ES2551459T3 - Método para producir un parche de ropinirol supersaturado - Google Patents
Método para producir un parche de ropinirol supersaturado Download PDFInfo
- Publication number
- ES2551459T3 ES2551459T3 ES14174708.9T ES14174708T ES2551459T3 ES 2551459 T3 ES2551459 T3 ES 2551459T3 ES 14174708 T ES14174708 T ES 14174708T ES 2551459 T3 ES2551459 T3 ES 2551459T3
- Authority
- ES
- Spain
- Prior art keywords
- adhesive agent
- agent layer
- patch
- ropinirole
- supersaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Método para producir un parche que comprende una capa de soporte y una capa de agente adhesivo dispuesta sobre al menos una superficie de la capa de soporte, comprendiendo el método: etapa A) obtener una composición de capa de agente adhesivo que comprende ropinirol libre en una cantidad que da como resultado del 5 al 13,2% en masa en relación con la masa total de una capa de agente adhesivo obtenida; etapa B) calentar la composición de capa de agente adhesivo a una temperatura en un intervalo de desde 50 hasta 76ºC durante de 5 minutos a 24 horas; y etapa C) enfriar la composición de capa de agente adhesivo calentada hasta temperatura normal a una velocidad promedio de disminución de temperatura de 1 a 20ºC/hora, obteniendo de ese modo la capa de 1agente adhesivo que comprende el ropinirol libre a una concentración supersaturada en forma disuelta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013137147 | 2013-06-28 | ||
| JP2013137147A JP5415645B1 (ja) | 2013-06-28 | 2013-06-28 | 貼付剤の製造方法、貼付剤及び包装体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2551459T3 true ES2551459T3 (es) | 2015-11-19 |
Family
ID=50202791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14174708.9T Active ES2551459T3 (es) | 2013-06-28 | 2014-06-27 | Método para producir un parche de ropinirol supersaturado |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9320728B2 (es) |
| EP (1) | EP2818161B1 (es) |
| JP (1) | JP5415645B1 (es) |
| KR (1) | KR101516122B1 (es) |
| CN (1) | CN104138366B (es) |
| CA (1) | CA2855309C (es) |
| ES (1) | ES2551459T3 (es) |
| TW (1) | TWI488644B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10716763B2 (en) | 2015-04-15 | 2020-07-21 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal patch containing ropinirole |
| WO2017006974A1 (ja) * | 2015-07-08 | 2017-01-12 | 王子ホールディングス株式会社 | 経皮吸収型貼付剤 |
| WO2017223402A1 (en) | 2016-06-23 | 2017-12-28 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
| KR102406536B1 (ko) | 2016-07-27 | 2022-06-08 | 코리움, 인크. | 도네페질 경피 전달 시스템 |
| CN110121344A (zh) * | 2016-12-28 | 2019-08-13 | 久光制药株式会社 | 含布托啡诺的贴附剂 |
| ES2971449T3 (es) | 2017-02-24 | 2024-06-05 | Hisamitsu Pharmaceutical Co | Parche cutáneo adhesivo y producto envasado del mismo |
| JP6704514B2 (ja) | 2017-04-25 | 2020-06-03 | 久光製薬株式会社 | 貼付剤 |
| US10898448B2 (en) | 2017-04-25 | 2021-01-26 | Hisamitsu Pharmaceutical Co., Inc. | Patch |
| DE102018120505A1 (de) | 2017-10-20 | 2019-04-25 | Amw Gmbh | Verhinderung der Kristallisation von Wirkstoffen in transdermalen Darreichungssystemen |
| US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| JP7285790B2 (ja) * | 2018-01-22 | 2023-06-02 | 株式会社カネカ | 皮膚貼付用粘着シート |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH066534B2 (ja) | 1986-10-09 | 1994-01-26 | 積水化学工業株式会社 | 経皮吸収貼付剤 |
| US4832953A (en) | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5308621A (en) | 1991-02-18 | 1994-05-03 | Commonwealth Scientific And Industrial Research Organisation | Ascorbic acid composition and transdermal administration method |
| GB9511366D0 (en) | 1995-06-06 | 1995-08-02 | Smithkline Beecham Plc | Novel formulations |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US5807570A (en) | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
| AU1120097A (en) | 1995-12-01 | 1997-06-27 | Alza Corporation | Improved method for preventing crystal formation in a dispersion of a liquid in a matrix |
| JP4205778B2 (ja) | 1998-04-17 | 2009-01-07 | 久光製薬株式会社 | 貼付製剤 |
| US20040142024A1 (en) | 1999-07-27 | 2004-07-22 | Hisamitsu Pharmaceutical Co., Inc. | Patch formulation for external use |
| ES2286028T3 (es) | 1999-07-27 | 2007-12-01 | Hisamitsu Pharmaceutical Co. Inc. | Parches para uso externo. |
| DE10060550C1 (de) | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| US7988991B2 (en) | 2001-03-07 | 2011-08-02 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch |
| JP4792193B2 (ja) | 2002-08-28 | 2011-10-12 | 久光製薬株式会社 | 貼付剤 |
| JP4354678B2 (ja) | 2002-08-28 | 2009-10-28 | 久光製薬株式会社 | 貼付剤 |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| US20080038328A1 (en) | 2004-05-28 | 2008-02-14 | Naruhito Higo | Pasting Preparation |
| JP5075334B2 (ja) | 2004-11-22 | 2012-11-21 | 久光製薬株式会社 | 薬物含有貼付剤 |
| GB0524961D0 (en) | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents for systemic effect |
| JP5243254B2 (ja) * | 2006-10-11 | 2013-07-24 | 久光製薬株式会社 | 結晶含有貼付剤 |
| US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| WO2009107478A1 (ja) * | 2008-02-27 | 2009-09-03 | 久光製薬株式会社 | 貼付剤及び包装体 |
| JP5485135B2 (ja) | 2008-02-27 | 2014-05-07 | 久光製薬株式会社 | 貼付製剤 |
| KR20120024562A (ko) * | 2009-04-24 | 2012-03-14 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 수용 포장 백, 및 첩부제의 보존 방법 |
| KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
| EP2564873A4 (en) | 2010-04-28 | 2013-11-06 | Hisamitsu Pharmaceutical Co | MEANS FOR THE SUPPRESSION OF SKIN IRRITATIONS AND TRANSDERMAL PREPARATION THEREOF |
| US9155710B2 (en) | 2011-05-31 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Ropinirole-containing patch and package thereof |
| JPWO2012165254A1 (ja) | 2011-05-31 | 2015-02-23 | 久光製薬株式会社 | ロピニロール含有貼付剤及びその包装体 |
| EP2786752B1 (en) * | 2011-12-01 | 2019-06-12 | Teikoku Seiyaku Co., Ltd. | Ropinirole-containing adhesive patch |
| JP5270035B1 (ja) | 2012-12-06 | 2013-08-21 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
| JP5307931B1 (ja) | 2012-12-27 | 2013-10-02 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
-
2013
- 2013-06-28 JP JP2013137147A patent/JP5415645B1/ja active Active
-
2014
- 2014-06-24 TW TW103121756A patent/TWI488644B/zh active
- 2014-06-25 KR KR1020140077844A patent/KR101516122B1/ko active IP Right Grant
- 2014-06-27 CN CN201410300630.0A patent/CN104138366B/zh active Active
- 2014-06-27 ES ES14174708.9T patent/ES2551459T3/es active Active
- 2014-06-27 CA CA2855309A patent/CA2855309C/en active Active
- 2014-06-27 US US14/317,976 patent/US9320728B2/en active Active
- 2014-06-27 EP EP14174708.9A patent/EP2818161B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5415645B1 (ja) | 2014-02-12 |
| CA2855309A1 (en) | 2014-10-16 |
| TWI488644B (zh) | 2015-06-21 |
| CN104138366B (zh) | 2016-05-11 |
| KR20150002491A (ko) | 2015-01-07 |
| CA2855309C (en) | 2015-02-17 |
| KR101516122B1 (ko) | 2015-04-29 |
| EP2818161A1 (en) | 2014-12-31 |
| CN104138366A (zh) | 2014-11-12 |
| US9320728B2 (en) | 2016-04-26 |
| TW201446268A (zh) | 2014-12-16 |
| US20150004215A1 (en) | 2015-01-01 |
| JP2015010066A (ja) | 2015-01-19 |
| EP2818161B1 (en) | 2015-10-07 |
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