AU2007334379B2 - Compounds useful as protein kinase inhibitors - Google Patents
Compounds useful as protein kinase inhibitors Download PDFInfo
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- AU2007334379B2 AU2007334379B2 AU2007334379A AU2007334379A AU2007334379B2 AU 2007334379 B2 AU2007334379 B2 AU 2007334379B2 AU 2007334379 A AU2007334379 A AU 2007334379A AU 2007334379 A AU2007334379 A AU 2007334379A AU 2007334379 B2 AU2007334379 B2 AU 2007334379B2
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- aliphatic
- compound
- optionally substituted
- cycloaliphatic
- independently
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| AU2007207533B8 (en) | 2006-01-17 | 2012-06-28 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of Janus kinases |
| US20110207796A1 (en) * | 2008-02-13 | 2011-08-25 | Elan Pharma International Limited | Alpha-synuclein kinase |
| JP5634990B2 (ja) | 2008-06-23 | 2014-12-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | タンパク質キナーゼ阻害剤 |
| AU2009271658B2 (en) | 2008-06-23 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| WO2010025073A1 (en) * | 2008-08-28 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Dihydroimidazo [ 1, 5-f] pteridines as polo-like kinase inhibitors |
| CN104151312B (zh) | 2009-06-17 | 2016-06-15 | 沃泰克斯药物股份有限公司 | 流感病毒复制抑制剂 |
| SG181908A1 (en) * | 2009-12-23 | 2012-08-30 | Elan Pharm Inc | Pteridinones as inhibitors of polo-like kinase |
| BR112013008526A2 (pt) | 2010-10-08 | 2016-07-12 | Elan Pharm Inc | inibidores de quinase do tipo polo |
| MX2013006836A (es) | 2010-12-16 | 2013-09-26 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| ES2804528T3 (es) | 2011-07-05 | 2021-02-08 | Vertex Pharma | Procesos y productos intermedios para la producción de azaindoles |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| AU2014302710B2 (en) * | 2013-06-24 | 2018-10-04 | Merck Patent Gmbh | Imidazole compounds as modulators of FSHR and uses thereof |
| HUE044667T2 (hu) | 2013-11-13 | 2019-11-28 | Vertex Pharma | Influenza vírus replikáció inhibitorok |
| RS57541B1 (sr) | 2013-11-13 | 2018-10-31 | Vertex Pharma | Postupci za pripremu inhibitora replikacije virusa gripa |
| WO2016183071A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Hetero-tricyclic compounds and their use for the treatment of cancer |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| US9708333B2 (en) | 2015-08-12 | 2017-07-18 | Incyte Corporation | Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| IL293496B2 (en) | 2016-03-28 | 2023-05-01 | Incyte Corp | Pyrrolotriazine compounds as TAM inhibitors |
| SMT202200011T1 (it) | 2017-09-27 | 2022-03-21 | Incyte Corp | Sali di derivati di pirrolotriazina utili come inibitori di tam |
| EP3813800B1 (en) | 2018-06-29 | 2025-05-07 | Incyte Corporation | Formulations of an axl/mer inhibitor |
| CN111217815B (zh) * | 2018-11-27 | 2021-06-18 | 沈阳药科大学 | 含有喋啶酮骨架的化合物及其制备方法和应用 |
| CN115697343A (zh) | 2020-03-06 | 2023-02-03 | 因赛特公司 | 包含axl/mer和pd-1/pd-l1抑制剂的组合疗法 |
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| WO2004076454A1 (de) * | 2003-02-26 | 2004-09-10 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
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| ES2324846T3 (es) | 1998-03-04 | 2009-08-17 | Bristol-Myers Squibb Company | Inhibidores de la proteina tirosina quinasa de imidazopirazina heterociclo-sustituida. |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| BRPI0718120A2 (pt) | 2006-10-25 | 2013-11-12 | Chroma Therapeutics Ltd | Derivados de pteridina como inibidores de cinase do tipo pólo úteis no tratamento de câncer |
| GB0621203D0 (en) | 2006-10-25 | 2006-12-06 | Chroma Therapeutics Ltd | PLK inhibitors |
| RU2339637C1 (ru) | 2007-04-05 | 2008-11-27 | Андрей Александрович Иващенко | Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием |
| UA98324C2 (ru) | 2007-04-05 | 2012-05-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076454A1 (de) * | 2003-02-26 | 2004-09-10 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
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| EP2102210B1 (en) | 2011-02-09 |
| WO2008076392A2 (en) | 2008-06-26 |
| US8557818B2 (en) | 2013-10-15 |
| US20120122879A1 (en) | 2012-05-17 |
| JP2010513285A (ja) | 2010-04-30 |
| JP5406725B2 (ja) | 2014-02-05 |
| CN101646671A (zh) | 2010-02-10 |
| AU2007334379A1 (en) | 2008-06-26 |
| CA2672612A1 (en) | 2008-06-26 |
| US8129387B2 (en) | 2012-03-06 |
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| DE602007012473D1 (de) | 2011-03-24 |
| EP2102210A2 (en) | 2009-09-23 |
| US20100099686A1 (en) | 2010-04-22 |
| NZ577638A (en) | 2012-03-30 |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |