería específica de secuencia y el método para determinar la preferencia de secuencia de proteínas de unión de híbrido de ADN-ARN Download PDF

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Publication number
ES2557633T3
ES2557633T3 ES12735348.0T ES12735348T ES2557633T3 ES 2557633 T3 ES2557633 T3 ES 2557633T3 ES 12735348 T ES12735348 T ES 12735348T ES 2557633 T3 ES2557633 T3 ES 2557633T3
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Spain
Prior art keywords
dna
rna
seq
sequence
rnase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12735348.0T
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English (en)
Spanish (es)
Inventor
Janusz Marek BUJNICKI
Agata Agnieszka SULEJ
Krzysztof Jerzy SKOWRONEK
Marcin NOWOTNY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miedzynarodowy Inst Biologii Molekularnej I Komorkowej
MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
Original Assignee
Miedzynarodowy Inst Biologii Molekularnej I Komorkowej
MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL395180A external-priority patent/PL222513B1/pl
Priority claimed from PL395179A external-priority patent/PL222512B1/pl
Application filed by Miedzynarodowy Inst Biologii Molekularnej I Komorkowej, MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ filed Critical Miedzynarodowy Inst Biologii Molekularnej I Komorkowej
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Publication of ES2557633T3 publication Critical patent/ES2557633T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26004—Ribonuclease H (3.1.26.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES12735348.0T 2011-06-08 2012-06-07 Ribonucleasa H modificada por ingeniería específica de secuencia y el método para determinar la preferencia de secuencia de proteínas de unión de híbrido de ADN-ARN Active ES2557633T3 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161494481P 2011-06-08 2011-06-08
US201161494494P 2011-06-08 2011-06-08
PL39517911 2011-06-08
PL395180A PL222513B1 (pl) 2011-06-08 2011-06-08 Sposób określania sekwencji preferowanych przez białko lub jego domeny wiążące specyficznie sekwencje w hybrydzie DNA-RNA
PL39518011 2011-06-08
PL395179A PL222512B1 (pl) 2011-06-08 2011-06-08 Endorybonukleaza przecinająca nić RNA w hybrydach DNA-RNA
US201161494481P 2011-06-08
US201161494494P 2011-06-08
PCT/PL2012/050019 WO2012169916A2 (en) 2011-06-08 2012-06-07 Sequence-specific engineered ribonuclease h and the method for determining the sequence preference of dna-rna hybrid binding proteins

Publications (1)

Publication Number Publication Date
ES2557633T3 true ES2557633T3 (es) 2016-01-27

Family

ID=47296662

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12735348.0T Active ES2557633T3 (es) 2011-06-08 2012-06-07 Ribonucleasa H modificada por ingeniería específica de secuencia y el método para determinar la preferencia de secuencia de proteínas de unión de híbrido de ADN-ARN

Country Status (10)

Country Link
US (1) US9353358B2 (enExample)
EP (2) EP2718430B1 (enExample)
JP (1) JP6022556B2 (enExample)
KR (1) KR20140066977A (enExample)
CN (1) CN103764820A (enExample)
AU (1) AU2012267270B2 (enExample)
CA (1) CA2837503C (enExample)
DK (1) DK2718430T3 (enExample)
ES (1) ES2557633T3 (enExample)
WO (1) WO2012169916A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3328353B1 (en) 2015-07-27 2024-04-10 Mary Kay, Inc. Topical skin formulations
CN108314736B (zh) * 2017-01-18 2021-08-31 李燕强 一种促进rna降解的方法
CN110846724B (zh) * 2019-12-03 2023-04-28 江西海普洛斯医学检验实验室有限公司 构建mRNA链特异文库的方法及试剂盒
US12416044B2 (en) * 2022-03-21 2025-09-16 Abclonal Science, Inc. T4 DNA ligase variants with increased ligation efficiency

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5459392A (en) 1977-10-14 1979-05-12 Rikagaku Kenkyusho Novel nuclease and its preparation
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
AU2002217830A1 (en) * 2000-11-15 2002-05-27 Isis Pharmaceuticals, Inc. Human rnase h1 mutants
WO2003087341A2 (en) 2002-01-23 2003-10-23 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
US20060057590A1 (en) 2004-09-14 2006-03-16 Azeddine Si-Ammour RNA probes
US20100055793A1 (en) 2005-07-25 2010-03-04 Johns Hopkins University Site-specific modification of the human genome using custom-designed zinc finger nucleases
US7804803B2 (en) 2005-07-25 2010-09-28 Honeywell International Inc. Neighbor based TDMA slot assignment
WO2009126632A1 (en) * 2008-04-08 2009-10-15 Archemix Corp. Compositions and methods for the use of mutant t3 rna polymerases in the synthesis of modified nucleic acid transcripts
WO2009146179A1 (en) 2008-04-15 2009-12-03 University Of Iowa Research Foundation Zinc finger nuclease for the cftr gene and methods of use thereof
KR20100080068A (ko) 2008-12-31 2010-07-08 주식회사 툴젠 신규한 징크 핑거 뉴클레아제 및 이의 용도
WO2011022427A1 (en) * 2009-08-18 2011-02-24 Archemix Corp. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics

Also Published As

Publication number Publication date
CA2837503C (en) 2018-01-02
EP2718430B1 (en) 2015-12-09
AU2012267270A1 (en) 2013-12-12
US9353358B2 (en) 2016-05-31
DK2718430T3 (en) 2016-02-08
EP2857506A3 (en) 2015-04-29
US20140094385A1 (en) 2014-04-03
JP6022556B2 (ja) 2016-11-09
WO2012169916A3 (en) 2013-03-07
EP2857506A2 (en) 2015-04-08
WO2012169916A2 (en) 2012-12-13
EP2718430A2 (en) 2014-04-16
CN103764820A (zh) 2014-04-30
AU2012267270B2 (en) 2015-06-11
KR20140066977A (ko) 2014-06-03
JP2014516569A (ja) 2014-07-17
CA2837503A1 (en) 2012-12-13

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