ES2359467T3 - Compuestos útiles como inhibidores de proteína quinasas. - Google Patents
Compuestos útiles como inhibidores de proteína quinasas. Download PDFInfo
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- ES2359467T3 ES2359467T3 ES07862967T ES07862967T ES2359467T3 ES 2359467 T3 ES2359467 T3 ES 2359467T3 ES 07862967 T ES07862967 T ES 07862967T ES 07862967 T ES07862967 T ES 07862967T ES 2359467 T3 ES2359467 T3 ES 2359467T3
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- aliphatic
- compound
- optionally substituted
- independently
- cycloaliphatic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87487806P | 2006-12-14 | 2006-12-14 | |
| US874878P | 2006-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2359467T3 true ES2359467T3 (es) | 2011-05-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07862967T Active ES2359467T3 (es) | 2006-12-14 | 2007-12-14 | Compuestos útiles como inhibidores de proteína quinasas. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8129387B2 (enExample) |
| EP (1) | EP2102210B1 (enExample) |
| JP (1) | JP5406725B2 (enExample) |
| CN (1) | CN101646671A (enExample) |
| AT (1) | ATE497961T1 (enExample) |
| AU (1) | AU2007334379B2 (enExample) |
| CA (1) | CA2672612A1 (enExample) |
| DE (1) | DE602007012473D1 (enExample) |
| ES (1) | ES2359467T3 (enExample) |
| MX (1) | MX2009006345A (enExample) |
| NZ (1) | NZ577638A (enExample) |
| WO (1) | WO2008076392A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2453548C2 (ru) | 2006-01-17 | 2012-06-20 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов янус-киназ |
| JP2011515072A (ja) * | 2008-02-13 | 2011-05-19 | エラン ファーマ インターナショナル リミテッド | α−シヌクレインキナーゼ |
| CN102076690A (zh) | 2008-06-23 | 2011-05-25 | 维泰克斯制药公司 | 蛋白激酶抑制剂 |
| AU2009271663B2 (en) | 2008-06-23 | 2014-04-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| WO2010025073A1 (en) * | 2008-08-28 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Dihydroimidazo [ 1, 5-f] pteridines as polo-like kinase inhibitors |
| TWI483941B (zh) | 2009-06-17 | 2015-05-11 | Vertex Pharma | 流感病毒複製之抑制劑 |
| SG181908A1 (en) * | 2009-12-23 | 2012-08-30 | Elan Pharm Inc | Pteridinones as inhibitors of polo-like kinase |
| BR112013008526A2 (pt) * | 2010-10-08 | 2016-07-12 | Elan Pharm Inc | inibidores de quinase do tipo polo |
| MX2013006836A (es) | 2010-12-16 | 2013-09-26 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| WO2013006634A2 (en) | 2011-07-05 | 2013-01-10 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for producing azaindoles |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| JP6523267B2 (ja) * | 2013-06-24 | 2019-05-29 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｓｈｒの調節剤としてのイミダゾール化合物及びその使用 |
| SMT201900450T1 (it) | 2013-11-13 | 2019-09-09 | Vertex Pharma | Inibitori della replicazione di virus dell’influenza |
| MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| US9708333B2 (en) | 2015-08-12 | 2017-07-18 | Incyte Corporation | Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| MX2018011792A (es) | 2016-03-28 | 2019-07-04 | Incyte Corp | Compuestos de pirrolotriazina como inhibidores de tyro3, axl y mer (tam). |
| EP3687996B1 (en) | 2017-09-27 | 2021-11-03 | Incyte Corporation | Salts of pyrrolotriazine derivatives useful as tam inhibitors |
| DK3813800T3 (da) | 2018-06-29 | 2025-06-02 | Incyte Corp | Formuleringer af en axl/mer-hæmmer |
| CN111217815B (zh) * | 2018-11-27 | 2021-06-18 | 沈阳药科大学 | 含有喋啶酮骨架的化合物及其制备方法和应用 |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69940808D1 (de) | 1998-03-04 | 2009-06-10 | Bristol Myers Squibb Co | Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren |
| CN101200457A (zh) * | 2003-02-26 | 2008-06-18 | 贝林格尔英格海姆法玛两合公司 | 二氢蝶啶酮、其制法及作为药物制剂的用途 |
| US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| BRPI0718120A2 (pt) | 2006-10-25 | 2013-11-12 | Chroma Therapeutics Ltd | Derivados de pteridina como inibidores de cinase do tipo pólo úteis no tratamento de câncer |
| GB0621203D0 (en) | 2006-10-25 | 2006-12-06 | Chroma Therapeutics Ltd | PLK inhibitors |
| RU2339637C1 (ru) | 2007-04-05 | 2008-11-27 | Андрей Александрович Иващенко | Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием |
| US8541437B2 (en) | 2007-04-05 | 2013-09-24 | Alla Chem, Llc | Substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles, methods for the production and use thereof |
-
2007
- 2007-12-14 EP EP07862967A patent/EP2102210B1/en not_active Not-in-force
- 2007-12-14 ES ES07862967T patent/ES2359467T3/es active Active
- 2007-12-14 US US12/448,258 patent/US8129387B2/en not_active Expired - Fee Related
- 2007-12-14 CN CN200780050825A patent/CN101646671A/zh active Pending
- 2007-12-14 WO PCT/US2007/025688 patent/WO2008076392A2/en not_active Ceased
- 2007-12-14 MX MX2009006345A patent/MX2009006345A/es active IP Right Grant
- 2007-12-14 DE DE602007012473T patent/DE602007012473D1/de active Active
- 2007-12-14 CA CA002672612A patent/CA2672612A1/en not_active Abandoned
- 2007-12-14 AT AT07862967T patent/ATE497961T1/de not_active IP Right Cessation
- 2007-12-14 JP JP2009541404A patent/JP5406725B2/ja not_active Expired - Fee Related
- 2007-12-14 NZ NZ577638A patent/NZ577638A/en not_active IP Right Cessation
- 2007-12-14 AU AU2007334379A patent/AU2007334379B2/en not_active Ceased
-
2012
- 2012-01-24 US US13/356,924 patent/US8557818B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101646671A (zh) | 2010-02-10 |
| AU2007334379B2 (en) | 2013-04-18 |
| NZ577638A (en) | 2012-03-30 |
| EP2102210B1 (en) | 2011-02-09 |
| ATE497961T1 (de) | 2011-02-15 |
| US8129387B2 (en) | 2012-03-06 |
| AU2007334379A1 (en) | 2008-06-26 |
| WO2008076392A2 (en) | 2008-06-26 |
| EP2102210A2 (en) | 2009-09-23 |
| MX2009006345A (es) | 2009-06-23 |
| CA2672612A1 (en) | 2008-06-26 |
| US20120122879A1 (en) | 2012-05-17 |
| US8557818B2 (en) | 2013-10-15 |
| DE602007012473D1 (de) | 2011-03-24 |
| JP5406725B2 (ja) | 2014-02-05 |
| JP2010513285A (ja) | 2010-04-30 |
| US20100099686A1 (en) | 2010-04-22 |
| WO2008076392A3 (en) | 2008-08-07 |
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