DK1687401T3 - Sted-spicifik inkorporing af redoxaktive aminosyrer i protiener - Google Patents

Sted-spicifik inkorporing af redoxaktive aminosyrer i protiener

Info

Publication number
DK1687401T3
DK1687401T3 DK04795276.7T DK04795276T DK1687401T3 DK 1687401 T3 DK1687401 T3 DK 1687401T3 DK 04795276 T DK04795276 T DK 04795276T DK 1687401 T3 DK1687401 T3 DK 1687401T3
Authority
DK
Denmark
Prior art keywords
protiens
redox
site
amino acids
active amino
Prior art date
Application number
DK04795276.7T
Other languages
Danish (da)
English (en)
Inventor
Lital Alfonta
Peter G Schultz
Zhiwen Zhang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK1687401T3 publication Critical patent/DK1687401T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK04795276.7T 2003-10-14 2004-10-13 Sted-spicifik inkorporing af redoxaktive aminosyrer i protiener DK1687401T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

Publications (1)

Publication Number Publication Date
DK1687401T3 true DK1687401T3 (da) 2013-02-04

Family

ID=34465242

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04795276.7T DK1687401T3 (da) 2003-10-14 2004-10-13 Sted-spicifik inkorporing af redoxaktive aminosyrer i protiener

Country Status (14)

Country Link
US (5) US7494796B2 (enExample)
EP (1) EP1687401B1 (enExample)
JP (1) JP5657850B2 (enExample)
CN (2) CN101532046A (enExample)
AU (1) AU2004282577B2 (enExample)
BR (1) BRPI0415308A (enExample)
CA (1) CA2541166A1 (enExample)
DK (1) DK1687401T3 (enExample)
ES (1) ES2396712T3 (enExample)
IL (3) IL174947A (enExample)
MX (1) MXPA06004087A (enExample)
PL (1) PL1687401T3 (enExample)
PT (1) PT1687401E (enExample)
WO (1) WO2005038002A2 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2322631T3 (en) * 2001-04-19 2015-01-12 Scripps Research Inst Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
ES2333422T3 (es) * 2002-10-16 2010-02-22 The Scripps Research Institute Sintesis de glicoproteinas.
EP1613735B1 (en) 2003-04-17 2012-01-25 The Scripps Research Institute Expanding the eukaryotic genetic code
CN102618605B (zh) 2003-06-18 2015-09-02 斯克利普斯研究院 非天然活性氨基酸遗传密码增加
ATE471385T1 (de) 2003-07-07 2010-07-15 Scripps Research Inst Zusammensetzungen aus orthogonalen lysyl-trna- und aminoacyl-trna-synthetasepaaren und deren verwendung
JP2008500050A (ja) * 2004-05-25 2008-01-10 ザ スクリップス リサーチ インスティテュート 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
JP2008513806A (ja) * 2004-09-22 2008-05-01 ザ スクリップス リサーチ インスティテュート Ｎｍｒ試験のための蛋白質の部位特異的標識
EP1807515A4 (en) 2004-10-27 2008-06-18 Scripps Research Inst Orthogonal translation components for the in vivo incorporation of unnatural amino acids
US8367588B2 (en) * 2005-10-12 2013-02-05 The Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
US7776535B2 (en) * 2006-02-06 2010-08-17 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
US7960141B2 (en) * 2006-03-09 2011-06-14 The Scripps Research Institute Systems for the expression of orthogonal translation components in eubacterial host cells
AU2007227592B2 (en) 2006-03-16 2011-11-24 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
CA2652894A1 (en) * 2006-05-23 2007-12-06 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
PT2052083E (pt) * 2006-09-21 2014-04-10 Scripps Research Inst Expressão geneticamente programada de proteínas seletivamente sulfatadas em eubactérias
US9624485B2 (en) 2006-10-18 2017-04-18 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
MX2010004464A (es) 2007-10-25 2010-06-07 Scripps Research Inst Incorporacion genetica de 3-aminotirosina a reductasas.
EP2220218A4 (en) * 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
US9249408B2 (en) * 2007-11-02 2016-02-02 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
KR20100105846A (ko) * 2007-12-11 2010-09-30 더 스크립스 리서치 인스티튜트 메틸영양요구성 효모 피키아 파스토리스에서의 생체 내 비천연 아미노산 발현
KR20100125290A (ko) * 2008-02-08 2010-11-30 더 스크립스 리서치 인스티튜트 유전적으로 코딩된 비천연 아미노산에 의한 면역 내성의 파괴
WO2010077608A1 (en) * 2008-12-09 2010-07-08 Wilson-Cook Medical Inc. Apparatus and methods for controlled release of tacking devices
JP5959201B2 (ja) 2008-12-10 2016-08-02 ザ スクリプス リサーチ インスティテュート 化学的に反応性の非天然アミノ酸を使用するキャリア−ペプチド接合体の製造
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
EP2394323B1 (en) * 2009-02-04 2017-05-24 Ben-gurion University Of The Negev Research And Development Authority Systems and methods for bio-electricity production
WO2014146575A1 (en) 2013-03-19 2014-09-25 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
CN114008176A (zh) 2019-06-17 2022-02-01 默克专利股份有限公司 基于液晶的光阀

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879905A (en) * 1996-08-29 1999-03-09 Massachusetts Institute Of Technology In vivo method of initiating protein synthesis with an amino acid other than methionine
DK2322631T3 (en) * 2001-04-19 2015-01-12 Scripps Research Inst Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
DK1578949T3 (da) 2002-10-16 2009-07-27 Scripps Research Inst Stedspecifik optagelse af keto-aminnosyrer hos proteiner
ES2333422T3 (es) 2002-10-16 2010-02-22 The Scripps Research Institute Sintesis de glicoproteinas.
MXPA05006836A (es) 2002-12-22 2005-08-16 Scripps Research Inst Colecciones ordenadas de proteinas.
EP1613735B1 (en) 2003-04-17 2012-01-25 The Scripps Research Institute Expanding the eukaryotic genetic code
CN102618605B (zh) 2003-06-18 2015-09-02 斯克利普斯研究院 非天然活性氨基酸遗传密码增加
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
ATE471385T1 (de) 2003-07-07 2010-07-15 Scripps Research Inst Zusammensetzungen aus orthogonalen lysyl-trna- und aminoacyl-trna-synthetasepaaren und deren verwendung
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof

Also Published As

Publication number Publication date
CA2541166A1 (en) 2005-04-28
IL201705A0 (en) 2011-08-01
JP2007508034A (ja) 2007-04-05
PT1687401E (pt) 2013-02-26
US20120100570A1 (en) 2012-04-26
EP1687401A4 (en) 2007-08-01
IL174947A0 (en) 2006-08-20
EP1687401A2 (en) 2006-08-09
AU2004282577B2 (en) 2009-10-29
CN1942579A (zh) 2007-04-04
US9783798B2 (en) 2017-10-10
WO2005038002A2 (en) 2005-04-28
US20110008782A1 (en) 2011-01-13
CN101532046A (zh) 2009-09-16
ES2396712T3 (es) 2013-02-25
MXPA06004087A (es) 2006-06-27
WO2005038002A3 (en) 2006-11-23
PL1687401T3 (pl) 2013-04-30
CN1942579B (zh) 2013-06-26
US7811801B2 (en) 2010-10-12
JP5657850B2 (ja) 2015-01-21
US20070009990A1 (en) 2007-01-11
US20050227318A1 (en) 2005-10-13
IL206889A0 (en) 2010-12-30
US7494796B2 (en) 2009-02-24
IL174947A (en) 2011-11-30
US8008041B2 (en) 2011-08-30
EP1687401B1 (en) 2012-11-21
US20090298124A1 (en) 2009-12-03
AU2004282577A1 (en) 2005-04-28
BRPI0415308A (pt) 2006-12-05
US8114654B2 (en) 2012-02-14

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