ES2371290T3 - Análisis secuencial de muestras biológicas. - Google Patents
Análisis secuencial de muestras biológicas. Download PDFInfo
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- ES2371290T3 ES2371290T3 ES07871481T ES07871481T ES2371290T3 ES 2371290 T3 ES2371290 T3 ES 2371290T3 ES 07871481 T ES07871481 T ES 07871481T ES 07871481 T ES07871481 T ES 07871481T ES 2371290 T3 ES2371290 T3 ES 2371290T3
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- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080032321A1 (en) * | 2006-08-07 | 2008-02-07 | General Electric Company | System and methods for analyzing images of tissue samples |
| US8060348B2 (en) * | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US8131476B2 (en) * | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US8305579B2 (en) | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
| US20100279272A1 (en) * | 2008-02-13 | 2010-11-04 | Michael Craig Burrell | Multiplexed analysis methods using sers-active nanoparticles |
| EP2389585A2 (en) * | 2009-01-22 | 2011-11-30 | Li-Cor, Inc. | Single molecule proteomics with dynamic probes |
| US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| US8568991B2 (en) * | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| US9176032B2 (en) | 2011-12-23 | 2015-11-03 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| IN2014DN07531A (enExample) | 2012-03-30 | 2015-04-24 | Clarient Diagnostic Services Inc | |
| KR20140145141A (ko) | 2012-03-30 | 2014-12-22 | 클래리언트 다이아그노스틱 서비시즈, 인크. | 생물학적 샘플의 영상 생성 방법 |
| US9606111B2 (en) | 2012-04-27 | 2017-03-28 | Bio-Rad Laboratories, Inc. | Stain-free protein quantification and normalization |
| US9150907B2 (en) | 2012-04-27 | 2015-10-06 | General Electric Company | Microfluidic flow cell assemblies and method of use |
| US20150141278A1 (en) * | 2012-05-30 | 2015-05-21 | Clarient Diagnostic Services, Inc. | Multiplexed assay method for lung cancer classification |
| US20150105283A1 (en) | 2012-05-30 | 2015-04-16 | Clarient Diagnostics Services, Inc. | Multiplexed diagnosis method for classical hodgkin lymphoma |
| US20140024024A1 (en) | 2012-07-17 | 2014-01-23 | General Electric Company | Methods of detecting dna, rna and protein in biological samples |
| US20140055853A1 (en) | 2012-08-27 | 2014-02-27 | General Electric Company | Open top microfluidic device for multiplexing |
| CN104854451B (zh) * | 2012-10-09 | 2018-04-06 | 犹他大学研究基金会 | 用荧光监测温度 |
| WO2014065889A2 (en) | 2012-10-28 | 2014-05-01 | Clarient Diagnostic Services, Inc. | Multiplexed method for diagnosing classical hodgkin lymphoma |
| US9135694B2 (en) | 2012-12-04 | 2015-09-15 | General Electric Company | Systems and methods for using an immunostaining mask to selectively refine ISH analysis results |
| EP2932270B1 (en) * | 2012-12-11 | 2018-10-24 | GE Healthcare Bio-Sciences Corp. | Photoactivated chemical bleaching of dyes |
| WO2014099222A1 (en) * | 2012-12-17 | 2014-06-26 | Clarient Diagnostic Services, Inc. | Chemical bleaching of dyes using radical photoinitiators |
| KR101789893B1 (ko) | 2012-12-20 | 2017-11-20 | 에프. 호프만-라 로슈 아게 | 의학적 측정 곡선들을 평가하기 위한 방법 |
| US11306360B2 (en) | 2012-12-26 | 2022-04-19 | Koninklijke Philips N.V. | Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions |
| US9932626B2 (en) | 2013-01-15 | 2018-04-03 | Quanterix Corporation | Detection of DNA or RNA using single molecule arrays and other techniques |
| EP2965087B1 (en) | 2013-03-06 | 2018-10-17 | General Electric Company | Methods of analyzing an h&e stained biological sample |
| CA2900842C (en) | 2013-03-12 | 2020-01-21 | Ventana Medical Systems, Inc. | Digitally enhanced microscopy for multiplexed histology |
| JP6417602B2 (ja) * | 2013-03-15 | 2018-11-07 | エーザイ インコーポレイテッド | 大腸直腸癌の予後を判定する方法 |
| EP3004372A1 (en) * | 2013-06-04 | 2016-04-13 | Roche Diagnostics GmbH | Novel compounds useful for fret and methods related thereto |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| US9778263B2 (en) * | 2013-11-13 | 2017-10-03 | General Electric Company | Quantitative in situ characterization of biological samples |
| US9858469B2 (en) | 2013-12-30 | 2018-01-02 | Ge Healthcare Bio-Sciences Corp. | Modular image analysis system and method |
| US20150198580A1 (en) | 2014-01-13 | 2015-07-16 | General Electric Company | Coverslip and methods for removing |
| EP4273263A3 (en) | 2014-07-30 | 2024-01-31 | President and Fellows of Harvard College | Systems and methods for determining nucleic acids |
| US12216673B2 (en) | 2014-09-25 | 2025-02-04 | Oracle International Corporation | Techniques for semantic searching |
| US10516980B2 (en) | 2015-10-24 | 2019-12-24 | Oracle International Corporation | Automatic redisplay of a user interface including a visualization |
| US10417247B2 (en) | 2014-09-25 | 2019-09-17 | Oracle International Corporation | Techniques for semantic searching |
| US10664488B2 (en) | 2014-09-25 | 2020-05-26 | Oracle International Corporation | Semantic searches in a business intelligence system |
| US10101322B2 (en) | 2015-02-13 | 2018-10-16 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| US9708349B2 (en) | 2015-02-13 | 2017-07-18 | General Electric Company | Borates for photoactivated chemical bleaching |
| CN106338423B (zh) | 2015-07-10 | 2020-07-14 | 三斯坎公司 | 组织学染色的空间复用 |
| CN114350752B (zh) | 2015-07-17 | 2025-02-25 | 布鲁克空间生物学公司 | 在横切面组织的用户定义区域中的基因表达的同时定量 |
| US11415516B2 (en) | 2015-10-28 | 2022-08-16 | Leica Microsystems Cms Gmbh | Method for reduction of autofluorescence from biological samples |
| JP2019509468A (ja) * | 2016-01-07 | 2019-04-04 | クリーティービー マイクロテック， インク．Ｃｒｅａｔｖ Ｍｉｃｒｏｔｅｃｈ， Ｉｎｃ． | 蛍光クエンチングおよび再染色を連続して使用した生体試料の複数表現型サブタイプ分類 |
| EP3414570B1 (en) * | 2016-02-08 | 2020-04-01 | Lunaphore Technologies SA | Methods of sample cycle multiplexing and in situ imaging |
| WO2017202962A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
| JP2020513796A (ja) | 2016-11-16 | 2020-05-21 | ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ | サイクリック蛍光イメージングのためのシステムおよび方法 |
| AU2017361521B2 (en) | 2016-11-21 | 2020-08-27 | Bruker Spatial Biology, Inc. | Chemical compositions and methods of using same |
| CN110050071A (zh) | 2016-12-09 | 2019-07-23 | 乌尔蒂维尤股份有限公司 | 用于使用标记的核酸成像剂进行多路复用成像的改进方法 |
| WO2018122245A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
| WO2018122249A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
| US20200150109A1 (en) | 2017-05-05 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases |
| WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| US10956237B2 (en) | 2017-06-02 | 2021-03-23 | Oracle International Corporation | Inter-application sharing of business intelligence data |
| US11614857B2 (en) | 2017-06-02 | 2023-03-28 | Oracle International Corporation | Importing, interpreting, and presenting data |
| US10917587B2 (en) | 2017-06-02 | 2021-02-09 | Oracle International Corporation | Importing and presenting data |
| US12019074B2 (en) * | 2017-06-08 | 2024-06-25 | Lumito Ab | Method of analysing a sample for at least one analyte |
| CN109781975B (zh) * | 2017-11-14 | 2022-05-06 | 河南乾坤科技有限公司 | 富集循环稀有细胞的试剂及方法 |
| EP3732611B1 (en) | 2018-01-11 | 2024-08-21 | Google LLC | Method for creating histopathological ground truth masks using slide restaining |
| KR102893736B1 (ko) | 2018-05-14 | 2025-11-28 | 브루커 스페이셜 바이올로지, 인크. | 화학 조성물 및 이의 사용 방법 |
| CA3122569A1 (en) | 2018-12-13 | 2020-06-18 | President And Fellows Of Harvard College | Amplification methods and systems for merfish and other applications |
| MX2021008121A (es) | 2019-01-03 | 2021-12-10 | Inst Nat Sante Rech Med | Metodos y composiciones farmaceuticas para mejorar las respuestas inmunitarias dependientes de celulas t cd8+ en sujetos que sufren de cancer. |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| US20220160692A1 (en) | 2019-04-09 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer |
| CN114072676B (zh) | 2019-06-03 | 2024-07-12 | 法国国家卫生及研究医学协会 | 调节治疗方案的方法 |
| EP4045686A1 (en) | 2019-10-17 | 2022-08-24 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for diagnosing nasal intestinal type adenocarcinomas |
| WO2021170777A1 (en) | 2020-02-28 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, prognosing and managing treatment of breast cancer |
| CN111351946B (zh) * | 2020-03-19 | 2023-08-18 | 中南大学湘雅二医院 | 用于红斑狼疮分型的AIM2+CD4+Trm细胞检测试剂盒及其应用 |
| EP4172621A1 (en) | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| JP7741831B2 (ja) | 2020-06-30 | 2025-09-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び／又は死亡のリスクを予測するための方法 |
| US20220062898A1 (en) | 2020-08-28 | 2022-03-03 | Leica Microsystems Cms Gmbh | Microfluidic Device for Image Multiplexing |
| KR20240012352A (ko) | 2021-03-23 | 2024-01-29 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | T 세포 림프종의 진단 및 치료 방법 |
| US12014830B2 (en) * | 2021-04-18 | 2024-06-18 | Mary Hitchcock Memorial Hospital, For Itself And On Behalf Of Dartmouth-Hitchcock Clinic | System and method for automation of surgical pathology processes using artificial intelligence |
| CN117377866A (zh) * | 2021-05-19 | 2024-01-09 | 莱卡微系统Cms有限责任公司 | 用于分析生物样品的方法和装置 |
| CA3228621A1 (en) * | 2021-08-09 | 2023-02-16 | Xin Huang | Compositions, kits, and methods for detecting preclinical alzheimer's disease |
| WO2023144303A1 (en) | 2022-01-31 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
| US20250035635A1 (en) | 2022-03-17 | 2025-01-30 | Institut National De La Sante Et De La Recherche Medicale | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| WO2023198648A1 (en) | 2022-04-11 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t-cell malignancies |
| WO2023198874A1 (en) | 2022-04-15 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t cell-lymphomas |
| WO2024003310A1 (en) | 2022-06-30 | 2024-01-04 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of acute lymphoblastic leukemia |
| US20260029402A1 (en) | 2022-07-22 | 2026-01-29 | Institut National de la Santé et de la Recherche Médicale | Garp as a biomarker and biotarget in t-cell malignancies |
| WO2024023283A1 (en) | 2022-07-29 | 2024-02-01 | Institut National de la Santé et de la Recherche Médicale | Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas |
| WO2024079192A1 (en) | 2022-10-12 | 2024-04-18 | Institut National de la Santé et de la Recherche Médicale | Cd81 as a biomarker and biotarget in t-cell malignancies |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405720A (en) * | 1981-03-04 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Silver stains for protein in gels |
| GB8405437D0 (en) | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
| JP3130513B2 (ja) * | 1989-04-19 | 2001-01-31 | イビデン株式会社 | 生体活性物質測定用装置 |
| US5843640A (en) | 1992-06-19 | 1998-12-01 | Northwestern University | Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells |
| WO1994009022A1 (en) | 1992-10-09 | 1994-04-28 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue |
| CA2167804A1 (en) | 1993-07-20 | 1995-02-02 | Robert H. Singer | In vivo nucleic acid hybridization method |
| FR2711671A1 (fr) | 1993-10-22 | 1995-05-05 | Centre Nat Rech Scient | Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire. |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| DE4421891C2 (de) | 1994-06-23 | 1996-05-15 | Helmut Prof Dr Med Feucht | Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene |
| US5571643A (en) * | 1994-07-22 | 1996-11-05 | Martin; Mark T. | Spectrophotometric quantitation of images in X-ray film and electrophoresis gel bands |
| EP0709466B1 (en) * | 1994-10-28 | 2006-09-27 | Gen-Probe Incorporated | Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5763152A (en) * | 1995-03-31 | 1998-06-09 | Fuji Photo Film Co., Ltd. | Silver halide photographic light-sensitive material |
| EP0801306A1 (en) | 1996-04-10 | 1997-10-15 | Becton, Dickinson and Company | Method for immunohistochemically quantitating co-localized molecules |
| DE19709348C2 (de) * | 1996-05-29 | 1999-07-01 | Schubert Walter Dr Md | Automatisches Multi-Epitop-Ligand-Kartierungsverfahren |
| WO1998002577A1 (en) | 1996-07-15 | 1998-01-22 | The Children's Medical Center Corporation | Method to co-detect introduced genes and their products |
| US6735531B2 (en) * | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
| DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6068979A (en) * | 1998-04-22 | 2000-05-30 | Lumigen, Inc. | Simplified sequential chemiluminescent detection |
| US6083486A (en) * | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| WO2000003034A2 (en) | 1998-07-10 | 2000-01-20 | Chromagen, Inc. | Novel polycyclic aromatic fluorogenic substrates for hydrolases |
| DE19835284C2 (de) | 1998-08-05 | 2001-03-01 | Tuhh Tech Gmbh | Vorrichtung und Verfahren zur automatischen Fokussierung und Belichtung von Bildaufnahmesystemen |
| US6573043B1 (en) * | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| JP4841724B2 (ja) | 1998-10-09 | 2011-12-21 | ベジェニクス ピーティーワイ リミテッド | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| US6087112A (en) * | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
| US20020044353A1 (en) * | 1999-02-10 | 2002-04-18 | Salzman David B. | Spintronic optical shutter |
| WO2000058507A1 (en) | 1999-03-30 | 2000-10-05 | Solexa Ltd. | Polynucleotide sequencing |
| US6391649B1 (en) * | 1999-05-04 | 2002-05-21 | The Rockefeller University | Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy |
| WO2001023610A2 (en) * | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| GB0002389D0 (en) * | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| DE10014685B4 (de) * | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
| WO2001086296A2 (en) * | 2000-05-05 | 2001-11-15 | Agilix Corporation | Highly multiplexed reporter carrier systems |
| IL136232A0 (en) | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
| US6545758B1 (en) * | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
| US20030044353A1 (en) * | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| JP2002323416A (ja) | 2001-02-20 | 2002-11-08 | Hitachi Ltd | 検査容器 |
| WO2002079771A1 (en) | 2001-03-30 | 2002-10-10 | The Samuel Roberts Noble Foundation, Inc. | Silver destaining method |
| US7219016B2 (en) * | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
| US20020173053A1 (en) * | 2001-04-27 | 2002-11-21 | Bassam Damaj | Multiple simultaneous antigen detection by immunohistochemistry |
| JP3899845B2 (ja) | 2001-05-23 | 2007-03-28 | 日本光電工業株式会社 | 染色標本の脱色方法および装置 |
| AU2002325196A1 (en) * | 2001-07-09 | 2003-01-29 | Kobenhavns Universitet | Epsti1, a gene induced by epithelial-stromal interaction in human breast cancer |
| US20040241688A1 (en) * | 2001-07-19 | 2004-12-02 | Cuneyt Bukusoglu | Human tissue specific drug screening procedure |
| DE10143757A1 (de) | 2001-09-06 | 2003-03-27 | Werner M | Methode zur Darstellung von Merkmalen in Geweben |
| US8323903B2 (en) * | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| WO2003061711A2 (en) * | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| US6731831B2 (en) | 2002-02-27 | 2004-05-04 | Xiang Zheng Tu | Optical switch array assembly for DNA probe synthesis and detection |
| US7166478B2 (en) * | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
| US7776195B2 (en) * | 2002-05-28 | 2010-08-17 | Autogenomics, Inc. | Integrated sample processing platform |
| JP2004041121A (ja) * | 2002-07-12 | 2004-02-12 | Hitachi Ltd | アレルギー解析方法及びシステム |
| AU2003291249A1 (en) * | 2002-12-18 | 2004-07-29 | Aclara Biosciences, Inc. | Multiplexed immunohistochemical assays using molecular tags |
| US20040241776A1 (en) | 2003-05-22 | 2004-12-02 | Agdia, Inc. | Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes |
| JP3936689B2 (ja) * | 2003-09-09 | 2007-06-27 | 日本碍子株式会社 | シアニン系有機色素劣化環境の検知方法 |
| US7463778B2 (en) * | 2004-01-30 | 2008-12-09 | Hewlett-Packard Development Company, L.P | Motion estimation for compressing multiple view images |
| JP4538628B2 (ja) | 2004-03-16 | 2010-09-08 | 学校法人慶應義塾 | 遺伝子発現検出方法 |
| JP4189495B2 (ja) * | 2004-08-02 | 2008-12-03 | 国立大学法人群馬大学 | ゲノムｄｎａのメチル化検出方法 |
| DK1907571T3 (en) * | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
| JP2007033159A (ja) * | 2005-07-25 | 2007-02-08 | Assay Corp | 蛍光分子で標識された測定対象物質 |
| EP1950566A4 (en) * | 2005-11-10 | 2008-11-26 | Univ Toyama Nat Univ Corp | METHOD FOR EVALUATING BINDING CHARACTERISTICS OF BIOSUBSTANCES AND BIOSUBSTANCE-BINDING SUBSTANCES |
| US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US8305579B2 (en) * | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
| US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
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- 2006-11-16 US US11/560,599 patent/US7629125B2/en active Active
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