ES2411962T3 - Métodos y composiciones para suministrar polinucleótidos - Google Patents

Métodos y composiciones para suministrar polinucleótidos Download PDF

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Publication number
ES2411962T3
ES2411962T3 ES04817807T ES04817807T ES2411962T3 ES 2411962 T3 ES2411962 T3 ES 2411962T3 ES 04817807 T ES04817807 T ES 04817807T ES 04817807 T ES04817807 T ES 04817807T ES 2411962 T3 ES2411962 T3 ES 2411962T3
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Prior art keywords
polynucleotide
polypeptide
mitochondrial
protein
prt
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Expired - Lifetime
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ES04817807T
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English (en)
Spanish (es)
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Shaharyar Khan
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Gencia Corp
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Gencia Corp
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

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  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Urology & Nephrology (AREA)
ES04817807T 2003-10-24 2004-10-25 Métodos y composiciones para suministrar polinucleótidos Expired - Lifetime ES2411962T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51398303P 2003-10-24 2003-10-24
US513983P 2003-10-24
US56843604P 2004-05-05 2004-05-05
US568436P 2004-05-05
PCT/US2004/035137 WO2005056752A2 (en) 2003-10-24 2004-10-25 Methods and compositions for delivering polynucleotides

Publications (1)

Publication Number Publication Date
ES2411962T3 true ES2411962T3 (es) 2013-07-09

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ES04817807T Expired - Lifetime ES2411962T3 (es) 2003-10-24 2004-10-25 Métodos y composiciones para suministrar polinucleótidos

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US (2) US8039587B2 (enExample)
EP (2) EP1687017B1 (enExample)
JP (2) JP4838722B2 (enExample)
AU (2) AU2004297533B2 (enExample)
CA (1) CA2543257C (enExample)
ES (1) ES2411962T3 (enExample)
WO (1) WO2005056752A2 (enExample)

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