ES2344310T3 - Formas cristalinas de un derivado de imidazol. - Google Patents

Formas cristalinas de un derivado de imidazol. Download PDF

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Publication number
ES2344310T3
ES2344310T3 ES06710609T ES06710609T ES2344310T3 ES 2344310 T3 ES2344310 T3 ES 2344310T3 ES 06710609 T ES06710609 T ES 06710609T ES 06710609 T ES06710609 T ES 06710609T ES 2344310 T3 ES2344310 T3 ES 2344310T3
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Prior art keywords
ethyl
dimethyl
phenyl
amino
imidazo
Prior art date
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Expired - Lifetime
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ES06710609T
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English (en)
Spanish (es)
Inventor
Naoaki Pfizer Japan Inc HARUTA
Tomoki Kato
Zheng Jane Pfizer Global R&D LI
Toyoharu c/o RaQualia Pharma Inc. NUMATA
Andrew Vincent Pfizer Global R&D TRASK
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Raqualia Pharma Inc
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Raqualia Pharma Inc
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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ES06710609T 2005-03-11 2006-03-01 Formas cristalinas de un derivado de imidazol. Expired - Lifetime ES2344310T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66059205P 2005-03-11 2005-03-11
US660592P 2005-03-11

Publications (1)

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ES2344310T3 true ES2344310T3 (es) 2010-08-24

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ES06710609T Expired - Lifetime ES2344310T3 (es) 2005-03-11 2006-03-01 Formas cristalinas de un derivado de imidazol.

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US (1) US7960407B2 (OSRAM)
EP (1) EP1861400B1 (OSRAM)
JP (1) JP5069415B2 (OSRAM)
KR (1) KR100911073B1 (OSRAM)
CN (1) CN101137656B (OSRAM)
AR (1) AR055567A1 (OSRAM)
AT (1) ATE469150T1 (OSRAM)
AU (1) AU2006221699A1 (OSRAM)
BE (1) BE2018C028I2 (OSRAM)
BR (1) BRPI0608819B8 (OSRAM)
CA (1) CA2600510C (OSRAM)
DE (1) DE602006014516D1 (OSRAM)
ES (1) ES2344310T3 (OSRAM)
FR (1) FR18C1028I2 (OSRAM)
IL (1) IL185145A0 (OSRAM)
IN (1) IN2014DN09939A (OSRAM)
MX (1) MX2007011110A (OSRAM)
NL (1) NL300944I2 (OSRAM)
PL (1) PL1861400T3 (OSRAM)
RU (1) RU2357968C1 (OSRAM)
TW (1) TW200643021A (OSRAM)
WO (1) WO2006095268A1 (OSRAM)
ZA (1) ZA200707568B (OSRAM)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
AU2009295308A1 (en) 2008-09-25 2010-04-01 Merck Canada Inc. Beta-carboline sulphonylurea derivatives as EP4 receptor antagonists
CA2754702C (en) * 2009-04-22 2016-06-07 Yukinori Take Selective ep4 antagonistic substance for treatment of cancer
BR112012020236A2 (pt) 2010-02-22 2016-05-17 Raqualia Pharma Inc uso de um composto com atividade antagonística de ep4 ou um sal farmaceuticamente aceitável do mesmo, uso de um composto da fórmula (i), (ii), (iii), (iv), (va) ou (vb), ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica e método para o tratamento de doenças mediadas por il-23 em um sujeito animal, incluindo um sujeito mamífero
RU2451680C1 (ru) 2011-02-21 2012-05-27 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство
RU2464042C1 (ru) * 2011-03-31 2012-10-20 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" КЛАТРАТНЫЙ КОМПЛЕКС β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ(ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО
US10391086B2 (en) 2013-03-19 2019-08-27 Askat Inc. Use of EP4 receptor antagonists in the treatment of cartilage disease
KR102239641B1 (ko) * 2013-03-19 2021-04-13 에스크엣 인크. 연골질환 치료에서의 ep4 수용체 길항제의 용도
US12109218B2 (en) 2014-12-09 2024-10-08 Aratana Therapeutics, Inc. Compositions of grapiprant and methods for using the same
CN105939713A (zh) * 2014-03-06 2016-09-14 阿莱塔纳治疗学股份有限公司 格拉匹纶组合物及其使用方法
CA2997697A1 (en) * 2014-03-06 2015-09-11 Aratana Therapeutics, Inc. Crystalline forms of grapiprant
US10342785B2 (en) 2016-11-04 2019-07-09 Askat Inc. Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer
AU2019255196A1 (en) 2018-04-16 2020-11-12 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
US10239885B1 (en) 2018-06-18 2019-03-26 Avista Pharma Solutions, Inc. Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist
CA3107023A1 (en) * 2018-07-11 2020-01-16 Arrys Therapeutics, Inc. Ep4 inhibitors and synthesis thereof
US20210315909A1 (en) 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
US11459331B2 (en) 2019-01-30 2022-10-04 Avista Pharma Solutions, Inc. Chemical compounds
EP3917935A4 (en) 2019-01-30 2022-11-16 Avista Pharma Solutions, Inc. SYNTHESIS PROCESS AND NEW INTERMEDIATES
US11254675B2 (en) 2019-08-12 2022-02-22 Cadila Healthcare Limited Process for preparation of grapiprant
WO2021226162A1 (en) 2020-05-05 2021-11-11 Arrys Therapeutics, Inc. Ep4 antagonists and their use in the treatment of proliferative diseases
KR20240042400A (ko) 2021-07-30 2024-04-02 라퀄리아 파마 인코포레이티드 결정질 형태
CN116478155B (zh) * 2022-01-17 2025-06-13 洛阳惠中兽药有限公司 一种格拉匹伦及其中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
HN2001000224A (es) * 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
IL164263A0 (en) * 2002-04-12 2005-12-18 Pfizer Use of ep4 receptor ligands on the treatment of il-6 involved diseases

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