AR055567A1 - Formas de crital de un derivado de imidazol y composicion farmaceutica - Google Patents
Formas de crital de un derivado de imidazol y composicion farmaceuticaInfo
- Publication number
- AR055567A1 AR055567A1 ARP060100886A ARP060100886A AR055567A1 AR 055567 A1 AR055567 A1 AR 055567A1 AR P060100886 A ARP060100886 A AR P060100886A AR P060100886 A ARP060100886 A AR P060100886A AR 055567 A1 AR055567 A1 AR 055567A1
- Authority
- AR
- Argentina
- Prior art keywords
- ethyl
- forms
- criminal
- pharmaceutical
- tit
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- HZVLFTCYCLXTGV-UHFFFAOYSA-N 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea Chemical compound CCC1=NC2=C(C)N=C(C)C=C2N1C(C=C1)=CC=C1CCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 HZVLFTCYCLXTGV-UHFFFAOYSA-N 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- 230000005855 radiation Effects 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66059205P | 2005-03-11 | 2005-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055567A1 true AR055567A1 (es) | 2007-08-22 |
Family
ID=36649530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100886A AR055567A1 (es) | 2005-03-11 | 2006-03-09 | Formas de crital de un derivado de imidazol y composicion farmaceutica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7960407B2 (OSRAM) |
| EP (1) | EP1861400B1 (OSRAM) |
| JP (1) | JP5069415B2 (OSRAM) |
| KR (1) | KR100911073B1 (OSRAM) |
| CN (1) | CN101137656B (OSRAM) |
| AR (1) | AR055567A1 (OSRAM) |
| AT (1) | ATE469150T1 (OSRAM) |
| AU (1) | AU2006221699A1 (OSRAM) |
| BR (1) | BRPI0608819B8 (OSRAM) |
| CA (1) | CA2600510C (OSRAM) |
| DE (1) | DE602006014516D1 (OSRAM) |
| ES (1) | ES2344310T3 (OSRAM) |
| IL (1) | IL185145A0 (OSRAM) |
| IN (1) | IN2014DN09939A (OSRAM) |
| MX (1) | MX2007011110A (OSRAM) |
| NL (1) | NL300944I2 (OSRAM) |
| PL (1) | PL1861400T3 (OSRAM) |
| RU (1) | RU2357968C1 (OSRAM) |
| TW (1) | TW200643021A (OSRAM) |
| WO (1) | WO2006095268A1 (OSRAM) |
| ZA (1) | ZA200707568B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009295308A1 (en) * | 2008-09-25 | 2010-04-01 | Merck Canada Inc. | Beta-carboline sulphonylurea derivatives as EP4 receptor antagonists |
| ES2960438T3 (es) | 2009-04-22 | 2024-03-04 | Askat Inc | Sustancia antagonista del receptor EP4 selectivo para el tratamiento del cáncer |
| BR112012020236A2 (pt) * | 2010-02-22 | 2016-05-17 | Raqualia Pharma Inc | uso de um composto com atividade antagonística de ep4 ou um sal farmaceuticamente aceitável do mesmo, uso de um composto da fórmula (i), (ii), (iii), (iv), (va) ou (vb), ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica e método para o tratamento de doenças mediadas por il-23 em um sujeito animal, incluindo um sujeito mamífero |
| RU2451680C1 (ru) | 2011-02-21 | 2012-05-27 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство |
| RU2464042C1 (ru) * | 2011-03-31 | 2012-10-20 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | КЛАТРАТНЫЙ КОМПЛЕКС β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ(ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО |
| US20160317514A1 (en) * | 2013-03-19 | 2016-11-03 | Askat Inc. | Use of ep4 receptor antagonists in the treatment of cartilage disease |
| US10391086B2 (en) | 2013-03-19 | 2019-08-27 | Askat Inc. | Use of EP4 receptor antagonists in the treatment of cartilage disease |
| PT3113774T (pt) | 2014-03-06 | 2022-02-28 | Elanco Animal Health Incorporated | Composições de grapiprant e métodos de utilização das mesmas |
| US12109218B2 (en) | 2014-12-09 | 2024-10-08 | Aratana Therapeutics, Inc. | Compositions of grapiprant and methods for using the same |
| JP6535683B2 (ja) * | 2014-03-06 | 2019-06-26 | アラタナ セラピューティクス、 インコーポレイテッド | グラピプラントの結晶型 |
| US10342785B2 (en) | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| JP2021522211A (ja) | 2018-04-16 | 2021-08-30 | アリーズ セラピューティクス, インコーポレイテッド | Ep4阻害剤およびその使用 |
| WO2019245590A1 (en) | 2018-06-18 | 2019-12-26 | Avista Pharma Solutions, Inc. | Chemical compounds |
| JP2021530487A (ja) * | 2018-07-11 | 2021-11-11 | アリーズ セラピューティクス, インコーポレイテッド | Ep4阻害剤およびその合成 |
| WO2020014465A1 (en) | 2018-07-11 | 2020-01-16 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3917932A4 (en) | 2019-01-30 | 2022-09-28 | Avista Pharma Solutions, Inc. | CHEMICAL COMPOUNDS |
| CA3128346A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Synthetic process and novel intermediates |
| US11254675B2 (en) | 2019-08-12 | 2022-02-22 | Cadila Healthcare Limited | Process for preparation of grapiprant |
| WO2021226162A1 (en) | 2020-05-05 | 2021-11-11 | Arrys Therapeutics, Inc. | Ep4 antagonists and their use in the treatment of proliferative diseases |
| CA3223173A1 (en) * | 2021-07-30 | 2023-02-02 | Raqualia Pharma Inc. | Crystalline forms |
| CN116478155B (zh) * | 2022-01-17 | 2025-06-13 | 洛阳惠中兽药有限公司 | 一种格拉匹伦及其中间体的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110296A (en) * | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| HN2001000224A (es) * | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| PL373246A1 (en) * | 2002-04-12 | 2005-08-22 | Pfizer Inc. | Use of ep4 receptor ligands in the treatment of il-6 involved diseases |
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|---|---|
| NL300944I2 (nl) | 2018-08-07 |
| KR20070103484A (ko) | 2007-10-23 |
| BRPI0608819A8 (pt) | 2017-10-10 |
| US7960407B2 (en) | 2011-06-14 |
| TW200643021A (en) | 2006-12-16 |
| RU2357968C1 (ru) | 2009-06-10 |
| JP2006249089A (ja) | 2006-09-21 |
| EP1861400A1 (en) | 2007-12-05 |
| CN101137656B (zh) | 2010-12-22 |
| WO2006095268A1 (en) | 2006-09-14 |
| MX2007011110A (es) | 2008-02-21 |
| IL185145A0 (en) | 2007-12-03 |
| US20090018158A1 (en) | 2009-01-15 |
| CN101137656A (zh) | 2008-03-05 |
| CA2600510A1 (en) | 2006-09-14 |
| ES2344310T3 (es) | 2010-08-24 |
| KR100911073B1 (ko) | 2009-08-06 |
| AU2006221699A1 (en) | 2006-09-14 |
| PL1861400T3 (pl) | 2010-09-30 |
| IN2014DN09939A (OSRAM) | 2015-08-14 |
| ZA200707568B (en) | 2009-09-30 |
| EP1861400B1 (en) | 2010-05-26 |
| CA2600510C (en) | 2010-11-02 |
| JP5069415B2 (ja) | 2012-11-07 |
| RU2007133802A (ru) | 2009-03-20 |
| BRPI0608819B8 (pt) | 2021-05-25 |
| BRPI0608819B1 (pt) | 2019-11-12 |
| DE602006014516D1 (OSRAM) | 2010-07-08 |
| ATE469150T1 (de) | 2010-06-15 |
| BRPI0608819A2 (pt) | 2010-01-26 |
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