AU2005221716A1 - X-ray contrast formulations comprising a mixture of iodinated monomer and dimer - Google Patents
X-ray contrast formulations comprising a mixture of iodinated monomer and dimer Download PDFInfo
- Publication number
- AU2005221716A1 AU2005221716A1 AU2005221716A AU2005221716A AU2005221716A1 AU 2005221716 A1 AU2005221716 A1 AU 2005221716A1 AU 2005221716 A AU2005221716 A AU 2005221716A AU 2005221716 A AU2005221716 A AU 2005221716A AU 2005221716 A1 AU2005221716 A1 AU 2005221716A1
- Authority
- AU
- Australia
- Prior art keywords
- composition
- independently
- dimer
- hydroxy
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 239000000539 dimer Substances 0.000 title claims abstract description 42
- 239000000178 monomer Substances 0.000 title claims abstract description 39
- 238000009472 formulation Methods 0.000 title abstract description 34
- 239000002872 contrast media Substances 0.000 claims abstract description 45
- -1 triiodo-substituted benzene Chemical class 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 25
- 238000012800 visualization Methods 0.000 claims abstract description 10
- 125000004122 cyclic group Chemical group 0.000 claims description 22
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims description 21
- 125000003545 alkoxy group Chemical group 0.000 claims description 18
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims description 18
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 15
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 13
- 229960004537 ioversol Drugs 0.000 claims description 13
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 239000012216 imaging agent Substances 0.000 claims description 11
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims description 11
- DLPPIGPJCKKVBA-UHFFFAOYSA-N Iosimenol Chemical group OCC(O)CNC(=O)C1=C(I)C(C(=O)N)=C(I)C(N(CC(O)CO)C(=O)CC(=O)N(CC(O)CO)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(N)=O)C=2I)I)=C1I DLPPIGPJCKKVBA-UHFFFAOYSA-N 0.000 claims description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
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- 125000001424 substituent group Chemical group 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
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- 229910052708 sodium Inorganic materials 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
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- 229960002569 versetamide Drugs 0.000 description 1
- AXFGWXLCWCNPHP-UHFFFAOYSA-N versetamide Chemical compound COCCNC(=O)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(=O)NCCOC AXFGWXLCWCNPHP-UHFFFAOYSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55224004P | 2004-03-11 | 2004-03-11 | |
| US60/552,240 | 2004-03-11 | ||
| PCT/US2005/008389 WO2005087272A2 (en) | 2004-03-11 | 2005-03-11 | X-ray contrast formulation comprising a mixture of iodinated monomer and dimer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005221716A1 true AU2005221716A1 (en) | 2005-09-22 |
Family
ID=34964357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005221716A Abandoned AU2005221716A1 (en) | 2004-03-11 | 2005-03-11 | X-ray contrast formulations comprising a mixture of iodinated monomer and dimer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8679460B2 (enExample) |
| EP (2) | EP2253332B1 (enExample) |
| JP (1) | JP2007528424A (enExample) |
| KR (1) | KR20070015517A (enExample) |
| CN (1) | CN1938050A (enExample) |
| AT (1) | ATE529135T1 (enExample) |
| AU (1) | AU2005221716A1 (enExample) |
| CA (1) | CA2559628A1 (enExample) |
| ES (1) | ES2374633T3 (enExample) |
| IL (1) | IL177888A0 (enExample) |
| NO (1) | NO20064629L (enExample) |
| WO (1) | WO2005087272A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011509943A (ja) * | 2008-01-14 | 2011-03-31 | マリンクロッド・インコーポレイテッド | イオシメノールを調製するためのプロセス |
| US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
| CN102271715A (zh) | 2009-01-09 | 2011-12-07 | 通用电气医疗集团股份有限公司 | 对比剂组合物 |
| CN102802671B (zh) * | 2010-03-23 | 2015-07-22 | 通用电气医疗集团股份有限公司 | 稳定的x射线诊断组合物的制备 |
| US20130039888A1 (en) | 2011-06-08 | 2013-02-14 | Nationwide Children's Hospital Inc. | Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders |
| JP2013091701A (ja) | 2011-10-25 | 2013-05-16 | Dow Corning Toray Co Ltd | 硬化性組成物 |
| EP2788087A4 (en) * | 2011-12-06 | 2015-08-26 | Ohio State Innovation Foundation | Non-ionic, low-osmolar contrast agents for the administration of antisense oligonucleotides and the treatment of diseases |
| NZ626988A (en) * | 2012-01-11 | 2015-10-30 | Ge Healthcare As | X-ray imaging contrast media with low iodine concentration and x-ray imaging process |
| WO2013180777A1 (en) * | 2012-05-30 | 2013-12-05 | Verrow Pharmaceuticals, Inc. | Stabilized formulations containing iodinated contrast agents and cyclodextrins |
| PT2879719T (pt) | 2012-08-01 | 2018-10-08 | Ohio State Innovation Foundation | Administração intratecal do vírus adeno-associado 9 recombinante |
| KR102151088B1 (ko) * | 2018-07-10 | 2020-09-02 | 한국원자력연구원 | 소체와 연결된 실 모양의 구조물 가시화 조성물 및 이의 가시화 방법 |
| CN112386712B (zh) * | 2020-11-09 | 2022-08-30 | 张洪 | 分子探针及其制备方法和用途 |
| CN119656340A (zh) * | 2024-12-13 | 2025-03-21 | 福安药业集团宁波天衡制药有限公司 | 一种碘佛醇注射液及其制备方法 |
| CN120899953B (zh) * | 2025-10-13 | 2025-12-12 | 浙江迪安鉴识科技有限公司 | 一种尸体用血管造影剂及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2511871A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
| US5698739A (en) | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| EP0619744A4 (en) * | 1991-12-03 | 1995-02-08 | Mallinckrodt Medical Inc | NON-IONIC RADIOGRAPHIC CONTRAST METHODS, COMPOSITIONS AND AGENTS. |
| IT1256248B (it) * | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
| DE19627309C2 (de) * | 1996-06-27 | 1999-07-29 | Schering Ag | Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel |
| ITMI20011706A1 (it) | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic |
| US8518373B2 (en) * | 2001-08-03 | 2013-08-27 | Bracco Imaging Spa | Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics |
| US7250153B2 (en) * | 2002-12-12 | 2007-07-31 | Biophysica Research, Inc. | Contrast media formulations having improved biological tolerance |
-
2005
- 2005-03-11 JP JP2007503103A patent/JP2007528424A/ja not_active Withdrawn
- 2005-03-11 AT AT05731581T patent/ATE529135T1/de not_active IP Right Cessation
- 2005-03-11 AU AU2005221716A patent/AU2005221716A1/en not_active Abandoned
- 2005-03-11 CA CA002559628A patent/CA2559628A1/en not_active Abandoned
- 2005-03-11 CN CNA2005800078749A patent/CN1938050A/zh active Pending
- 2005-03-11 ES ES05731581T patent/ES2374633T3/es not_active Expired - Lifetime
- 2005-03-11 KR KR1020067018308A patent/KR20070015517A/ko not_active Withdrawn
- 2005-03-11 EP EP10174231A patent/EP2253332B1/en not_active Expired - Lifetime
- 2005-03-11 WO PCT/US2005/008389 patent/WO2005087272A2/en not_active Ceased
- 2005-03-11 EP EP05731581A patent/EP1725268B1/en not_active Expired - Lifetime
- 2005-03-11 US US10/588,674 patent/US8679460B2/en not_active Expired - Fee Related
-
2006
- 2006-09-04 IL IL177888A patent/IL177888A0/en unknown
- 2006-10-10 NO NO20064629A patent/NO20064629L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1725268A2 (en) | 2006-11-29 |
| KR20070015517A (ko) | 2007-02-05 |
| IL177888A0 (en) | 2006-12-31 |
| EP1725268B1 (en) | 2011-10-19 |
| ATE529135T1 (de) | 2011-11-15 |
| WO2005087272A3 (en) | 2006-06-22 |
| EP2253332A2 (en) | 2010-11-24 |
| EP2253332A3 (en) | 2011-03-23 |
| ES2374633T3 (es) | 2012-02-20 |
| NO20064629L (no) | 2006-11-28 |
| WO2005087272A2 (en) | 2005-09-22 |
| US20080317675A1 (en) | 2008-12-25 |
| CN1938050A (zh) | 2007-03-28 |
| US8679460B2 (en) | 2014-03-25 |
| JP2007528424A (ja) | 2007-10-11 |
| EP2253332B1 (en) | 2012-10-10 |
| CA2559628A1 (en) | 2005-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |