TR200101865T2 - İmidazol bileşimleri ve onların tıbbi kullanımları. - Google Patents

İmidazol bileşimleri ve onların tıbbi kullanımları.

Info

Publication number
TR200101865T2
TR200101865T2 TR2001/01865T TR200101865T TR200101865T2 TR 200101865 T2 TR200101865 T2 TR 200101865T2 TR 2001/01865 T TR2001/01865 T TR 2001/01865T TR 200101865 T TR200101865 T TR 200101865T TR 200101865 T2 TR200101865 T2 TR 200101865T2
Authority
TR
Turkey
Prior art keywords
activity
compositions
smooth muscle
medicinal uses
imidazole
Prior art date
Application number
TR2001/01865T
Other languages
English (en)
Inventor
Kayakiri Hiroshi
Abe Yoshito
Hamashima Hitoshi
Sawada Hitoshi
Ishibashi Naoki
Setoi Hiroyuki
Oku Teruo
Yamasaki Noritsugu
Imoto Takafumi
Hiramura Takahiro
Original Assignee
Fujisawa Pharmaceutical Co .Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co .Ltd. filed Critical Fujisawa Pharmaceutical Co .Ltd.
Publication of TR200101865T2 publication Critical patent/TR200101865T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Asagidaki genel formül (1) ile gösterilen midazol bilesimleri: burada her bir sembol tarifnamede tanimlandigi gibidir ve onlarin tuzlari ve onlari içeren farmasötik bir kompozisyon saglanmistir. Bu bilesimler bir hipoglisemik faaliyete dayali tedavi edilebilir hastaliklar ve bir cGMP-PDE önleyici faaliyet, bir düzgün kas rhatlama faaliyeti, bir bronkodilatlama faaliyeti, bir vasodilatlama faaliyeti, bir düzgün kas hücre önleyici faaliyet ve bir alerji önleyici faaliyete dayali tedavi edilebilir hastaliklarin tedavisi için yararlidir.
TR2001/01865T 1998-12-24 1999-12-20 İmidazol bileşimleri ve onların tıbbi kullanımları. TR200101865T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP36736298 1998-12-24
JP22883899 1999-08-12

Publications (1)

Publication Number Publication Date
TR200101865T2 true TR200101865T2 (tr) 2001-12-21

Family

ID=26528483

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01865T TR200101865T2 (tr) 1998-12-24 1999-12-20 İmidazol bileşimleri ve onların tıbbi kullanımları.

Country Status (19)

Country Link
US (1) US7060721B1 (tr)
EP (1) EP1142879B1 (tr)
KR (1) KR20010094731A (tr)
CN (1) CN1170822C (tr)
AR (1) AR022019A1 (tr)
AT (1) ATE375332T1 (tr)
AU (1) AU758325C (tr)
BR (1) BR9917112A (tr)
CA (1) CA2356838A1 (tr)
CZ (1) CZ20012338A3 (tr)
DE (1) DE69937307T2 (tr)
ES (1) ES2292262T3 (tr)
HK (1) HK1043791A1 (tr)
HU (1) HUP0104657A3 (tr)
IL (1) IL143802A0 (tr)
RU (1) RU2238937C2 (tr)
TR (1) TR200101865T2 (tr)
TW (1) TWI239330B (tr)
WO (1) WO2000039097A1 (tr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0009037D0 (en) * 2000-04-13 2000-05-31 Novartis Ag Organic compounds
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
AU2012200214B2 (en) * 2004-05-14 2013-10-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
ES2249992B1 (es) * 2004-09-13 2007-03-01 Ferrer Internacional, S.A. Un procedimiento para fabricar compuestos enantiomericos del imidazol.
BRPI0615150A2 (pt) * 2005-08-10 2017-06-20 Takeda Pharmaceuticals Co agente para a profilaxia ou tratamento de diabete, sensibilizador de insulina, composto, pró-droga, agente farmacêutico, e, uso do composto ou um sal do mesmo ou uma pró-droga do mesmo
JP2009534366A (ja) * 2006-04-21 2009-09-24 アストラゼネカ アクチボラグ Ｅｄｇ−１拮抗剤として使用するためのイミダゾール誘導体
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
WO2008099794A1 (en) * 2007-02-09 2008-08-21 Takeda Pharmaceutical Company Limited Fused ring compounds as partial agonists of ppar-gamma
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
KR100868898B1 (ko) * 2007-07-30 2008-11-14 한국기계연구원 적층형 ｐｚｔ를 이용한 압전펌프
EP2200975A1 (en) 2007-09-07 2010-06-30 Theravance, Inc. Dual-acting antihypertensive agents
ATE555099T1 (de) 2007-12-11 2012-05-15 Theravance Inc Dual wirkende benzimidazol-derivate und deren verwendung als blutdrucksenkende mittel
JP2011518884A (ja) 2008-04-29 2011-06-30 セラヴァンス， インコーポレーテッド 二重活性抗高血圧剤
US8124636B2 (en) * 2008-04-30 2012-02-28 Hoffmann-La Roche Inc. Imidazolidinone derivatives as 11B-HSD1 inhibitors
US7863309B2 (en) 2008-07-24 2011-01-04 Theravance, Inc. Dual-acting antihypertensive agents
CA2760748A1 (en) * 2009-05-15 2010-11-18 Kai Rossen Process for the preparation of a compound useful as an inhibitor of tafia
US7956054B2 (en) 2009-07-07 2011-06-07 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
WO2011011232A1 (en) 2009-07-22 2011-01-27 Theravance, Inc. Dual-acting oxazole antihypertensive agents
US8481549B2 (en) * 2010-01-19 2013-07-09 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
CN112585126B (zh) 2018-09-04 2024-05-07 中外制药株式会社 四环化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215994A (en) 1990-09-25 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic derivatives
TW235963B (tr) 1992-01-16 1994-12-11 Shionogi & Co
US6166219A (en) 1995-12-28 2000-12-26 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
RU2199532C2 (ru) 1997-06-27 2003-02-27 Фудзисава Фармасьютикал Ко., Лтд. Сульфонамидное соединение
US6242474B1 (en) * 1997-06-27 2001-06-05 Fujisawa Pharmaceutical Co., Ltd. Aromatic ring derivatives

Also Published As

Publication number Publication date
WO2000039097A1 (fr) 2000-07-06
HK1043791A1 (en) 2002-09-27
AR022019A1 (es) 2002-09-04
TWI239330B (en) 2005-09-11
US7060721B1 (en) 2006-06-13
DE69937307T2 (de) 2008-02-07
DE69937307D1 (de) 2007-11-22
CN1335837A (zh) 2002-02-13
ES2292262T3 (es) 2008-03-01
BR9917112A (pt) 2002-01-29
CA2356838A1 (en) 2000-07-06
HUP0104657A2 (hu) 2002-05-29
AU1690500A (en) 2000-07-31
IL143802A0 (en) 2002-04-21
CN1170822C (zh) 2004-10-13
EP1142879B1 (en) 2007-10-10
HUP0104657A3 (en) 2002-07-29
EP1142879A4 (en) 2002-02-06
AU758325B2 (en) 2003-03-20
AU758325C (en) 2004-10-07
EP1142879A1 (en) 2001-10-10
RU2238937C2 (ru) 2004-10-27
CZ20012338A3 (cs) 2001-12-12
ATE375332T1 (de) 2007-10-15
KR20010094731A (ko) 2001-11-01

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