ES2292262T3 - Compuestos de imidazol y su uso medicinal. - Google Patents
Compuestos de imidazol y su uso medicinal. Download PDFInfo
- Publication number
- ES2292262T3 ES2292262T3 ES99959929T ES99959929T ES2292262T3 ES 2292262 T3 ES2292262 T3 ES 2292262T3 ES 99959929 T ES99959929 T ES 99959929T ES 99959929 T ES99959929 T ES 99959929T ES 2292262 T3 ES2292262 T3 ES 2292262T3
- Authority
- ES
- Spain
- Prior art keywords
- chloro
- acid
- benzyl
- methylimidazol
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36736298 | 1998-12-24 | ||
| JP10-367362 | 1998-12-24 | ||
| JP22883899 | 1999-08-12 | ||
| JP11-228838 | 1999-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2292262T3 true ES2292262T3 (es) | 2008-03-01 |
Family
ID=26528483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99959929T Expired - Lifetime ES2292262T3 (es) | 1998-12-24 | 1999-12-20 | Compuestos de imidazol y su uso medicinal. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7060721B1 (zh) |
| EP (1) | EP1142879B1 (zh) |
| KR (1) | KR20010094731A (zh) |
| CN (1) | CN1170822C (zh) |
| AR (1) | AR022019A1 (zh) |
| AT (1) | ATE375332T1 (zh) |
| AU (1) | AU758325C (zh) |
| BR (1) | BR9917112A (zh) |
| CA (1) | CA2356838A1 (zh) |
| CZ (1) | CZ20012338A3 (zh) |
| DE (1) | DE69937307T2 (zh) |
| ES (1) | ES2292262T3 (zh) |
| HK (1) | HK1043791A1 (zh) |
| HU (1) | HUP0104657A3 (zh) |
| IL (1) | IL143802A0 (zh) |
| RU (1) | RU2238937C2 (zh) |
| TR (1) | TR200101865T2 (zh) |
| TW (1) | TWI239330B (zh) |
| WO (1) | WO2000039097A1 (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0009037D0 (en) * | 2000-04-13 | 2000-05-31 | Novartis Ag | Organic compounds |
| US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
| AU2012200214B2 (en) * | 2004-05-14 | 2013-10-24 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| ES2249992B1 (es) * | 2004-09-13 | 2007-03-01 | Ferrer Internacional, S.A. | Un procedimiento para fabricar compuestos enantiomericos del imidazol. |
| JP4094660B1 (ja) * | 2005-08-10 | 2008-06-04 | 武田薬品工業株式会社 | 糖尿病治療剤 |
| JP2009534366A (ja) * | 2006-04-21 | 2009-09-24 | アストラゼネカ アクチボラグ | Ｅｄｇ−１拮抗剤として使用するためのイミダゾール誘導体 |
| TW200838501A (en) | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
| TW200838515A (en) * | 2007-02-09 | 2008-10-01 | Takeda Pharmaceutical | Fused ring compound |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| TWI406850B (zh) | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
| KR100868898B1 (ko) * | 2007-07-30 | 2008-11-14 | 한국기계연구원 | 적층형 ｐｚｔ를 이용한 압전펌프 |
| JP2010538071A (ja) | 2007-09-07 | 2010-12-09 | セラヴァンス， インコーポレーテッド | 二重作用性降圧剤 |
| ES2385773T3 (es) | 2007-12-11 | 2012-07-31 | Theravance, Inc. | Derivados de benzoimidazol, de doble acción, y su utilización como agentes antihipertensivos |
| EP2297113A1 (en) | 2008-04-29 | 2011-03-23 | Theravance, Inc. | Dual-acting antihypertensive agents |
| US8124636B2 (en) * | 2008-04-30 | 2012-02-28 | Hoffmann-La Roche Inc. | Imidazolidinone derivatives as 11B-HSD1 inhibitors |
| WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
| BRPI1010571A2 (pt) * | 2009-05-15 | 2019-09-24 | Sanofi Sa | processo para a preparação de um composto útil como um inibidor de tafla. |
| JP5833000B2 (ja) | 2009-07-07 | 2015-12-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | 二重に作用するピラゾール抗高血圧症薬 |
| JP2012533626A (ja) | 2009-07-22 | 2012-12-27 | セラヴァンス， インコーポレーテッド | 二重作用オキサゾール降圧剤 |
| EP2526095A1 (en) | 2010-01-19 | 2012-11-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| AU2019337018B2 (en) * | 2018-09-04 | 2024-03-07 | Chugai Seiyaku Kabushiki Kaisha | Method of producing tetracyclic compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215994A (en) | 1990-09-25 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic derivatives |
| TW235963B (zh) | 1992-01-16 | 1994-12-11 | Shionogi & Co | |
| IL124969A (en) | 1995-12-28 | 2002-09-12 | Fujisawa Pharmaceutical Co | History of benzimidazole, processes for their preparation and pharmaceutical preparations containing them |
| EP1000932B9 (en) | 1997-06-27 | 2005-12-28 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| US6348474B1 (en) | 1997-06-27 | 2002-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Sulfonamide compounds and medicinal use thereof |
-
1999
- 1999-12-20 CA CA002356838A patent/CA2356838A1/en not_active Abandoned
- 1999-12-20 TR TR2001/01865T patent/TR200101865T2/xx unknown
- 1999-12-20 IL IL14380299A patent/IL143802A0/xx unknown
- 1999-12-20 US US09/869,135 patent/US7060721B1/en not_active Expired - Fee Related
- 1999-12-20 AU AU16905/00A patent/AU758325C/en not_active Ceased
- 1999-12-20 ES ES99959929T patent/ES2292262T3/es not_active Expired - Lifetime
- 1999-12-20 CN CNB998163600A patent/CN1170822C/zh not_active Expired - Fee Related
- 1999-12-20 BR BR9917112-0A patent/BR9917112A/pt not_active IP Right Cessation
- 1999-12-20 DE DE69937307T patent/DE69937307T2/de not_active Expired - Fee Related
- 1999-12-20 AT AT99959929T patent/ATE375332T1/de not_active IP Right Cessation
- 1999-12-20 CZ CZ20012338A patent/CZ20012338A3/cs unknown
- 1999-12-20 WO PCT/JP1999/007160 patent/WO2000039097A1/ja not_active Application Discontinuation
- 1999-12-20 HU HU0104657A patent/HUP0104657A3/hu unknown
- 1999-12-20 RU RU2001120723A patent/RU2238937C2/ru not_active IP Right Cessation
- 1999-12-20 KR KR1020017008097A patent/KR20010094731A/ko not_active Application Discontinuation
- 1999-12-20 EP EP99959929A patent/EP1142879B1/en not_active Expired - Lifetime
- 1999-12-22 TW TW088122630A patent/TWI239330B/zh not_active IP Right Cessation
- 1999-12-23 AR ARP990106750A patent/AR022019A1/es unknown
-
2002
- 2002-07-18 HK HK02105326A patent/HK1043791A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1142879B1 (en) | 2007-10-10 |
| CN1335837A (zh) | 2002-02-13 |
| HK1043791A1 (en) | 2002-09-27 |
| CA2356838A1 (en) | 2000-07-06 |
| TR200101865T2 (tr) | 2001-12-21 |
| HUP0104657A2 (hu) | 2002-05-29 |
| KR20010094731A (ko) | 2001-11-01 |
| DE69937307T2 (de) | 2008-02-07 |
| WO2000039097A1 (fr) | 2000-07-06 |
| AU1690500A (en) | 2000-07-31 |
| BR9917112A (pt) | 2002-01-29 |
| US7060721B1 (en) | 2006-06-13 |
| EP1142879A1 (en) | 2001-10-10 |
| AU758325B2 (en) | 2003-03-20 |
| ATE375332T1 (de) | 2007-10-15 |
| DE69937307D1 (de) | 2007-11-22 |
| RU2238937C2 (ru) | 2004-10-27 |
| AR022019A1 (es) | 2002-09-04 |
| CZ20012338A3 (cs) | 2001-12-12 |
| TWI239330B (en) | 2005-09-11 |
| HUP0104657A3 (en) | 2002-07-29 |
| EP1142879A4 (en) | 2002-02-06 |
| AU758325C (en) | 2004-10-07 |
| IL143802A0 (en) | 2002-04-21 |
| CN1170822C (zh) | 2004-10-13 |
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