ES2374633T3 - Formulación de contraste por rayos x que comprende una mezcla de monómero y dímero yodado. - Google Patents
Formulación de contraste por rayos x que comprende una mezcla de monómero y dímero yodado. Download PDFInfo
- Publication number
- ES2374633T3 ES2374633T3 ES05731581T ES05731581T ES2374633T3 ES 2374633 T3 ES2374633 T3 ES 2374633T3 ES 05731581 T ES05731581 T ES 05731581T ES 05731581 T ES05731581 T ES 05731581T ES 2374633 T3 ES2374633 T3 ES 2374633T3
- Authority
- ES
- Spain
- Prior art keywords
- independently
- composition
- hydroxy
- optionally substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000000203 mixture Substances 0.000 title claims abstract description 118
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- 238000009472 formulation Methods 0.000 title description 37
- 229910052740 iodine Inorganic materials 0.000 title description 11
- 239000011630 iodine Substances 0.000 title description 10
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 title description 2
- -1 hydroxypropyl Chemical group 0.000 claims abstract description 57
- 239000000539 dimer Substances 0.000 claims abstract description 46
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 31
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 28
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims abstract description 28
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract description 26
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims abstract description 24
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims abstract description 21
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract description 21
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 20
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 19
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 15
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims abstract description 12
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 10
- 238000012800 visualization Methods 0.000 claims abstract description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 8
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 7
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 6
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- NJKDOADNQSYQEV-UHFFFAOYSA-N iomeprol Chemical compound OCC(=O)N(C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NJKDOADNQSYQEV-UHFFFAOYSA-N 0.000 claims description 4
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
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- 150000001768 cations Chemical class 0.000 claims description 2
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- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims description 2
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- GKODZWOPPOTFGA-UHFFFAOYSA-N tris(hydroxyethyl)aminomethane Chemical compound OCCC(N)(CCO)CCO GKODZWOPPOTFGA-UHFFFAOYSA-N 0.000 claims 1
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- 229920003023 plastic Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000007487 urography Methods 0.000 description 1
- AXFGWXLCWCNPHP-UHFFFAOYSA-N versetamide Chemical compound COCCNC(=O)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(=O)NCCOC AXFGWXLCWCNPHP-UHFFFAOYSA-N 0.000 description 1
- 229960002569 versetamide Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55224004P | 2004-03-11 | 2004-03-11 | |
| US552240P | 2004-03-11 | ||
| PCT/US2005/008389 WO2005087272A2 (en) | 2004-03-11 | 2005-03-11 | X-ray contrast formulation comprising a mixture of iodinated monomer and dimer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2374633T3 true ES2374633T3 (es) | 2012-02-20 |
Family
ID=34964357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05731581T Expired - Lifetime ES2374633T3 (es) | 2004-03-11 | 2005-03-11 | Formulación de contraste por rayos x que comprende una mezcla de monómero y dímero yodado. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8679460B2 (enExample) |
| EP (2) | EP1725268B1 (enExample) |
| JP (1) | JP2007528424A (enExample) |
| KR (1) | KR20070015517A (enExample) |
| CN (1) | CN1938050A (enExample) |
| AT (1) | ATE529135T1 (enExample) |
| AU (1) | AU2005221716A1 (enExample) |
| CA (1) | CA2559628A1 (enExample) |
| ES (1) | ES2374633T3 (enExample) |
| IL (1) | IL177888A0 (enExample) |
| NO (1) | NO20064629L (enExample) |
| WO (1) | WO2005087272A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8445725B2 (en) * | 2008-01-14 | 2013-05-21 | Mallinckrodt Llc | Process for the preparation of iosimenol |
| US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
| US20110256068A1 (en) * | 2009-01-09 | 2011-10-20 | Wistand Lars-Goeran | Contrast media compositions |
| BR112012023063A2 (pt) * | 2010-03-23 | 2016-05-17 | Ge Healthcare As | processo para a preparação de uma composição para raio x, e, composição de diagnóstico para raio x |
| US20130039888A1 (en) | 2011-06-08 | 2013-02-14 | Nationwide Children's Hospital Inc. | Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders |
| JP2013091701A (ja) | 2011-10-25 | 2013-05-16 | Dow Corning Toray Co Ltd | 硬化性組成物 |
| US9725716B2 (en) * | 2011-12-06 | 2017-08-08 | Ohio State Innovation Foundation and Research Institute at Nationwide Children's Hospital | Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease |
| CA2862495A1 (en) | 2012-01-11 | 2013-07-18 | Ge Healthcare As | X-ray imaging contrast media with low iodine concentration and x-ray imaging process |
| HK1206939A1 (en) * | 2012-05-30 | 2016-01-22 | Verrow Pharmaceuticals, Inc. | Stabilized formulations containing iodinated contrast agents and cyclodextrins |
| EP2879719B1 (en) | 2012-08-01 | 2018-07-04 | Nationwide Children's Hospital | Intrathecal delivery of recombinant adeno-associated virus 9 |
| KR102151088B1 (ko) * | 2018-07-10 | 2020-09-02 | 한국원자력연구원 | 소체와 연결된 실 모양의 구조물 가시화 조성물 및 이의 가시화 방법 |
| CN112386712B (zh) * | 2020-11-09 | 2022-08-30 | 张洪 | 分子探针及其制备方法和用途 |
| CN119656340A (zh) * | 2024-12-13 | 2025-03-21 | 福安药业集团宁波天衡制药有限公司 | 一种碘佛醇注射液及其制备方法 |
| CN120899953B (zh) * | 2025-10-13 | 2025-12-12 | 浙江迪安鉴识科技有限公司 | 一种尸体用血管造影剂及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2511871A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
| US5698739A (en) | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| CA2124559A1 (en) * | 1991-12-03 | 1993-06-10 | Mills Thomas Kneller | Nonionic x-ray contrast agents, compositions and methods |
| IT1256248B (it) | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
| DE19627309C2 (de) * | 1996-06-27 | 1999-07-29 | Schering Ag | Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel |
| US8518373B2 (en) * | 2001-08-03 | 2013-08-27 | Bracco Imaging Spa | Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics |
| ITMI20011706A1 (it) | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic |
| US7250153B2 (en) * | 2002-12-12 | 2007-07-31 | Biophysica Research, Inc. | Contrast media formulations having improved biological tolerance |
-
2005
- 2005-03-11 KR KR1020067018308A patent/KR20070015517A/ko not_active Withdrawn
- 2005-03-11 CA CA002559628A patent/CA2559628A1/en not_active Abandoned
- 2005-03-11 ES ES05731581T patent/ES2374633T3/es not_active Expired - Lifetime
- 2005-03-11 AU AU2005221716A patent/AU2005221716A1/en not_active Abandoned
- 2005-03-11 EP EP05731581A patent/EP1725268B1/en not_active Expired - Lifetime
- 2005-03-11 WO PCT/US2005/008389 patent/WO2005087272A2/en not_active Ceased
- 2005-03-11 US US10/588,674 patent/US8679460B2/en not_active Expired - Fee Related
- 2005-03-11 JP JP2007503103A patent/JP2007528424A/ja not_active Withdrawn
- 2005-03-11 EP EP10174231A patent/EP2253332B1/en not_active Expired - Lifetime
- 2005-03-11 AT AT05731581T patent/ATE529135T1/de not_active IP Right Cessation
- 2005-03-11 CN CNA2005800078749A patent/CN1938050A/zh active Pending
-
2006
- 2006-09-04 IL IL177888A patent/IL177888A0/en unknown
- 2006-10-10 NO NO20064629A patent/NO20064629L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007528424A (ja) | 2007-10-11 |
| AU2005221716A1 (en) | 2005-09-22 |
| CA2559628A1 (en) | 2005-09-22 |
| IL177888A0 (en) | 2006-12-31 |
| EP2253332A3 (en) | 2011-03-23 |
| US20080317675A1 (en) | 2008-12-25 |
| EP1725268B1 (en) | 2011-10-19 |
| EP1725268A2 (en) | 2006-11-29 |
| EP2253332A2 (en) | 2010-11-24 |
| US8679460B2 (en) | 2014-03-25 |
| ATE529135T1 (de) | 2011-11-15 |
| CN1938050A (zh) | 2007-03-28 |
| KR20070015517A (ko) | 2007-02-05 |
| NO20064629L (no) | 2006-11-28 |
| EP2253332B1 (en) | 2012-10-10 |
| WO2005087272A2 (en) | 2005-09-22 |
| WO2005087272A3 (en) | 2006-06-22 |
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