AU2009243812B2 - NIP thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 - Google Patents

NIP thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Download PDF

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Publication number
AU2009243812B2
AU2009243812B2 AU2009243812A AU2009243812A AU2009243812B2 AU 2009243812 B2 AU2009243812 B2 AU 2009243812B2 AU 2009243812 A AU2009243812 A AU 2009243812A AU 2009243812 A AU2009243812 A AU 2009243812A AU 2009243812 B2 AU2009243812 B2 AU 2009243812B2
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Prior art keywords
thiazol
carboxylic acid
piperidin
carbonyl
cyclopropyl
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Ceased
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AU2009243812A
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AU2009243812A1 (en
Inventor
Denis Carniato
Christine Charon
Liliane Doare
Caroline Leriche
Didier Roche
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Merck Patent GmbH
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
AU2009243812A 2008-05-05 2009-04-08 NIP thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Ceased AU2009243812B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08290424 2008-05-05
EP08290424.4 2008-05-05
PCT/EP2009/002607 WO2009135581A2 (en) 2008-05-05 2009-04-08 Novel nip thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

Publications (2)

Publication Number Publication Date
AU2009243812A1 AU2009243812A1 (en) 2009-11-12
AU2009243812B2 true AU2009243812B2 (en) 2014-06-05

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AU2009243812A Ceased AU2009243812B2 (en) 2008-05-05 2009-04-08 NIP thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

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US (1) US8546575B2 (enExample)
EP (1) EP2271405B1 (enExample)
JP (1) JP5735412B2 (enExample)
KR (1) KR101604366B1 (enExample)
CN (1) CN102015026B (enExample)
AR (1) AR072666A1 (enExample)
AU (1) AU2009243812B2 (enExample)
BR (1) BRPI0911497B8 (enExample)
CA (1) CA2723431C (enExample)
CO (1) CO6331305A2 (enExample)
EA (2) EA201300759A1 (enExample)
EC (1) ECSP10010656A (enExample)
ES (1) ES2432383T3 (enExample)
IL (1) IL208989A (enExample)
MX (1) MX2010011917A (enExample)
NZ (1) NZ589691A (enExample)
WO (1) WO2009135581A2 (enExample)
ZA (1) ZA201008723B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008257693B2 (en) * 2007-06-01 2011-01-27 F. Hoffmann-La Roche Ag Piperidine-amide derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2015005305A1 (ja) 2013-07-09 2015-01-15 小野薬品工業株式会社 Ａｌｘｒ作動化合物
CN104910083A (zh) * 2015-07-13 2015-09-16 佛山市赛维斯医药科技有限公司 烷氧苯基三氮唑亚砜类11β-HSD1抑制剂、制备方法及其用途
CN104910084A (zh) * 2015-07-13 2015-09-16 佛山市赛维斯医药科技有限公司 末端胺基取代的三氮唑亚砜类化合物、其制备方法及其用途
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
BR112020004356A2 (pt) * 2017-09-08 2020-12-01 Pi Industries Ltd. novos compostos heterocíclicos fungicidas

Citations (4)

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Publication number Priority date Publication date Assignee Title
US20060069102A1 (en) * 2004-09-20 2006-03-30 4 Sc Ag Novel heterocyclic NF-kB inhibitors
EP1832568A1 (de) * 2006-03-09 2007-09-12 Saltigo GmbH Verfahren zur Herstellung von Chlor-1,4-Dimethoxybenzol
WO2007104557A2 (en) * 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors
US20070231263A1 (en) * 2004-04-13 2007-10-04 Jun Qiu Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754709B2 (en) * 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
BRPI0709595A2 (pt) * 2006-03-15 2011-07-19 4Sc Ag inibidores de nf-kapab heterocìclicos

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070231263A1 (en) * 2004-04-13 2007-10-04 Jun Qiu Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders
US20060069102A1 (en) * 2004-09-20 2006-03-30 4 Sc Ag Novel heterocyclic NF-kB inhibitors
EP1832568A1 (de) * 2006-03-09 2007-09-12 Saltigo GmbH Verfahren zur Herstellung von Chlor-1,4-Dimethoxybenzol
WO2007104557A2 (en) * 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors

Also Published As

Publication number Publication date
CN102015026A (zh) 2011-04-13
US8546575B2 (en) 2013-10-01
WO2009135581A9 (en) 2010-11-11
CN102015026B (zh) 2015-11-25
CA2723431A1 (en) 2009-11-12
AU2009243812A1 (en) 2009-11-12
WO2009135581A3 (en) 2010-08-19
BRPI0911497A2 (pt) 2019-01-15
IL208989A (en) 2014-01-30
CA2723431C (en) 2016-11-22
KR20110004468A (ko) 2011-01-13
AR072666A1 (es) 2010-09-15
JP2011521907A (ja) 2011-07-28
MX2010011917A (es) 2010-11-26
EA201001737A1 (ru) 2011-06-30
KR101604366B1 (ko) 2016-03-17
EP2271405A2 (en) 2011-01-12
WO2009135581A2 (en) 2009-11-12
BRPI0911497B8 (pt) 2021-05-25
CO6331305A2 (es) 2011-10-20
JP5735412B2 (ja) 2015-06-17
EA018920B1 (ru) 2013-11-29
BRPI0911497B1 (pt) 2021-01-26
EA201300759A1 (ru) 2013-11-29
IL208989A0 (en) 2011-01-31
EP2271405B1 (en) 2013-07-24
NZ589691A (en) 2012-11-30
ECSP10010656A (es) 2011-01-31
ZA201008723B (en) 2012-01-25
US20110060007A1 (en) 2011-03-10
ES2432383T3 (es) 2013-12-03

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