ES2519440T3 - Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis - Google Patents
Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis Download PDFInfo
- Publication number
- ES2519440T3 ES2519440T3 ES01959315.1T ES01959315T ES2519440T3 ES 2519440 T3 ES2519440 T3 ES 2519440T3 ES 01959315 T ES01959315 T ES 01959315T ES 2519440 T3 ES2519440 T3 ES 2519440T3
- Authority
- ES
- Spain
- Prior art keywords
- neisseria meningitidis
- preparation
- vme
- strain
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000588650 Neisseria meningitidis Species 0.000 title abstract 8
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 13
- 241000124008 Mammalia Species 0.000 abstract 4
- 230000028993 immune response Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22149500P | 2000-07-27 | 2000-07-27 | |
| US221495P | 2000-07-27 | ||
| PCT/US2001/023842 WO2002009643A2 (en) | 2000-07-27 | 2001-07-27 | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2519440T3 true ES2519440T3 (es) | 2014-11-07 |
Family
ID=22828056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01959315.1T Expired - Lifetime ES2519440T3 (es) | 2000-07-27 | 2001-07-27 | Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6936261B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1322328B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5511117B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20030024811A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2001280883A1 (cg-RX-API-DMAC10.html) |
| BR (1) | BRPI0112928B1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2416137C (cg-RX-API-DMAC10.html) |
| CR (1) | CR6880A (cg-RX-API-DMAC10.html) |
| EC (1) | ECSP034447A (cg-RX-API-DMAC10.html) |
| ES (1) | ES2519440T3 (cg-RX-API-DMAC10.html) |
| MX (1) | MXPA03000822A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2002009643A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7935675B1 (en) * | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| JP5074644B2 (ja) | 1998-05-29 | 2012-11-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 組合わせの髄膜炎菌b/cワクチン |
| US10967045B2 (en) | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| NZ545647A (en) | 1999-05-19 | 2008-02-29 | Chiron Srl | Combination neisserial compositions |
| PT2275552E (pt) | 1999-10-29 | 2015-12-07 | Glaxosmithkline Biolog Sa | Péptidos antigénicos de neisseria |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| DE60131430T2 (de) | 2000-01-14 | 2008-10-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
| BR0107679A (pt) | 2000-01-17 | 2004-07-06 | Chiron Spa | Vacina de vesìcula de membrana externa (omv) compreendendo proteìnas de membrana externa do grupo sérico b de neisseria meningitidis |
| NO20002828D0 (no) * | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| AU2001280883A1 (en) * | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| WO2003054161A2 (en) | 2001-12-20 | 2003-07-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| AU2003239666A1 (en) * | 2002-05-14 | 2003-11-11 | Affitech As | Antibody screening libraries |
| GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| JP4740738B2 (ja) * | 2002-08-02 | 2011-08-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| RU2364418C2 (ru) * | 2002-08-02 | 2009-08-20 | ГлаксоСмитКлайн Байолоджикалз с.а. | ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB- |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| WO2004054611A1 (en) * | 2002-12-16 | 2004-07-01 | Nasjonalt Folkehelseinstitutt | Meningococcal vaccine based on outer membrane proteins porb2 and pora |
| EP2191844B1 (en) | 2003-01-30 | 2014-03-05 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| WO2005077409A1 (en) * | 2004-02-18 | 2005-08-25 | The University Of Newcastle Research Associates Limited | A vaccine formulated for administration to mucosa of the lungs |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| EP2682126B1 (en) | 2005-01-27 | 2016-11-23 | Children's Hospital & Research Center at Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| KR101408113B1 (ko) | 2005-06-27 | 2014-06-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| US20090269362A1 (en) * | 2005-07-25 | 2009-10-29 | Sant Andrea J | Method for Controlling Immunodominance |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| US8414899B2 (en) * | 2006-04-11 | 2013-04-09 | Yeda Research And Development Co. Ltd. | Vaccines comprising multimeric HSP60 peptide carriers |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| WO2009006620A1 (en) * | 2007-07-03 | 2009-01-08 | Children's Hospital & Research Center At Oakland | Oligosialic acid derivatives, methods of manufacture, and immunological uses |
| WO2009006591A1 (en) * | 2007-07-03 | 2009-01-08 | Children's Hospital & Research Center At Oakland | Inhibitors of polysialic acid de-n-acetylase and methods for using the same |
| US8097591B2 (en) * | 2007-07-03 | 2012-01-17 | Children's Hospital & Research Center Oakland | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting |
| EP2185576A4 (en) * | 2007-08-02 | 2011-01-12 | Childrens Hosp & Res Ct Oak | FHBP- AND LPXL1-BASED VESICIUM VACCINES FOR BROADBAND PROTECTION AGAINST NEISSERIA MENINGITIDIS-RELATED DISEASES |
| ATE553774T1 (de) | 2007-10-19 | 2012-05-15 | Novartis Ag | Meningokokkenimpfstoffformulierungen |
| BRPI0907843A2 (pt) | 2008-02-21 | 2015-08-04 | Novartis Ag | Polipeptídeos de fhbp menigocócicos |
| CA2726512A1 (en) * | 2008-06-09 | 2009-12-17 | Novartis Ag | Antibodies against neisserial factor h binding protein |
| WO2010022462A2 (en) * | 2008-08-28 | 2010-03-04 | The University Of Queensland | Mutant bacterial glycoproteins and uses thereof |
| EP2331562A4 (en) | 2008-09-03 | 2012-07-04 | Childrens Hosp & Res Ct Oak | PEPTIDES WITH AN EPITOPE OF A DOMAIN OF THE FACTOR H-BINDING PROTEIN AND METHOD OF USE |
| GB0816284D0 (en) * | 2008-09-05 | 2008-10-15 | Nat Biolog Standards Board | Vaccine |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| US20100189737A1 (en) | 2008-12-17 | 2010-07-29 | Arico Beatrice | Meningococcal vaccines including hemoglobin receptor |
| AU2010258677B2 (en) | 2009-06-10 | 2016-10-06 | Glaxosmithkline Biologicals S.A. | Benzonaphthyridine-containing vaccines |
| CN102596240B (zh) | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
| EP2470205A1 (en) | 2009-08-27 | 2012-07-04 | Novartis AG | Adjuvant comprising aluminium, oligonucleotide and polycation |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為tlr活性調節劑之化合物及組合物 |
| GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
| WO2011039631A2 (en) | 2009-09-30 | 2011-04-07 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
| BR112012010531A2 (pt) | 2009-10-27 | 2019-09-24 | Novartis Ag | "polipeptídeos de modificação meningocócica fhbp" |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| MX339146B (es) | 2009-12-15 | 2016-05-13 | Novartis Ag | Suspension homogenea de compuestos inmunopotenciadores y usos de los mismos. |
| WO2012020326A1 (en) | 2010-03-18 | 2012-02-16 | Novartis Ag | Adjuvanted vaccines for serogroup b meningococcus |
| EA023725B1 (ru) | 2010-03-23 | 2016-07-29 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
| CA2810971C (en) | 2010-09-10 | 2020-11-03 | Novartis Ag | Developments in meningococcal outer membrane vesicles |
| WO2012153302A1 (en) | 2011-05-12 | 2012-11-15 | Novartis Ag | Antipyretics to enhance tolerability of vesicle-based vaccines |
| JP5957541B2 (ja) | 2012-02-02 | 2016-07-27 | ノバルティス アーゲー | 髄膜炎菌における増加したタンパク質発現のためのプロモータ |
| WO2013132040A2 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | In vitro potency assay for protein-based meningococcal vaccines |
| BR112014031386A2 (pt) | 2012-06-14 | 2017-08-01 | Pasteur Institut | vacinas para meningococos do sorogrupo x |
| US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
| EP2897635A1 (en) | 2012-09-18 | 2015-07-29 | Novartis AG | Outer membrane vesicles |
| WO2014122232A1 (en) | 2013-02-07 | 2014-08-14 | Novartis Ag | Pharmaceutical compositions comprising vesicles |
| EP3110442B1 (en) | 2014-02-28 | 2020-10-14 | GlaxoSmithKline Biologicals SA | Modified meningococcal fhbp polypeptides |
| WO2018042017A2 (en) | 2016-09-02 | 2018-03-08 | Glaxosmithkline Biologicals Sa | Vaccines for neisseria gonorrhoeae |
| JP7369690B2 (ja) * | 2017-09-08 | 2023-10-26 | エヴェロ バイオサイエンシズ,インコーポレーテッド | 細菌の細胞外小胞 |
| EP3607967A1 (en) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
| WO2025021712A1 (en) | 2023-07-21 | 2025-01-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB202311230D0 (en) | 2023-07-21 | 2023-09-06 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| WO2025175304A2 (en) * | 2024-02-16 | 2025-08-21 | Sanofi Pasteur Inc. | Process for the preparation of deoxycholic acid |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4601903A (en) | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
| US4727136A (en) | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| RU2023448C1 (ru) | 1987-07-30 | 1994-11-30 | Сентро Насьональ Де Биопрепарадос | Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в |
| ES2070312T5 (es) * | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
| NL9201716A (nl) * | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| WO1999024578A2 (en) | 1997-11-06 | 1999-05-20 | Chiron S.P.A. | Neisserial antigens |
| CN1224708C (zh) | 1998-01-14 | 2005-10-26 | 启龙股份公司 | 脑膜炎奈瑟氏球菌抗原 |
| EP2261350A3 (en) | 1998-05-01 | 2012-01-04 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| JP5074644B2 (ja) | 1998-05-29 | 2012-11-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 組合わせの髄膜炎菌b/cワクチン |
| EP1559795A3 (en) | 1998-10-09 | 2005-11-09 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
| GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| US20030215469A1 (en) | 1998-11-02 | 2003-11-20 | Microbiological Research Authority | Multicomponent meningococcal vaccine |
| WO2000026384A1 (en) | 1998-11-03 | 2000-05-11 | De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Lps with reduced toxicity from genetically modified gram negative bacteria |
| US7081244B2 (en) | 1999-02-22 | 2006-07-25 | Health Protection Agency | Neisserial vaccine compositions and methods |
| DE60042114D1 (de) | 1999-04-30 | 2009-06-10 | Craig J Venter Inst Inc | Genomische sequenzen von neisseria und verfahren zu ihrer verwendung |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| AU1917501A (en) | 1999-11-12 | 2001-06-06 | University Of Iowa Research Foundation, The | Control of neisserial membrane synthesis |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| BR0107679A (pt) | 2000-01-17 | 2004-07-06 | Chiron Spa | Vacina de vesìcula de membrana externa (omv) compreendendo proteìnas de membrana externa do grupo sérico b de neisseria meningitidis |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| AU2001280883A1 (en) | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0024200D0 (en) | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
| GB0103169D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| PT2248822T (pt) | 2001-07-27 | 2017-02-14 | Glaxosmithkline Biologicals Sa | Adesinas de meningococos |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| EP1374892A1 (en) | 2002-06-28 | 2004-01-02 | Braun, Jan Matthias, Dr. | Medicament for the treatment of diseases due to infection by Neisseria Meningitidis |
| JP4740738B2 (ja) | 2002-08-02 | 2011-08-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| DE60335477D1 (de) | 2002-10-11 | 2011-02-03 | Novartis Vaccines & Diagnostic | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP2682126B1 (en) | 2005-01-27 | 2016-11-23 | Children's Hospital & Research Center at Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| EP2185576A4 (en) | 2007-08-02 | 2011-01-12 | Childrens Hosp & Res Ct Oak | FHBP- AND LPXL1-BASED VESICIUM VACCINES FOR BROADBAND PROTECTION AGAINST NEISSERIA MENINGITIDIS-RELATED DISEASES |
-
2001
- 2001-07-27 AU AU2001280883A patent/AU2001280883A1/en not_active Abandoned
- 2001-07-27 US US09/917,222 patent/US6936261B2/en not_active Expired - Lifetime
- 2001-07-27 WO PCT/US2001/023842 patent/WO2002009643A2/en not_active Ceased
- 2001-07-27 CA CA2416137A patent/CA2416137C/en not_active Expired - Lifetime
- 2001-07-27 MX MXPA03000822A patent/MXPA03000822A/es active IP Right Grant
- 2001-07-27 BR BRPI0112928-7A patent/BRPI0112928B1/pt not_active IP Right Cessation
- 2001-07-27 EP EP01959315.1A patent/EP1322328B1/en not_active Expired - Lifetime
- 2001-07-27 KR KR10-2003-7001130A patent/KR20030024811A/ko not_active Ceased
- 2001-07-27 ES ES01959315.1T patent/ES2519440T3/es not_active Expired - Lifetime
- 2001-07-27 JP JP2002515198A patent/JP5511117B2/ja not_active Expired - Lifetime
-
2003
- 2003-01-14 CR CR6880A patent/CR6880A/es unknown
- 2003-01-24 EC EC2003004447A patent/ECSP034447A/es unknown
-
2005
- 2005-03-15 US US11/081,882 patent/US8980285B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030024811A (ko) | 2003-03-26 |
| BRPI0112928B1 (pt) | 2017-08-29 |
| US8980285B2 (en) | 2015-03-17 |
| BR0112928A (pt) | 2003-08-26 |
| AU2001280883A1 (en) | 2002-02-13 |
| ECSP034447A (es) | 2003-04-25 |
| CA2416137C (en) | 2013-01-29 |
| JP2004512269A (ja) | 2004-04-22 |
| MXPA03000822A (es) | 2004-11-01 |
| EP1322328B1 (en) | 2014-08-20 |
| EP1322328A4 (en) | 2005-07-20 |
| US6936261B2 (en) | 2005-08-30 |
| BRPI0112928B8 (cg-RX-API-DMAC10.html) | 2021-05-25 |
| WO2002009643A3 (en) | 2002-05-30 |
| CR6880A (es) | 2006-08-09 |
| EP1322328A2 (en) | 2003-07-02 |
| JP5511117B2 (ja) | 2014-06-04 |
| CA2416137A1 (en) | 2002-02-07 |
| US20020110569A1 (en) | 2002-08-15 |
| US20060029621A1 (en) | 2006-02-09 |
| WO2002009643A2 (en) | 2002-02-07 |
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