ES2267546T3 - Agentes anestesicos dermicos. - Google Patents

Agentes anestesicos dermicos. Download PDF

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Publication number
ES2267546T3
ES2267546T3 ES00941227T ES00941227T ES2267546T3 ES 2267546 T3 ES2267546 T3 ES 2267546T3 ES 00941227 T ES00941227 T ES 00941227T ES 00941227 T ES00941227 T ES 00941227T ES 2267546 T3 ES2267546 T3 ES 2267546T3
Authority
ES
Spain
Prior art keywords
compound
hydrogen
formula
radical
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00941227T
Other languages
English (en)
Spanish (es)
Inventor
A. K. Gunnar Aberg
George L. Wright
Jan L. Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bridge Pharma Inc
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Application granted granted Critical
Publication of ES2267546T3 publication Critical patent/ES2267546T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES00941227T 1999-06-10 2000-06-06 Agentes anestesicos dermicos. Expired - Lifetime ES2267546T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13835399P 1999-06-10 1999-06-10
US138353P 1999-06-10
US17926700P 2000-01-31 2000-01-31
US179267P 2000-01-31

Publications (1)

Publication Number Publication Date
ES2267546T3 true ES2267546T3 (es) 2007-03-16

Family

ID=26836123

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00941227T Expired - Lifetime ES2267546T3 (es) 1999-06-10 2000-06-06 Agentes anestesicos dermicos.

Country Status (18)

Country Link
US (1) US6413987B1 (enExample)
EP (1) EP1185267B1 (enExample)
JP (1) JP2003501469A (enExample)
CN (1) CN1355700A (enExample)
AT (1) ATE335482T1 (enExample)
AU (1) AU777517B2 (enExample)
BR (1) BR0011028A (enExample)
CA (1) CA2376819C (enExample)
CY (1) CY1105721T1 (enExample)
DE (1) DE60029954T2 (enExample)
DK (1) DK1185267T3 (enExample)
ES (1) ES2267546T3 (enExample)
IL (2) IL146190A0 (enExample)
MX (1) MXPA01012632A (enExample)
NO (1) NO323856B1 (enExample)
NZ (1) NZ515143A (enExample)
PT (1) PT1185267E (enExample)
WO (1) WO2000076510A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1321139T3 (da) * 2001-12-21 2007-01-02 Chiesi Farma Spa 2-indanylaminoderivater til behandling af kronisk, akut eller inflammatorisk smerte
RU2343145C2 (ru) 2002-11-26 2009-01-10 Маруиси Фармасьютикал Ко., Лтд. Производные изоиндолина
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
WO2006036936A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
US20090137628A1 (en) * 2005-09-23 2009-05-28 Bridge Pharma, Inc. Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain
US20110218218A1 (en) * 2005-09-23 2011-09-08 Bridge Pharma, Inc. Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain
US7592458B2 (en) * 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
CN107661293A (zh) * 2008-01-22 2018-02-06 得克萨斯大学体系董事会 用于局部麻醉和/或疼痛缓解的含有萃取溶剂的挥发性麻醉剂组合物
KR102014203B1 (ko) * 2011-02-18 2019-08-26 아사나 바이오사이언시스 엘엘씨 아미노인단 화합물 및 통증 치료에서 그것의 용도
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
CA2853279C (en) 2011-10-24 2021-03-23 Endo Pharmaceuticals Inc. Cyclohexylamines
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
US20170296484A1 (en) 2015-11-23 2017-10-19 Grace Therapeutics Llc Topical Film-Forming Spray
EA202191506A1 (ru) 2018-12-19 2021-10-08 Нортик Холдингз Инк. Терапевтическая композиция интраназального лидокаина

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760018A (fr) * 1969-12-19 1971-06-08 Christiaens Sa A Nouveau derives du 2-amino-indane, leur preparation et leur utilisation
US3923813A (en) 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
AR206505A1 (es) * 1972-09-18 1976-07-30 Christiaens Sa A Procedimiento para obtener nuevos derivados de n-fenil-n-aminoalquil-2-aminoindano
ZA738419B (en) * 1972-11-06 1974-09-25 Christiaens Sa A New derivatives of 2-aminoindane,the preparation and use thereof
GB1462036A (en) 1973-02-05 1977-01-19 Manuf Prod Pharma Aminoindane derivatives
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes

Also Published As

Publication number Publication date
IL146190A0 (en) 2002-07-25
EP1185267A1 (en) 2002-03-13
WO2000076510A9 (en) 2002-07-04
DE60029954D1 (de) 2006-09-21
NO323856B1 (no) 2007-07-16
CA2376819C (en) 2008-09-02
BR0011028A (pt) 2002-02-19
NO20016037L (no) 2002-02-11
NZ515143A (en) 2004-05-28
US6413987B1 (en) 2002-07-02
WO2000076510A1 (en) 2000-12-21
AU777517B2 (en) 2004-10-21
JP2003501469A (ja) 2003-01-14
NO20016037D0 (no) 2001-12-10
PT1185267E (pt) 2006-12-29
EP1185267A4 (en) 2003-09-03
DK1185267T3 (da) 2006-12-11
MXPA01012632A (es) 2004-03-19
ATE335482T1 (de) 2006-09-15
CN1355700A (zh) 2002-06-26
DE60029954T2 (de) 2007-03-08
CY1105721T1 (el) 2010-12-22
EP1185267B1 (en) 2006-08-09
CA2376819A1 (en) 2000-12-21
IL146190A (en) 2008-11-03
AU5596300A (en) 2001-01-02

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