ES2400026T3 - N-arilpiridinonas sustituidas como inhibidores fibróticos - Google Patents
N-arilpiridinonas sustituidas como inhibidores fibróticos Download PDFInfo
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- ES2400026T3 ES2400026T3 ES08771632T ES08771632T ES2400026T3 ES 2400026 T3 ES2400026 T3 ES 2400026T3 ES 08771632 T ES08771632 T ES 08771632T ES 08771632 T ES08771632 T ES 08771632T ES 2400026 T3 ES2400026 T3 ES 2400026T3
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- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical compound C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 description 1
- 229960001522 ximelagatran Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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Landscapes
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94513607P | 2007-06-20 | 2007-06-20 | |
| US945136P | 2007-06-20 | ||
| PCT/US2008/067732 WO2008157786A1 (en) | 2007-06-20 | 2008-06-20 | Substituted n-aryl pyridinones as fibrotic inhibitors |
Publications (1)
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| ES2400026T3 true ES2400026T3 (es) | 2013-04-05 |
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| ES08771632T Active ES2400026T3 (es) | 2007-06-20 | 2008-06-20 | N-arilpiridinonas sustituidas como inhibidores fibróticos |
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| EP (1) | EP2170828B1 (OSRAM) |
| JP (1) | JP5587184B2 (OSRAM) |
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| CN (2) | CN104892498A (OSRAM) |
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| DK (1) | DK2170828T3 (OSRAM) |
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| HK (1) | HK1214251A1 (OSRAM) |
| IL (1) | IL202840A (OSRAM) |
| NZ (1) | NZ599643A (OSRAM) |
| WO (1) | WO2008157786A1 (OSRAM) |
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| WO2010065755A1 (en) * | 2008-12-04 | 2010-06-10 | Concert Pharmaceuticals, Inc. | Deuterated pyridinones |
| AU2010248758A1 (en) * | 2009-05-15 | 2011-11-24 | Intermune, Inc. | Methods of treating HIV patients with anti-fibrotics |
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- 2008-06-20 JP JP2010513457A patent/JP5587184B2/ja active Active
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- 2008-06-20 DK DK08771632.0T patent/DK2170828T3/da active
- 2008-06-20 US US12/143,484 patent/US8383823B2/en active Active
- 2008-06-20 CN CN201510221701.2A patent/CN104892498A/zh active Pending
- 2008-06-20 KR KR1020167000072A patent/KR101767849B1/ko active Active
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- 2008-06-20 AU AU2008265595A patent/AU2008265595B2/en active Active
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- 2008-06-20 WO PCT/US2008/067732 patent/WO2008157786A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| US20150250777A1 (en) | 2015-09-10 |
| US8383823B2 (en) | 2013-02-26 |
| US20080319026A1 (en) | 2008-12-25 |
| US9062001B2 (en) | 2015-06-23 |
| EP2170828B1 (en) | 2012-11-21 |
| US8969576B2 (en) | 2015-03-03 |
| KR20100050466A (ko) | 2010-05-13 |
| NZ599643A (en) | 2013-11-29 |
| JP2010530897A (ja) | 2010-09-16 |
| IL202840A (en) | 2014-07-31 |
| JP5587184B2 (ja) | 2014-09-10 |
| US20140348928A1 (en) | 2014-11-27 |
| AU2008265595A1 (en) | 2008-12-24 |
| WO2008157786A1 (en) | 2008-12-24 |
| DK2170828T3 (da) | 2013-03-04 |
| US20140107040A1 (en) | 2014-04-17 |
| US8969575B2 (en) | 2015-03-03 |
| IL202840A0 (en) | 2010-06-30 |
| US9504677B2 (en) | 2016-11-29 |
| US8680123B1 (en) | 2014-03-25 |
| CA2691379A1 (en) | 2008-12-24 |
| CN104892498A (zh) | 2015-09-09 |
| CA2691379C (en) | 2015-06-09 |
| AU2008265595B2 (en) | 2014-12-04 |
| KR101767849B1 (ko) | 2017-08-11 |
| EP2170828A1 (en) | 2010-04-07 |
| US20140235677A1 (en) | 2014-08-21 |
| KR101583737B1 (ko) | 2016-01-11 |
| KR20160007684A (ko) | 2016-01-20 |
| CN101842355A (zh) | 2010-09-22 |
| HK1214251A1 (zh) | 2016-07-22 |
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