CN101532046A - 将氧化还原活性氨基酸位点特异地掺入蛋白质 - Google Patents
将氧化还原活性氨基酸位点特异地掺入蛋白质 Download PDFInfo
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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| DK2322631T3 (en) * | 2001-04-19 | 2015-01-12 | Scripps Research Inst | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar |
| CA2500653A1 (en) * | 2002-10-16 | 2004-04-29 | The Scripps Research Institute | Glycoprotein synthesis |
| KR101171397B1 (ko) | 2003-04-17 | 2012-08-07 | 더 스크립스 리서치 인스티튜트 | 진핵 유전자 코드의 확장 |
| CA2527877A1 (en) | 2003-06-18 | 2005-01-13 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
| ES2301099T3 (es) * | 2003-07-07 | 2008-06-16 | The Scripps Research Institute | Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas. |
| MXPA06013586A (es) * | 2004-05-25 | 2007-11-09 | Scripss Res Inst | Incorporacion especifica del sitio de aminoacidos no naturales que contienen atomos pesados en proteinas para la determinacion de la estructura cristalina. |
| DE102004031258A1 (de) * | 2004-06-29 | 2006-02-09 | Jennissen, Herbert P., Prof. Dr. | Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen |
| WO2006036779A2 (en) * | 2004-09-22 | 2006-04-06 | The Scripps Research Institute | Site-specific labeling of proteins for nmr studies |
| WO2006110182A2 (en) | 2004-10-27 | 2006-10-19 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US8367588B2 (en) * | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US7776535B2 (en) | 2006-02-06 | 2010-08-17 | Franklin And Marshall College | Site-specific incorporation of fluorinated amino acids into proteins |
| ES2432391T3 (es) * | 2006-03-09 | 2013-12-03 | The Scripps Research Institute | Sistema para la expresión de componentes de traducción ortogonales en células huésped eubacterianas |
| BRPI0709603A2 (pt) | 2006-03-16 | 2011-07-19 | Scripps Research Inst | expressão de proteìnas geneticamente programada contendo o aminoácido não natural fenilselenocisteìna |
| CA2652894A1 (en) * | 2006-05-23 | 2007-12-06 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| EP2052083B1 (en) | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| EP2069481A4 (en) | 2006-10-18 | 2010-01-06 | Scripps Research Inst | GENETIC ASSEMBLY OF UNNATURAL AMINO ACIDS IN PROTEINS IN MAMMALIAN CELLS |
| WO2008137452A1 (en) * | 2007-05-04 | 2008-11-13 | Kenergy Royalty Company, Llc | Implantable high efficiency digital stimulation device |
| CA2703736A1 (en) | 2007-10-25 | 2009-04-30 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| CA2704494A1 (en) * | 2007-11-02 | 2009-05-14 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| US20090148887A1 (en) * | 2007-11-02 | 2009-06-11 | The Scripps Research Institute | Genetically encoded boronate amino acid |
| EP2889370A1 (en) | 2007-12-11 | 2015-07-01 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris |
| JP2011514322A (ja) * | 2008-02-08 | 2011-05-06 | ザ スクリプス リサーチ インスティチュート | 遺伝的にコードされる非天然アミノ酸による免疫寛容解除 |
| EP2373224A1 (en) * | 2008-12-09 | 2011-10-12 | Wilson-Cook Medical Inc. | Apparatus and methods for controlled release of tacking devices |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| JP5959201B2 (ja) | 2008-12-10 | 2016-08-02 | ザ スクリプス リサーチ インスティテュート | 化学的に反応性の非天然アミノ酸を使用するキャリア−ペプチド接合体の製造 |
| WO2010089741A1 (en) * | 2009-02-04 | 2010-08-12 | Ben-Gurion University Of The Negev Research And Development Authority | Systems and methods for bio-electricity production |
| EP2976362B1 (en) | 2013-03-19 | 2019-10-23 | Beijing Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
| US20150331624A1 (en) * | 2014-05-19 | 2015-11-19 | Kabushiki Kaisha Toshiba | Host-controlled flash translation layer snapshot |
| KR101956042B1 (ko) * | 2017-07-13 | 2019-03-08 | 서강대학교산학협력단 | 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법 |
| KR20220024586A (ko) | 2019-06-17 | 2022-03-03 | 메르크 파텐트 게엠베하 | 액정-기반 광 밸브 |
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| DK2322631T3 (en) | 2001-04-19 | 2015-01-12 | Scripps Research Inst | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar |
| US7432092B2 (en) | 2002-10-16 | 2008-10-07 | The Scripps Research Institute | Site specific incorporation of keto amino acids into proteins |
| CA2500653A1 (en) | 2002-10-16 | 2004-04-29 | The Scripps Research Institute | Glycoprotein synthesis |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| KR101171397B1 (ko) | 2003-04-17 | 2012-08-07 | 더 스크립스 리서치 인스티튜트 | 진핵 유전자 코드의 확장 |
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| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| ES2301099T3 (es) | 2003-07-07 | 2008-06-16 | The Scripps Research Institute | Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas. |
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| PT1687401E (pt) | 2013-02-26 |
| WO2005038002A3 (en) | 2006-11-23 |
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| EP1687401B1 (en) | 2012-11-21 |
| AU2004282577B2 (en) | 2009-10-29 |
| ES2396712T3 (es) | 2013-02-25 |
| US9783798B2 (en) | 2017-10-10 |
| AU2004282577A1 (en) | 2005-04-28 |
| MXPA06004087A (es) | 2006-06-27 |
| EP1687401A2 (en) | 2006-08-09 |
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| US8114654B2 (en) | 2012-02-14 |
| IL206889A0 (en) | 2010-12-30 |
| IL174947A (en) | 2011-11-30 |
| PL1687401T3 (pl) | 2013-04-30 |
| CN1942579A (zh) | 2007-04-04 |
| CA2541166A1 (en) | 2005-04-28 |
| IL201705A0 (en) | 2011-08-01 |
| JP5657850B2 (ja) | 2015-01-21 |
| IL174947A0 (en) | 2006-08-20 |
| US20050227318A1 (en) | 2005-10-13 |
| US7811801B2 (en) | 2010-10-12 |
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| US20110008782A1 (en) | 2011-01-13 |
| US20120100570A1 (en) | 2012-04-26 |
| CN1942579B (zh) | 2013-06-26 |
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