AU777517B2 - Dermal anesthetic agents - Google Patents

Dermal anesthetic agents Download PDF

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Publication number
AU777517B2
AU777517B2 AU55963/00A AU5596300A AU777517B2 AU 777517 B2 AU777517 B2 AU 777517B2 AU 55963/00 A AU55963/00 A AU 55963/00A AU 5596300 A AU5596300 A AU 5596300A AU 777517 B2 AU777517 B2 AU 777517B2
Authority
AU
Australia
Prior art keywords
formula
group
hydrogen
anesthesia
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU55963/00A
Other languages
English (en)
Other versions
AU5596300A (en
Inventor
A. K. Gunnar Aberg
Jan L. Chen
George L. Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bridge Pharma Inc
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Publication of AU5596300A publication Critical patent/AU5596300A/en
Application granted granted Critical
Publication of AU777517B2 publication Critical patent/AU777517B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU55963/00A 1999-06-10 2000-06-06 Dermal anesthetic agents Ceased AU777517B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13835399P 1999-06-10 1999-06-10
US60/138353 1999-06-10
US17926700P 2000-01-31 2000-01-31
US60/179267 2000-01-31
PCT/US2000/015490 WO2000076510A1 (en) 1999-06-10 2000-06-06 Dermal anesthetic agents

Publications (2)

Publication Number Publication Date
AU5596300A AU5596300A (en) 2001-01-02
AU777517B2 true AU777517B2 (en) 2004-10-21

Family

ID=26836123

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55963/00A Ceased AU777517B2 (en) 1999-06-10 2000-06-06 Dermal anesthetic agents

Country Status (18)

Country Link
US (1) US6413987B1 (enExample)
EP (1) EP1185267B1 (enExample)
JP (1) JP2003501469A (enExample)
CN (1) CN1355700A (enExample)
AT (1) ATE335482T1 (enExample)
AU (1) AU777517B2 (enExample)
BR (1) BR0011028A (enExample)
CA (1) CA2376819C (enExample)
CY (1) CY1105721T1 (enExample)
DE (1) DE60029954T2 (enExample)
DK (1) DK1185267T3 (enExample)
ES (1) ES2267546T3 (enExample)
IL (2) IL146190A0 (enExample)
MX (1) MXPA01012632A (enExample)
NO (1) NO323856B1 (enExample)
NZ (1) NZ515143A (enExample)
PT (1) PT1185267E (enExample)
WO (1) WO2000076510A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1321139E (pt) * 2001-12-21 2007-01-31 Chiesi Farma Spa Derivados de 2-indanilamino para a terapêutica da cor crónica
CN100548980C (zh) 2002-11-26 2009-10-14 丸石制药株式会社 异吲哚啉衍生物
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
CA2622418A1 (en) * 2005-09-23 2007-04-05 Bridge Pharma, Inc. Indanylamines and their use for local anesthesia and chronic pain
US20110218218A1 (en) * 2005-09-23 2011-09-08 Bridge Pharma, Inc. Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
CA2712731C (en) 2008-01-22 2016-05-03 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
CA2826648C (en) * 2011-02-18 2019-06-04 Endo Pharmaceuticals Inc. Aminoindane compounds and use thereof in treating pain
JP6130383B2 (ja) 2011-09-30 2017-05-17 エンドゥ ファーマシューティカルズ，インコーポレイティド ピリジン誘導体
ES2596215T3 (es) 2011-10-24 2017-01-05 Asana Biosciences, Llc Ciclohexilaminas
WO2014028675A1 (en) * 2012-08-15 2014-02-20 Endo Pharmaceuticals Inc. Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
US20170296484A1 (en) 2015-11-23 2017-10-19 Grace Therapeutics Llc Topical Film-Forming Spray
AU2019403903A1 (en) 2018-12-19 2021-06-24 Acasti Pharma U.S., Inc. Therapeutic composition of intranasal lidocaine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923887A (en) * 1973-02-05 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindane, the preparation and use thereof
US3923815A (en) * 1972-11-06 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindane thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760018A (fr) * 1969-12-19 1971-06-08 Christiaens Sa A Nouveau derives du 2-amino-indane, leur preparation et leur utilisation
US3923813A (en) 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
AR206505A1 (es) * 1972-09-18 1976-07-30 Christiaens Sa A Procedimiento para obtener nuevos derivados de n-fenil-n-aminoalquil-2-aminoindano
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923815A (en) * 1972-11-06 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindane thereof
US3923887A (en) * 1973-02-05 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindane, the preparation and use thereof

Also Published As

Publication number Publication date
ES2267546T3 (es) 2007-03-16
DE60029954T2 (de) 2007-03-08
MXPA01012632A (es) 2004-03-19
NO20016037L (no) 2002-02-11
CA2376819A1 (en) 2000-12-21
WO2000076510A9 (en) 2002-07-04
ATE335482T1 (de) 2006-09-15
JP2003501469A (ja) 2003-01-14
CA2376819C (en) 2008-09-02
AU5596300A (en) 2001-01-02
DE60029954D1 (de) 2006-09-21
NO323856B1 (no) 2007-07-16
IL146190A0 (en) 2002-07-25
NO20016037D0 (no) 2001-12-10
BR0011028A (pt) 2002-02-19
PT1185267E (pt) 2006-12-29
CN1355700A (zh) 2002-06-26
IL146190A (en) 2008-11-03
WO2000076510A1 (en) 2000-12-21
CY1105721T1 (el) 2010-12-22
DK1185267T3 (da) 2006-12-11
EP1185267B1 (en) 2006-08-09
NZ515143A (en) 2004-05-28
US6413987B1 (en) 2002-07-02
EP1185267A1 (en) 2002-03-13
EP1185267A4 (en) 2003-09-03

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