ES2278647T3 - Nuevos procedimientos y composiciones que comprenden opioides y antagonistas de opioides. - Google Patents
Nuevos procedimientos y composiciones que comprenden opioides y antagonistas de opioides. Download PDFInfo
- Publication number
- ES2278647T3 ES2278647T3 ES00992256T ES00992256T ES2278647T3 ES 2278647 T3 ES2278647 T3 ES 2278647T3 ES 00992256 T ES00992256 T ES 00992256T ES 00992256 T ES00992256 T ES 00992256T ES 2278647 T3 ES2278647 T3 ES 2278647T3
- Authority
- ES
- Spain
- Prior art keywords
- opioid
- compound
- opioids
- compounds
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940005483 opioid analgesics Drugs 0.000 title claims description 35
- 239000000203 mixture Substances 0.000 title claims description 30
- 238000000034 method Methods 0.000 title description 20
- 239000003887 narcotic antagonist Substances 0.000 title description 4
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- 230000002093 peripheral effect Effects 0.000 claims abstract description 17
- 239000008203 oral pharmaceutical composition Substances 0.000 claims abstract description 3
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 32
- 239000005557 antagonist Substances 0.000 claims description 17
- 229960005181 morphine Drugs 0.000 claims description 16
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims description 6
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- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims description 3
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
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| US450806 | 1982-12-17 | ||
| US45080699A | 1999-11-29 | 1999-11-29 |
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| ES2278647T3 true ES2278647T3 (es) | 2007-08-16 |
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| ES00992256T Expired - Lifetime ES2278647T3 (es) | 1999-11-29 | 2000-11-29 | Nuevos procedimientos y composiciones que comprenden opioides y antagonistas de opioides. |
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| JP (1) | JP2003528819A (https=) |
| AU (1) | AU784541B2 (https=) |
| CA (1) | CA2392362A1 (https=) |
| CY (1) | CY1106359T1 (https=) |
| DE (1) | DE60032940T2 (https=) |
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| MX (1) | MXPA02005335A (https=) |
| NZ (1) | NZ518562A (https=) |
| PT (1) | PT1244447E (https=) |
| WO (1) | WO2001037785A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| JP2001526228A (ja) | 1997-12-22 | 2001-12-18 | ユーロ−セルティーク，エス．エイ． | オピオイド作動薬／拮抗薬の併用 |
| HU229705B1 (en) | 2000-02-08 | 2014-05-28 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations |
| CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
| US20030022909A1 (en) * | 2001-06-05 | 2003-01-30 | University Of Chicago | Use of methylnaltrexone to treat immune suppression |
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| US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
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| DE3851081T2 (de) * | 1987-04-16 | 1995-02-16 | Lilly Co Eli | Piperidine als Opioid-Antagoniste. |
| US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
-
2000
- 2000-11-29 ES ES00992256T patent/ES2278647T3/es not_active Expired - Lifetime
- 2000-11-29 WO PCT/US2000/042315 patent/WO2001037785A2/en not_active Ceased
- 2000-11-29 CA CA002392362A patent/CA2392362A1/en not_active Abandoned
- 2000-11-29 PT PT00992256T patent/PT1244447E/pt unknown
- 2000-11-29 JP JP2001539402A patent/JP2003528819A/ja active Pending
- 2000-11-29 DK DK00992256T patent/DK1244447T3/da active
- 2000-11-29 DE DE60032940T patent/DE60032940T2/de not_active Expired - Lifetime
- 2000-11-29 AU AU39706/01A patent/AU784541B2/en not_active Ceased
- 2000-11-29 EP EP00992256A patent/EP1244447B1/en not_active Expired - Lifetime
- 2000-11-29 MX MXPA02005335A patent/MXPA02005335A/es active IP Right Grant
- 2000-11-29 NZ NZ518562A patent/NZ518562A/en unknown
- 2000-11-29 IL IL14960000A patent/IL149600A0/xx unknown
-
2002
- 2002-05-12 IL IL149600A patent/IL149600A/en not_active IP Right Cessation
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2007
- 2007-03-07 CY CY20071100318T patent/CY1106359T1/el unknown
Also Published As
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|---|---|
| NZ518562A (en) | 2005-04-29 |
| EP1244447B1 (en) | 2007-01-10 |
| MXPA02005335A (es) | 2003-01-28 |
| CY1106359T1 (el) | 2011-10-12 |
| JP2003528819A (ja) | 2003-09-30 |
| DK1244447T3 (da) | 2007-04-23 |
| WO2001037785A9 (en) | 2002-08-29 |
| WO2001037785A2 (en) | 2001-05-31 |
| DE60032940T2 (de) | 2007-11-08 |
| IL149600A0 (en) | 2002-11-10 |
| AU3970601A (en) | 2001-06-04 |
| PT1244447E (pt) | 2007-02-28 |
| WO2001037785A3 (en) | 2002-01-10 |
| EP1244447A2 (en) | 2002-10-02 |
| IL149600A (en) | 2010-06-16 |
| DE60032940D1 (de) | 2007-02-22 |
| AU784541B2 (en) | 2006-04-27 |
| CA2392362A1 (en) | 2001-05-31 |
| EP1244447A4 (en) | 2003-06-04 |
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