ES2410857T3 - Nuevo procedimiento - Google Patents
Nuevo procedimiento Download PDFInfo
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- ES2410857T3 ES2410857T3 ES07704356T ES07704356T ES2410857T3 ES 2410857 T3 ES2410857 T3 ES 2410857T3 ES 07704356 T ES07704356 T ES 07704356T ES 07704356 T ES07704356 T ES 07704356T ES 2410857 T3 ES2410857 T3 ES 2410857T3
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- gene
- thymidine
- thf
- udr
- coli
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- 108010000742 dTMP kinase Proteins 0.000 description 1
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 1
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- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 description 1
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- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
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- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 229960000689 nevirapine Drugs 0.000 description 1
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 description 1
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- 101150101723 nrdA gene Proteins 0.000 description 1
- 101150037566 nrdB gene Proteins 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
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- 229960000311 ritonavir Drugs 0.000 description 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
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- 235000019364 tetracycline Nutrition 0.000 description 1
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- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
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- 235000011178 triphosphate Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/385—Pyrimidine nucleosides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602339.4A GB0602339D0 (en) | 2006-02-06 | 2006-02-06 | Novel process |
| GB0602339 | 2006-02-06 | ||
| PCT/EP2007/051072 WO2007090810A1 (en) | 2006-02-06 | 2007-02-05 | Novel process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2410857T3 true ES2410857T3 (es) | 2013-07-03 |
Family
ID=36101118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07704356T Active ES2410857T3 (es) | 2006-02-06 | 2007-02-05 | Nuevo procedimiento |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8263384B2 (https=) |
| EP (2) | EP1981972B1 (https=) |
| JP (1) | JP5230447B2 (https=) |
| KR (1) | KR101371954B1 (https=) |
| CN (1) | CN101379185B (https=) |
| ES (1) | ES2410857T3 (https=) |
| GB (1) | GB0602339D0 (https=) |
| SI (1) | SI1981972T1 (https=) |
| WO (1) | WO2007090810A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7572065B2 (en) | 2007-01-24 | 2009-08-11 | Adc Telecommunications, Inc. | Hardened fiber optic connector |
| JP2010518837A (ja) * | 2007-02-19 | 2010-06-03 | エボニック デグサ ゲーエムベーハー | ホルメート−ｔｈｆ−シンテターゼおよび／またはグリシン開裂活性を有するコリネ型細菌 |
| CN113755416B (zh) * | 2020-06-05 | 2023-08-15 | 苏州华赛生物工程技术有限公司 | 具有新合成路径生产β-胸苷的重组微生物及生产β-胸苷的方法 |
| CN111748537B (zh) * | 2020-08-04 | 2021-11-26 | 浙江华睿生物技术有限公司 | 一种尿苷磷酸酶突变体及其应用 |
| KR102398032B1 (ko) * | 2020-09-22 | 2022-05-19 | 비피진 주식회사 | 암 치료를 위한 5''-뉴클레오티다아제 변이체 |
| CN112126666B (zh) * | 2020-09-22 | 2022-04-08 | 廊坊梅花生物技术开发有限公司 | 核苷高产菌及其构建方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68916708T2 (de) | 1988-05-31 | 1994-12-01 | Zeneca Ltd | Herstellung eines Desoxyribonucleosids. |
| US5213972A (en) * | 1989-12-08 | 1993-05-25 | Chemgen Corporation | Fermentation process for the production of pyrimidine deoxyribonucleosides |
| JP3916345B2 (ja) | 1999-06-26 | 2007-05-16 | 均 西谷 | 両開きドア |
| DE60035781T2 (de) * | 1999-07-01 | 2008-08-07 | Glaxo Group Ltd., Greenford | Vektoren, zellen und verfahren zur herstellung von pyrimidindeoxyribonucleosiden |
-
2006
- 2006-02-06 GB GBGB0602339.4A patent/GB0602339D0/en not_active Ceased
-
2007
- 2007-02-05 US US12/278,227 patent/US8263384B2/en active Active
- 2007-02-05 EP EP07704356A patent/EP1981972B1/en active Active
- 2007-02-05 WO PCT/EP2007/051072 patent/WO2007090810A1/en not_active Ceased
- 2007-02-05 CN CN200780004615XA patent/CN101379185B/zh active Active
- 2007-02-05 KR KR1020087019203A patent/KR101371954B1/ko not_active Expired - Fee Related
- 2007-02-05 SI SI200731240T patent/SI1981972T1/sl unknown
- 2007-02-05 JP JP2008553741A patent/JP5230447B2/ja not_active Expired - Fee Related
- 2007-02-05 EP EP10175884A patent/EP2287294A1/en not_active Withdrawn
- 2007-02-05 ES ES07704356T patent/ES2410857T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| GB0602339D0 (en) | 2006-03-15 |
| EP2287294A1 (en) | 2011-02-23 |
| JP5230447B2 (ja) | 2013-07-10 |
| EP1981972A1 (en) | 2008-10-22 |
| WO2007090810A1 (en) | 2007-08-16 |
| US20090081735A1 (en) | 2009-03-26 |
| JP2009525738A (ja) | 2009-07-16 |
| KR101371954B1 (ko) | 2014-03-07 |
| US8263384B2 (en) | 2012-09-11 |
| KR20080093118A (ko) | 2008-10-20 |
| EP1981972B1 (en) | 2013-03-20 |
| CN101379185B (zh) | 2012-08-29 |
| CN101379185A (zh) | 2009-03-04 |
| SI1981972T1 (sl) | 2013-07-31 |
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