ES2531215T3 - Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos - Google Patents

Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos Download PDF

Info

Publication number
ES2531215T3
ES2531215T3 ES07717465T ES07717465T ES2531215T3 ES 2531215 T3 ES2531215 T3 ES 2531215T3 ES 07717465 T ES07717465 T ES 07717465T ES 07717465 T ES07717465 T ES 07717465T ES 2531215 T3 ES2531215 T3 ES 2531215T3
Authority
ES
Spain
Prior art keywords
weakly basic
coating
water
organic acid
disposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07717465T
Other languages
English (en)
Inventor
Gopi Venkatesh
Jin-Wang Lai
Nehal Vyas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals Inc
Original Assignee
Aptalis Pharmatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptalis Pharmatech Inc filed Critical Aptalis Pharmatech Inc
Application granted granted Critical
Publication of ES2531215T3 publication Critical patent/ES2531215T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Abstract

Una forma de dosificación farmacéutica multiparticulada que comprende perlas de liberación sostenida (LS) y/o uno o más poblaciones de perlas de liberación pulsátil controlada (LPC) de: un fármaco débilmente básico, fármaco débilmente básico que comprende un agente de bloqueo selectivo de la serotonina 5-HT3 que contiene nitrógeno (N), o una sal farmacéuticamente aceptable del mismo, que tiene un pKa en el intervalo de aproximadamente 5 a 14, y una solubilidad no superior a aproximadamente 200 μg/ml a pH 6,8, y al menos un ácido orgánico farmacéuticamente aceptable como solubilizador; en la que el fármaco débilmente básico y el ácido orgánico no entran en contacto entre sí en la forma de dosificación; en la que dichas perlas de LS comprenden: un recubrimiento (barrera) de LS que comprende un polímero insoluble en agua solo o en combinación con un polímero hidrosoluble; estando dicho recubrimiento (barrera) de LS dispuesto sobre perlas de liberación inmediata (LI) que comprenden: el fármaco débilmente básico dispuesto sobre un recubrimiento de barrera interior que comprende un polímero insoluble en agua solo o en combinación con un polímero hidrosoluble o un polímero entérico; estando dicho recubrimiento de barrera interior dispuesto sobre partículas de núcleo de ácido orgánico que comprenden al menos un ácido orgánico farmacéuticamente aceptable; y en la que dichas perlas de LPC comprenden: un recubrimiento exterior de tiempo de retardo que comprende un polímero insoluble en agua en combinación con un polímero entérico, proporcionando dicho recubrimiento exterior de tiempo de retardo un tiempo de retardo de aproximadamente 2 a aproximadamente 17 horas antes del inicio de la liberación del fármaco débilmente básico; estando dicho recubrimiento exterior de tiempo de retardo dispuesto sobre perlas de liberación inmediata (LI) que comprenden: el fármaco débilmente básico dispuesto sobre un recubrimiento de barrera interior que comprende un polímero insoluble en agua solo o en combinación con un polímero hidrosoluble o un polímero entérico; estando dicho recubrimiento de barrera interior dispuesto sobre partículas de núcleo de ácido orgánico que comprenden al menos un ácido orgánico farmacéuticamente aceptable; en donde dicha forma de dosificación es adecuada para una pauta de dosificación de una vez al día en pacientes que necesitan dicha medicación.
ES07717465T 2006-01-27 2007-01-29 Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos Active ES2531215T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76275006P 2006-01-27 2006-01-27
PCT/US2007/061217 WO2007090082A2 (en) 2006-01-27 2007-01-29 Drug delivery systems comprising weakly basic selective serotonin 5-ht3 blocking agent and organic acids

Publications (1)

Publication Number Publication Date
ES2531215T3 true ES2531215T3 (es) 2015-03-11

Family

ID=38325269

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11001973.4T Active ES2550035T3 (es) 2006-01-27 2007-01-29 Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos
ES07717465T Active ES2531215T3 (es) 2006-01-27 2007-01-29 Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES11001973.4T Active ES2550035T3 (es) 2006-01-27 2007-01-29 Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos

Country Status (14)

Country Link
US (1) US20070190145A1 (es)
EP (2) EP2363117B1 (es)
JP (3) JP5433236B2 (es)
KR (1) KR101413613B1 (es)
CN (2) CN101410094B (es)
AU (1) AU2007211091B8 (es)
BR (1) BRPI0707324A2 (es)
CA (1) CA2640460C (es)
ES (2) ES2550035T3 (es)
IL (1) IL193020A0 (es)
NZ (1) NZ570039A (es)
RU (1) RU2490012C2 (es)
WO (1) WO2007090082A2 (es)
ZA (1) ZA200806497B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007090091A2 (en) * 2006-01-27 2007-08-09 Eurand, Inc. Drug delivery systems comprising weakly basic drugs and organic acids
EP2187873B1 (en) * 2007-08-13 2018-07-25 Abuse Deterrent Pharmaceutical Llc Abuse resistant drugs, method of use and method of making
CN101951767A (zh) * 2007-12-10 2011-01-19 欧兰德股份有限公司 包含苯海拉明的口服崩解片剂
BRPI0821761A2 (pt) * 2007-12-21 2015-06-16 Eurand Inc Composições de comprimidos de desintegração oral de temazepam
KR101752080B1 (ko) 2007-12-28 2017-06-28 임팩스 라보라토리즈, 인코포레이티드 레보도파 방출 제어형 제제 및 이의 용도
EP2090297A1 (en) * 2008-02-13 2009-08-19 Boehringer Ingelheim International GmbH Formulations of flibanserin
US8133506B2 (en) * 2008-03-12 2012-03-13 Aptalis Pharmatech, Inc. Drug delivery systems comprising weakly basic drugs and organic acids
TWI519322B (zh) * 2008-04-15 2016-02-01 愛戴爾製藥股份有限公司 包含弱鹼性藥物及控制釋放劑型之組合物
WO2010026993A1 (ja) * 2008-09-03 2010-03-11 武田薬品工業株式会社 製剤における吸収性改善方法および吸収性が改善された製剤
WO2010096814A1 (en) * 2009-02-23 2010-08-26 Eurand, Inc. Controlled-release compositions comprising a proton pump inhibitor
RU2589823C2 (ru) * 2009-04-09 2016-07-10 Алкермес Фарма Айэленд Лимитед Композиция для доставки лекарственных средств
US20110003005A1 (en) * 2009-07-06 2011-01-06 Gopi Venkatesh Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions
BR112012012999A2 (pt) 2009-11-30 2019-04-02 Aptalis Pharmatech Inc Composição farmacêutica, e composição de tablete de desintegração oral (odt) outablete de dispersão rápida (rdt)
WO2011066289A1 (en) * 2009-11-30 2011-06-03 Eurand, Inc. Ondansetron orally disintegrating tablet compositions for prevention of nausea and vomiting
KR101143997B1 (ko) * 2010-03-04 2012-05-09 한미사이언스 주식회사 유산균 제제 및 5-ｈｔ4 수용체 효능제를 함유하는 경구 투여용 복합 제제 및 이의 제조방법
GB201004020D0 (en) 2010-03-11 2010-04-21 Acacia Pharma Ltd New therapeutic use
US9011912B2 (en) 2010-10-07 2015-04-21 Abon Pharmaceuticals, Llc Extended-release oral dosage forms for poorly soluble amine drugs
AU2011336300B2 (en) 2010-12-02 2015-05-21 Adare Pharmaceuticals, Inc. Rapidly dispersing granules, orally disintegrating tablets and methods
US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
EP3054929B1 (en) 2013-10-07 2020-08-05 Impax Laboratories, LLC Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
US9649279B2 (en) * 2013-12-16 2017-05-16 Massachusetts Institute Of Technology Fortified micronutrient salt formulations
AU2015228545B2 (en) * 2014-03-11 2020-03-12 Redhill Biopharma Ltd. Ondansetron extended release solid dosage forms for treating either nausea, vomiting or diarrhea symptoms
EP3200764B1 (en) * 2014-10-01 2020-07-22 Oxytone Bioscience B.V. Orally disintegrating solid pharmaceutical dosage unit containing a partus control substance
JP6607509B2 (ja) * 2014-10-01 2019-11-20 オキシトーン バイオサイエンス ビー．ブイ． 分娩制御物質を含有する口腔内崩壊性固形医薬投与単位
CN104473895A (zh) * 2014-11-20 2015-04-01 美吉斯制药（厦门）有限公司 拉莫三嗪口腔崩解缓释片
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
CN108624005B (zh) * 2017-03-24 2021-10-29 华东理工大学 基于poc和介孔纳米微球的双因子缓释系统
CN116261451A (zh) 2020-07-24 2023-06-13 凯瑞康宁生物工程有限公司 γ-羟基丁酸衍生物的药物组合物和药物动力学
KR20230058151A (ko) 2020-10-05 2023-05-02 엑스더블유파마 리미티드 감마-하이드록시부티르산 유도체의 변형된 방출 조성물
WO2022198033A1 (en) 2021-03-19 2022-09-22 XWPharma Ltd. Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative
CN117715538A (zh) * 2021-05-03 2024-03-15 剑桥糖质科学有限公司 可溶性糖和不溶性糖的组合物及相关方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634584A (en) * 1969-02-13 1972-01-11 American Home Prod Sustained action dosage form
GB1468172A (en) * 1973-03-28 1977-03-23 Benzon As Alfred Oral drug preparations
US3954959A (en) * 1973-03-28 1976-05-04 A/S Alfred Benzon Oral drug preparations
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
DD146547A5 (de) * 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
DE2950977A1 (de) * 1978-12-22 1980-07-10 Donald E Panoz Neue galenische zubereitungsform fuer die orale verabreichung von medikamenten mit programmierter besetzung, sowie verfahren zu ihrer herstellung
US4381546A (en) * 1979-03-02 1983-04-26 Paradyne Corporation System for the quantitative measurement of impairments in the communication channel of a quadrature amplitude modulation data communication system
DE3000979A1 (de) * 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
DE3124090A1 (de) * 1981-06-19 1983-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale dipyridamolformen
DE3126703A1 (de) * 1981-07-07 1983-01-27 Dr. Karl Thomae Gmbh, 7950 Biberach Bromhexin-retardform und verfahren zu ihrer herstellung
DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
IE56459B1 (en) * 1983-12-21 1991-08-14 Elan Corp Ltd Controlled absorption pharmaceutical formulation
US4894240A (en) * 1983-12-22 1990-01-16 Elan Corporation Plc Controlled absorption diltiazem formulation for once-daily administration
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
JPS62114910A (ja) * 1985-11-13 1987-05-26 エラン　コ−ポレ−シヨン　ピ−　エル　シ− 吸収がコントロ−ルされた医薬製剤
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
IE58401B1 (en) * 1986-06-20 1993-09-08 Elan Corp Plc Controlled absorption pharmaceutical composition
DE3627423A1 (de) * 1986-08-13 1988-02-18 Thomae Gmbh Dr K Arzneimittel enthaltend dipyridamol oder mopidamol und o-acetylsalicylsaeure bzw. deren physiologisch vertraegliche salze, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung der thrombusbildung
DE69201793T2 (de) * 1991-05-20 1995-09-21 Marion Laboratories Inc Mehrschichtige zubereitung mit kontrollierter freisetzung.
US5464632C1 (en) * 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
JPH0710745A (ja) * 1993-06-22 1995-01-13 Tanabe Seiyaku Co Ltd 放出開始時間制御型腸デリバリー経口製剤
JPH08157392A (ja) * 1994-12-01 1996-06-18 Kanegafuchi Chem Ind Co Ltd 放出制御型製剤
SI9500173B (sl) * 1995-05-19 2002-02-28 Lek, Trofazna farmacevtska oblika s konstantnim in kontroliranim sproščanjem amorfne učinkovine za enkrat dnevno aplikacijo
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5705190A (en) * 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs
US5840329A (en) * 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
EP1058538B9 (en) * 1998-03-06 2013-01-02 Aptalis Pharma S.r.l. Fast disintegrating tablets
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
MXPA01004381A (es) * 1998-11-02 2005-09-08 Elan Corp Plc Composicion de multiparticulado de liberacion modificada.
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6936275B2 (en) * 1999-12-20 2005-08-30 Scolr, Inc. Amino acid modulated extended release dosage form
EP1248595A4 (en) * 2000-01-20 2006-06-14 Delsys Pharmaceutical Corp PHARMACEUTICAL FORMS FOR THE STEP BY STEP REDUCTION OF MEDICAMENTS
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
US6500457B1 (en) * 2000-08-14 2002-12-31 Peirce Management, Llc Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
SK6182003A3 (en) * 2000-10-30 2004-03-02 Teva Pharma Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
US8765176B2 (en) * 2001-06-20 2014-07-01 Takeda Pharmaceutical Campany Limited Method of manufacturing tablet
US6500454B1 (en) * 2001-10-04 2002-12-31 Eurand Pharmaceuticals Ltd. Timed, sustained release systems for propranolol
DE10149674A1 (de) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
US20040019096A1 (en) * 2001-10-23 2004-01-29 Vlassios Andronis Novel formulations of carvedilol
US6663888B2 (en) * 2001-12-14 2003-12-16 Eurand Pharmaceuticals Ltd. Pulsatile release histamine H2 antagonist dosage form
MY139719A (en) * 2002-02-12 2009-10-30 Glaxo Group Ltd Oral dosage form for controlled drug release
TWI355936B (en) * 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
WO2004096182A1 (en) * 2003-04-30 2004-11-11 Ranbaxy Laboratories Limited Extended release matrix tablets of carvedilol
DE10353186A1 (de) * 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz
WO2005077341A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Orally disintegrating pharmaceutical compositions of ondansetron
US8545881B2 (en) * 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
ZA200701576B (en) * 2004-04-30 2008-09-25 Astellas Pharma Inc Time-limited release type granular pharmaceutical composition for oral administration and intraoral rapid disintegration tablet containing the composition
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
CA2584957C (en) 2004-10-21 2015-08-25 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US20060280795A1 (en) * 2005-06-08 2006-12-14 Dexcel Pharma Technologies, Ltd. Specific time-delayed burst profile delivery system
WO2007073702A2 (es) * 2005-12-29 2007-07-05 Osmotica Corp. Comprimido multicapa con combinación de triple liberación
SI1940366T1 (sl) * 2006-10-24 2009-08-31 Helsinn Healthcare Sa Mehke kapsule, ki obsegajo palonosetron hidroklorid, z izboljšano stabilnostjo in biorazpoložljivostjo
US8133506B2 (en) * 2008-03-12 2012-03-13 Aptalis Pharmatech, Inc. Drug delivery systems comprising weakly basic drugs and organic acids

Also Published As

Publication number Publication date
WO2007090082A2 (en) 2007-08-09
JP2013249305A (ja) 2013-12-12
ES2550035T3 (es) 2015-11-04
CN101410094B (zh) 2013-04-17
JP2016014048A (ja) 2016-01-28
NZ570039A (en) 2011-07-29
EP1976491B1 (en) 2014-12-17
EP2363117A1 (en) 2011-09-07
CA2640460A1 (en) 2007-08-09
AU2007211091A8 (en) 2013-08-29
JP5918179B2 (ja) 2016-05-18
KR101413613B1 (ko) 2014-07-10
JP5433236B2 (ja) 2014-03-05
KR20080098627A (ko) 2008-11-11
RU2490012C2 (ru) 2013-08-20
US20070190145A1 (en) 2007-08-16
RU2008134912A (ru) 2010-03-10
BRPI0707324A2 (pt) 2011-05-03
ZA200806497B (en) 2009-12-30
CN103211779B (zh) 2016-03-16
JP2009524697A (ja) 2009-07-02
AU2007211091A1 (en) 2007-08-09
EP1976491A2 (en) 2008-10-08
AU2007211091B8 (en) 2013-08-29
IL193020A0 (en) 2009-09-22
WO2007090082A3 (en) 2007-12-21
CN103211779A (zh) 2013-07-24
EP2363117B1 (en) 2015-08-19
CN101410094A (zh) 2009-04-15
AU2007211091B2 (en) 2013-05-02
CA2640460C (en) 2015-05-26

Similar Documents

Publication Publication Date Title
ES2531215T3 (es) Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos
WO2007090091A3 (en) Drug delivery systems comprising weakly basic drugs and organic acids
MXPA02007762A (es) Sistema de suministro de farmaco pulsativos temporalizados.
NZ587897A (en) Drug delivery systems comprising weakly basic drugs and organic acids
CO5690530A2 (es) Sistema de suministro de farmacos
RS51688B (en) METHOTREXATE CONCENTRATED SOLUTIONS
WO2013101897A3 (en) Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid
AR062583A1 (es) Sistema de suministro de farmaco oral gastro-retentivo de liberacion extendida para valsartan
JP2012502015A5 (es)
CO6150127A2 (es) Formulaciones de flibanserina y metodo para fabricarlas
PE20191048A1 (es) Formas de dosificacion farmaceutica
JP2008044951A5 (es)
CO6260019A2 (es) Metodos para el tratamiento de desordenes gastrointestinales independientes de la ingesta de alimento
ES2571703T3 (es) Formulaciones de oxicodona de una vez al día
WO2008062440A3 (en) Programmable buoyant delivery technology
FR19C1030I1 (fr) Systeme d'administration de medicament pour administrer des substances pharmaceutiquement actives pauvrement hydrosolubles
AR057904A1 (es) Medicamentos que comprenden un agente antimuscerinico y un corticoesteroide
HRP20171742T4 (hr) 2,4,6-trifluor-n-[6-(1-metilpiperidin-4-karbonil)piridin-2-il]benzamid, namijenjen liječenju migrene oralnom ili intravenskom primjenom
JP2016539921A5 (es)
UY33061A (es) Composiciones para comprimidos desintegrables oralmente de ondansetrón para prevenir náuseas y vómitos
ECSP078014A (es) Regimen de dosificacion para prasugrel
JP2018039810A5 (es)
ECSP066318A (es) Composición para la liberación de una base debil por un periodo extendido de tiempo
WO2008013630A3 (en) Calcium aluminosilicate pharmaceutical
BR0013719A (pt) Dosagem oral de liberaçâo controlada, apropriada para administração oral