JP2004521904A5 - - Google Patents
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- Publication number
- JP2004521904A5 JP2004521904A5 JP2002564005A JP2002564005A JP2004521904A5 JP 2004521904 A5 JP2004521904 A5 JP 2004521904A5 JP 2002564005 A JP2002564005 A JP 2002564005A JP 2002564005 A JP2002564005 A JP 2002564005A JP 2004521904 A5 JP2004521904 A5 JP 2004521904A5
- Authority
- JP
- Japan
- Prior art keywords
- flumazenil
- medicament
- cocaine dependence
- administered
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 99
- OFBIFZUFASYYRE-UHFFFAOYSA-N flumazenil Chemical compound C1N(C)C(=O)C2=CC(F)=CC=C2N2C=NC(C(=O)OCC)=C21 OFBIFZUFASYYRE-UHFFFAOYSA-N 0.000 claims description 91
- 229960004381 flumazenil Drugs 0.000 claims description 91
- 208000022497 Cocaine-Related disease Diseases 0.000 claims description 79
- 201000006145 cocaine dependence Diseases 0.000 claims description 78
- 206010013663 drug dependence Diseases 0.000 claims description 78
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 58
- 229940079593 drug Drugs 0.000 claims description 39
- 238000011282 treatment Methods 0.000 claims description 39
- 229960003920 cocaine Drugs 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 9
- 206010039897 Sedation Diseases 0.000 claims description 6
- 230000036280 sedation Effects 0.000 claims description 6
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical group CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 229960004414 clomethiazole Drugs 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims description 4
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 3
- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 claims description 3
- 229960002464 fluoxetine Drugs 0.000 claims description 3
- 238000007911 parenteral administration Methods 0.000 claims description 3
- 229960004526 piracetam Drugs 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 235000019156 vitamin B Nutrition 0.000 claims description 3
- 239000011720 vitamin B Substances 0.000 claims description 3
- 229940046001 vitamin b complex Drugs 0.000 claims description 3
- 229940024606 amino acid Drugs 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 229960002563 disulfiram Drugs 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 7
- 206010048010 Withdrawal syndrome Diseases 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 229940049706 benzodiazepine Drugs 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 150000001557 benzodiazepines Chemical class 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 3
- 229960004134 propofol Drugs 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 2
- 229960003805 amantadine Drugs 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 229960002802 bromocriptine Drugs 0.000 description 2
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 238000011458 pharmacological treatment Methods 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 241001539473 Euphoria Species 0.000 description 1
- 206010015535 Euphoric mood Diseases 0.000 description 1
- 102000004300 GABA-A Receptors Human genes 0.000 description 1
- 108090000839 GABA-A Receptors Proteins 0.000 description 1
- 102000017934 GABA-B receptor Human genes 0.000 description 1
- 108060003377 GABA-B receptor Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- RMUCZJUITONUFY-UHFFFAOYSA-N Phenelzine Chemical compound NNCCC1=CC=CC=C1 RMUCZJUITONUFY-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 1
- 229960001058 bupropion Drugs 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229960004205 carbidopa Drugs 0.000 description 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- NJMYODHXAKYRHW-DVZOWYKESA-N cis-flupenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C2/1 NJMYODHXAKYRHW-DVZOWYKESA-N 0.000 description 1
- 201000001272 cocaine abuse Diseases 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960003914 desipramine Drugs 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940052760 dopamine agonists Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 208000028327 extreme fatigue Diseases 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 229940083609 fluoxetine 20 mg Drugs 0.000 description 1
- 229960002419 flupentixol Drugs 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000013101 initial test Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000007449 liver function test Methods 0.000 description 1
- -1 maprolitin Chemical compound 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 229960001797 methadone Drugs 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 229960004851 pergolide Drugs 0.000 description 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960000964 phenelzine Drugs 0.000 description 1
- 229940088697 piracetam 800 mg Drugs 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 230000003304 psychophysiological effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200100342 | 2001-02-15 | ||
| PCT/ES2002/000061 WO2002064213A1 (es) | 2001-02-15 | 2002-02-08 | Empleo de flumazenilo en la elaboracion de un medicamento para el tratamiento de la dependencia de cocaina |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008117980A Division JP2008201799A (ja) | 2001-02-15 | 2008-04-30 | コカイン依存症治療用薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004521904A JP2004521904A (ja) | 2004-07-22 |
| JP2004521904A5 true JP2004521904A5 (https=) | 2008-06-26 |
| JP4272885B2 JP4272885B2 (ja) | 2009-06-03 |
Family
ID=8496743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002564005A Expired - Lifetime JP4272885B2 (ja) | 2001-02-15 | 2002-02-08 | コカイン依存症治療用薬剤 |
| JP2008117980A Pending JP2008201799A (ja) | 2001-02-15 | 2008-04-30 | コカイン依存症治療用薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008117980A Pending JP2008201799A (ja) | 2001-02-15 | 2008-04-30 | コカイン依存症治療用薬剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7186711B2 (https=) |
| EP (1) | EP1378267B1 (https=) |
| JP (2) | JP4272885B2 (https=) |
| KR (1) | KR100712571B1 (https=) |
| CN (1) | CN1327843C (https=) |
| AT (1) | ATE363923T1 (https=) |
| AU (1) | AU2002231811B2 (https=) |
| BR (1) | BR0207866A (https=) |
| CA (1) | CA2436511C (https=) |
| CY (1) | CY1106845T1 (https=) |
| DE (1) | DE60220512T2 (https=) |
| DK (1) | DK1378267T3 (https=) |
| ES (1) | ES2287255T3 (https=) |
| IL (1) | IL157144A0 (https=) |
| MX (1) | MXPA03007281A (https=) |
| NZ (1) | NZ528164A (https=) |
| PT (1) | PT1378267E (https=) |
| RU (1) | RU2322985C2 (https=) |
| UA (1) | UA79586C2 (https=) |
| WO (1) | WO2002064213A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050192271A1 (en) * | 2003-07-15 | 2005-09-01 | Hythiam, Inc. | Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse |
| CA2436511C (en) * | 2001-02-15 | 2009-08-04 | Juan Jose Legarda Ibanez | Use of flumazenil to produce a medicament for the treatment of cocaine dependency |
| JP2008538748A (ja) | 2005-04-07 | 2008-11-06 | ハイシアム， インコーポレイテッド | 不安、物質乱用及び依存の予防のための改良型方法及び組成物 |
| US7855196B2 (en) | 2005-08-22 | 2010-12-21 | Pierre Mainville | Composition comprising a benzodiazepine agonist and a benzodiazepine antagonist |
| ES2289935B1 (es) * | 2006-07-14 | 2008-12-16 | Juan Jose Legarda Ibañez | Empleo de flumazenilo en la elaboracion de un medicamento para el tratamiento de la patologia depresiva. |
| US20110034442A1 (en) * | 2007-08-08 | 2011-02-10 | Jaun Jose Legarda Ibanez | Use and Methods of Use for an Antagonist of the Serotin3 Receptor (5-HT3) and a Selective Modulator of Chloride Channels for the Treatment of Addiction to or Dependence on Medicines/Drugs or Nervous System Disorders |
| US9396280B2 (en) * | 2008-06-23 | 2016-07-19 | Microsoft Technology Licensing, Llc | Command driven web site browsing |
| ES2702848T3 (es) | 2011-02-23 | 2019-03-05 | Coeruleus Ltd | Complejos de flumazenil, composiciones que los comprenden y usos de los mismos |
| US9308616B2 (en) | 2013-01-21 | 2016-04-12 | Innovative Finishes LLC | Refurbished component, electronic device including the same, and method of refurbishing a component of an electronic device |
| WO2015054730A1 (en) * | 2013-10-14 | 2015-04-23 | Palmaya Pty Ltd | Compositions and methods of administering same |
| CN107115359A (zh) * | 2016-02-24 | 2017-09-01 | 郑恩哲 | 阻断海洛因或吗啡毒品中毒路径的点滴处方及其应用 |
| EP3661500B1 (en) | 2017-07-31 | 2026-01-07 | Novartis AG | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028611A (en) * | 1989-06-29 | 1991-07-02 | The Regents Of The University Of Minnesota | Treatment for cocaine use |
| SE9100860D0 (sv) * | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | New use |
| US5229120A (en) * | 1992-02-05 | 1993-07-20 | Devincent James F | Treatment for cocaine abuse |
| GB9225859D0 (en) * | 1992-12-11 | 1993-02-03 | Smithkline Beecham Plc | Novel treatment |
| GB9420010D0 (en) | 1994-10-01 | 1994-11-16 | Marck Sharp & Dohme Limited | Nucleic acids |
| EP1133299A1 (en) * | 1998-11-23 | 2001-09-19 | Sepracor Inc. | 2-hydroxymethylolanzapine compositions and methods |
| EP1125579A3 (en) * | 2000-01-18 | 2003-01-02 | Pfizer Products Inc. | Uses of agrp-melanocortin receptor binding modulating compounds |
| CA2436511C (en) | 2001-02-15 | 2009-08-04 | Juan Jose Legarda Ibanez | Use of flumazenil to produce a medicament for the treatment of cocaine dependency |
| US6740677B2 (en) | 2002-08-19 | 2004-05-25 | Hong Xue | Methods of treating benzodiazepine site (BZD-S) associated syndromes using 2′ hydroxyflavonoids |
-
2002
- 2002-02-08 CA CA002436511A patent/CA2436511C/en not_active Expired - Fee Related
- 2002-02-08 WO PCT/ES2002/000061 patent/WO2002064213A1/es not_active Ceased
- 2002-02-08 PT PT02711879T patent/PT1378267E/pt unknown
- 2002-02-08 MX MXPA03007281A patent/MXPA03007281A/es active IP Right Grant
- 2002-02-08 JP JP2002564005A patent/JP4272885B2/ja not_active Expired - Lifetime
- 2002-02-08 ES ES02711879T patent/ES2287255T3/es not_active Expired - Lifetime
- 2002-02-08 BR BR0207866-0A patent/BR0207866A/pt not_active Application Discontinuation
- 2002-02-08 NZ NZ528164A patent/NZ528164A/xx unknown
- 2002-02-08 EP EP02711879A patent/EP1378267B1/en not_active Expired - Lifetime
- 2002-02-08 CN CNB028049411A patent/CN1327843C/zh not_active Expired - Fee Related
- 2002-02-08 AU AU2002231811A patent/AU2002231811B2/en not_active Ceased
- 2002-02-08 AT AT02711879T patent/ATE363923T1/de active
- 2002-02-08 KR KR1020037010718A patent/KR100712571B1/ko not_active Expired - Fee Related
- 2002-02-08 DK DK02711879T patent/DK1378267T3/da active
- 2002-02-08 IL IL15714402A patent/IL157144A0/xx unknown
- 2002-02-08 DE DE60220512T patent/DE60220512T2/de not_active Expired - Lifetime
- 2002-02-08 RU RU2003127718/15A patent/RU2322985C2/ru not_active IP Right Cessation
- 2002-08-02 UA UA2003098460A patent/UA79586C2/uk unknown
-
2003
- 2003-07-15 US US10/622,068 patent/US7186711B2/en not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/615,460 patent/US20070142364A1/en not_active Abandoned
-
2007
- 2007-09-05 CY CY20071101148T patent/CY1106845T1/el unknown
-
2008
- 2008-04-30 JP JP2008117980A patent/JP2008201799A/ja active Pending
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