ES2374582T3 - Espirobenzazepinas usadas como antagonistas de vasopresina. - Google Patents
Espirobenzazepinas usadas como antagonistas de vasopresina. Download PDFInfo
- Publication number
- ES2374582T3 ES2374582T3 ES07842799T ES07842799T ES2374582T3 ES 2374582 T3 ES2374582 T3 ES 2374582T3 ES 07842799 T ES07842799 T ES 07842799T ES 07842799 T ES07842799 T ES 07842799T ES 2374582 T3 ES2374582 T3 ES 2374582T3
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- Spain
- Prior art keywords
- phenyl
- compound
- carbonyl
- spiro
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
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- Anesthesiology (AREA)
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- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82665406P | 2006-09-22 | 2006-09-22 | |
| US826654P | 2006-09-22 | ||
| PCT/US2007/078917 WO2008036755A1 (en) | 2006-09-22 | 2007-09-19 | Spiro benzazepines used as vasopressin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2374582T3 true ES2374582T3 (es) | 2012-02-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07842799T Active ES2374582T3 (es) | 2006-09-22 | 2007-09-19 | Espirobenzazepinas usadas como antagonistas de vasopresina. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7825110B2 (enExample) |
| EP (1) | EP2078022B1 (enExample) |
| JP (1) | JP2010504351A (enExample) |
| CN (1) | CN101541806A (enExample) |
| AT (1) | ATE532786T1 (enExample) |
| AU (1) | AU2007299818B2 (enExample) |
| CA (1) | CA2665849A1 (enExample) |
| CY (1) | CY1112270T1 (enExample) |
| DK (1) | DK2078022T3 (enExample) |
| ES (1) | ES2374582T3 (enExample) |
| PL (1) | PL2078022T3 (enExample) |
| PT (1) | PT2078022E (enExample) |
| SI (1) | SI2078022T1 (enExample) |
| WO (1) | WO2008036755A1 (enExample) |
Families Citing this family (11)
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| WO2013057944A1 (ja) * | 2011-10-19 | 2013-04-25 | 興和株式会社 | 新規なスピロインドリン化合物、及びそれを含有する医薬 |
| US10214520B2 (en) | 2014-07-15 | 2019-02-26 | Gruenenthal Gmbh | Substituted azaspiro(4.5)decane derivatives |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| EP3321271B1 (en) | 2015-07-07 | 2024-05-29 | Japan Tobacco Inc. | Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof |
| MX2019007542A (es) * | 2016-12-21 | 2019-11-18 | Japan Tobacco Inc | Proceso para la preparación de derivados de 7h-pirrolo [2, 3-d] pirimidina y sus intermedios sintéticos. |
| IL273228B2 (en) * | 2017-09-15 | 2025-04-01 | Azevan Pharmaceuticals Inc | Preparations and methods for treating brain injury |
| US20200337590A1 (en) | 2018-01-16 | 2020-10-29 | Bayer Aktiengesellschaft | Assistance in the treatment of cardiac insufficiency |
| TW202220958A (zh) * | 2020-08-07 | 2022-06-01 | 美商卡司馬療法公司 | Ｔｒｐｍｌ調節劑 |
| JP7627343B2 (ja) * | 2020-11-26 | 2025-02-05 | シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド | 新規ベンズアゼピンスピロ環式誘導体 |
| CN112939864B (zh) * | 2021-01-29 | 2022-05-06 | 中国医科大学 | 螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物 |
| EP4491699A1 (de) | 2023-07-13 | 2025-01-15 | Klueber Lubrication München GmbH & Co. KG | Phthalimidverbindungen als basisöl für schmierstoffzusammensetzungen |
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| US4617302A (en) * | 1984-10-15 | 1986-10-14 | Eli Lilly And Company | Inotropic agents |
| WO1991005549A1 (en) * | 1989-10-20 | 1991-05-02 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| JP2905909B2 (ja) * | 1991-04-19 | 1999-06-14 | 大塚製薬株式会社 | バソプレシン拮抗剤 |
| US5985869A (en) * | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
| US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2708605A1 (fr) | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| CA2143117A1 (en) | 1992-10-07 | 1994-04-14 | Ben E. Evans | Tocolytic oxytocin receptor antagonists |
| US5512563A (en) | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AUPP150098A0 (en) | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| JP4916639B2 (ja) | 2000-07-05 | 2012-04-18 | オーソーマクニール ファーマシューティカル， インコーポレイテッド | バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン |
| CA2432825A1 (en) * | 2000-12-15 | 2002-06-20 | Emory University | Nonpeptide agonists and antagonists of vasopressin receptors |
| US7011898B2 (en) * | 2003-03-21 | 2006-03-14 | Air Products And Chemicals, Inc. | Method of joining ITM materials using a partially or fully-transient liquid phase |
| DK1633719T3 (da) | 2003-06-17 | 2010-01-04 | Janssen Pharmaceutica Nv | Substituerede spirobenzazepiner |
| HRP20051005A2 (en) | 2003-06-17 | 2006-09-30 | Janssen Pharmaceutica N.V. | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives |
| CA2637838A1 (en) | 2006-01-20 | 2007-07-26 | Janssen Pharmaceutica N.V. | Novel solid forms of (4r)-1-¬4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl|-1,2,3,5-tetrahydro-spiro¬4h-1-benzazepine-4,1'-¬2|cyclopentene|-3'-carboxylic acid |
-
2007
- 2007-09-19 SI SI200730800T patent/SI2078022T1/sl unknown
- 2007-09-19 PT PT07842799T patent/PT2078022E/pt unknown
- 2007-09-19 ES ES07842799T patent/ES2374582T3/es active Active
- 2007-09-19 WO PCT/US2007/078917 patent/WO2008036755A1/en not_active Ceased
- 2007-09-19 CN CNA2007800432003A patent/CN101541806A/zh active Pending
- 2007-09-19 JP JP2009529369A patent/JP2010504351A/ja active Pending
- 2007-09-19 EP EP07842799A patent/EP2078022B1/en active Active
- 2007-09-19 AU AU2007299818A patent/AU2007299818B2/en not_active Expired - Fee Related
- 2007-09-19 DK DK07842799.4T patent/DK2078022T3/da active
- 2007-09-19 CA CA002665849A patent/CA2665849A1/en not_active Abandoned
- 2007-09-19 US US11/857,891 patent/US7825110B2/en not_active Expired - Fee Related
- 2007-09-19 PL PL07842799T patent/PL2078022T3/pl unknown
- 2007-09-19 AT AT07842799T patent/ATE532786T1/de active
-
2012
- 2012-01-24 CY CY20121100081T patent/CY1112270T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2665849A1 (en) | 2008-03-27 |
| AU2007299818B2 (en) | 2012-08-02 |
| DK2078022T3 (da) | 2012-02-13 |
| PL2078022T3 (pl) | 2012-04-30 |
| US7825110B2 (en) | 2010-11-02 |
| WO2008036755A1 (en) | 2008-03-27 |
| ATE532786T1 (de) | 2011-11-15 |
| PT2078022E (pt) | 2012-01-11 |
| US20080076753A1 (en) | 2008-03-27 |
| EP2078022B1 (en) | 2011-11-09 |
| EP2078022A1 (en) | 2009-07-15 |
| JP2010504351A (ja) | 2010-02-12 |
| SI2078022T1 (sl) | 2012-01-31 |
| AU2007299818A1 (en) | 2008-03-27 |
| CN101541806A (zh) | 2009-09-23 |
| CY1112270T1 (el) | 2015-12-09 |
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