ES2523401T3 - Intermedios de un nuevo procedimiento para la preparación de derivados de 5-benciliden-2-alquilimino-3- feniltiazolidin-4-ona - Google Patents

Intermedios de un nuevo procedimiento para la preparación de derivados de 5-benciliden-2-alquilimino-3- feniltiazolidin-4-ona Download PDF

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Publication number
ES2523401T3
ES2523401T3 ES12000613.5T ES12000613T ES2523401T3 ES 2523401 T3 ES2523401 T3 ES 2523401T3 ES 12000613 T ES12000613 T ES 12000613T ES 2523401 T3 ES2523401 T3 ES 2523401T3
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ES
Spain
Prior art keywords
hydroxy
thiazolidin
benc
iliden
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12000613.5T
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English (en)
Spanish (es)
Inventor
Stefan Abele
Martin Bolli
Gunther Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2523401T3 publication Critical patent/ES2523401T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES12000613.5T 2006-11-23 2007-11-22 Intermedios de un nuevo procedimiento para la preparación de derivados de 5-benciliden-2-alquilimino-3- feniltiazolidin-4-ona Active ES2523401T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WOPCT/IB2006/054409 2006-11-23
IB2006054409 2006-11-23

Publications (1)

Publication Number Publication Date
ES2523401T3 true ES2523401T3 (es) 2014-11-25

Family

ID=39316391

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12000613.5T Active ES2523401T3 (es) 2006-11-23 2007-11-22 Intermedios de un nuevo procedimiento para la preparación de derivados de 5-benciliden-2-alquilimino-3- feniltiazolidin-4-ona
ES07849225T Active ES2410793T3 (es) 2006-11-23 2007-11-22 Nuevo procedimiento para la preparación de derivados de 2-imino-tiazolidin-4-ona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES07849225T Active ES2410793T3 (es) 2006-11-23 2007-11-22 Nuevo procedimiento para la preparación de derivados de 2-imino-tiazolidin-4-ona

Country Status (13)

Country Link
US (1) US8263780B2 (cg-RX-API-DMAC10.html)
EP (2) EP2489662B1 (cg-RX-API-DMAC10.html)
JP (1) JP4669564B2 (cg-RX-API-DMAC10.html)
KR (1) KR101255879B1 (cg-RX-API-DMAC10.html)
CN (2) CN101541772B (cg-RX-API-DMAC10.html)
AU (1) AU2007323042B2 (cg-RX-API-DMAC10.html)
CA (1) CA2669069C (cg-RX-API-DMAC10.html)
DK (2) DK2489662T3 (cg-RX-API-DMAC10.html)
ES (2) ES2523401T3 (cg-RX-API-DMAC10.html)
IL (1) IL198847A (cg-RX-API-DMAC10.html)
MX (1) MX2009005048A (cg-RX-API-DMAC10.html)
TW (1) TWI460166B (cg-RX-API-DMAC10.html)
WO (1) WO2008062376A2 (cg-RX-API-DMAC10.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2352555T3 (es) 2003-11-21 2011-02-21 Actelion Pharmaceuticals Ltd. Derivados de 5-(benc-(z)-iliden)tiazolidin-4-ona como agentes inmunosupresores.
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
HRP20170246T4 (hr) 2008-03-17 2020-02-07 Actelion Pharmaceuticals Ltd. Režim doziranja za selektivni agonist s1p1-receptora
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
JP6322630B2 (ja) 2012-08-17 2018-05-09 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ （２Ｚ，５Ｚ）−５−（３−クロロ−４−（（Ｒ）−２，３−ジヒドロキシプロポキシ）ベンジリデン）−２−（プロピルイミノ）−３−（ｏ−トリル）チアゾリジン−４−オンの製造方法及び前記方法において使用される中間体
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
MY188764A (en) 2014-12-11 2021-12-30 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11220488B2 (en) 2017-09-19 2022-01-11 Teva Pharmaceuticals International Gmbh Crystalline polymorph of Ponesimod
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
MX2022000421A (es) * 2019-07-10 2022-02-10 Bayer Ag Procedimiento para preparar 2-(fenilimino)-1,3-tiazolidin-4-onas.
EP3997076A1 (de) * 2019-07-10 2022-05-18 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-(phenylimino)-1,3-thiazolidin-4-onen
KR20220093330A (ko) 2019-10-31 2022-07-05 이도르시아 파마슈티컬스 리미티드 Cxcr7 안타고니스트와 s1p1 수용체 조절인자의 조합
KR20200019639A (ko) 2020-01-30 2020-02-24 전대연 만남의 스마트 도착시스템
KR20220143032A (ko) * 2020-02-18 2022-10-24 바이엘 악티엔게젤샤프트 2-(페닐이미노)-3-알킬-1,3-티아졸리딘-4-온의 제조 방법
US20240368094A1 (en) 2021-08-17 2024-11-07 Teva Czech Industries S.R.O Polymorphs of ponesimod
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152691A1 (en) * 2022-02-10 2023-08-17 Metrochem Api Pvt Ltd Process for the preparation of ponesimod and its intermediates thereof
CN117924210A (zh) * 2024-01-22 2024-04-26 赣南师范大学 一种2-亚氨基噻唑烷-4-酮类化合物的制备方法

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OA03835A (fr) 1970-07-17 1971-12-24 Rhone Poulenc Sa Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent.
WO1991017151A1 (en) 1990-04-27 1991-11-14 Orion-Yhtymä Oy New pharmacologically active catechol derivatives
TW221689B (cg-RX-API-DMAC10.html) * 1991-08-27 1994-03-11 Otsuka Pharma Co Ltd
CN1037842C (zh) * 1993-02-26 1998-03-25 大制药株式会社 取代的噻唑烷衍生物及其药物组合物和用途
KR960022486A (ko) 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
US6353006B1 (en) * 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
EP1219612B1 (en) 1999-09-14 2008-04-23 Shionogi & Co., Ltd. 2-imino-1,3-thiazine derivatives
DE69934027T2 (de) * 1999-11-12 2007-06-21 Fujimoto Brothers Co., Ltd., Matubara 2-(n-cyanimino)thiazolidin-4-on derivate
US20050019825A9 (en) * 2002-03-15 2005-01-27 Qing Dong Common ligand mimics: pseudothiohydantoins
EA011807B1 (ru) 2002-07-10 2009-06-30 Лаборатуар Сероно Са Азолидинонвинильные производные конденсированного бензола
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
ATE411302T1 (de) * 2002-11-22 2008-10-15 Smithkline Beecham Corp Thiazolidin-4-ones um hyak3 proteinen zu hemmen
US20040167192A1 (en) * 2003-01-16 2004-08-26 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
ES2352555T3 (es) * 2003-11-21 2011-02-21 Actelion Pharmaceuticals Ltd. Derivados de 5-(benc-(z)-iliden)tiazolidin-4-ona como agentes inmunosupresores.
JP2007523957A (ja) * 2004-02-25 2007-08-23 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
WO2006094233A1 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N,n'-dicyclic isothiourea sirtuin modulators
HRP20170246T4 (hr) * 2008-03-17 2020-02-07 Actelion Pharmaceuticals Ltd. Režim doziranja za selektivni agonist s1p1-receptora
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms

Also Published As

Publication number Publication date
CA2669069A1 (en) 2008-05-29
JP4669564B2 (ja) 2011-04-13
IL198847A (en) 2015-07-30
CN103087004A (zh) 2013-05-08
US20100317867A1 (en) 2010-12-16
CA2669069C (en) 2015-02-17
EP2094676A2 (en) 2009-09-02
JP2010510976A (ja) 2010-04-08
CN101541772B (zh) 2013-04-17
AU2007323042B2 (en) 2012-12-20
WO2008062376A2 (en) 2008-05-29
WO2008062376A3 (en) 2008-07-10
EP2094676B1 (en) 2013-04-10
DK2489662T3 (da) 2014-10-20
TW200831474A (en) 2008-08-01
CN101541772A (zh) 2009-09-23
KR20090081009A (ko) 2009-07-27
DK2094676T3 (da) 2013-06-10
AU2007323042A1 (en) 2008-05-29
EP2489662B1 (en) 2014-08-06
TWI460166B (zh) 2014-11-11
KR101255879B1 (ko) 2013-04-17
US20110201821A2 (en) 2011-08-18
US8263780B2 (en) 2012-09-11
ES2410793T3 (es) 2013-07-03
IL198847A0 (en) 2010-02-17
EP2489662A1 (en) 2012-08-22
MX2009005048A (es) 2009-05-25
BRPI0718986A2 (pt) 2014-02-11

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