ES2396712T3 - Incorporación específica para sitio de aminoácidos activos por rédox en proteínas - Google Patents

Incorporación específica para sitio de aminoácidos activos por rédox en proteínas Download PDF

Info

Publication number
ES2396712T3
ES2396712T3 ES04795276T ES04795276T ES2396712T3 ES 2396712 T3 ES2396712 T3 ES 2396712T3 ES 04795276 T ES04795276 T ES 04795276T ES 04795276 T ES04795276 T ES 04795276T ES 2396712 T3 ES2396712 T3 ES 2396712T3
Authority
ES
Spain
Prior art keywords
trna
cell
amino acid
amino acids
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04795276T
Other languages
English (en)
Spanish (es)
Inventor
Lital Alfonta
Peter G. Schultz
Zhiwen Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of ES2396712T3 publication Critical patent/ES2396712T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES04795276T 2003-10-14 2004-10-13 Incorporación específica para sitio de aminoácidos activos por rédox en proteínas Expired - Lifetime ES2396712T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
US511532P 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

Publications (1)

Publication Number Publication Date
ES2396712T3 true ES2396712T3 (es) 2013-02-25

Family

ID=34465242

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04795276T Expired - Lifetime ES2396712T3 (es) 2003-10-14 2004-10-13 Incorporación específica para sitio de aminoácidos activos por rédox en proteínas

Country Status (14)

Country Link
US (5) US8008041B2 (enExample)
EP (1) EP1687401B1 (enExample)
JP (1) JP5657850B2 (enExample)
CN (2) CN101532046A (enExample)
AU (1) AU2004282577B2 (enExample)
BR (1) BRPI0415308A (enExample)
CA (1) CA2541166A1 (enExample)
DK (1) DK1687401T3 (enExample)
ES (1) ES2396712T3 (enExample)
IL (3) IL174947A (enExample)
MX (1) MXPA06004087A (enExample)
PL (1) PL1687401T3 (enExample)
PT (1) PT1687401E (enExample)
WO (1) WO2005038002A2 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158418A0 (en) * 2001-04-19 2004-05-12 Scripps Research Inst In vivo incorporation of unnatural amino acids
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
CN103289960B (zh) 2003-04-17 2017-04-26 斯克利普斯研究院 扩展真核生物遗传密码
BRPI0411475A (pt) 2003-06-18 2006-07-25 Scripps Research Inst adições de código genético de aminoácido reativo não natural
EP1666604B1 (en) * 2003-07-07 2008-02-13 The Scripps Research Institute Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
AU2005248392A1 (en) * 2004-05-25 2005-12-08 Irm, Llc Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
WO2006036779A2 (en) * 2004-09-22 2006-04-06 The Scripps Research Institute Site-specific labeling of proteins for nmr studies
EP2383340B1 (en) * 2004-10-27 2014-07-16 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
US8367588B2 (en) * 2005-10-12 2013-02-05 The Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
US7776535B2 (en) 2006-02-06 2010-08-17 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
WO2007103490A2 (en) * 2006-03-09 2007-09-13 The Scripps Research Institute System for the expression of orthogonal translation components in eubacterial host cells
BRPI0709603A2 (pt) * 2006-03-16 2011-07-19 Scripps Research Inst expressão de proteìnas geneticamente programada contendo o aminoácido não natural fenilselenocisteìna
BRPI0711811A2 (pt) * 2006-05-23 2011-12-06 Scripps Research Inst aminoácidos de cumarina fluorescente geneticamente codificados
RU2009110152A (ru) * 2006-09-21 2010-10-27 Зе Скрипс Ресеч Инститьют (Us) Генетически закодированная формула селективно-сульфатных белков в эубактерии
KR20090094812A (ko) 2006-10-18 2009-09-08 더 스크립스 리서치 인스티튜트 포유동물 세포에서 비천연 아미노산의 단백질 내로의 유전적 도입
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
EP2217707B1 (en) 2007-10-25 2014-10-15 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
EP2220218A4 (en) * 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
US9249408B2 (en) * 2007-11-02 2016-02-02 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
CA2708760A1 (en) * 2007-12-11 2009-06-18 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
BRPI0906388A2 (pt) * 2008-02-08 2015-07-07 Scripps Research Inst Quebra de tolerância imunológica com um aminoácido não natural geneticamente codificado
EP2373224A1 (en) * 2008-12-09 2011-10-12 Wilson-Cook Medical Inc. Apparatus and methods for controlled release of tacking devices
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
US8609383B2 (en) 2008-12-10 2013-12-17 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
WO2010089741A1 (en) * 2009-02-04 2010-08-12 Ben-Gurion University Of The Negev Research And Development Authority Systems and methods for bio-electricity production
US10233249B2 (en) 2013-03-19 2019-03-19 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
CN114008176A (zh) 2019-06-17 2022-02-01 默克专利股份有限公司 基于液晶的光阀

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879905A (en) * 1996-08-29 1999-03-09 Massachusetts Institute Of Technology In vivo method of initiating protein synthesis with an amino acid other than methionine
IL158418A0 (en) * 2001-04-19 2004-05-12 Scripps Research Inst In vivo incorporation of unnatural amino acids
MXPA05003978A (es) 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
WO2004035743A2 (en) 2002-10-16 2004-04-29 The Scripps Research Institute Site specific incorporation of keto amino acids into proteins
MXPA05006836A (es) 2002-12-22 2005-08-16 Scripps Research Inst Colecciones ordenadas de proteinas.
CN103289960B (zh) 2003-04-17 2017-04-26 斯克利普斯研究院 扩展真核生物遗传密码
BRPI0411475A (pt) 2003-06-18 2006-07-25 Scripps Research Inst adições de código genético de aminoácido reativo não natural
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
EP1666604B1 (en) 2003-07-07 2008-02-13 The Scripps Research Institute Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof

Also Published As

Publication number Publication date
CN1942579A (zh) 2007-04-04
US20090298124A1 (en) 2009-12-03
JP5657850B2 (ja) 2015-01-21
MXPA06004087A (es) 2006-06-27
WO2005038002A2 (en) 2005-04-28
IL201705A0 (en) 2011-08-01
AU2004282577A1 (en) 2005-04-28
DK1687401T3 (da) 2013-02-04
AU2004282577B2 (en) 2009-10-29
US8114654B2 (en) 2012-02-14
IL174947A0 (en) 2006-08-20
US20070009990A1 (en) 2007-01-11
US20120100570A1 (en) 2012-04-26
PL1687401T3 (pl) 2013-04-30
JP2007508034A (ja) 2007-04-05
US20110008782A1 (en) 2011-01-13
BRPI0415308A (pt) 2006-12-05
CN101532046A (zh) 2009-09-16
US7811801B2 (en) 2010-10-12
CN1942579B (zh) 2013-06-26
IL174947A (en) 2011-11-30
WO2005038002A3 (en) 2006-11-23
CA2541166A1 (en) 2005-04-28
EP1687401A2 (en) 2006-08-09
US20050227318A1 (en) 2005-10-13
PT1687401E (pt) 2013-02-26
US7494796B2 (en) 2009-02-24
EP1687401A4 (en) 2007-08-01
US9783798B2 (en) 2017-10-10
IL206889A0 (en) 2010-12-30
EP1687401B1 (en) 2012-11-21
US8008041B2 (en) 2011-08-30

Similar Documents

Publication Publication Date Title
ES2301099T3 (es) Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas.
US8114654B2 (en) Site-specific incorporation of redox active amino acids into proteins
EP1994165B1 (en) Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
ES2666693T3 (es) Incorporación in vivo de alquinil aminoácidos a proteínas en eubacterias
ES2432391T3 (es) Sistema para la expresión de componentes de traducción ortogonales en células huésped eubacterianas
ES2456331T3 (es) Expresión genéticamente programada de proteínas sulfatadas selectivamente en eubacterias
BRPI0718389A2 (pt) incorporação genética de aminoácidos antinaturais em proteìnas em células de mamìferos
ES2348487T3 (es) Composiciones de parejas aminoacil-trna sintetasa y trna-lisil ortogonales y usos de las mismas.
EP1914314B1 (en) Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof