ES2307593T3 - Antagonistas del receptor a2a de adenosina para el tratamiento y la prevencion de la fibrosis hepatica, la cirrosis y la esteatosis hepatica. - Google Patents
Antagonistas del receptor a2a de adenosina para el tratamiento y la prevencion de la fibrosis hepatica, la cirrosis y la esteatosis hepatica. Download PDFInfo
- Publication number
- ES2307593T3 ES2307593T3 ES01910529T ES01910529T ES2307593T3 ES 2307593 T3 ES2307593 T3 ES 2307593T3 ES 01910529 T ES01910529 T ES 01910529T ES 01910529 T ES01910529 T ES 01910529T ES 2307593 T3 ES2307593 T3 ES 2307593T3
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- Prior art keywords
- adenosine
- receptor
- cirrhosis
- hepatic
- fibrosis
- Prior art date
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- Expired - Lifetime
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18154600P | 2000-02-10 | 2000-02-10 | |
| US181546P | 2000-02-10 |
Publications (1)
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|---|---|
| ES2307593T3 true ES2307593T3 (es) | 2008-12-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES01910529T Expired - Lifetime ES2307593T3 (es) | 2000-02-10 | 2001-02-12 | Antagonistas del receptor a2a de adenosina para el tratamiento y la prevencion de la fibrosis hepatica, la cirrosis y la esteatosis hepatica. |
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| US6196459B1 (en) * | 1998-05-11 | 2001-03-06 | Ubiq Incorporated | Smart card personalization in a multistation environment |
| WO2003080649A2 (en) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| ITRM20070088A1 (it) * | 2007-02-19 | 2008-08-20 | Francesco Fringuelli | Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico. |
| KR20100053647A (ko) * | 2007-08-10 | 2010-05-20 | 글락소스미스클라인 엘엘씨 | 바이러스 감염증을 치료하기 위한 질소 함유 바이시클릭 화합물 |
| EP2217233B1 (en) * | 2007-10-26 | 2018-08-08 | New York University School of Medicine | Methods and compositions for treating hepatic diseases |
| EP2236137B1 (en) * | 2008-01-31 | 2015-06-24 | Astellas Pharma Inc. | Pharmaceutical composition for treatment of fatty liver diseases |
| WO2010040003A2 (en) * | 2008-10-01 | 2010-04-08 | The Scripps Research Institute | Human a2a adenosine receptor crystals and uses thereof |
| US20100204265A1 (en) * | 2009-02-09 | 2010-08-12 | Genelabs Technologies, Inc. | Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections |
| EP2405917B1 (en) | 2009-03-13 | 2014-04-23 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
| HUE025704T2 (en) * | 2009-03-20 | 2016-04-28 | Sigma Tau Ind Farmaceuti | Oxidized triazolyl purine derivatives used as adenosine A2A receptor ligands and their use as medicaments |
| EP2499142B1 (en) | 2009-11-09 | 2016-09-21 | Advinus Therapeutics Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| DK2531492T3 (en) | 2010-02-05 | 2016-07-04 | Heptares Therapeutics Ltd | 1,2,4-triazin-4-amine derivatives |
| WO2012066330A1 (en) | 2010-11-17 | 2012-05-24 | Heptares Therapeutics Limited | Compounds useful as a2a receptor inhibitors |
| KR20200022027A (ko) | 2017-06-30 | 2020-03-02 | 리부 세라퓨틱스 에스.에이. | 아데노신 A2A 수용체의 이미다조[1,2,a]피라진 조절물질 |
| AU2018389313B2 (en) | 2017-12-19 | 2021-08-19 | Impetis Biosciences Ltd. | Pharmaceutical composition for the treatment of cancer |
| AU2019205661B2 (en) | 2018-01-04 | 2022-06-30 | Impetis Biosciences Ltd. | Tricyclic compounds, compositions and medicinal applications thereof |
| WO2020128036A1 (en) | 2018-12-21 | 2020-06-25 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a receptor |
| WO2025018901A1 (en) | 2023-07-17 | 2025-01-23 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a and a2b receptor |
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| US4705658A (en) | 1986-04-07 | 1987-11-10 | Capsule Technology International, Ltd. | Method for drying gelatin in the manufacture of hard shell gelatin capsules |
| US5063233A (en) | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
| US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| US5036381A (en) | 1990-06-15 | 1991-07-30 | Motorola, Inc. | Multiple electronic devices within a single carrier structure |
| GB2264948B (en) | 1992-03-13 | 1996-10-16 | Merck & Co Inc | Human adenosine receptors |
| US5426101A (en) | 1992-09-30 | 1995-06-20 | Merrell Dow Pharmaceuticals Inc. | 2-substituted adenosines with A-2 receptor affinity |
| AU6516494A (en) | 1993-04-15 | 1994-11-08 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| US5877180A (en) * | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| US5859019A (en) | 1997-03-07 | 1999-01-12 | Trustees Of The University Of Pennsylvania | Methods for protecting against cardiac ischemia by administering adenosine A2a receptor antagonists |
| CA2289731A1 (en) * | 1997-05-09 | 1998-11-12 | The United States Of America, Represented By The Secretary, Department O F Health And Human Services | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| AU7449598A (en) * | 1997-05-23 | 1998-12-11 | Nippon Shinyaku Co. Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
| US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
| US6303619B1 (en) * | 1998-03-12 | 2001-10-16 | University Of Virginia | Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors |
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
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2001
- 2001-02-12 ES ES01910529T patent/ES2307593T3/es not_active Expired - Lifetime
- 2001-02-12 CA CA002398908A patent/CA2398908C/en not_active Expired - Fee Related
- 2001-02-12 AT AT01910529T patent/ATE394104T1/de not_active IP Right Cessation
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- 2001-02-12 DK DK01910529T patent/DK1272897T3/da active
- 2001-02-12 PT PT01910529T patent/PT1272897E/pt unknown
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- 2001-02-12 US US09/780,365 patent/US6555545B2/en not_active Expired - Lifetime
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- 2001-02-12 DE DE60133887T patent/DE60133887D1/de not_active Expired - Lifetime
- 2001-02-12 JP JP2001557366A patent/JP2004502640A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3812401A (en) | 2001-08-20 |
| JP2004502640A (ja) | 2004-01-29 |
| PT1272897E (pt) | 2008-08-18 |
| WO2001058241A9 (en) | 2002-10-17 |
| ATE394104T1 (de) | 2008-05-15 |
| DK1272897T3 (da) | 2008-09-15 |
| EP1272897A2 (en) | 2003-01-08 |
| EP1272897B1 (en) | 2008-05-07 |
| CA2398908A1 (en) | 2001-08-16 |
| AU2001238124B2 (en) | 2006-05-25 |
| US6555545B2 (en) | 2003-04-29 |
| DE60133887D1 (de) | 2008-06-19 |
| CA2398908C (en) | 2009-12-15 |
| WO2001058241A2 (en) | 2001-08-16 |
| US20020002145A1 (en) | 2002-01-03 |
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