ES2343481T3 - Antagonistas del receptor cgrp. - Google Patents
Antagonistas del receptor cgrp. Download PDFInfo
- Publication number
- ES2343481T3 ES2343481T3 ES07796984T ES07796984T ES2343481T3 ES 2343481 T3 ES2343481 T3 ES 2343481T3 ES 07796984 T ES07796984 T ES 07796984T ES 07796984 T ES07796984 T ES 07796984T ES 2343481 T3 ES2343481 T3 ES 2343481T3
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- Prior art keywords
- alkyl
- ring
- aliphatic
- optionally substituted
- heteroaryl
- Prior art date
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US83239706P | 2006-07-21 | 2006-07-21 | |
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| ES2343481T3 true ES2343481T3 (es) | 2010-08-02 |
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| CA (1) | CA2658573A1 (cg-RX-API-DMAC7.html) |
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| ES (1) | ES2343481T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008011190A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2380592B1 (en) | 2005-11-14 | 2018-03-07 | Teva Pharmaceuticals International GmbH | Antagonist antibody directed against calcitonin gene-related peptide |
| EA200870521A1 (ru) | 2006-05-09 | 2009-04-28 | Мерк Энд Ко., Инк. | Замещенные спироциклические антагонисты cgrp-рецепторов |
| EP2227257B1 (en) | 2008-01-07 | 2013-06-26 | Salutaris Medical Devices, Inc. | Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
| US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
| US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| ES2689322T3 (es) * | 2008-03-04 | 2018-11-13 | Teva Pharmaceuticals International Gmbh | Métodos para tratar el dolor crónico |
| BRPI0908276B8 (pt) * | 2008-03-04 | 2021-05-25 | Labrys Biologics Inc | uso de um anticorpo antagonista anti-cgrp para a fabricação de um medicamento para a prevenção e/ou tratamento de dor de osteoartrite |
| AU2009228453A1 (en) * | 2008-03-28 | 2009-10-01 | Merck Sharp & Dohme Corp. | Monocyclic CGRP receptor antagonists |
| EP2331101A4 (en) * | 2008-09-08 | 2012-08-29 | Merck Sharp & Dohme | MONOCYCLIC AMID-CGRP RECEPTOR ANTAGONISTS |
| USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| BR112012004464B8 (pt) | 2009-08-28 | 2021-05-25 | Labrys Biologics Inc | uso de um anticorpo antagonista anti-cgrp para preparar uma composição farmacêutica para tratar e/ou prevenir dor visceral e/ou um ou mais sintomas de dor visceral, em que a dor visceral está associada á cistite intersticial (ic), e dita composição farmacêutica |
| SG10201604040PA (en) | 2011-05-20 | 2016-07-28 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
| CN103957935B (zh) | 2011-05-20 | 2018-04-03 | 奥尔德生物控股有限责任公司 | 抗cgrp或抗cgrp‑r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途 |
| JP6374789B2 (ja) | 2011-05-20 | 2018-08-15 | アルダーバイオ・ホールディングズ・エルエルシー | 羞明または光嫌悪症を予防または抑制する抗ｃｇｒｐ抗体および抗体断片のそれを必要とする対象、特に片頭痛患者における使用 |
| AR093308A1 (es) | 2012-11-01 | 2015-05-27 | Incyte Corp | Derivados triciclicos fusionados de tiofeno como inhibidores de jak |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| CN103804367B (zh) * | 2014-02-28 | 2016-09-14 | 天津药物研究院 | 苯并氮杂卓衍生物、其制备方法和用途 |
| HRP20240159T1 (hr) | 2014-03-21 | 2024-04-12 | Teva Pharmaceuticals International Gmbh | Antagonistička protutijela usmjerena protiv peptida povezanog s genom kalcitonina i postupci koji ih koriste |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| PE20170300A1 (es) | 2014-04-30 | 2017-04-19 | Incyte Corp | Procesos para preparar un inhibidor de jak 1 y nuevas formas de este |
| FR3030521B1 (fr) * | 2014-12-23 | 2019-07-26 | Galderma Research & Development | Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique |
| CA2988601C (en) | 2015-07-02 | 2021-12-07 | F. Hoffmann-La Roche Ag | Bicyclic lactams and methods of use thereof |
| EA201891620A1 (ru) | 2016-02-05 | 2019-02-28 | Денали Терапьютикс Инк. | Ингибиторы взаимодействующей с рецептором протеинкиназы 1 |
| USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| WO2018055574A1 (en) | 2016-09-23 | 2018-03-29 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| EP3526219B1 (en) | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Bicyclic pyridone lactams and methods of use thereof |
| EP3552017B1 (en) | 2016-12-09 | 2022-02-23 | Denali Therapeutics Inc. | Compounds useful as ripk1 inhibitors |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| EP4424328A3 (en) | 2018-03-30 | 2024-12-04 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
| WO2019204537A1 (en) | 2018-04-20 | 2019-10-24 | Genentech, Inc. | N-[4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol e-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs) |
| JOP20210156A1 (ar) | 2019-01-08 | 2023-01-30 | H Lundbeck As | علاج إسعافي وعلاج سريع للصداع باستخدام أجسام مضادة لـ cgrp |
| AU2020202454A1 (en) | 2020-04-06 | 2021-10-21 | H. Lundbeck A/S | Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies |
| KR20240132504A (ko) | 2022-01-12 | 2024-09-03 | 데날리 테라퓨틱스 인크. | (s)-5-벤질-n-(5-메틸-4-옥소-2,3,4,5-테트라하이드로피리도 [3,2-b][1,4]옥사제핀-3-일)-4h-1,2,4-트리아졸-3-카복사미드의 결정질 형태 |
| EP4462999A4 (en) * | 2022-01-14 | 2025-12-24 | Enko Chem Inc | PROTOPORPHYRINOGEN OXIDASE INHIBITORS |
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| AU2004222383B2 (en) * | 2003-03-14 | 2009-10-01 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirohydantoin CGRP receptor antagonists |
| WO2004083187A1 (en) * | 2003-03-14 | 2004-09-30 | Merck & Co. Inc. | Monocyclic anilide spirohydantoin cgrp receptor antagonists |
| EP1605936B1 (en) * | 2003-03-14 | 2011-07-20 | Merck Sharp & Dohme Corp. | Aryl spirohydantoin cgrp receptor antagonists |
| JP4584914B2 (ja) * | 2003-03-14 | 2010-11-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ベノジアゼピンスピロヒダントインｃｇｒｐ受容体拮抗物質 |
| US7288559B2 (en) * | 2003-03-14 | 2007-10-30 | Merck + Co, Inc. | Carboxamide spirohydantoin CGRP receptor antagonists |
| CA2579847A1 (en) * | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Bicyclic anilide spirolactam cgrp receptor antagonists |
| US7390798B2 (en) * | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| JP2008512489A (ja) * | 2004-09-13 | 2008-04-24 | メルク エンド カムパニー インコーポレーテッド | 三環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗薬 |
| JP2008515895A (ja) * | 2004-10-07 | 2008-05-15 | メルク エンド カムパニー インコーポレーテッド | Ｃｇｒｐ受容体拮抗薬 |
| US7384930B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
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| EP2049532A1 (en) | 2009-04-22 |
| ATE469895T1 (de) | 2010-06-15 |
| JP5511379B2 (ja) | 2014-06-04 |
| US20090186882A1 (en) | 2009-07-23 |
| US7842686B2 (en) | 2010-11-30 |
| CA2658573A1 (en) | 2008-01-24 |
| JP2009544618A (ja) | 2009-12-17 |
| EP2049532B1 (en) | 2010-06-02 |
| CN101516875A (zh) | 2009-08-26 |
| AU2007275577A1 (en) | 2008-01-24 |
| DE602007006961D1 (de) | 2010-07-15 |
| WO2008011190A1 (en) | 2008-01-24 |
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