ES2432383T3 - Derivados de nip-tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa - Google Patents
Derivados de nip-tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa Download PDFInfo
- Publication number
- ES2432383T3 ES2432383T3 ES09741800T ES09741800T ES2432383T3 ES 2432383 T3 ES2432383 T3 ES 2432383T3 ES 09741800 T ES09741800 T ES 09741800T ES 09741800 T ES09741800 T ES 09741800T ES 2432383 T3 ES2432383 T3 ES 2432383T3
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- Spain
- Prior art keywords
- thiazol
- piperidin
- carboxylic acid
- octahydro
- quinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003112 inhibitor Substances 0.000 title description 34
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 title description 6
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 title description 6
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- PDSUQUPFEPWPHQ-UHFFFAOYSA-N [4-[4-(3,4,4a,5,6,7,8,8a-octahydro-2h-quinoline-1-carbonyl)-1,3-thiazol-2-yl]piperidin-1-yl]-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)N1CCC(C=2SC=C(N=2)C(=O)N2C3CCCCC3CCC2)CC1 PDSUQUPFEPWPHQ-UHFFFAOYSA-N 0.000 claims abstract description 4
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290424 | 2008-05-05 | ||
| EP08290424 | 2008-05-05 | ||
| PCT/EP2009/002607 WO2009135581A2 (en) | 2008-05-05 | 2009-04-08 | Novel nip thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2432383T3 true ES2432383T3 (es) | 2013-12-03 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09741800T Active ES2432383T3 (es) | 2008-05-05 | 2009-04-08 | Derivados de nip-tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa |
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| NZ (1) | NZ589691A (enExample) |
| WO (1) | WO2009135581A2 (enExample) |
| ZA (1) | ZA201008723B (enExample) |
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| AU2008257693B2 (en) * | 2007-06-01 | 2011-01-27 | F. Hoffmann-La Roche Ag | Piperidine-amide derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2015005305A1 (ja) | 2013-07-09 | 2015-01-15 | 小野薬品工業株式会社 | Ａｌｘｒ作動化合物 |
| CN104910083A (zh) * | 2015-07-13 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 烷氧苯基三氮唑亚砜类11β-HSD1抑制剂、制备方法及其用途 |
| CN104910084A (zh) * | 2015-07-13 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 末端胺基取代的三氮唑亚砜类化合物、其制备方法及其用途 |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| BR112020004356A2 (pt) * | 2017-09-08 | 2020-12-01 | Pi Industries Ltd. | novos compostos heterocíclicos fungicidas |
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| US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US20070231263A1 (en) * | 2004-04-13 | 2007-10-04 | Jun Qiu | Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders |
| EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| DE102006010923A1 (de) | 2006-03-09 | 2007-09-13 | Saltigo Gmbh | Verfahren zur Herstellung von Chlor-1,4-dimethoxybenzol |
| EP1994017A2 (en) | 2006-03-15 | 2008-11-26 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| BRPI0709595A2 (pt) * | 2006-03-15 | 2011-07-19 | 4Sc Ag | inibidores de nf-kapab heterocìclicos |
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| US8546575B2 (en) | 2013-10-01 |
| WO2009135581A9 (en) | 2010-11-11 |
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| CA2723431A1 (en) | 2009-11-12 |
| AU2009243812A1 (en) | 2009-11-12 |
| WO2009135581A3 (en) | 2010-08-19 |
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| IL208989A (en) | 2014-01-30 |
| CA2723431C (en) | 2016-11-22 |
| KR20110004468A (ko) | 2011-01-13 |
| AR072666A1 (es) | 2010-09-15 |
| JP2011521907A (ja) | 2011-07-28 |
| MX2010011917A (es) | 2010-11-26 |
| EA201001737A1 (ru) | 2011-06-30 |
| KR101604366B1 (ko) | 2016-03-17 |
| EP2271405A2 (en) | 2011-01-12 |
| WO2009135581A2 (en) | 2009-11-12 |
| BRPI0911497B8 (pt) | 2021-05-25 |
| CO6331305A2 (es) | 2011-10-20 |
| JP5735412B2 (ja) | 2015-06-17 |
| EA018920B1 (ru) | 2013-11-29 |
| BRPI0911497B1 (pt) | 2021-01-26 |
| EA201300759A1 (ru) | 2013-11-29 |
| IL208989A0 (en) | 2011-01-31 |
| EP2271405B1 (en) | 2013-07-24 |
| NZ589691A (en) | 2012-11-30 |
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| ECSP10010656A (es) | 2011-01-31 |
| ZA201008723B (en) | 2012-01-25 |
| US20110060007A1 (en) | 2011-03-10 |
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