ES2434693T3 - Bencimidazoles y composiciones farmacéuticas de los mismos - Google Patents

Bencimidazoles y composiciones farmacéuticas de los mismos Download PDF

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Publication number
ES2434693T3
ES2434693T3 ES08799882T ES08799882T ES2434693T3 ES 2434693 T3 ES2434693 T3 ES 2434693T3 ES 08799882 T ES08799882 T ES 08799882T ES 08799882 T ES08799882 T ES 08799882T ES 2434693 T3 ES2434693 T3 ES 2434693T3
Authority
ES
Spain
Prior art keywords
aryl
cycloalkyl
alkyl
heterocyclic
condensed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08799882T
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English (en)
Spanish (es)
Inventor
Iwao Ojima
Seung-Yub Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Application granted granted Critical
Publication of ES2434693T3 publication Critical patent/ES2434693T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES08799882T 2007-04-20 2008-04-21 Bencimidazoles y composiciones farmacéuticas de los mismos Active ES2434693T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91298007P 2007-04-20 2007-04-20
US912980P 2007-04-20
PCT/US2008/005084 WO2008130669A1 (en) 2007-04-20 2008-04-21 Benzimidazoles and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ES2434693T3 true ES2434693T3 (es) 2013-12-17

Family

ID=39875833

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08799882T Active ES2434693T3 (es) 2007-04-20 2008-04-21 Bencimidazoles y composiciones farmacéuticas de los mismos

Country Status (17)

Country Link
US (1) US8232410B2 (enExample)
EP (1) EP2154966B1 (enExample)
JP (1) JP5400032B2 (enExample)
CN (1) CN101677553A (enExample)
AU (1) AU2008242488B2 (enExample)
BR (1) BRPI0810244A2 (enExample)
CA (1) CA2684594C (enExample)
DK (1) DK2154966T3 (enExample)
EA (1) EA016726B1 (enExample)
ES (1) ES2434693T3 (enExample)
HR (1) HRP20131103T1 (enExample)
IN (1) IN2009KN03959A (enExample)
MX (1) MX2009011281A (enExample)
PL (1) PL2154966T3 (enExample)
PT (1) PT2154966E (enExample)
SI (1) SI2154966T1 (enExample)
WO (1) WO2008130669A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232310B2 (en) 2006-12-29 2012-07-31 Georgetown University Targeting of EWS-FLI1 as anti-tumor therapy
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
WO2013116823A1 (en) * 2012-02-02 2013-08-08 The Research Foundation Of State University Of New York Benzimidazoles and uses thereof
WO2013142326A1 (en) * 2012-03-23 2013-09-26 The Research Foundation Of State University Of New York 5-carbonylamino-/(sulfonamido-) substituted benz imidazoles and use thereof treatment of tuberculosis
NZ700612A (en) * 2012-04-12 2016-09-30 Univ Georgetown Methods and compositions for treating ewings sarcoma family of tumors
CN103333170B (zh) * 2013-06-14 2016-08-10 清华大学 苯并咪唑类化合物及其用途
US9511050B2 (en) 2013-10-24 2016-12-06 Georgetown University Methods and compositions for treating cancer
CN106061951A (zh) * 2013-11-22 2016-10-26 纽约州立大学研究基金会 苯并咪唑及其在结核病治疗中的用途
US10287617B2 (en) 2014-03-11 2019-05-14 Colorado State University Research Foundation Methods for in vitro—in vivo efficacy determination
US11279714B2 (en) * 2014-06-20 2022-03-22 Institut Pasteur Korea Anti-infective compounds
CN111777596A (zh) 2014-10-09 2020-10-16 英克特诺治疗公司 吲哚酮化合物及其用途
WO2017172368A1 (en) 2016-03-31 2017-10-05 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
CN109789127B (zh) 2016-07-29 2022-03-25 英克特诺治疗公司 吲哚啉酮化合物的用途
CN111303092B (zh) * 2020-04-07 2021-05-25 山东昌邑灶户盐化有限公司 2,4-二硝基-6-氯苯胺衍生物、合成方法及其应用
TW202317546A (zh) 2021-07-09 2023-05-01 美商普萊克斯姆公司 調節ikzf2之芳基化合物及醫藥組合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61170732A (ja) * 1985-01-25 1986-08-01 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US7405235B2 (en) * 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CA2582356A1 (en) * 2004-09-30 2006-04-13 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
EP2008210A1 (en) 2006-03-15 2008-12-31 Csir Modulation of phosphoryl transferase activity of glutamine synthetase

Also Published As

Publication number Publication date
PL2154966T3 (pl) 2014-03-31
SI2154966T1 (sl) 2014-02-28
EP2154966B1 (en) 2013-08-21
US8232410B2 (en) 2012-07-31
EP2154966A1 (en) 2010-02-24
PT2154966E (pt) 2013-11-13
IN2009KN03959A (enExample) 2015-08-28
CA2684594A1 (en) 2008-10-30
HRP20131103T1 (hr) 2013-12-20
WO2008130669A1 (en) 2008-10-30
AU2008242488A1 (en) 2008-10-30
CN101677553A (zh) 2010-03-24
DK2154966T3 (da) 2013-11-18
MX2009011281A (es) 2010-03-08
EA200901423A1 (ru) 2010-06-30
EP2154966A4 (en) 2010-12-15
JP2010524947A (ja) 2010-07-22
AU2008242488B2 (en) 2014-10-30
US20100256203A1 (en) 2010-10-07
EA016726B1 (ru) 2012-07-30
BRPI0810244A2 (pt) 2014-09-30
CA2684594C (en) 2015-10-06
JP5400032B2 (ja) 2014-01-29

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