CA2682525C - Production of a viable, storable worm egg suspension - Google Patents
Production of a viable, storable worm egg suspension Download PDFInfo
- Publication number
- CA2682525C CA2682525C CA2682525A CA2682525A CA2682525C CA 2682525 C CA2682525 C CA 2682525C CA 2682525 A CA2682525 A CA 2682525A CA 2682525 A CA2682525 A CA 2682525A CA 2682525 C CA2682525 C CA 2682525C
- Authority
- CA
- Canada
- Prior art keywords
- suspension
- intestine
- inflammatory disease
- pharmaceutical preparation
- eggs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000725 suspension Substances 0.000 title claims abstract description 65
- 238000004519 manufacturing process Methods 0.000 title abstract description 6
- 235000013601 eggs Nutrition 0.000 claims abstract description 62
- 238000000034 method Methods 0.000 claims abstract description 41
- 239000003755 preservative agent Substances 0.000 claims abstract description 39
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 31
- 230000002335 preservative effect Effects 0.000 claims abstract description 18
- 241000700605 Viruses Species 0.000 claims abstract description 14
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 9
- 241000894006 Bacteria Species 0.000 claims abstract description 8
- 241000233866 Fungi Species 0.000 claims abstract description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 42
- 244000000013 helminth Species 0.000 claims description 35
- 244000005700 microbiome Species 0.000 claims description 34
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 28
- 230000003071 parasitic effect Effects 0.000 claims description 24
- 241000960389 Trichuris suis Species 0.000 claims description 21
- 210000000936 intestine Anatomy 0.000 claims description 21
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 20
- 230000008569 process Effects 0.000 claims description 19
- 238000010306 acid treatment Methods 0.000 claims description 16
- 235000010199 sorbic acid Nutrition 0.000 claims description 16
- 239000004334 sorbic acid Substances 0.000 claims description 16
- 229940075582 sorbic acid Drugs 0.000 claims description 16
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 15
- 208000027866 inflammatory disease Diseases 0.000 claims description 15
- 239000005711 Benzoic acid Substances 0.000 claims description 14
- 108010034145 Helminth Proteins Proteins 0.000 claims description 14
- 235000010233 benzoic acid Nutrition 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 11
- 230000001332 colony forming effect Effects 0.000 claims description 10
- 241000282412 Homo Species 0.000 claims description 8
- 150000007513 acids Chemical class 0.000 claims description 8
- 208000011231 Crohn disease Diseases 0.000 claims description 7
- 230000000638 stimulation Effects 0.000 claims description 7
- 230000037406 food intake Effects 0.000 claims description 6
- 208000037976 chronic inflammation Diseases 0.000 claims description 5
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 150000005168 4-hydroxybenzoic acids Chemical class 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 210000003289 regulatory T cell Anatomy 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 claims 1
- 238000000746 purification Methods 0.000 abstract description 12
- 230000035899 viability Effects 0.000 abstract description 7
- 238000003860 storage Methods 0.000 abstract description 5
- 241000556956 Tritrichomonas suis Species 0.000 abstract 1
- 230000035784 germination Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 17
- 235000011149 sulphuric acid Nutrition 0.000 description 13
- 238000012360 testing method Methods 0.000 description 10
- 238000011534 incubation Methods 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 4
- 241000714201 Feline calicivirus Species 0.000 description 3
- 241000714177 Murine leukemia virus Species 0.000 description 3
- 241000702619 Porcine parvovirus Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 241000228245 Aspergillus niger Species 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000244206 Nematoda Species 0.000 description 2
- FXUDFNITAMQPKO-UHFFFAOYSA-M S(O)(O)(=O)=O.C(C=CC=CC)(=O)[O-].[K+] Chemical compound S(O)(O)(=O)=O.C(C=CC=CC)(=O)[O-].[K+] FXUDFNITAMQPKO-UHFFFAOYSA-M 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 230000006037 cell lysis Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 241000244188 Ascaris suum Species 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 208000006968 Helminthiasis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241001489151 Trichuris Species 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- -1 p-hydroxybenzoic acid ester Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/124—Disinfecting agents, e.g. antimicrobials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006838.2 | 2007-04-02 | ||
| EP07006838A EP1977643A1 (de) | 2007-04-02 | 2007-04-02 | Herstellung einer viablen, lagerfähigen Wurmeiersuspension |
| PCT/EP2008/002542 WO2008119534A1 (de) | 2007-04-02 | 2008-03-31 | Herstellung einer viablen, lagerfähigen wurmeiersuspension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2682525A1 CA2682525A1 (en) | 2008-10-09 |
| CA2682525C true CA2682525C (en) | 2015-11-17 |
Family
ID=38330156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2682525A Expired - Fee Related CA2682525C (en) | 2007-04-02 | 2008-03-31 | Production of a viable, storable worm egg suspension |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9017700B2 (enExample) |
| EP (2) | EP1977643A1 (enExample) |
| JP (1) | JP5483731B2 (enExample) |
| CN (1) | CN101646340B (enExample) |
| AT (1) | ATE520304T1 (enExample) |
| AU (1) | AU2008234080B2 (enExample) |
| CA (1) | CA2682525C (enExample) |
| CY (1) | CY1111898T1 (enExample) |
| DK (1) | DK2129216T3 (enExample) |
| ES (1) | ES2368536T3 (enExample) |
| HR (1) | HRP20110715T1 (enExample) |
| ME (1) | ME01257B (enExample) |
| PL (1) | PL2129216T3 (enExample) |
| PT (1) | PT2129216E (enExample) |
| RS (1) | RS51938B (enExample) |
| RU (1) | RU2483740C2 (enExample) |
| SI (1) | SI2129216T1 (enExample) |
| UA (1) | UA96480C2 (enExample) |
| WO (1) | WO2008119534A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201402909D0 (en) * | 2014-02-19 | 2014-04-02 | Univ Southampton | Treating infection |
| US9603875B1 (en) * | 2016-01-07 | 2017-03-28 | NeuOva, LLC | Method of making a consumable product with purified embryonated Trichuris suis ova |
| FR3085687B1 (fr) * | 2018-09-07 | 2021-05-14 | Nolivade | Composition et procede de conservation |
| CN109370908A (zh) * | 2018-11-16 | 2019-02-22 | 中农威特生物科技股份有限公司 | 一种鸡球虫卵囊的培养和保存液及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2059417C1 (ru) * | 1992-10-01 | 1996-05-10 | Данилевич Василий Николаевич | Способ стерилизации питательных сред |
| AU740776B2 (en) * | 1997-12-31 | 2001-11-15 | University Of Iowa Research Foundation, The | Use of parasitic biological agents for prevention and control of autoimmune diseases |
| DE10163115A1 (de) * | 2001-12-24 | 2003-07-03 | Alpha Biocare Gmbh | Reinigung und Desinfektion von Eiern von Nematoden und Plathelminthen |
| US20050118655A1 (en) | 2003-11-17 | 2005-06-02 | University Of Iowa Research Foundation | Use of parasitic biological agents for diseases prevention and control |
| PL1968618T3 (pl) * | 2005-12-30 | 2017-10-31 | Parasite Tech A/S | Kompozycja zawierająca jaja pasożytów oraz sposoby izolowania i przechowywania jaj pasożytów |
-
2007
- 2007-04-02 EP EP07006838A patent/EP1977643A1/de not_active Withdrawn
-
2008
- 2008-03-31 PL PL08734901T patent/PL2129216T3/pl unknown
- 2008-03-31 ME MEP-2011-165A patent/ME01257B/me unknown
- 2008-03-31 PT PT08734901T patent/PT2129216E/pt unknown
- 2008-03-31 CN CN2008800104022A patent/CN101646340B/zh not_active Expired - Fee Related
- 2008-03-31 US US12/594,074 patent/US9017700B2/en not_active Expired - Fee Related
- 2008-03-31 HR HR20110715T patent/HRP20110715T1/hr unknown
- 2008-03-31 CA CA2682525A patent/CA2682525C/en not_active Expired - Fee Related
- 2008-03-31 UA UAA200910740A patent/UA96480C2/ru unknown
- 2008-03-31 JP JP2010501415A patent/JP5483731B2/ja not_active Expired - Fee Related
- 2008-03-31 AU AU2008234080A patent/AU2008234080B2/en not_active Ceased
- 2008-03-31 EP EP08734901A patent/EP2129216B1/de active Active
- 2008-03-31 WO PCT/EP2008/002542 patent/WO2008119534A1/de not_active Ceased
- 2008-03-31 DK DK08734901.5T patent/DK2129216T3/da active
- 2008-03-31 RU RU2009140308/15A patent/RU2483740C2/ru not_active IP Right Cessation
- 2008-03-31 SI SI200830386T patent/SI2129216T1/sl unknown
- 2008-03-31 RS RS20110416A patent/RS51938B/sr unknown
- 2008-03-31 AT AT08734901T patent/ATE520304T1/de active
- 2008-03-31 ES ES08734901T patent/ES2368536T3/es active Active
-
2011
- 2011-09-30 CY CY20111100945T patent/CY1111898T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1977643A1 (de) | 2008-10-08 |
| JP2010523506A (ja) | 2010-07-15 |
| EP2129216A1 (de) | 2009-12-09 |
| WO2008119534A1 (de) | 2008-10-09 |
| US9017700B2 (en) | 2015-04-28 |
| HK1133551A1 (en) | 2010-04-01 |
| CN101646340B (zh) | 2013-01-02 |
| AU2008234080A1 (en) | 2008-10-09 |
| RS51938B (sr) | 2012-02-29 |
| ES2368536T3 (es) | 2011-11-18 |
| DK2129216T3 (da) | 2011-10-24 |
| RU2483740C2 (ru) | 2013-06-10 |
| US20110008390A1 (en) | 2011-01-13 |
| CN101646340A (zh) | 2010-02-10 |
| PT2129216E (pt) | 2011-09-27 |
| AU2008234080B2 (en) | 2013-08-29 |
| UA96480C2 (ru) | 2011-11-10 |
| SI2129216T1 (sl) | 2011-11-30 |
| ME01257B (me) | 2013-06-20 |
| ATE520304T1 (de) | 2011-09-15 |
| CY1111898T1 (el) | 2015-11-04 |
| RU2009140308A (ru) | 2011-05-10 |
| HRP20110715T1 (hr) | 2011-11-30 |
| PL2129216T3 (pl) | 2011-11-30 |
| JP5483731B2 (ja) | 2014-05-07 |
| CA2682525A1 (en) | 2008-10-09 |
| EP2129216B1 (de) | 2011-08-17 |
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