ES2482097T3 - Preparación de antibacterianos de ácido piridoncarboxílico - Google Patents

Preparación de antibacterianos de ácido piridoncarboxílico Download PDF

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Publication number
ES2482097T3
ES2482097T3 ES09163080.6T ES09163080T ES2482097T3 ES 2482097 T3 ES2482097 T3 ES 2482097T3 ES 09163080 T ES09163080 T ES 09163080T ES 2482097 T3 ES2482097 T3 ES 2482097T3
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ES
Spain
Prior art keywords
isolate
preparation
difluoropyridin
dihydroquinolin
oxo
Prior art date
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Active
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ES09163080.6T
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English (en)
Inventor
Anthony Haight
David Barnes
Geoff Zhang
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AbbVie Inc
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AbbVie Inc
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Publication of ES2482097T3 publication Critical patent/ES2482097T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un proceso para preparar ácido 1-(6-amino-3,5-difluoropiridin-2-il)-8-cloro-6-fluoro-7-(3-hidroxiazetidin-1-il)-4-oxo- 1,4-dihidroquinolin-3-carboxílico o una de sus sales, que comprende: (a) hacer reaccionar 1-(6-amino-3,5-difluoropiridin-2-il)-6-fluoro-7-(3-isobutiriloxi)azetidin-1-il)-4-oxo-1,4- dihidroquinolin-3-carboxilato de etilo o una de sus sales y N-clorosuccinimida en acetato de etilo y en presencia de ácido y aislar o no aislar el producto; o hacer reaccionar 1-(6-amino-3,5-difluoropiridin-2-il)-10 6-fluoro-7-(3-isobutiriloxi)azetidin-1-il)-4-oxo-1,4- dihidroquinolin-3-carboxilato de etilo o una de sus sales y N-clorosuccinimida en una mezcla de acetato de metilo y acetato de etilo y en presencia de ácido sulfúrico y aislar o no aislar el producto; y (b) hacer reaccionar el producto de la etapa (a) e hidróxido de sodio.

Description

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Claims (1)

  1. imagen1
ES09163080.6T 2004-07-30 2005-07-29 Preparación de antibacterianos de ácido piridoncarboxílico Active ES2482097T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59289304P 2004-07-30 2004-07-30
US592893P 2004-07-30

Publications (1)

Publication Number Publication Date
ES2482097T3 true ES2482097T3 (es) 2014-08-01

Family

ID=35385404

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10187876.7T Active ES2506143T3 (es) 2004-07-30 2005-07-29 Preparación de sustancias antibacterianas de ácido piridonacarboxílico
ES09163080.6T Active ES2482097T3 (es) 2004-07-30 2005-07-29 Preparación de antibacterianos de ácido piridoncarboxílico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES10187876.7T Active ES2506143T3 (es) 2004-07-30 2005-07-29 Preparación de sustancias antibacterianas de ácido piridonacarboxílico

Country Status (7)

Country Link
EP (4) EP2305666B1 (es)
JP (1) JP5274012B2 (es)
CA (1) CA2575148C (es)
ES (2) ES2506143T3 (es)
HK (1) HK1156311A1 (es)
MX (1) MX2007001134A (es)
WO (1) WO2006015194A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2346855T3 (en) * 2008-09-24 2017-07-24 Melinta Therapeutics Inc PROCEDURE FOR PREPARING QUINOLONE COMPOSITIONS
JP6063123B2 (ja) 2008-11-15 2017-01-18 メリンタ セラピューティクス、インク 抗菌性組成物
CN103936717B (zh) * 2013-01-22 2016-08-10 上海医药工业研究院 一种delafloxacin中间体及其制备方法
CN103936718B (zh) * 2013-01-22 2016-06-29 上海医药工业研究院 一种高纯度delafloxacin的制备方法
CN103709100A (zh) * 2013-12-31 2014-04-09 南京工业大学 一种8-氯代喹诺酮衍生物的制备方法
CN104876911A (zh) * 2014-02-27 2015-09-02 南京工业大学 一种简易的方法合成德拉沙星
TWI732337B (zh) 2014-06-20 2021-07-01 美商梅琳塔有限責任公司 醫藥組成物及其用途
MX2017006319A (es) 2014-11-14 2017-08-10 Melinta Therapeutics Inc Método para tratar, prevenir o reducir el riesgo de infección cutánea.
CN106256824B (zh) * 2015-06-18 2020-10-27 重庆医药工业研究院有限责任公司 一种高纯度德拉沙星葡甲胺盐的制备方法
CN105968099B (zh) * 2016-05-12 2018-09-25 扬子江药业集团有限公司 一种德拉沙星的精制方法
CN107778293B (zh) * 2016-08-29 2023-06-16 鲁南制药集团股份有限公司 一种改进的德拉沙星的制备方法
CN108033948A (zh) * 2017-12-28 2018-05-15 北京沃邦医药科技有限公司 一种德拉沙星及其中间体的制备
CN108084161A (zh) * 2017-12-28 2018-05-29 北京沃邦医药科技有限公司 德拉沙星及其中间体的制备方法
CN110790744A (zh) * 2018-08-03 2020-02-14 南京优科生物医药研究有限公司 吡啶酮羧酸衍生物、制备方法及其组合物
CN113527262B (zh) * 2021-06-22 2022-07-15 安徽普利药业有限公司 一种德拉沙星及其葡甲胺盐的精制方法
CN114031607B (zh) * 2021-11-16 2023-01-10 海南普利制药股份有限公司 一种德拉沙星及其中间体的精制方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
EP0339406A1 (en) * 1988-04-19 1989-11-02 Hokuriku Pharmaceutical Co.,Ltd Quinoline-3-carboxylic acid derivatives, process for preparing the same, and composition exhibiting excellent antibacterial effect containing the same
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
JPH082710A (ja) 1994-06-17 1996-01-09 Ricoh Co Ltd 給紙装置
PT911327E (pt) 1995-09-22 2002-05-31 Wakunaga Pharma Co Ltd Novos derivados do acido piridonocarboxilico ou seus sais e agente antibacteriano compreendendo os mesmos como o ingrediente activo
JPH11292873A (ja) * 1998-04-07 1999-10-26 Dainippon Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法およびその中間体
JP2001002648A (ja) * 1999-06-17 2001-01-09 Kikkoman Corp Ｎ−置換アゼパン誘導体及びそれらの塩
WO2001017991A1 (fr) * 1999-09-02 2001-03-15 Wakunaga Pharmaceutical Co., Ltd. Derive d'acide quinolinecarboxylique ou son sel
US7220736B2 (en) * 2000-04-28 2007-05-22 Tanabe Seiyaku Co., Ltd. Pyrimidine compounds
FR2827281B1 (fr) * 2001-07-16 2003-12-19 Sanofi Synthelabo Procede pour la preparation de la 4-methylamino-4-phenylpiperidine

Also Published As

Publication number Publication date
EP2305666A1 (en) 2011-04-06
JP5274012B2 (ja) 2013-08-28
EP2100892A1 (en) 2009-09-16
EP2100892B1 (en) 2014-04-23
CA2575148A1 (en) 2006-02-09
WO2006015194A3 (en) 2006-04-20
EP2816033A1 (en) 2014-12-24
HK1156311A1 (en) 2012-06-08
ES2506143T3 (es) 2014-10-13
MX2007001134A (es) 2007-04-17
WO2006015194A2 (en) 2006-02-09
JP2008508309A (ja) 2008-03-21
EP1789392A2 (en) 2007-05-30
CA2575148C (en) 2012-07-17
EP2305666B1 (en) 2014-06-25

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