ES2368536T3 - Preparación de una suspensión de huevos de helmintos almacenable viable. - Google Patents
Preparación de una suspensión de huevos de helmintos almacenable viable. Download PDFInfo
- Publication number
- ES2368536T3 ES2368536T3 ES08734901T ES08734901T ES2368536T3 ES 2368536 T3 ES2368536 T3 ES 2368536T3 ES 08734901 T ES08734901 T ES 08734901T ES 08734901 T ES08734901 T ES 08734901T ES 2368536 T3 ES2368536 T3 ES 2368536T3
- Authority
- ES
- Spain
- Prior art keywords
- suspension
- eggs
- acid
- helminths
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000013601 eggs Nutrition 0.000 title claims abstract description 55
- 239000000725 suspension Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 244000000013 helminth Species 0.000 claims abstract description 50
- 239000003755 preservative agent Substances 0.000 claims abstract description 39
- 108010034145 Helminth Proteins Proteins 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 27
- 241000960389 Trichuris suis Species 0.000 claims abstract description 16
- 238000010306 acid treatment Methods 0.000 claims abstract description 14
- 230000002335 preservative effect Effects 0.000 claims abstract description 12
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 11
- 230000003071 parasitic effect Effects 0.000 claims abstract description 8
- 241000282412 Homo Species 0.000 claims abstract description 7
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 7
- 230000037406 food intake Effects 0.000 claims abstract description 6
- 230000000638 stimulation Effects 0.000 claims abstract description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 3
- 230000001105 regulatory effect Effects 0.000 claims abstract description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 42
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 35
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 28
- 241000700605 Viruses Species 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 17
- 244000005700 microbiome Species 0.000 claims description 17
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 16
- 235000010199 sorbic acid Nutrition 0.000 claims description 16
- 239000004334 sorbic acid Substances 0.000 claims description 16
- 229940075582 sorbic acid Drugs 0.000 claims description 16
- 239000005711 Benzoic acid Substances 0.000 claims description 15
- 235000010233 benzoic acid Nutrition 0.000 claims description 14
- 150000007513 acids Chemical class 0.000 claims description 9
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 8
- 230000001332 colony forming effect Effects 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- 241000233866 Fungi Species 0.000 claims description 7
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 7
- 208000011231 Crohn disease Diseases 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 18
- 244000052616 bacterial pathogen Species 0.000 description 17
- 235000011149 sulphuric acid Nutrition 0.000 description 13
- 238000012360 testing method Methods 0.000 description 11
- 210000001161 mammalian embryo Anatomy 0.000 description 10
- 238000000746 purification Methods 0.000 description 10
- 238000011534 incubation Methods 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 7
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000002779 inactivation Effects 0.000 description 6
- 210000004698 lymphocyte Anatomy 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000035899 viability Effects 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000714201 Feline calicivirus Species 0.000 description 3
- 241000714177 Murine leukemia virus Species 0.000 description 3
- 241000702619 Porcine parvovirus Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000006968 Helminthiasis Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000244206 Nematoda Species 0.000 description 2
- 208000030852 Parasitic disease Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000006037 cell lysis Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 241000244188 Ascaris suum Species 0.000 description 1
- 101000765308 Aspergillus niger N-(5'-phosphoribosyl)anthranilate isomerase Proteins 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 229910021577 Iron(II) chloride Inorganic materials 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241001489145 Trichuris trichiura Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 239000008183 oral pharmaceutical preparation Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/124—Disinfecting agents, e.g. antimicrobials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006838 | 2007-04-02 | ||
| EP07006838A EP1977643A1 (de) | 2007-04-02 | 2007-04-02 | Herstellung einer viablen, lagerfähigen Wurmeiersuspension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2368536T3 true ES2368536T3 (es) | 2011-11-18 |
Family
ID=38330156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08734901T Active ES2368536T3 (es) | 2007-04-02 | 2008-03-31 | Preparación de una suspensión de huevos de helmintos almacenable viable. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9017700B2 (enExample) |
| EP (2) | EP1977643A1 (enExample) |
| JP (1) | JP5483731B2 (enExample) |
| CN (1) | CN101646340B (enExample) |
| AT (1) | ATE520304T1 (enExample) |
| AU (1) | AU2008234080B2 (enExample) |
| CA (1) | CA2682525C (enExample) |
| CY (1) | CY1111898T1 (enExample) |
| DK (1) | DK2129216T3 (enExample) |
| ES (1) | ES2368536T3 (enExample) |
| HR (1) | HRP20110715T1 (enExample) |
| ME (1) | ME01257B (enExample) |
| PL (1) | PL2129216T3 (enExample) |
| PT (1) | PT2129216E (enExample) |
| RS (1) | RS51938B (enExample) |
| RU (1) | RU2483740C2 (enExample) |
| SI (1) | SI2129216T1 (enExample) |
| UA (1) | UA96480C2 (enExample) |
| WO (1) | WO2008119534A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201402909D0 (en) * | 2014-02-19 | 2014-04-02 | Univ Southampton | Treating infection |
| US9603875B1 (en) * | 2016-01-07 | 2017-03-28 | NeuOva, LLC | Method of making a consumable product with purified embryonated Trichuris suis ova |
| FR3085687B1 (fr) * | 2018-09-07 | 2021-05-14 | Nolivade | Composition et procede de conservation |
| CN109370908A (zh) * | 2018-11-16 | 2019-02-22 | 中农威特生物科技股份有限公司 | 一种鸡球虫卵囊的培养和保存液及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2059417C1 (ru) * | 1992-10-01 | 1996-05-10 | Данилевич Василий Николаевич | Способ стерилизации питательных сред |
| AU740776B2 (en) * | 1997-12-31 | 2001-11-15 | University Of Iowa Research Foundation, The | Use of parasitic biological agents for prevention and control of autoimmune diseases |
| DE10163115A1 (de) * | 2001-12-24 | 2003-07-03 | Alpha Biocare Gmbh | Reinigung und Desinfektion von Eiern von Nematoden und Plathelminthen |
| US20050118655A1 (en) | 2003-11-17 | 2005-06-02 | University Of Iowa Research Foundation | Use of parasitic biological agents for diseases prevention and control |
| PL1968618T3 (pl) * | 2005-12-30 | 2017-10-31 | Parasite Tech A/S | Kompozycja zawierająca jaja pasożytów oraz sposoby izolowania i przechowywania jaj pasożytów |
-
2007
- 2007-04-02 EP EP07006838A patent/EP1977643A1/de not_active Withdrawn
-
2008
- 2008-03-31 PL PL08734901T patent/PL2129216T3/pl unknown
- 2008-03-31 ME MEP-2011-165A patent/ME01257B/me unknown
- 2008-03-31 PT PT08734901T patent/PT2129216E/pt unknown
- 2008-03-31 CN CN2008800104022A patent/CN101646340B/zh not_active Expired - Fee Related
- 2008-03-31 US US12/594,074 patent/US9017700B2/en not_active Expired - Fee Related
- 2008-03-31 HR HR20110715T patent/HRP20110715T1/hr unknown
- 2008-03-31 CA CA2682525A patent/CA2682525C/en not_active Expired - Fee Related
- 2008-03-31 UA UAA200910740A patent/UA96480C2/ru unknown
- 2008-03-31 JP JP2010501415A patent/JP5483731B2/ja not_active Expired - Fee Related
- 2008-03-31 AU AU2008234080A patent/AU2008234080B2/en not_active Ceased
- 2008-03-31 EP EP08734901A patent/EP2129216B1/de active Active
- 2008-03-31 WO PCT/EP2008/002542 patent/WO2008119534A1/de not_active Ceased
- 2008-03-31 DK DK08734901.5T patent/DK2129216T3/da active
- 2008-03-31 RU RU2009140308/15A patent/RU2483740C2/ru not_active IP Right Cessation
- 2008-03-31 SI SI200830386T patent/SI2129216T1/sl unknown
- 2008-03-31 RS RS20110416A patent/RS51938B/sr unknown
- 2008-03-31 AT AT08734901T patent/ATE520304T1/de active
- 2008-03-31 ES ES08734901T patent/ES2368536T3/es active Active
-
2011
- 2011-09-30 CY CY20111100945T patent/CY1111898T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1977643A1 (de) | 2008-10-08 |
| JP2010523506A (ja) | 2010-07-15 |
| EP2129216A1 (de) | 2009-12-09 |
| WO2008119534A1 (de) | 2008-10-09 |
| US9017700B2 (en) | 2015-04-28 |
| HK1133551A1 (en) | 2010-04-01 |
| CN101646340B (zh) | 2013-01-02 |
| AU2008234080A1 (en) | 2008-10-09 |
| RS51938B (sr) | 2012-02-29 |
| CA2682525C (en) | 2015-11-17 |
| DK2129216T3 (da) | 2011-10-24 |
| RU2483740C2 (ru) | 2013-06-10 |
| US20110008390A1 (en) | 2011-01-13 |
| CN101646340A (zh) | 2010-02-10 |
| PT2129216E (pt) | 2011-09-27 |
| AU2008234080B2 (en) | 2013-08-29 |
| UA96480C2 (ru) | 2011-11-10 |
| SI2129216T1 (sl) | 2011-11-30 |
| ME01257B (me) | 2013-06-20 |
| ATE520304T1 (de) | 2011-09-15 |
| CY1111898T1 (el) | 2015-11-04 |
| RU2009140308A (ru) | 2011-05-10 |
| HRP20110715T1 (hr) | 2011-11-30 |
| PL2129216T3 (pl) | 2011-11-30 |
| JP5483731B2 (ja) | 2014-05-07 |
| CA2682525A1 (en) | 2008-10-09 |
| EP2129216B1 (de) | 2011-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2641970C2 (ru) | Жидкие стабильные вирусные вакцины | |
| ES3058227T3 (en) | Prevention of infection by highly pathogenic viruses using topical application of povidone-iodine on mucous membranes | |
| US20240261313A1 (en) | Kit for preventing or treating filovirus and flavivirus diseases | |
| CA2682525C (en) | Production of a viable, storable worm egg suspension | |
| EP0185042B1 (fr) | Vaccin contre les maladies dues a des microorganismes tels que des mycoplasmes, sa preparation et membranes de microorganismes en tant que principe actif | |
| do Nascimento et al. | In vitro evaluation of bacterial leakage along the implant-abutment interface of an external-hex implant after saliva incubation. | |
| TWI761434B (zh) | 用於預防或控制球蟲病之不含抗生素的組合物 | |
| PT88145B (pt) | Processo para a preparacao de uma composicao farmaceutica destinada a prevencao e ao tratamento de doencas bacterianas ou virais | |
| JP5240811B2 (ja) | マダイ滑走細菌症ワクチン及びマダイ滑走細菌症ワクチン組成物並びにマダイ滑走細菌症の予防法 | |
| KR960003606B1 (ko) | 가금류의 대장균증 백신 | |
| ES2328141T3 (es) | Valvula de nodavirus inactivado. | |
| WO2012042857A1 (ja) | 粘膜アジュバント組成物 | |
| HK1133551B (en) | Production of a viable, storable worm egg suspension | |
| WO2023249480A1 (en) | Oral rinse composition | |
| RU2583555C1 (ru) | Препарат для профилактики и лечения диареи у телят | |
| Abu-Elnaga et al. | Studies on the using of 2-Phenoxyethanol as an alternative to Thiomersal as a preservative in Foot-and-Mouth Disease vaccine | |
| Perkins | Infectious diseases of young horses. | |
| Nematollahi et al. | Relationship between virulence of Streptococcus iniae strains, factors of oxidative activity and cytotoxicity in rainbow trout (Oncorhynchus mykiss) spleen macrophages | |
| WO2013055540A1 (en) | Non-chemotherapeutic antibiotic treatment for infections in cattle | |
| HU191303B (en) | Process for producing vaccine for treating infective laryngitis and trachitis of fowls |