ES2279600T3 - Sistema de microcolumna para separacion magnetica. - Google Patents

Sistema de microcolumna para separacion magnetica. Download PDF

Info

Publication number
ES2279600T3
ES2279600T3 ES99301719T ES99301719T ES2279600T3 ES 2279600 T3 ES2279600 T3 ES 2279600T3 ES 99301719 T ES99301719 T ES 99301719T ES 99301719 T ES99301719 T ES 99301719T ES 2279600 T3 ES2279600 T3 ES 2279600T3
Authority
ES
Spain
Prior art keywords
microcolumn
separating
matrix
column
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99301719T
Other languages
English (en)
Spanish (es)
Inventor
Stefan Miltenyi
Gregor Siebenkotten
Mathias Koester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miltenyi Biotec GmbH
Original Assignee
Miltenyi Biotec GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miltenyi Biotec GmbH filed Critical Miltenyi Biotec GmbH
Application granted granted Critical
Publication of ES2279600T3 publication Critical patent/ES2279600T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/034—Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications

Landscapes

  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ES99301719T 1998-03-12 1999-03-08 Sistema de microcolumna para separacion magnetica. Expired - Lifetime ES2279600T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42178 1998-03-12
US4217898A 1998-03-21 1998-03-21

Publications (1)

Publication Number Publication Date
ES2279600T3 true ES2279600T3 (es) 2007-08-16

Family

ID=21920470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99301719T Expired - Lifetime ES2279600T3 (es) 1998-03-12 1999-03-08 Sistema de microcolumna para separacion magnetica.

Country Status (6)

Country Link
US (3) US6602422B1 (fr)
EP (1) EP0941766B1 (fr)
JP (1) JPH11319628A (fr)
CA (1) CA2262834C (fr)
DE (1) DE69934449T2 (fr)
ES (1) ES2279600T3 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3668075B2 (ja) * 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたＳＮＰｓ高速スコアリング方法
EP3427834A1 (fr) * 2001-07-26 2019-01-16 Handylab, Inc. Procedes et systemes de traitement microfluidique
US7135183B1 (en) * 2001-08-06 2006-11-14 Academia Sinica Immuno-modulating antitumor activities of Ganoderma lucidum (Reishi) polysaccharides
US7687064B2 (en) * 2001-08-06 2010-03-30 Academia Sinica Methods and compositions associated with administration of an extract of Ganoderma lucidum
WO2005065267A2 (fr) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Clarification de cellules magnetophoretiques
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060013926A1 (en) * 2004-07-16 2006-01-19 Lindsey H M Magnetic dispensing funnel
US20070196833A1 (en) * 2005-04-21 2007-08-23 Gjerde Douglas T Open channel solid phase extraction systems and methods
GB2425498A (en) * 2005-04-25 2006-11-01 Dynal Biotech Asa A magnetic separation device
WO2007008192A1 (fr) * 2005-07-07 2007-01-18 Inventive Technologies, Inc. Entonnoir de distribution magnetique
TWI386220B (zh) * 2005-10-14 2013-02-21 Academia Sinica 真菌免疫刺激組合物及其用途
DE102005053463A1 (de) * 2005-11-06 2007-05-10 Aj Innuscreen Gmbh Vorrichtung und Verfahren zur automatisierten Isolierung und Aufreinigung von Nukleinsäuren aus beliebigen komplexen Ausgangsmaterialien
US20080214442A1 (en) * 2006-09-21 2008-09-04 Alice Yu Anti-Viral Effect of an Extract of Ganoderma Lucidum
WO2008036421A2 (fr) * 2006-09-21 2008-03-27 Academia Sinica Amélioration apportée par le reishi de l'adhesion et de la differentiation cellulaires progénitrices de tissu humain
US20080131954A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
US7828149B2 (en) * 2007-05-22 2010-11-09 Multi-Comp, Inc. Sealed blister assembly
US8268177B2 (en) 2007-08-13 2012-09-18 Agency For Science, Technology And Research Microfluidic separation system
US7785600B2 (en) * 2007-08-30 2010-08-31 Wyntek Corporation Compositions and methods for treating allergies, auto-immune diseases, and improving skin condition by ganoderma lucidum (reishi) polysaccharides
US7947283B2 (en) * 2007-08-30 2011-05-24 Wyntek Corporation Compositions and methods for treating psoriasis by Ganoderma lucidum (Reishi) polysaccharides
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
US8071105B2 (en) * 2008-04-21 2011-12-06 Academia Sinica Reishi F3 sub fraction polysaccharides and methods of using same
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
JP5752042B2 (ja) * 2009-11-13 2015-07-22 ユニバーサル・バイオ・リサーチ株式会社 磁性試薬、磁性試薬キット、磁性担体処理方法およびその処理装置
TWI362964B (en) 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
DE102010042723A1 (de) * 2010-10-20 2012-04-26 Miltenyi Biotec Gmbh Vorrichtung und Verfahren zur Separation von Neél- und Brown-magnetischen Partikeln
TWI407101B (zh) 2011-04-11 2013-09-01 Ind Tech Res Inst 磁分離單元、磁性分離裝置以及分離生化試樣內磁性物質之方法
EP2809448A1 (fr) 2012-01-30 2014-12-10 Kaivogen Oy Séparation de nanomatériaux luminescents
CN103350029B (zh) * 2013-07-24 2016-01-20 江苏旌凯中科超导高技术有限公司 一种立式干法高梯度超导磁分离系统及其应用工艺
US10625272B2 (en) 2015-11-18 2020-04-21 Industrial Technology Research Institute Magnetic separator
US11226271B2 (en) 2016-03-07 2022-01-18 X-Zell Biotech Pte Ltd Systems and methods for identifying rare cells
USD783209S1 (en) * 2016-03-08 2017-04-04 Kerry Morris Telescopic pet food funnel with handle
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
EP3563154B1 (fr) * 2016-12-28 2021-07-28 Cytiva Sweden AB Particules magnétiques de liaison à l'immunoglobuline
US10329787B2 (en) * 2017-02-07 2019-06-25 Kurt Franklyn Laffy Anchor device
EP3400983B1 (fr) 2017-05-09 2019-11-27 Miltenyi Biotec B.V. & Co. KG Système de colonne rechargeable
CN108296013B (zh) * 2018-03-02 2023-11-14 浙江大学 一种超顺磁纳米微粒的分离装置及其应用
AU2020246969A1 (en) 2019-03-27 2021-09-16 Cytiva Sweden Ab A method for separating biomolecules
EP4115981A1 (fr) 2021-07-09 2023-01-11 Miltenyi Biotec B.V. & Co. KG Séparation magnétique avec champ magnétique rotatif/colonne rotative
CN113583865A (zh) * 2021-10-08 2021-11-02 深圳市瑞沃德生命科技有限公司 分选柱的制备方法及分选柱
CN113699038A (zh) * 2021-10-27 2021-11-26 深圳市瑞沃德生命科技有限公司 分选柱的制备方法及分选柱

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4046681A (en) * 1975-07-10 1977-09-06 Sala Magnetics, Inc. Multiple matrix assembly and matrix unit for magnetic separator with simplified sealing
JPS604721B2 (ja) * 1976-12-11 1985-02-06 株式会社井上ジャパックス研究所 改良されたフイルタ
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
JPS5845714A (ja) * 1981-08-20 1983-03-17 Unitika Ltd 濾過方法
DE3200988A1 (de) * 1982-01-14 1983-07-28 Thomas A. Dr. 6900 Heidelberg Reed Verfahren und vorrichtung zur abtrennung von organischen stoffen aus einer suspension oder loesung
DK111582A (da) * 1982-03-12 1983-09-13 Niro Atomizer As Hoejgradient magnetisk separator
US4508625A (en) 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
GB2170736B (en) * 1984-12-19 1988-02-03 Bio Separation Ltd Process for magnetic separation of metals from aqueous media
US4666595A (en) 1985-09-16 1987-05-19 Coulter Electronics, Inc. Apparatus for acoustically removing particles from a magnetic separation matrix
US4664796A (en) 1985-09-16 1987-05-12 Coulter Electronics, Inc. Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium
DE68916843T2 (de) * 1988-04-26 1995-02-02 Nippon Telegraph & Telephone Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben.
US5108933A (en) * 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
US6020210A (en) * 1988-12-28 2000-02-01 Miltenvi Biotech Gmbh Methods and materials for high gradient magnetic separation of biological materials
AU4746590A (en) * 1988-12-28 1990-08-01 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
DD298055A5 (de) * 1989-09-14 1992-02-06 ����������@�����������@���Kk�� Methode und nuetzlicher apparat zur darstellung pharmazeutischer zusammensetzungen
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
GB9106284D0 (en) * 1991-03-25 1991-05-08 Cryogenic Consult Improvements in and relating to magnetic separators
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
US5759391A (en) * 1991-03-25 1998-06-02 Stadtmuller; Adam Magnetic separators
US5858223A (en) * 1991-03-25 1999-01-12 Carpco, Inc. Magnetic separators
DE4124778A1 (de) * 1991-07-26 1993-01-28 Univ Schiller Jena Verfahren und anordnung zur analyse von agglutinationsreaktionen
FR2688127B1 (fr) * 1992-03-05 1995-07-07 David Ets Georges Casier pour le rangement des bouteilles.
GB2269486B (en) 1992-07-31 1996-05-08 Communicate Ltd Printed circuit connector assembly
US5897783A (en) * 1992-09-24 1999-04-27 Amersham International Plc Magnetic separation method
FI932866A0 (fi) * 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
US6103127A (en) * 1993-06-08 2000-08-15 Cortex Biochem, Inc. Methods for removing hazardous organic molecules from liquid waste
US5439586A (en) * 1993-09-15 1995-08-08 The Terry Fox Laboratory Of The British Columbia Cancer Agnecy Magnetic filter with ordered wire array
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus

Also Published As

Publication number Publication date
US20030127382A1 (en) 2003-07-10
EP0941766B1 (fr) 2006-12-20
US6602422B1 (en) 2003-08-05
JPH11319628A (ja) 1999-11-24
EP0941766A2 (fr) 1999-09-15
EP0941766A3 (fr) 2000-03-22
DE69934449D1 (de) 2007-02-01
DE69934449T2 (de) 2007-09-27
CA2262834C (fr) 2008-09-09
CA2262834A1 (fr) 1999-09-12
US6471860B1 (en) 2002-10-29

Similar Documents

Publication Publication Date Title
ES2279600T3 (es) Sistema de microcolumna para separacion magnetica.
ES2202427T3 (es) Aparato de separacion magnetica.
ES2682451T3 (es) Método de enriquecimiento magnético
ES2315238T3 (es) Metodo para mezclar particulas magneticas con un fluido.
ES2423930T3 (es) Dispositivos actuadores de gotitas y métodos que emplean perlas magnéticas
FI120863B (fi) Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite
ES2245088T3 (es) Dispositivo y procedimiento para la transferencia de particulas magneticas.
EP0986436B1 (fr) Dispositif magnetique de separation de cellules et procede pour la separation
Safarik et al. Magnetic techniques for the isolation and purification of proteins and peptides
JP4594467B2 (ja) 常磁性粒子を用いた核酸の精製とその操作方法
JP3085709B2 (ja) 磁気分離機、磁気分離方法、リガンド測定方法ならびに分離方法
ES2871032T3 (es) Imán anular de núcleo macizo
KR20050100216A (ko) 물방울형 셀 서스펜션을 이용한 세포 분리 장치 및 방법
ES2269399T3 (es) Aislamiento de acido nucleico.
CA2249393A1 (fr) Procedes destines a l'isolement de matieres biologiques cibles au moyen de particules magnetiques de silice
ES2242877T3 (es) Sistema para la separacion de particulas que se atraen magneticamente.
WO2010089138A9 (fr) Dispositifs, systèmes et procédés pour la séparation de particules magnétiques
CA2380919A1 (fr) Systeme et methode de manipulation de particules a sensibilite magnetique dans des echantillons de liquide afin de recueillir de l'adn ou de l'arn
CA2473376A1 (fr) Methode permettant d'isoler des acides nucleiques et des proteines contenus dans un echantillon unique
JP7396777B2 (ja) 磁気分離
US20220112483A1 (en) Discontinuous Wall Hollow Core Magnet
CA2294749C (fr) Dispositif et procede de concentration et purification de molecules biologiques en une etape
US5693784A (en) Methods for creating agglomerates from colloidal particles
ES2904624T3 (es) Método para aislar ácido nucleico altamente puro con partículas magnéticas
US20090029482A1 (en) Functional particle, and method for separation of target substance using the same