ES2513394T3 - Combinación farmacéutica de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y un antiepiléptico - Google Patents
Combinación farmacéutica de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y un antiepiléptico Download PDFInfo
- Publication number
- ES2513394T3 ES2513394T3 ES09778335.1T ES09778335T ES2513394T3 ES 2513394 T3 ES2513394 T3 ES 2513394T3 ES 09778335 T ES09778335 T ES 09778335T ES 2513394 T3 ES2513394 T3 ES 2513394T3
- Authority
- ES
- Spain
- Prior art keywords
- methylpropyl
- dimethylamino
- phenol
- ethyl
- antiepileptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- KWTWDQCKEHXFFR-UHFFFAOYSA-N 3-[1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)CC(C)C(CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000003556 anti-epileptic effect Effects 0.000 title abstract 2
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 abstract 1
- 229960000623 carbamazepine Drugs 0.000 abstract 1
- PCOBBVZJEWWZFR-UHFFFAOYSA-N ezogabine Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 PCOBBVZJEWWZFR-UHFFFAOYSA-N 0.000 abstract 1
- 229960002623 lacosamide Drugs 0.000 abstract 1
- VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 abstract 1
- 229960001848 lamotrigine Drugs 0.000 abstract 1
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 abstract 1
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960003312 retigabine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960004394 topiramate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08015625 | 2008-09-05 | ||
| EP08015625 | 2008-09-05 | ||
| PCT/EP2009/006424 WO2010025931A2 (en) | 2008-09-05 | 2009-09-04 | Pharmaceutical combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2513394T3 true ES2513394T3 (es) | 2014-10-27 |
Family
ID=40345058
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09778335.1T Active ES2513394T3 (es) | 2008-09-05 | 2009-09-04 | Combinación farmacéutica de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y un antiepiléptico |
| ES14000597T Active ES2719900T3 (es) | 2008-09-05 | 2009-09-04 | Combinación farmacéutica de 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol y pregabalina o gabapentina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14000597T Active ES2719900T3 (es) | 2008-09-05 | 2009-09-04 | Combinación farmacéutica de 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol y pregabalina o gabapentina |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20100063148A1 (OSRAM) |
| EP (2) | EP2735338B1 (OSRAM) |
| JP (4) | JP5731387B2 (OSRAM) |
| KR (3) | KR101730924B1 (OSRAM) |
| CN (2) | CN102159284B (OSRAM) |
| AR (2) | AR073361A1 (OSRAM) |
| AU (3) | AU2009289776A1 (OSRAM) |
| BR (1) | BRPI0920521A2 (OSRAM) |
| CA (1) | CA2735857C (OSRAM) |
| CL (1) | CL2011000317A1 (OSRAM) |
| CO (1) | CO6382142A2 (OSRAM) |
| CY (2) | CY1115751T1 (OSRAM) |
| DK (2) | DK2331210T3 (OSRAM) |
| EC (1) | ECSP11010869A (OSRAM) |
| ES (2) | ES2513394T3 (OSRAM) |
| HR (2) | HRP20140663T1 (OSRAM) |
| HU (1) | HUE043278T2 (OSRAM) |
| IL (3) | IL211135A (OSRAM) |
| LT (1) | LT2735338T (OSRAM) |
| MX (1) | MX2011002339A (OSRAM) |
| PE (5) | PE20190914A1 (OSRAM) |
| PL (2) | PL2735338T3 (OSRAM) |
| PT (2) | PT2331210E (OSRAM) |
| RU (2) | RU2674150C1 (OSRAM) |
| SI (2) | SI2331210T1 (OSRAM) |
| TR (1) | TR201904388T4 (OSRAM) |
| WO (1) | WO2010025931A2 (OSRAM) |
| ZA (1) | ZA201101449B (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI312285B (en) * | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US20060159743A1 (en) * | 2001-10-25 | 2006-07-20 | Depomed, Inc. | Methods of treating non-nociceptive pain states with gastric retentive gabapentin |
| US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
| US20090176882A1 (en) | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| EP2462990B2 (en) | 2006-06-15 | 2018-04-18 | UCB Pharma GmbH | Pharmaceutical composition comprising lacosamide and levetiracetam with synergistic anticonvulsant effect |
| RU2674150C1 (ru) * | 2008-09-05 | 2018-12-05 | Грюненталь Гмбх | Фармацевтическая комбинация |
| US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| FR2943246B1 (fr) * | 2009-03-19 | 2011-07-29 | Biocodex | Compose pour son utilisation dans le traitement des neuropathies peripheriques |
| EP2582366B1 (en) | 2010-06-15 | 2015-10-28 | Grünenthal GmbH | Pharmaceutical combination for the treatment of pain |
| AU2011276170B2 (en) | 2010-07-06 | 2016-03-10 | Grunenthal Gmbh | Novel gastro- retentive dosage forms comprising a GABA Analog and an opioid |
| RU2544552C2 (ru) | 2010-07-30 | 2015-03-20 | Торэй Индастриз, Инк. | Терапевтическое средство или профилактическое средство для нейропатической боли |
| CN103501775A (zh) * | 2011-03-04 | 2014-01-08 | 格吕伦塔尔有限公司 | 他喷他多的胃肠外给药 |
| EP2753302B1 (en) * | 2011-07-20 | 2018-11-28 | Torrent Pharmaceuticals Ltd. | Pharmaceutical composition of tapentadol |
| TR201802128T4 (tr) * | 2011-07-29 | 2018-03-21 | Gruenenthal Gmbh | İntratekal veya epidural yolla 3-[(1s,2s)-3-(dimetilamino)-1-etil-2-metilpropil]fenol uygulaması. |
| US9320725B2 (en) * | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid |
| US8912226B2 (en) * | 2012-05-18 | 2014-12-16 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
| US9855286B2 (en) | 2012-05-18 | 2018-01-02 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
| US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
| US20130310435A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol |
| US9345689B2 (en) * | 2012-05-18 | 2016-05-24 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant |
| US9308196B2 (en) * | 2012-05-18 | 2016-04-12 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam |
| KR20150075408A (ko) * | 2012-11-01 | 2015-07-03 | 토렌트 파마슈티칼스 리미티드 | 비경구용 타펜타돌의 약학 조성물 |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| CN103655523A (zh) * | 2013-12-24 | 2014-03-26 | 南京艾德凯腾生物医药有限责任公司 | 他喷他多组合物 |
| WO2017112701A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| HRP20250898T1 (hr) | 2015-12-22 | 2025-09-26 | Zogenix International Limited | Pripravci fenfluramina i postupci njihove pripreme |
| JP2019526544A (ja) | 2016-08-24 | 2019-09-19 | ゾゲニクス インターナショナル リミテッド | ５−ｈｔ２ｂアゴニストの形成を阻害するための製剤およびその使用方法 |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| KR20190081385A (ko) | 2017-12-29 | 2019-07-09 | 강원대학교산학협력단 | 옥스카바제핀을 유효성분으로 함유하는 허혈성 뇌혈관 질환 예방용 조성물 |
| WO2019216919A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| SG11202104378SA (en) | 2018-11-19 | 2021-05-28 | Zogenix International Ltd | Methods of treating rett syndrome using fenfluramine |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| US6562865B1 (en) * | 1999-08-20 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Composition comprising a tramadol material and an anticonvulsant drug |
| EP1471909A4 (en) * | 2002-01-16 | 2007-07-25 | Endo Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM |
| IL162932A0 (en) * | 2002-02-22 | 2005-11-20 | Warner Lambert Co | Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2 |
| WO2007005716A2 (en) * | 2005-06-30 | 2007-01-11 | Cinergen, Llc | Methods of treatment and compositions for use thereof |
| US20090082466A1 (en) * | 2006-01-27 | 2009-03-26 | Najib Babul | Abuse Resistant and Extended Release Formulations and Method of Use Thereof |
| RU2465263C2 (ru) * | 2006-04-28 | 2012-10-27 | Грюненталь Гмбх | Фармацевтическая комбинация, включающая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и нестероидный противовоспалительный препарат |
| WO2008027442A2 (en) * | 2006-08-30 | 2008-03-06 | Theraquest Biosciences, Llc | Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use |
| PL2596784T3 (pl) * | 2007-11-23 | 2017-06-30 | Grünenthal GmbH | Kompozycje tapentadolu |
| CA2710538A1 (en) * | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of a (3s)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| RU2674150C1 (ru) * | 2008-09-05 | 2018-12-05 | Грюненталь Гмбх | Фармацевтическая комбинация |
-
2009
- 2009-09-04 RU RU2014138166A patent/RU2674150C1/ru active
- 2009-09-04 PE PE2018003303A patent/PE20190914A1/es unknown
- 2009-09-04 PL PL14000597T patent/PL2735338T3/pl unknown
- 2009-09-04 PE PE2014001116A patent/PE20142371A1/es active IP Right Grant
- 2009-09-04 RU RU2011112444/15A patent/RU2571501C2/ru active
- 2009-09-04 MX MX2011002339A patent/MX2011002339A/es active IP Right Grant
- 2009-09-04 AU AU2009289776A patent/AU2009289776A1/en not_active Abandoned
- 2009-09-04 EP EP14000597.6A patent/EP2735338B1/en not_active Not-in-force
- 2009-09-04 HU HUE14000597A patent/HUE043278T2/hu unknown
- 2009-09-04 KR KR1020167018592A patent/KR101730924B1/ko not_active Expired - Fee Related
- 2009-09-04 ES ES09778335.1T patent/ES2513394T3/es active Active
- 2009-09-04 ES ES14000597T patent/ES2719900T3/es active Active
- 2009-09-04 PL PL09778335T patent/PL2331210T3/pl unknown
- 2009-09-04 LT LTEP14000597.6T patent/LT2735338T/lt unknown
- 2009-09-04 DK DK09778335.1T patent/DK2331210T3/da active
- 2009-09-04 SI SI200931014T patent/SI2331210T1/sl unknown
- 2009-09-04 DK DK14000597.6T patent/DK2735338T3/en active
- 2009-09-04 HR HRP20140663AT patent/HRP20140663T1/hr unknown
- 2009-09-04 PT PT97783351T patent/PT2331210E/pt unknown
- 2009-09-04 PE PE2014001115A patent/PE20142357A1/es active IP Right Grant
- 2009-09-04 KR KR1020177010825A patent/KR101851120B1/ko not_active Expired - Fee Related
- 2009-09-04 CN CN200980135117.8A patent/CN102159284B/zh not_active Expired - Fee Related
- 2009-09-04 EP EP09778335.1A patent/EP2331210B1/en active Active
- 2009-09-04 AR ARP090103405A patent/AR073361A1/es not_active Application Discontinuation
- 2009-09-04 CA CA2735857A patent/CA2735857C/en not_active Expired - Fee Related
- 2009-09-04 WO PCT/EP2009/006424 patent/WO2010025931A2/en not_active Ceased
- 2009-09-04 SI SI200931945T patent/SI2735338T1/sl unknown
- 2009-09-04 PE PE2014001117A patent/PE20142372A1/es active IP Right Grant
- 2009-09-04 JP JP2011525465A patent/JP5731387B2/ja active Active
- 2009-09-04 CN CN201510736012.5A patent/CN105520924B/zh not_active Expired - Fee Related
- 2009-09-04 BR BRPI0920521A patent/BRPI0920521A2/pt not_active Application Discontinuation
- 2009-09-04 KR KR1020117005044A patent/KR101641519B1/ko not_active Expired - Fee Related
- 2009-09-04 US US12/554,235 patent/US20100063148A1/en not_active Abandoned
- 2009-09-04 TR TR2019/04388T patent/TR201904388T4/tr unknown
- 2009-09-04 PT PT14000597T patent/PT2735338T/pt unknown
- 2009-09-04 PE PE2011000206A patent/PE20110291A1/es active IP Right Grant
-
2011
- 2011-02-09 IL IL211135A patent/IL211135A/en active IP Right Grant
- 2011-02-14 CL CL2011000317A patent/CL2011000317A1/es unknown
- 2011-02-16 CO CO11018461A patent/CO6382142A2/es active IP Right Grant
- 2011-02-23 ZA ZA2011/01449A patent/ZA201101449B/en unknown
- 2011-03-04 EC EC2011010869A patent/ECSP11010869A/es unknown
-
2014
- 2014-09-16 CY CY20141100748T patent/CY1115751T1/el unknown
- 2014-12-12 JP JP2014251851A patent/JP2015096530A/ja active Pending
-
2015
- 2015-02-24 IL IL237391A patent/IL237391A/en active IP Right Grant
- 2015-02-24 IL IL237392A patent/IL237392B/en active IP Right Grant
-
2016
- 2016-05-11 AU AU2016203053A patent/AU2016203053B2/en not_active Ceased
- 2016-12-12 JP JP2016240032A patent/JP2017071636A/ja active Pending
-
2018
- 2018-04-26 AU AU2018202879A patent/AU2018202879B2/en not_active Ceased
-
2019
- 2019-03-13 HR HRP20190500TT patent/HRP20190500T1/hr unknown
- 2019-03-27 CY CY20191100357T patent/CY1121492T1/el unknown
- 2019-04-02 JP JP2019070282A patent/JP2019131578A/ja active Pending
- 2019-07-19 AR ARP190102034A patent/AR117613A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2513394T3 (es) | Combinación farmacéutica de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y un antiepiléptico | |
| EA201170042A1 (ru) | Композиции для осветления цвета кожи | |
| ES2560676T3 (es) | Combinación farmacéutica para el tratamiento del dolor | |
| CL2012003009A1 (es) | Acido3-(((3-butil-3-etil-(metiloxi)-1-1-dioxido-5-fenil-2,3,4,5-tetrahidro-1,4benxotiazepin-8-il)-metil)-amino)-pentanodioco; composicion farmaceutica que lo comprende; y su uso en un tastorno metabolico. pct. | |
| CO6270312A2 (es) | Moduladores de gpr40 bifenilo-sustituidos | |
| CL2012000537A1 (es) | Mezcla fungicida sinergica que comprende un compuesto derivado de 5-fluoro-2-{(4-metilbenzil)oxi}pirimidina-4-amino y otro fungicida; y composicion fungicida que la comprende. | |
| CL2007002424A1 (es) | Compuestos derivados de isoxazolidina; composicion farmaceutica que comprende a dicho compuesto, util para el tratamiento de trastornos asociados con hiperproliferacion como cancer. | |
| ECSP12011858A (es) | Tratamiento de cáncer (es) resistente (s) a antagonistas de notch1 usando antagonistas de notch3 | |
| BRPI0803374A2 (pt) | compostos polihidróxi como agentes de extinção de polimerização | |
| CO6382157A2 (es) | Compuestos pirazina como inhibidores de fosfodiesterasa 10 | |
| CO6321189A2 (es) | Compuestos de tiazol y oxazol de bencen-sulfonamida | |
| EA201200046A1 (ru) | Новые соединения, фармацевтическая композиция и связанные с ними способы | |
| CR9223A (es) | 18-metil-19-nor-17-pregn-4-en-21, 17-carbolactonas,asi como preparaciones farmaceuticas que las contienen | |
| UY31015A1 (es) | Mezclas pesticidas que comprenden compuestos de cianosulfoximina | |
| CL2009000402A1 (es) | Compuestos derivados de 2-amino-acetamida sustituida; composicion farmaceutica; utiles en el tratamiento de enfermedades pulmonares, enfermedad reumatica, enfermedad autoinmune, entre otras. | |
| DOP2011000183A (es) | Polimorfos de(s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c][1,2-oxaborol-1-ol | |
| EA201200484A1 (ru) | Фармацевтическая композиция с действующими веществами - метформином и ситаглиптином или вилдаглиптином | |
| IL207811A0 (en) | Kit, composition, product or medicament for treating cognitive impairment | |
| CL2011002233A1 (es) | Metodo para tratar o prevenir el cancer, que comprende administrar una combinacion farmaceutica sinergica de: a) (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y b) 3-(6,7-bis(2-metoxietoxi)quinazolin-4-ilamino)benzonitrilo; composicion farmaceutica; y kit farmaceutico. | |
| CL2012001031A1 (es) | Compuestos derivados de 2-oxo-1-pirrolidinil-imidazotiadiazol; composición farmacéutica que los comprende; útiles para el tratamiento de la epilepsia, transtornos neurológicos, entre otros. | |
| DK2478054T3 (da) | Polyamidsammensætning, som indeholder polyamid 4,10 | |
| BR112012014621A2 (pt) | processo para a preparação de compostos de quelato | |
| BRPI1014222A2 (pt) | composto, composição farmacêutica,e, métodos para tratar distúrbio(s) cognitivo(s) ou indicações com déficit(s) na cognição, mal de alzheimer, e distúrbio bipolar | |
| BRPI0914940A8 (pt) | Composições nutritivas contendo punicalaginas | |
| MY147634A (en) | New crystalline forms |