ES2531994T3 - Cebadores de polinucleótidos para detectar mutaciones de PIK3CA - Google Patents
Cebadores de polinucleótidos para detectar mutaciones de PIK3CA Download PDFInfo
- Publication number
- ES2531994T3 ES2531994T3 ES10158523.0T ES10158523T ES2531994T3 ES 2531994 T3 ES2531994 T3 ES 2531994T3 ES 10158523 T ES10158523 T ES 10158523T ES 2531994 T3 ES2531994 T3 ES 2531994T3
- Authority
- ES
- Spain
- Prior art keywords
- primer
- mutations
- pik3ca
- mutation
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000035772 mutation Effects 0.000 title abstract description 28
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 title abstract description 11
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 title abstract description 11
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 abstract description 7
- 101150063858 Pik3ca gene Proteins 0.000 abstract description 3
- 239000012634 fragment Substances 0.000 abstract 2
- 238000009396 hybridization Methods 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 description 10
- 241000239226 Scorpiones Species 0.000 description 9
- 238000003556 assay Methods 0.000 description 9
- 102200085789 rs121913279 Human genes 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 5
- 102200085788 rs121913279 Human genes 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 description 4
- 206010033128 Ovarian cancer Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 1
- 239000004114 Ammonium polyphosphate Substances 0.000 description 1
- 108091093088 Amplicon Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000019694 serous adenocarcinoma Diseases 0.000 description 1
- 208000004548 serous cystadenocarcinoma Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719034 | 2007-09-28 | ||
| GB0719034A GB2453173A (en) | 2007-09-28 | 2007-09-28 | Polynucleotide primers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2531994T3 true ES2531994T3 (es) | 2015-03-23 |
Family
ID=38701889
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10158523.0T Active ES2531994T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES12169604T Active ES2531055T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES10158519.8T Active ES2532141T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES12169599.3T Active ES2620289T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES12169586.0T Active ES2622885T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES12169594.4T Active ES2532225T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12169604T Active ES2531055T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES10158519.8T Active ES2532141T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES12169599.3T Active ES2620289T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES12169586.0T Active ES2622885T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES12169594.4T Active ES2532225T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8901285B2 (ko) |
| EP (7) | EP2505671B1 (ko) |
| JP (1) | JP5719593B2 (ko) |
| KR (4) | KR101548758B1 (ko) |
| CN (4) | CN103834724B (ko) |
| AU (1) | AU2008303400B2 (ko) |
| BR (1) | BRPI0817444A2 (ko) |
| CA (2) | CA3010064A1 (ko) |
| ES (6) | ES2531994T3 (ko) |
| GB (1) | GB2453173A (ko) |
| MX (1) | MX2010003486A (ko) |
| RU (1) | RU2491289C2 (ko) |
| WO (1) | WO2009040557A2 (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10190171B2 (en) | 2007-09-28 | 2019-01-29 | Qiagen Manchester Limited | Polynucleotide primers for detecting PIK3CA mutations |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3246332B1 (en) * | 2010-01-12 | 2019-07-10 | Siemens Healthcare Diagnostics Inc. | Oligonucleotides and methods for detecting pik3ca mutations |
| JP2013081450A (ja) * | 2011-09-27 | 2013-05-09 | Arkray Inc | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用試薬キット |
| CN102453765B (zh) * | 2011-11-03 | 2013-07-24 | 厦门艾德生物医药科技有限公司 | Pik3ca基因驱动突变的检测探针、引物及试剂盒 |
| SG10201608001RA (en) | 2012-03-29 | 2016-11-29 | Novartis Ag | Pharmaceutical diagnostic |
| CN102816839A (zh) * | 2012-07-06 | 2012-12-12 | 杭州艾迪康医学检验中心有限公司 | 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒 |
| EP2711432A1 (en) * | 2012-09-21 | 2014-03-26 | Genomica S.A.U. | Method for detection of BRAF and PI3K mutations |
| CA2899712C (en) * | 2013-03-13 | 2021-01-05 | F. Hoffmann-La Roche Ag | Methods and compositions for detecting mutations in the human pi3kca (pik3ca) gene |
| CN103773837A (zh) * | 2013-06-25 | 2014-05-07 | 宁波有成生物医药科技有限公司 | 一种pik3ca基因突变荧光定量pcr检测试剂盒及检测方法 |
| RU2549682C1 (ru) * | 2013-10-21 | 2015-04-27 | Общество с ограниченной ответственностью "БИОЧИП-ИМБ" | Способ анализа соматических мутаций в гене pi3k с использованием lna-блокирующей мультиплексной пцр и последующей гибридизацией с олигонуклеотидным биологическим микрочипом (биочипом) |
| WO2015161274A1 (en) * | 2014-04-18 | 2015-10-22 | Blueprint Medicines Corporation | Pik3ca fusions |
| CN105274188A (zh) * | 2014-05-29 | 2016-01-27 | 北京雅康博生物科技有限公司 | Pik3ca基因突变检测试剂盒 |
| CN106715723B (zh) * | 2014-08-07 | 2021-03-30 | 法马西斯特有限责任公司 | 测定样品中pik3ca突变状态的方法 |
| US10276072B2 (en) * | 2014-09-03 | 2019-04-30 | Washme Properties, Llc | Illuminated sign |
| CN105441533B (zh) * | 2014-11-29 | 2019-07-05 | 上海赛安生物医药科技有限公司 | Pik3ca基因突变检测体系及其试剂盒 |
| CN104531875A (zh) * | 2014-12-30 | 2015-04-22 | 宁波有成生物医药科技有限公司 | 一种MyD88基因突变荧光定量PCR检测试剂盒及检测方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5846824A (en) | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| GB9208135D0 (en) | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
| US20030225013A1 (en) * | 2002-05-31 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of phosphoinositide-3-kinase, regulatory subunit 4, p150 expression |
| US5847972A (en) | 1993-09-24 | 1998-12-08 | Eick; Stephen Gregory | Method and apparatus for graphically analzying a log-file |
| US6043062A (en) | 1995-02-17 | 2000-03-28 | The Regents Of The University Of California | Constitutively active phosphatidylinositol 3-kinase and uses thereof |
| US5948664A (en) | 1996-02-29 | 1999-09-07 | The Regents Of The University Of California | PI 3-kinase polypeptides |
| US6133419A (en) * | 1996-11-01 | 2000-10-17 | Onyx Pharmaceuticals, Inc. | Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof |
| US6277563B1 (en) | 1997-01-16 | 2001-08-21 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US5955277A (en) | 1997-05-05 | 1999-09-21 | Novo Nordisk A/S | Mutant cDNA encoding the p85α subunit of phosphatidylinositol 3-kinase |
| US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| US7122373B1 (en) | 1998-05-14 | 2006-10-17 | Nuvelo, Inc. | Human genes and gene expression products V |
| US8101349B2 (en) | 1997-12-23 | 2012-01-24 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells and their methods of use II |
| US6537751B1 (en) | 1998-04-21 | 2003-03-25 | Genset S.A. | Biallelic markers for use in constructing a high density disequilibrium map of the human genome |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6274237B1 (en) * | 1999-05-21 | 2001-08-14 | Chisso Corporation | Potentially crimpable composite fiber and a non-woven fabric using the same |
| JP2003530309A (ja) * | 1999-10-26 | 2003-10-14 | イミューソル インコーポレイテッド | 増殖性皮膚疾患又は増殖性眼疾患を治療するリボザイム療法 |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| WO2002027028A1 (en) | 2000-09-28 | 2002-04-04 | Atairgin Technologies, Inc. | A method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes |
| USH2191H1 (en) * | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| CN1358850A (zh) * | 2000-12-13 | 2002-07-17 | 上海博德基因开发有限公司 | 一种新的多肽——人磷脂酰肌醇3(PtdIns 3)－激酶17.6和编码这种多肽的多核苷酸 |
| CA2372542A1 (en) | 2001-02-20 | 2002-08-20 | Pfizer Products Inc. | Transgenic animals containing a dominant negative mutant form of the p85 subunit of pi-3 kinase |
| US20030162174A1 (en) * | 2001-06-11 | 2003-08-28 | Sutherland John W. | Detecting nucleic acid deletion sequences |
| WO2003025175A2 (fr) | 2001-09-17 | 2003-03-27 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
| US20030182669A1 (en) | 2002-03-19 | 2003-09-25 | Rockman Howard A. | Phosphoinositide 3-kinase mediated inhibition of GPCRs |
| US7955800B2 (en) | 2002-06-25 | 2011-06-07 | Advpharma Inc. | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients |
| DE60332948D1 (de) * | 2002-07-19 | 2010-07-22 | Althea Technologies Inc | Strategien zur genexpressionsanalyse |
| US7217807B2 (en) * | 2002-11-26 | 2007-05-15 | Rosetta Genomics Ltd | Bioinformatically detectable group of novel HIV regulatory genes and uses thereof |
| US20070054278A1 (en) | 2003-11-18 | 2007-03-08 | Applera Corporation | Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof |
| CA2560696C (en) | 2004-03-02 | 2019-06-25 | The Johns Hopkins University | Mutations of the pik3ca gene in human cancers |
| EP1753875A2 (en) * | 2004-05-07 | 2007-02-21 | Applera Corporation | Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof |
| WO2005116265A2 (en) * | 2004-05-26 | 2005-12-08 | Wyeth | Probe arrays for expression profiling of rat genes |
| KR20070106029A (ko) | 2005-02-24 | 2007-10-31 | 암젠 인코포레이티드 | 상피세포 성장 인자 수용체 돌연변이 |
| WO2006094149A2 (en) | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
| EP1861958B1 (en) * | 2005-03-14 | 2011-01-26 | Koninklijke Philips Electronics N.V. | MEASURING AND MONITORING QoS IN SERVICE DIFFERENTIATED WIRELESS NETWORKS |
| GB2424886A (en) * | 2005-04-04 | 2006-10-11 | Dxs Ltd | Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations |
| EP1948816B1 (en) * | 2005-10-24 | 2011-12-07 | The Johns Hopkins University | Improved methods for beaming |
| JP4477575B2 (ja) * | 2005-12-14 | 2010-06-09 | 株式会社日立製作所 | 大腸がんの検査に使用する遺伝子セット |
| WO2007106407A2 (en) * | 2006-03-10 | 2007-09-20 | Wyeth | Microarray for monitoring gene expression in multiple strains of streptococcus pneumoniae |
| GB2453173A (en) | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
| AU2008333714A1 (en) | 2007-12-03 | 2009-06-11 | Enzon Pharmaceuticals, Inc. | RNA antagonist compounds for the modulation of PIK3CA expression |
-
2007
- 2007-09-28 GB GB0719034A patent/GB2453173A/en not_active Withdrawn
-
2008
- 2008-09-29 CN CN201310752306.8A patent/CN103834724B/zh not_active Expired - Fee Related
- 2008-09-29 ES ES10158523.0T patent/ES2531994T3/es active Active
- 2008-09-29 MX MX2010003486A patent/MX2010003486A/es active IP Right Grant
- 2008-09-29 WO PCT/GB2008/003306 patent/WO2009040557A2/en active Application Filing
- 2008-09-29 EP EP12169586.0A patent/EP2505671B1/en not_active Not-in-force
- 2008-09-29 ES ES12169604T patent/ES2531055T3/es active Active
- 2008-09-29 EP EP12169604.1A patent/EP2508624B1/en not_active Not-in-force
- 2008-09-29 AU AU2008303400A patent/AU2008303400B2/en not_active Ceased
- 2008-09-29 CA CA3010064A patent/CA3010064A1/en not_active Abandoned
- 2008-09-29 CN CN201310752451.6A patent/CN103695558B/zh not_active Expired - Fee Related
- 2008-09-29 EP EP12169594.4A patent/EP2505672B1/en not_active Not-in-force
- 2008-09-29 EP EP10158519.8A patent/EP2236627B1/en not_active Not-in-force
- 2008-09-29 KR KR1020107009180A patent/KR101548758B1/ko active IP Right Grant
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10190171B2 (en) | 2007-09-28 | 2019-01-29 | Qiagen Manchester Limited | Polynucleotide primers for detecting PIK3CA mutations |
| US10196692B2 (en) | 2007-09-28 | 2019-02-05 | Qiagen Manchester Limited | Polynucleotide primers for detecting PIK3CA mutations |
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