ES2309822T3 - Derivado de amida del acido pirrolopiridina-2-carboxilico util como inhibidor de la glucogeno-fosforilasa. - Google Patents

Derivado de amida del acido pirrolopiridina-2-carboxilico util como inhibidor de la glucogeno-fosforilasa. Download PDF

Info

Publication number
ES2309822T3
ES2309822T3 ES05815826T ES05815826T ES2309822T3 ES 2309822 T3 ES2309822 T3 ES 2309822T3 ES 05815826 T ES05815826 T ES 05815826T ES 05815826 T ES05815826 T ES 05815826T ES 2309822 T3 ES2309822 T3 ES 2309822T3
Authority
ES
Spain
Prior art keywords
compound
alkyl
formula
baselineskip
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05815826T
Other languages
English (en)
Spanish (es)
Inventor
Jozsef Repasi
Andras Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prosidion Ltd
Original Assignee
Prosidion Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prosidion Ltd filed Critical Prosidion Ltd
Application granted granted Critical
Publication of ES2309822T3 publication Critical patent/ES2309822T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
ES05815826T 2004-12-02 2005-12-02 Derivado de amida del acido pirrolopiridina-2-carboxilico util como inhibidor de la glucogeno-fosforilasa. Expired - Lifetime ES2309822T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63246304P 2004-12-02 2004-12-02
US632463P 2004-12-02

Publications (1)

Publication Number Publication Date
ES2309822T3 true ES2309822T3 (es) 2008-12-16

Family

ID=35735250

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05815826T Expired - Lifetime ES2309822T3 (es) 2004-12-02 2005-12-02 Derivado de amida del acido pirrolopiridina-2-carboxilico util como inhibidor de la glucogeno-fosforilasa.

Country Status (10)

Country Link
US (1) US8664397B2 (enExample)
EP (1) EP1819704B1 (enExample)
JP (1) JP2008521874A (enExample)
AT (1) ATE400574T1 (enExample)
DE (1) DE602005008099D1 (enExample)
DK (1) DK1819704T3 (enExample)
ES (1) ES2309822T3 (enExample)
PL (1) PL1819704T3 (enExample)
PT (1) PT1819704E (enExample)
WO (1) WO2006059165A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP2394647A1 (en) 2006-11-02 2011-12-14 Aestus Therapeutics, Inc. Methods of treating neuropathic pain by modulation of glycogenolysis or glycolysis pathways
CN103626826B (zh) * 2013-09-30 2015-10-21 承德医学院 含偶氮键的糖原磷酸化酶抑制剂胆酸类衍生物、其制备方法及医药用途
CN103626837B (zh) * 2013-09-30 2016-11-23 承德医学院 含生物可裂解二肽的糖原磷酸化酶抑制剂胆酸类衍生物、其制备方法及医药用途
CN103626825B (zh) * 2013-09-30 2015-10-07 承德医学院 靶向肝脏的糖原磷酸化酶抑制剂胆酸类衍生物、其制备方法及医药用途
CN103819486B (zh) * 2014-01-27 2016-08-17 承德医学院 标记血清糖原磷酸化酶浓度水平的光亲和标记探针分子、其制备方法及医药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0021831D0 (en) 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
AU2004240946B8 (en) 2003-05-21 2012-01-12 Prosidion Limited Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phoshorylase
US7405210B2 (en) * 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase

Also Published As

Publication number Publication date
US8664397B2 (en) 2014-03-04
EP1819704B1 (en) 2008-07-09
EP1819704A1 (en) 2007-08-22
DK1819704T3 (da) 2008-10-20
HK1107984A1 (en) 2008-04-25
US20080293761A1 (en) 2008-11-27
PT1819704E (pt) 2008-10-06
JP2008521874A (ja) 2008-06-26
PL1819704T3 (pl) 2008-12-31
WO2006059165A1 (en) 2006-06-08
DE602005008099D1 (de) 2008-08-21
ATE400574T1 (de) 2008-07-15

Similar Documents

Publication Publication Date Title
ES2211806T3 (es) Derivados beta-carbolina utiles como inhibidores de la fosfodiesterasa.
ES2255306T3 (es) Derivados de quinolina y su uso como agentes antibacterianos.
ES2242419T3 (es) Compuestos de naftiridina y sus analogos azaisostericos como agentes antibacterianos.
EP1518855B1 (en) Diaminopyrimidinecarboxa mide derivative
CN103814028B (zh) 作为组织蛋白酶c抑制剂的取代的n-[1-氰基-2-(苯基)乙基]-2-氮杂双环[2.2.1]庚烷-3-甲酰胺
ES2230316T3 (es) Derivados de pirrolopiridinona sustituidos utiles como inhibidores de la fosfodiesterasa.
EP0626956B1 (en) Quinolylbenzofuran derivatives as leukotriene antagonists
JP6437929B2 (ja) カテプシンｃの置換二環式１−カルボン酸（ベンジル−シアノ−メチル）−アミド阻害剤
ES2262824T3 (es) Compuestos de n-formil hidroxilamina como inhibidores de pdf.
EP2970228B1 (en) Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin c
CN105829307A (zh) 用作tnf活性调节剂的四氢咪唑并吡啶衍生物
BRPI0611522A2 (pt) composto inibidor de enzima, seu uso, composição farmacêutica e método de inibição de atividade de uma enzima hdac
ES2282857T3 (es) Derivados de bifenilcarboxamida y su uso como inhibidores de quinasa p38.
JPH0625284A (ja) 環状イミド誘導体
JP6434528B2 (ja) 置換ピリドン及びピラジノン、並びに好中球エラスターゼ活性の阻害剤としてのその使用
ES2353309T3 (es) Hidrazidas del ácido pirrolopiridin-2-carboxílico como inhibidores de glucógeno fosforilasa.
ES2324173T3 (es) Amidas del acido pirrolopiridin-2-carboxilico.
AU6259101A (en) 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity
CZ292379B6 (cs) Tetrahydrochinolinové deriváty, způsob jejich výroby a farmaceutický prostředek s jejich obsahem
ES2309822T3 (es) Derivado de amida del acido pirrolopiridina-2-carboxilico util como inhibidor de la glucogeno-fosforilasa.
ES2208595T3 (es) Derivados del acido hidroxamico.
ES2243779T3 (es) Nuevos derivados amidas heteroaromaticas de 3 beta-amino azabiciclooctano, su procedimiento de preparacion y sus aplicaciones en terapeutica.
CN101300226B (zh) 对组蛋白脱乙酰酶具有抑制活性的烷基氨甲酰基萘氧基辛烯酰基羟基酰胺衍生物及其制备方法
KR20010023830A (ko) 호중구 엘라스타제 억제제로서의 피롤로피롤론 유도체
JP3473956B2 (ja) 抗増殖剤およびｇａｒｆｔ阻害剤として有用な化合物