ES2301547T3 - Tratamiento de trastornos del cartilago. - Google Patents
Tratamiento de trastornos del cartilago. Download PDFInfo
- Publication number
- ES2301547T3 ES2301547T3 ES01937482T ES01937482T ES2301547T3 ES 2301547 T3 ES2301547 T3 ES 2301547T3 ES 01937482 T ES01937482 T ES 01937482T ES 01937482 T ES01937482 T ES 01937482T ES 2301547 T3 ES2301547 T3 ES 2301547T3
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- Prior art keywords
- igf
- igfbp
- peptide
- binding
- cartilage
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20449000P | 2000-05-16 | 2000-05-16 | |
| US204490P | 2000-05-16 | ||
| US24898500P | 2000-11-15 | 2000-11-15 | |
| US248985P | 2000-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2301547T3 true ES2301547T3 (es) | 2008-07-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01937482T Expired - Lifetime ES2301547T3 (es) | 2000-05-16 | 2001-05-16 | Tratamiento de trastornos del cartilago. |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20030069177A1 (xx) |
| EP (1) | EP1282437B1 (xx) |
| AT (1) | ATE389416T1 (xx) |
| AU (1) | AU2001263215A1 (xx) |
| DE (1) | DE60133271T2 (xx) |
| DK (1) | DK1282437T3 (xx) |
| ES (1) | ES2301547T3 (xx) |
| HK (1) | HK1050321A1 (xx) |
| WO (1) | WO2001087323A2 (xx) |
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| EP1099443A1 (en) | 1999-11-11 | 2001-05-16 | Sulzer Orthopedics Ltd. | Transplant/implant device and method for its production |
| US7387889B2 (en) * | 2002-08-22 | 2008-06-17 | Massachusetts Institute Of Technology | Measurement of concentrations and binding energetics |
| ES2405080T3 (es) * | 2003-02-26 | 2013-05-30 | Zimmer Orthobiologics, Inc. | Preparado para la reparación de un tejido cartilaginoso, en particular de defectos de cartílagos articulares |
| CA2558497A1 (en) * | 2004-03-05 | 2005-09-15 | Synthes (U.S.A.) | Use of a mixture for the production of an agent for treating defective or degenerated cartilage in the production of natural cartilage replacement in vitro |
| US20080031819A1 (en) * | 2004-06-09 | 2008-02-07 | Beth Israel Deaconess Medical Center | Compositions and Methods that Enhance Articular Cartilage Repair |
| EP1764117A1 (en) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
| US7850983B2 (en) | 2006-02-07 | 2010-12-14 | Spinalcyte, Llc | Methods and compositions for repair of cartilage using an in vivo bioreactor |
| CL2007002502A1 (es) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| US20100137204A1 (en) * | 2006-12-29 | 2010-06-03 | Zheng Xin Dong | Glp-1 pharmaceutical compositions |
| EP3470093B1 (en) | 2008-10-06 | 2020-08-19 | 3-D Matrix Ltd. | Tissue plug |
| BRPI0922344A2 (pt) | 2008-12-19 | 2017-10-24 | 3B Pharmaceuticals Gmbh | inibidores de tfpi e métodos de uso |
| ES2983470T3 (es) | 2010-03-19 | 2024-10-23 | Takeda Pharmaceuticals Co | Inhibidores del TFPI y métodos de uso |
| EP3760707A1 (en) * | 2011-11-09 | 2021-01-06 | Spinalcyte, LLC | Dermal fibroblasts for treatment of degenerative disc disease |
| JP2015514070A (ja) | 2012-03-21 | 2015-05-18 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | Ｔｆｐｉ阻害剤および使用方法 |
| WO2014004467A1 (en) * | 2012-06-25 | 2014-01-03 | The Brigham And Women's Hospital, Inc. | Selective cartilage therapy |
| WO2014008400A2 (en) | 2012-07-06 | 2014-01-09 | 3-D Matrix, Inc. | Fill-finish process for peptide solutions |
| CN105452447A (zh) | 2013-06-19 | 2016-03-30 | 脊核细胞有限责任公司 | 用于软骨细胞应用的脂肪细胞 |
| WO2015136370A2 (en) | 2014-03-10 | 2015-09-17 | 3-D Matrix, Ltd. | Sterilization and filtration of peptide compositions |
| EP3116524B1 (en) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary bulla |
| JP6628733B2 (ja) | 2014-03-10 | 2020-01-15 | 株式会社スリー・ディー・マトリックス | 自己組織化ペプチド組成物 |
| WO2017120092A1 (en) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
| CN117085140A (zh) | 2017-12-15 | 2023-11-21 | 立美基股份有限公司 | 表面活性剂肽纳米结构及在药物递送中的用途 |
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| US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US3721252A (en) * | 1971-04-01 | 1973-03-20 | Catheter And Instr Corp | Spring guide washer |
| US4444047A (en) * | 1979-06-29 | 1984-04-24 | Vdo Adolf Schindling A.G. | Apparatus for determining the fuel consumption of injection internal combustion engines |
| NO154236C (no) | 1979-07-16 | 1986-08-20 | Ciba Geigy Ag | Etterbehandling av med flammebeskyttelsesmiddel behandlede, celluloseholdige fibermaterialer med flytende ammoniakk. |
| US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| WO1985000831A1 (en) | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
| AU598205B2 (en) * | 1985-08-22 | 1990-06-21 | Gropep Pty Ltd | Peptide analogues of mammalian insulin-like growth factor-1 |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
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-
2001
- 2001-05-16 WO PCT/US2001/015904 patent/WO2001087323A2/en active Application Filing
- 2001-05-16 AT AT01937482T patent/ATE389416T1/de active
- 2001-05-16 US US09/858,935 patent/US20030069177A1/en not_active Abandoned
- 2001-05-16 DE DE60133271T patent/DE60133271T2/de not_active Expired - Lifetime
- 2001-05-16 EP EP01937482A patent/EP1282437B1/en not_active Expired - Lifetime
- 2001-05-16 DK DK01937482T patent/DK1282437T3/da active
- 2001-05-16 ES ES01937482T patent/ES2301547T3/es not_active Expired - Lifetime
- 2001-05-16 AU AU2001263215A patent/AU2001263215A1/en not_active Abandoned
-
2002
- 2002-10-16 US US10/271,869 patent/US7423017B2/en not_active Expired - Fee Related
-
2003
- 2003-04-04 HK HK03102436A patent/HK1050321A1/xx not_active IP Right Cessation
-
2007
- 2007-10-30 US US11/929,468 patent/US7947650B2/en not_active Expired - Fee Related
- 2007-11-02 US US11/934,582 patent/US8110548B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100130411A1 (en) | 2010-05-27 |
| DK1282437T3 (da) | 2008-06-30 |
| EP1282437B1 (en) | 2008-03-19 |
| US20030069177A1 (en) | 2003-04-10 |
| EP1282437A2 (en) | 2003-02-12 |
| WO2001087323A2 (en) | 2001-11-22 |
| DE60133271T2 (de) | 2009-04-23 |
| US8110548B2 (en) | 2012-02-07 |
| US7423017B2 (en) | 2008-09-09 |
| US7947650B2 (en) | 2011-05-24 |
| DE60133271D1 (de) | 2008-04-30 |
| AU2001263215A1 (en) | 2001-11-26 |
| US20030211992A1 (en) | 2003-11-13 |
| HK1050321A1 (en) | 2003-06-20 |
| WO2001087323A3 (en) | 2002-04-11 |
| US20090011988A1 (en) | 2009-01-08 |
| ATE389416T1 (de) | 2008-04-15 |
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