ES2385606T8 - Arilimidazolonas y ariltriazolonas sustituidas como inhibidores de receptores de vasopresina - Google Patents

Arilimidazolonas y ariltriazolonas sustituidas como inhibidores de receptores de vasopresina Download PDF

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Publication number
ES2385606T8
ES2385606T8 ES07725514T ES07725514T ES2385606T8 ES 2385606 T8 ES2385606 T8 ES 2385606T8 ES 07725514 T ES07725514 T ES 07725514T ES 07725514 T ES07725514 T ES 07725514T ES 2385606 T8 ES2385606 T8 ES 2385606T8
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ES
Spain
Prior art keywords
aryltriazolones
arylimidazolones
substituted
receptor inhibitors
vasopressin receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07725514T
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English (en)
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ES2385606T3 (es
Inventor
Heinrich Meier
Eckhard Bender
Ulf Brüggemeier
Ingo Flamme
Dagmar Karthaus
Peter Kolkhof
Daniel Meibom
Dirk Schneider
Verena Voehringer
Chantal FÜRSTNER
Jörg Keldenich
Dieter Lang
Elisabeth Pook
Carsten Schmeck
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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Publication of ES2385606T3 publication Critical patent/ES2385606T3/es
Publication of ES2385606T8 publication Critical patent/ES2385606T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES07725514T 2006-05-23 2007-05-23 Arilimidazolonas y ariltriazolonas sustituidas como inhibidores de receptores de vasopresina Active ES2385606T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006024024A DE102006024024A1 (de) 2006-05-23 2006-05-23 Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung
DE102006024024 2006-05-23
PCT/EP2007/004615 WO2007134862A1 (de) 2006-05-23 2007-05-21 Substituierte arylimidaz0l0ne und -triaz0l0ne als inhibitoren der vasopressin-rezeptoren

Publications (2)

Publication Number Publication Date
ES2385606T3 ES2385606T3 (es) 2012-07-27
ES2385606T8 true ES2385606T8 (es) 2013-05-14

Family

ID=38353593

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07725514T Active ES2385606T3 (es) 2006-05-23 2007-05-23 Arilimidazolonas y ariltriazolonas sustituidas como inhibidores de receptores de vasopresina

Country Status (29)

Country Link
US (2) US8084481B2 (es)
EP (1) EP2027096B8 (es)
JP (1) JP5247684B2 (es)
KR (1) KR101426574B1 (es)
CN (1) CN101495458B (es)
AR (1) AR061114A1 (es)
AU (1) AU2007253572B9 (es)
BR (1) BRPI0711975A2 (es)
CA (1) CA2652834C (es)
DE (1) DE102006024024A1 (es)
DK (1) DK2027096T3 (es)
DO (1) DOP2007000102A (es)
EC (1) ECSP088904A (es)
ES (1) ES2385606T3 (es)
GT (1) GT200800250A (es)
HN (1) HN2008001720A (es)
IL (1) IL195142A (es)
MA (1) MA30500B1 (es)
MX (1) MX2008014797A (es)
PE (1) PE20080706A1 (es)
PL (1) PL2027096T3 (es)
PT (1) PT2027096E (es)
RU (1) RU2460724C2 (es)
SV (1) SV2009003098A (es)
TN (1) TNSN08443A1 (es)
TW (1) TW200817336A (es)
UY (1) UY30364A1 (es)
WO (1) WO2007134862A1 (es)
ZA (1) ZA200809860B (es)

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JP6387669B2 (ja) * 2013-04-26 2018-09-12 大正製薬株式会社 アゾール誘導体を含有する医薬
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Also Published As

Publication number Publication date
US20090312381A1 (en) 2009-12-17
AU2007253572B2 (en) 2013-06-20
HK1136820A1 (en) 2010-07-09
DOP2007000102A (es) 2007-12-31
KR101426574B1 (ko) 2014-08-06
DK2027096T3 (da) 2012-09-10
IL195142A0 (en) 2009-09-22
US20130005704A1 (en) 2013-01-03
PL2027096T3 (pl) 2012-10-31
KR20090014214A (ko) 2009-02-06
CA2652834C (en) 2015-01-27
AR061114A1 (es) 2008-08-06
PT2027096E (pt) 2012-07-12
IL195142A (en) 2013-07-31
SV2009003098A (es) 2009-04-28
ECSP088904A (es) 2008-12-30
MA30500B1 (fr) 2009-06-01
BRPI0711975A2 (pt) 2012-02-22
RU2008150598A (ru) 2010-06-27
JP2009537581A (ja) 2009-10-29
TNSN08443A1 (en) 2010-04-14
UY30364A1 (es) 2008-01-02
HN2008001720A (es) 2009-06-10
RU2460724C2 (ru) 2012-09-10
JP5247684B2 (ja) 2013-07-24
CA2652834A1 (en) 2007-11-29
US8084481B2 (en) 2011-12-27
ZA200809860B (en) 2010-02-24
TW200817336A (en) 2008-04-16
AU2007253572B9 (en) 2013-07-25
WO2007134862A1 (de) 2007-11-29
MX2008014797A (es) 2008-12-02
EP2027096B1 (de) 2012-05-23
DE102006024024A1 (de) 2007-11-29
PE20080706A1 (es) 2008-08-07
AU2007253572A1 (en) 2007-11-29
EP2027096A1 (de) 2009-02-25
GT200800250A (es) 2009-09-14
EP2027096B8 (de) 2012-09-26
ES2385606T3 (es) 2012-07-27
CN101495458A (zh) 2009-07-29
CN101495458B (zh) 2014-01-29

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