ES2269661T3 - El uso de flumazenil en el desarrollo de un farmaco para el tratamiento de dependencia del alcohol. - Google Patents
El uso de flumazenil en el desarrollo de un farmaco para el tratamiento de dependencia del alcohol. Download PDFInfo
- Publication number
- ES2269661T3 ES2269661T3 ES02716090T ES02716090T ES2269661T3 ES 2269661 T3 ES2269661 T3 ES 2269661T3 ES 02716090 T ES02716090 T ES 02716090T ES 02716090 T ES02716090 T ES 02716090T ES 2269661 T3 ES2269661 T3 ES 2269661T3
- Authority
- ES
- Spain
- Prior art keywords
- flumazenil
- administration
- alcohol
- treatment
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OFBIFZUFASYYRE-UHFFFAOYSA-N flumazenil Chemical compound C1N(C)C(=O)C2=CC(F)=CC=C2N2C=NC(C(=O)OCC)=C21 OFBIFZUFASYYRE-UHFFFAOYSA-N 0.000 title claims abstract description 83
- 229960004381 flumazenil Drugs 0.000 title claims abstract description 83
- 238000011282 treatment Methods 0.000 title claims description 36
- 208000007848 Alcoholism Diseases 0.000 title abstract description 26
- 201000007930 alcohol dependence Diseases 0.000 title abstract description 26
- 238000011161 development Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 238000001990 intravenous administration Methods 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 16
- 229940079593 drug Drugs 0.000 abstract description 14
- 230000009467 reduction Effects 0.000 description 10
- 241000857916 Gerra Species 0.000 description 9
- 229940049706 benzodiazepine Drugs 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 208000019901 Anxiety disease Diseases 0.000 description 6
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 6
- 208000029650 alcohol withdrawal Diseases 0.000 description 6
- 230000036506 anxiety Effects 0.000 description 6
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 206010039897 Sedation Diseases 0.000 description 4
- 150000001557 benzodiazepines Chemical class 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 230000036280 sedation Effects 0.000 description 4
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical compound CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 230000007882 cirrhosis Effects 0.000 description 3
- 208000019425 cirrhosis of liver Diseases 0.000 description 3
- 229960004414 clomethiazole Drugs 0.000 description 3
- 230000001149 cognitive effect Effects 0.000 description 3
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 description 3
- 208000030159 metabolic disease Diseases 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 3
- 229960004134 propofol Drugs 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 206010048010 Withdrawal syndrome Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 208000037805 labour Diseases 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 238000011458 pharmacological treatment Methods 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 206010012225 Delirium tremens Diseases 0.000 description 1
- 102000005915 GABA Receptors Human genes 0.000 description 1
- 108010005551 GABA Receptors Proteins 0.000 description 1
- 102000004300 GABA-A Receptors Human genes 0.000 description 1
- 108090000839 GABA-A Receptors Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WYCLKVQLVUQKNZ-UHFFFAOYSA-N Halazepam Chemical compound N=1CC(=O)N(CC(F)(F)F)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 WYCLKVQLVUQKNZ-UHFFFAOYSA-N 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 description 1
- ZGUGWUXLJSTTMA-UHFFFAOYSA-N Promazinum Chemical compound C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZGUGWUXLJSTTMA-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229960004538 alprazolam Drugs 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000000749 benzodiazepine receptor blocking agent Substances 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229940120889 dipyrone Drugs 0.000 description 1
- 229960002563 disulfiram Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229940083609 fluoxetine 20 mg Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960002158 halazepam Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000007449 liver function test Methods 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 231100000663 medical toxicology Toxicity 0.000 description 1
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960004526 piracetam Drugs 0.000 description 1
- 229940088697 piracetam 800 mg Drugs 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960003598 promazine Drugs 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003304 psychophysiological effect Effects 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200100106 | 2001-01-17 | ||
| ES200100106 | 2001-01-17 | ||
| PCT/ES2002/000008 WO2002056964A1 (es) | 2001-01-17 | 2002-01-10 | Empleo de flumazenilo en la elaboración de una medicación para el tratamiento de la dependencia de alcohol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2269661T3 true ES2269661T3 (es) | 2007-04-01 |
Family
ID=8496426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02716090T Expired - Lifetime ES2269661T3 (es) | 2001-01-17 | 2002-01-10 | El uso de flumazenil en el desarrollo de un farmaco para el tratamiento de dependencia del alcohol. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7348321B2 (https=) |
| EP (1) | EP1374952B1 (https=) |
| JP (2) | JP2004519461A (https=) |
| KR (1) | KR100712570B1 (https=) |
| CN (1) | CN1486205A (https=) |
| AT (1) | ATE338575T1 (https=) |
| AU (1) | AU2002226427B2 (https=) |
| BR (1) | BR0206549A (https=) |
| CA (1) | CA2433833C (https=) |
| CR (1) | CR7049A (https=) |
| CY (1) | CY1107500T1 (https=) |
| DE (1) | DE60214527T2 (https=) |
| DK (1) | DK1374952T3 (https=) |
| ES (1) | ES2269661T3 (https=) |
| IL (1) | IL156798A0 (https=) |
| MX (1) | MXPA03006411A (https=) |
| NZ (2) | NZ539400A (https=) |
| PT (1) | PT1374952E (https=) |
| RU (1) | RU2300378C2 (https=) |
| UA (1) | UA78199C2 (https=) |
| WO (1) | WO2002056964A1 (https=) |
| ZA (1) | ZA200305922B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050192271A1 (en) * | 2003-07-15 | 2005-09-01 | Hythiam, Inc. | Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse |
| US20060172996A1 (en) * | 2005-02-03 | 2006-08-03 | Halikas James A | Method of preventing relapse in the abstinent substance dependent individual |
| US20060172998A1 (en) * | 2005-02-03 | 2006-08-03 | Halikas James A | Method of preventing relapse in the abstinent substance dependent individual |
| JP2008538748A (ja) | 2005-04-07 | 2008-11-06 | ハイシアム， インコーポレイテッド | 不安、物質乱用及び依存の予防のための改良型方法及び組成物 |
| US20060263304A1 (en) * | 2005-05-23 | 2006-11-23 | Halikas James A | Method of controlling alcohol intake and reversing alcohol effects |
| EP3251670A1 (en) | 2007-08-06 | 2017-12-06 | Biotie Therapies, Inc. | Methods for treating dependence |
| US20110034442A1 (en) * | 2007-08-08 | 2011-02-10 | Jaun Jose Legarda Ibanez | Use and Methods of Use for an Antagonist of the Serotin3 Receptor (5-HT3) and a Selective Modulator of Chloride Channels for the Treatment of Addiction to or Dependence on Medicines/Drugs or Nervous System Disorders |
| US9283212B2 (en) | 2009-02-20 | 2016-03-15 | Palmaya Pty Ltd | Pharmaceutical preparation and delivery system |
| US8387589B2 (en) * | 2009-04-29 | 2013-03-05 | Marine Canada Acqusition Inc. | Position sensor for an output shaft used in a shift and throttle system |
| US20100280684A1 (en) * | 2009-04-29 | 2010-11-04 | Pierre Garon | Synchronization of shift and throttle controls in a marine vessel |
| US8930050B2 (en) * | 2009-04-29 | 2015-01-06 | Marine Canada Acquisition Inc. | Method and system for increasing or decreasing engine throttle in a marine vessel |
| US8347859B2 (en) * | 2009-04-29 | 2013-01-08 | Marine Canada Acquisition Inc. | Automatic throttle calibration in a marine vessel |
| US8406944B2 (en) * | 2010-02-10 | 2013-03-26 | Pierre Garon | Control system and method for starting and stopping marine engines |
| US8845490B2 (en) | 2010-02-10 | 2014-09-30 | Marine Canada Acquisition Inc. | Method and system for delaying shift and throttle commands based on engine speed in a marine vessel |
| US8182396B2 (en) * | 2010-02-10 | 2012-05-22 | Marine Canada Acquisition In.c | Method and system for delaying shift and throttle commands based on engine speed in a marine vessel |
| ES2702848T3 (es) | 2011-02-23 | 2019-03-05 | Coeruleus Ltd | Complejos de flumazenil, composiciones que los comprenden y usos de los mismos |
| RU2468799C1 (ru) * | 2011-08-03 | 2012-12-10 | Общество с ограниченной ответственностью "Урал Крафт" | Способ купирования алкогольного абстинентного синдрома посредством блокады бензодиазепиновых рецепторов |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316893A (en) * | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
| US5519017A (en) * | 1990-03-29 | 1996-05-21 | Lts Lohmann Therapie-Systeme Gmbh + Co. Kg | Pharmaceutic formulation for the treatment of alcoholism |
| SE9100860D0 (sv) * | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | New use |
| GB9420010D0 (en) * | 1994-10-01 | 1994-11-16 | Marck Sharp & Dohme Limited | Nucleic acids |
| US20030176456A1 (en) * | 2001-12-21 | 2003-09-18 | June Harry L. | Methods for reducing alcohol cravings in chronic alcoholics |
| US6740677B2 (en) * | 2002-08-19 | 2004-05-25 | Hong Xue | Methods of treating benzodiazepine site (BZD-S) associated syndromes using 2′ hydroxyflavonoids |
-
2002
- 2002-01-10 KR KR1020037009461A patent/KR100712570B1/ko not_active Expired - Fee Related
- 2002-01-10 PT PT02716090T patent/PT1374952E/pt unknown
- 2002-01-10 DE DE60214527T patent/DE60214527T2/de not_active Expired - Lifetime
- 2002-01-10 ZA ZA200305922A patent/ZA200305922B/en unknown
- 2002-01-10 RU RU2003125274/15A patent/RU2300378C2/ru not_active IP Right Cessation
- 2002-01-10 BR BR0206549-5A patent/BR0206549A/pt not_active Application Discontinuation
- 2002-01-10 EP EP02716090A patent/EP1374952B1/en not_active Expired - Lifetime
- 2002-01-10 DK DK02716090T patent/DK1374952T3/da active
- 2002-01-10 JP JP2002557469A patent/JP2004519461A/ja active Pending
- 2002-01-10 CN CNA028038029A patent/CN1486205A/zh active Pending
- 2002-01-10 AT AT02716090T patent/ATE338575T1/de active
- 2002-01-10 NZ NZ539400A patent/NZ539400A/en not_active IP Right Cessation
- 2002-01-10 MX MXPA03006411A patent/MXPA03006411A/es active IP Right Grant
- 2002-01-10 AU AU2002226427A patent/AU2002226427B2/en not_active Ceased
- 2002-01-10 CA CA002433833A patent/CA2433833C/en not_active Expired - Fee Related
- 2002-01-10 WO PCT/ES2002/000008 patent/WO2002056964A1/es not_active Ceased
- 2002-01-10 NZ NZ527583A patent/NZ527583A/xx not_active IP Right Cessation
- 2002-01-10 IL IL15679802A patent/IL156798A0/xx unknown
- 2002-01-10 ES ES02716090T patent/ES2269661T3/es not_active Expired - Lifetime
- 2002-10-01 UA UA2003087768A patent/UA78199C2/uk unknown
-
2003
- 2003-07-15 US US10/621,229 patent/US7348321B2/en not_active Expired - Lifetime
- 2003-08-06 CR CR7049A patent/CR7049A/es unknown
-
2006
- 2006-11-14 CY CY20061101651T patent/CY1107500T1/el unknown
-
2008
- 2008-02-06 US US12/026,643 patent/US20080132492A1/en not_active Abandoned
- 2008-04-28 JP JP2008116697A patent/JP2008201796A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20040092509A1 (en) | 2004-05-13 |
| KR20040020046A (ko) | 2004-03-06 |
| PT1374952E (pt) | 2006-12-29 |
| KR100712570B1 (ko) | 2007-05-02 |
| NZ539400A (en) | 2006-04-28 |
| RU2003125274A (ru) | 2005-01-20 |
| EP1374952B1 (en) | 2006-09-06 |
| UA78199C2 (en) | 2007-03-15 |
| AU2002226427B2 (en) | 2006-11-16 |
| ZA200305922B (en) | 2004-08-02 |
| JP2008201796A (ja) | 2008-09-04 |
| MXPA03006411A (es) | 2004-12-02 |
| CR7049A (es) | 2008-02-20 |
| DE60214527T2 (de) | 2007-04-05 |
| DE60214527D1 (de) | 2006-10-19 |
| CN1486205A (zh) | 2004-03-31 |
| HK1061661A1 (en) | 2004-09-30 |
| US20080132492A1 (en) | 2008-06-05 |
| DK1374952T3 (da) | 2007-01-02 |
| EP1374952A1 (en) | 2004-01-02 |
| RU2300378C2 (ru) | 2007-06-10 |
| JP2004519461A (ja) | 2004-07-02 |
| NZ527583A (en) | 2006-03-31 |
| IL156798A0 (en) | 2004-02-08 |
| CA2433833A1 (en) | 2002-07-25 |
| CY1107500T1 (el) | 2013-03-13 |
| BR0206549A (pt) | 2004-02-25 |
| CA2433833C (en) | 2009-06-02 |
| WO2002056964A1 (es) | 2002-07-25 |
| US7348321B2 (en) | 2008-03-25 |
| ATE338575T1 (de) | 2006-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2269661T3 (es) | El uso de flumazenil en el desarrollo de un farmaco para el tratamiento de dependencia del alcohol. | |
| BR112020012473A2 (pt) | escetamina para o tratamento da depressão | |
| BR112012003730A2 (pt) | terapia com acetato de glatirâmer de baixa frequência | |
| JP2008201799A (ja) | コカイン依存症治療用薬剤 | |
| JP2004519461A5 (https=) | ||
| CN105358160A (zh) | 亚硝酸盐的药物制剂及其用途 | |
| CN109528626A (zh) | 鼻内较低剂量强度睾酮凝胶制剂及其用于治疗性快感缺失病或性欲减退疾患的应用 | |
| US20070142266A1 (en) | Combination comprising a P-gp inhibitor and an anti-epileptic drug | |
| Safarinejad | Midodrine for the treatment of organic anejaculation but not spinal cord injury: a prospective randomized placebo-controlled double-blind clinical study | |
| JP2004521904A5 (https=) | ||
| Greenblatt et al. | Pharmacokinetics of benzodiazepine hypnotics | |
| US20230372364A1 (en) | Method of treating gaba mediated disorders | |
| AU2006246490B2 (en) | Use of flumazenil in developing a drug for the treatment of alcohol dependence | |
| Kyomen | The use of levetiracetam to decrease mania in elderly bipolar patients | |
| HK1061661B (en) | Use of flumazenil in developing a drug for the treatment of alcohol dependence | |
| ES2289935B1 (es) | Empleo de flumazenilo en la elaboracion de un medicamento para el tratamiento de la patologia depresiva. | |
| Hemank et al. | BUPROPION TOXICITY: AN OVERVIEW | |
| Rajagopal | Nocebo effect | |
| Barclay | The Geriatric Population | |
| Renner Jr et al. | 16 Drug Addiction | |
| Madeira et al. | Late-Onset Bipolar Disorder | |
| AU2006200922A1 (en) | Use of flumazenil to produce a medicament for the treatment of cocaine dependency |