ES2380340T3 - Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento - Google Patents

Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento Download PDF

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Publication number
ES2380340T3
ES2380340T3 ES04817014T ES04817014T ES2380340T3 ES 2380340 T3 ES2380340 T3 ES 2380340T3 ES 04817014 T ES04817014 T ES 04817014T ES 04817014 T ES04817014 T ES 04817014T ES 2380340 T3 ES2380340 T3 ES 2380340T3
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Prior art keywords
peptide
growth factor
assembly
binding
compound
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English (en)
Spanish (es)
Inventor
Samuel I. Stupp
Jack J. J. M. DONNERS
Gabriel A. Silva
Heather A. Behanna
Shawn G. Anthony
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Northwestern University
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Northwestern University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES04817014T 2003-12-05 2004-12-06 Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento Active ES2380340T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52750403P 2003-12-05 2003-12-05
US527504P 2003-12-05
PCT/US2004/040550 WO2005056039A1 (en) 2003-12-05 2004-12-06 Self-assembling peptide amphiphiles and related methods for growth factor delivery

Publications (1)

Publication Number Publication Date
ES2380340T3 true ES2380340T3 (es) 2012-05-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES04817014T Active ES2380340T3 (es) 2003-12-05 2004-12-06 Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento

Country Status (12)

Country Link
US (3) US7544661B2 (US20050209145A1-20050922-C00001.png)
EP (2) EP1696945B1 (US20050209145A1-20050922-C00001.png)
JP (2) JP4851939B2 (US20050209145A1-20050922-C00001.png)
KR (1) KR20070004560A (US20050209145A1-20050922-C00001.png)
CN (2) CN102225964A (US20050209145A1-20050922-C00001.png)
AT (1) ATE541580T1 (US20050209145A1-20050922-C00001.png)
AU (2) AU2004296181A1 (US20050209145A1-20050922-C00001.png)
CA (1) CA2549164A1 (US20050209145A1-20050922-C00001.png)
ES (1) ES2380340T3 (US20050209145A1-20050922-C00001.png)
MX (1) MXPA06006388A (US20050209145A1-20050922-C00001.png)
NZ (1) NZ547671A (US20050209145A1-20050922-C00001.png)
WO (1) WO2005056039A1 (US20050209145A1-20050922-C00001.png)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
AU2003215280A1 (en) 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) * 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
AU2003304152A1 (en) * 2002-09-23 2005-01-21 Northwestern University Self-assembled peptide-amphiphiles and self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
CA2515651A1 (en) * 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
CN102225964A (zh) 2003-12-05 2011-10-26 西北大学 自组装的肽两亲物和用于生长因子传递的相关方法
EP1696944A4 (en) * 2003-12-05 2008-11-05 Univ Northwestern BRANCHED PEPTIDE AMPHIPHILES, RELATED EPITOPES COMPOUNDS AND SELF-ASSOCIATED STRUCTURES THEREOF
US7923109B2 (en) * 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
CA2590336A1 (en) 2005-01-21 2006-07-27 Northwestern University Methods and compositions for encapsulation of cells
MX2007010771A (es) 2005-03-04 2008-03-10 Univ Northwestern Anfifilos peptidicos para union a heparina angiogenicos.
US9162005B2 (en) * 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
JP4766528B2 (ja) * 2005-06-27 2011-09-07 株式会社メニコン 自己組織化ペプチドおよびそれより得られるゲル
CN100475836C (zh) * 2005-12-09 2009-04-08 中国人民解放军军事医学科学院野战输血研究所 间充质干细胞亲和肽的筛选与用途
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
AU2007219714A1 (en) * 2006-02-28 2007-09-07 Regenertech Pty Limited Tissue regeneration II
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
US20090098652A1 (en) * 2007-08-17 2009-04-16 Northwestern University Self assembling peptide systems and methods
US20090291113A1 (en) * 2008-04-14 2009-11-26 Adocia Osteogenic composition comprising a growth factor, a soluble cation salt and organic support
US20090291114A1 (en) * 2008-04-14 2009-11-26 Adocia Osteogenic composition comprising a growth factor/amphiphilic polymer complex, a soluble cation salt and an organic support
CN102076280B (zh) * 2008-06-24 2014-08-27 生物活性外科公司 掺入有干细胞或其它生物活性物质的外科缝合线
KR20110042107A (ko) 2008-08-07 2011-04-22 바이오엑티브 써지컬, 아이엔씨. 의료 장치 및 이식물을 위한 줄기 세포 포획 및 고정화 코팅
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
US8883967B2 (en) * 2009-03-27 2014-11-11 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
AU2010236584A1 (en) * 2009-04-13 2011-11-10 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
WO2011002258A2 (ko) * 2009-07-02 2011-01-06 한양대학교 산학협력단 아르기닌 기제 양친성 펩티드 마이셀
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
SG184345A1 (en) * 2010-03-31 2012-11-29 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US8940858B2 (en) * 2010-05-17 2015-01-27 Northwestern University Fibrous microcapsules and methods of assembly and use thereof
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
WO2012031015A1 (en) * 2010-09-01 2012-03-08 The Regents Of The University Of California Cell culture screen for agents that control adipogenesis and myofibroblast differentiation
EP4079292A1 (en) * 2010-09-24 2022-10-26 The Brigham and Women's Hospital, Inc. Nanostructured gels capable of controlled release of encapsulated agents
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
US20130101628A1 (en) * 2011-04-29 2013-04-25 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
CN105008396A (zh) 2012-11-25 2015-10-28 加利福尼亚大学董事会 刺激皮下脂肪形成的肽
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
CN111978409B (zh) * 2013-03-15 2024-01-26 因斯瑞拜奥有限公司 自组装合成蛋白
US9339476B2 (en) 2013-08-22 2016-05-17 Arch Biosurgery, Inc. Implantable meshes for controlling the movement of fluids
US9517275B2 (en) 2013-09-30 2016-12-13 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
MX2016006988A (es) * 2013-11-30 2017-02-17 Agency Science Tech & Res Nuevos peptidos hidrofobos ultracortos que se autoensamblan en hidrogeles nanofibrosos y sus usos.
WO2015184125A1 (en) 2014-05-28 2015-12-03 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
US20160159869A1 (en) * 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
DE102015000363A1 (de) 2015-01-20 2016-07-21 Emc Microcollections Gmbh Neue modular funktionalisierbare Peptid-Hydrogele
US10792327B2 (en) * 2015-04-14 2020-10-06 Northwestern University Supramolecular gylcosaminoglycans
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
JP6908284B2 (ja) 2015-10-14 2021-07-21 ノースウエスタン ユニバーシティＮｏｒｔｈｗｅｓｔｅｒｎ Ｕｎｉｖｅｒｓｉｔｙ 骨伝導性複合材料
WO2018093449A1 (en) * 2016-09-09 2018-05-24 Research Foundation Of The City University Of New York Self-assembling peptide polymer
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US10752656B2 (en) 2016-10-21 2020-08-25 Northwestern University Anti-microbial supramolecular structures
US10818377B2 (en) 2016-11-16 2020-10-27 University Of Washington Computational design of self-assembling cyclic protein homo-oligomers
CN106749522B (zh) * 2016-11-23 2023-11-14 华东理工大学 一种含有聚组氨酸的抗癌多肽及其制备与应用
US20200095341A1 (en) 2016-11-30 2020-03-26 Universiteit Twente Functionalization of biopolymers with growth factor-binding peptides
US11174288B2 (en) * 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
US10584146B2 (en) 2016-12-07 2020-03-10 Uchicago Argonne, Llc Heme peptide materials for anti-inflammatory regenerative nanobiomedicine
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
AU2018266131B2 (en) 2017-05-08 2021-07-29 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
WO2019195741A1 (en) * 2018-04-06 2019-10-10 Northwestern University Bdnf mimetic peptide amphiphiles
WO2020076453A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
EP3972657A4 (en) * 2019-05-20 2023-07-26 Convalesce Inc. HYDROGELS, METHODS OF MAKING AND METHODS OF USE
CN110283231B (zh) * 2019-06-03 2021-04-27 中南民族大学 一种基于两亲性寡肽自组装新型溶致液晶的制备和应用
US11964000B2 (en) 2020-04-10 2024-04-23 Northwestern University Cancer treatment methods using nanofiber stabilized growth factors
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
US12116461B2 (en) 2020-08-21 2024-10-15 Northwestern University Host-guest interactions for pa superstructure formation
EP4240393A4 (en) * 2020-11-06 2024-10-23 The Medical College Of Wisconsin Inc PEPTIDE INHIBITORS OF HUMAN MITOCHONDRIAL CLEAVAGE PROTEIN 1 AND METHODS OF USE
WO2023010082A1 (en) * 2021-07-29 2023-02-02 Northwestern University SELF-ASSEMBLING PEPTIDE AMPHIPHILES DISPLAYING A TRANSFORMING GROWTH FACTOR BETA 1 (TGF-β1) MIMETIC EPITOPE
AU2022326548A1 (en) * 2021-08-09 2024-02-29 Gel4Med, Inc. Self-assembling amphiphilic peptide hydrogels for treatment of nerve injury
WO2024064661A2 (en) * 2022-09-20 2024-03-28 The Curators Of The University Of Missouri Amino acid-modified lipids for rna delivery
CN117986325A (zh) * 2024-01-25 2024-05-07 中国人民解放军军事科学院军事医学研究院 一种多肽单体分子mbp、多肽共组装纳米粒及其应用

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) * 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) * 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5110604A (en) 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (ja) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol 短繊維型螺旋状分子会合体の長さ制御方法
DE4026978A1 (de) * 1990-08-25 1992-02-27 Bayer Ag Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung
WO1992019195A1 (en) 1991-04-25 1992-11-12 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
JPH11510837A (ja) * 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (fr) 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
SE9504347D0 (sv) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) * 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) * 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
JP3862760B2 (ja) 1996-06-12 2006-12-27 トレスパファン、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング 低い薄膜干渉を示す透明なバリヤコーティング
US6085206A (en) * 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) * 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6132730A (en) 1997-01-22 2000-10-17 Board Of Regents, The University Of Texas System Combined tissue factor and factor VIIa methods and compositions for coagulation and tumor treatment
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
GB2348426B (en) 1997-04-03 2001-06-27 California Inst Of Techn Enzyme-mediated modification of fibrin for tissue engineering
US6181909B1 (en) * 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) * 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
DE69841850D1 (de) * 1997-12-02 2010-09-30 Artecel Sciences Inc Differenzierung in osteoblasten der fettgewebe-stromalen zellen und ihre verwendungen
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (sv) 1998-03-30 2003-04-15 Viranative Ab Näringsmedium innehållande metionin samt användning av detta
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
IL141688A0 (en) 1998-09-04 2002-03-10 Scios Inc Hydrogel compositions for the controlled release administration of growth factors
CA2277732A1 (en) 1998-09-15 2000-03-15 Isotis B.V. Method for coating medical implants
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
CA2359318C (en) 1999-02-01 2009-06-30 Donald Elbert Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
WO2000045831A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
CA2364415A1 (en) 1999-03-02 2000-09-08 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) * 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
JP2002542301A (ja) 1999-04-22 2002-12-10 アイトゲネシッシェ、テヒニッシェ、ホッホシューレ（エーテーハー） ヘパリン含有マトリックスからの増殖因子の制御放出
US20090087878A9 (en) 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
JP2003503071A (ja) 1999-06-30 2003-01-28 アドバンスド セル テクノロジー、インコーポレイテッド 脱分化レシピエント細胞への細胞質移入
US6444723B1 (en) * 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
AU2466601A (en) * 1999-12-28 2001-07-09 Regents Of The University Of Michigan, The Process for ex vivo formation of mammalian bone and uses thereof
US20040018969A1 (en) * 2000-01-31 2004-01-29 Rosen Craig A. Nucleic acids, proteins, and antibodies
WO2001055208A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
CA2399216A1 (en) 2000-02-04 2001-08-09 Isotis N.V. Proteinaceous coating
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
AU5503001A (en) 2000-04-28 2001-11-12 University College Dublin Amphiphilic macrocyclic derivatives and their analogues
CN1465018A (zh) * 2000-05-11 2003-12-31 南加利福尼亚大学 机器翻译技术
CA2421271A1 (en) * 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Human and mouse targeting peptides identified by phage display
AU2002245205B2 (en) * 2000-10-19 2007-07-19 Ecole Polytechnique Federale De Lausanne Block copolymers for multifunctional self-assembled systems
EP1334365B1 (en) * 2000-11-06 2007-02-21 Thrasos, Inc. Screening methods for bone morphogenetic mimetics
CA2436740A1 (en) * 2001-01-23 2002-08-01 Educational Testing Service Methods for automated essay analysis
JP5057629B2 (ja) 2001-02-06 2012-10-24 マサチューセッツ インスティテュート オブ テクノロジー ペプチド足場での組織細胞のカプセル化およびその使用
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
US7179784B2 (en) * 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
AU2002361601A1 (en) 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
AU2003215280A1 (en) * 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
WO2003090255A2 (en) 2002-04-18 2003-10-30 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
WO2004024778A2 (en) 2002-07-23 2004-03-25 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
AU2003304152A1 (en) 2002-09-23 2005-01-21 Northwestern University Self-assembled peptide-amphiphiles and self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
WO2005003292A2 (en) 2002-11-12 2005-01-13 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
CN100364672C (zh) 2003-02-11 2008-01-30 西北大学 纳米晶体表面涂层和肽亲水脂分子纳米纤维向其上附着的方法和材料
CA2515651A1 (en) * 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
CN102225964A (zh) 2003-12-05 2011-10-26 西北大学 自组装的肽两亲物和用于生长因子传递的相关方法
EP1696944A4 (en) * 2003-12-05 2008-11-05 Univ Northwestern BRANCHED PEPTIDE AMPHIPHILES, RELATED EPITOPES COMPOUNDS AND SELF-ASSOCIATED STRUCTURES THEREOF
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
US7241461B2 (en) 2004-03-23 2007-07-10 Lifeline Nutraceuticals Corporation Compositions for alleviating inflammation and oxidative stress in a mammal
CA2590336A1 (en) 2005-01-21 2006-07-27 Northwestern University Methods and compositions for encapsulation of cells
CA2593112A1 (en) 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
MX2007010771A (es) 2005-03-04 2008-03-10 Univ Northwestern Anfifilos peptidicos para union a heparina angiogenicos.
ES2363758T3 (es) 2005-08-15 2011-08-16 Vegenics Pty Ltd Vegf y pdgf modificados con propiedades angiogénicas mejoradas.
CN1915438A (zh) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8772228B2 (en) * 2007-02-14 2014-07-08 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US20090098652A1 (en) * 2007-08-17 2009-04-16 Northwestern University Self assembling peptide systems and methods
AU2010236584A1 (en) * 2009-04-13 2011-11-10 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use

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US20090269847A1 (en) 2009-10-29
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